Epigenetics Of Aging And Longevity

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Epigenetics of Aging and Longevity

Alexey Moskalev,Alexander M. Vaiserman
Epigenetics of Aging and Longevity Book PDF

Author : Alexey Moskalev,Alexander M. Vaiserman
Publisher : Academic Press
Page : 544 pages
File Size : 47,5 Mb
Release : 2017-11-17
Category : Medical
ISBN : 9780128110836

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Epigenetics of Aging and Longevity by Alexey Moskalev,Alexander M. Vaiserman Pdf

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Epigenetics of Aging

Trygve O. Tollefsbol
Epigenetics of Aging Book PDF

Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
Page : 469 pages
File Size : 51,5 Mb
Release : 2009-11-11
Category : Medical
ISBN : 9781441906397

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Epigenetics of Aging by Trygve O. Tollefsbol Pdf

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Longevity Genes

Gil Atzmon, PhD
Longevity Genes Book PDF

Author : Gil Atzmon, PhD
Publisher : Springer
Page : 194 pages
File Size : 50,9 Mb
Release : 2015-04-27
Category : Medical
ISBN : 9781493924042

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Longevity Genes by Gil Atzmon, PhD Pdf

The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.

Nutrition, Exercise and Epigenetics: Ageing Interventions

Byung Pal Yu
Nutrition Exercise and Epigenetics Ageing Interventions Book PDF

Author : Byung Pal Yu
Publisher : Springer
Page : 278 pages
File Size : 44,7 Mb
Release : 2015-02-11
Category : Medical
ISBN : 9783319148304

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Nutrition, Exercise and Epigenetics: Ageing Interventions by Byung Pal Yu Pdf

This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena. Among the highlights are chapter-length discussion of such topics as: how anti-inflammatory action of calorie restriction underlies the retardation of ageing and age-related diseases (Chapter 3); epigenetic modification of gene expression by exercise (Chapter 5); the role of functional foods and their bioactive components in bone health (Chapter 8); and an account of the first decade of a study of calorie restriction in nonhuman primates, conducted by the National Institute on Ageing.

Epigenetics and Human Longevity

Healthspan Institute
Epigenetics and Human Longevity Book PDF

Author : Healthspan Institute
Publisher : Independently Published
Page : 0 pages
File Size : 50,9 Mb
Release : 2023-10-31
Category : Electronic
ISBN : 9798866070077

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Epigenetics and Human Longevity by Healthspan Institute Pdf

"Epigenetics and Human Longevity" delves into the intricate world of epigenetics, the study of heritable changes that don't alter the DNA sequence but influence gene activity. Beginning with a foundational understanding, the book explores the dynamic nature of the epigenome and its profound implications for aging. Readers are introduced to the revolutionary concept of the epigenetic clock, revealing how lifestyle choices such as diet, exercise, and even stress can influence our biological versus chronological age. The book also dives deep into the potential of caloric restriction and its molecular mechanisms in extending lifespan. Pivotal discussions on histone modifications, transgenerational epigenetic inheritance, and the implications of epigenetic changes in age-related diseases provide comprehensive insights. The text concludes with a forward-looking examination of epigenetic therapies, the potential of pharmacology in longevity, and the ethical considerations therein, making it a holistic resource for understanding the nexus between epigenetics and human aging.

Lifespan

David A. Sinclair,Matthew D. LaPlante
Lifespan Book PDF

Author : David A. Sinclair,Matthew D. LaPlante
Publisher : Atria Books
Page : 432 pages
File Size : 41,8 Mb
Release : 2019-09-10
Category : Science
ISBN : 9781501191978

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Lifespan by David A. Sinclair,Matthew D. LaPlante Pdf

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Environmental Epigenetics

L. Joseph Su,Tung-chin Chiang
Environmental Epigenetics Book PDF

Author : L. Joseph Su,Tung-chin Chiang
Publisher : Springer
Page : 321 pages
File Size : 49,6 Mb
Release : 2015-05-18
Category : Medical
ISBN : 9781447166788

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Environmental Epigenetics by L. Joseph Su,Tung-chin Chiang Pdf

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Senescence

Jolanta Dorszewska,Wojciech Kozubski
Senescence Book PDF

Author : Jolanta Dorszewska,Wojciech Kozubski
Publisher : BoD – Books on Demand
Page : 167 pages
File Size : 55,6 Mb
Release : 2017-08-30
Category : Medical
ISBN : 9789535134619

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Senescence by Jolanta Dorszewska,Wojciech Kozubski Pdf

In the second half of the twentieth century, life expectancy was prolonged, and the number of elderly people increased. The effect of population aging increases in the frequency of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, epilepsy, and stroke. Also, a higher incidence of infections, autoimmune diseases, and malignant cancers is observed in elderly people. The aging process is difficult to define. Are physiological changes in elderly people controlled by specific genes? Is aging process a pathophysiology affecting different organs with different severity? Finding answers to these questions may help prevent age-related diseases and improve the quality of life of old people. This book was made as a compendium on contemporary challenges in senescence.

Aging and Health - A Systems Biology Perspective

A.I. Yashin,S.M. Jazwinski
Aging and Health A Systems Biology Perspective Book PDF

Author : A.I. Yashin,S.M. Jazwinski
Publisher : Karger Medical and Scientific Publishers
Page : 206 pages
File Size : 41,7 Mb
Release : 2014-10-09
Category : Science
ISBN : 9783318027303

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Aging and Health - A Systems Biology Perspective by A.I. Yashin,S.M. Jazwinski Pdf

Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.

Lifespan

David Sinclair,Matthew D. Laplante
Lifespan Book PDF

Author : David Sinclair,Matthew D. Laplante
Publisher : Unknown
Page : 0 pages
File Size : 41,6 Mb
Release : 2019-09-10
Category : Electronic
ISBN : 1982135875

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Lifespan by David Sinclair,Matthew D. Laplante Pdf

It's a seemingly undeniable truth that aging is inevitable. But what if everything we've been taught to believe about aging is wrong? As Dr. David Sinclair, a leading world authority on genetics and longevity, reveals in this groundbreaking book, Aging is a disease, and that disease is treatable. This eye-opening and provocative work takes us to the front lines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs-many from Dr. David Sinclair's own lab at Harvard-that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and pivotal to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger but actually become younger. Through page-turning narrative, Dr. Sinclair invites the reader into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes that have been shown to help us live younger and healthier for longer. At once a road map for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it. Book jacket.

Anti-aging Drugs

Alexander M Vaiserman
Anti aging Drugs Book PDF

Author : Alexander M Vaiserman
Publisher : Royal Society of Chemistry
Page : 570 pages
File Size : 47,6 Mb
Release : 2017-01-18
Category : Medical
ISBN : 9781782629856

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Anti-aging Drugs by Alexander M Vaiserman Pdf

Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.

Biomarkers of Human Aging

Alexey Moskalev
Biomarkers of Human Aging Book PDF

Author : Alexey Moskalev
Publisher : Unknown
Page : 421 pages
File Size : 44,9 Mb
Release : 2019
Category : Aging
ISBN : 3030249727

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Biomarkers of Human Aging by Alexey Moskalev Pdf

This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the "epigenetic clock," as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.

Molecular Basis of Nutrition and Aging

Marco Malavolta,Eugenio Mocchegiani
Molecular Basis of Nutrition and Aging Book PDF

Author : Marco Malavolta,Eugenio Mocchegiani
Publisher : Academic Press
Page : 784 pages
File Size : 46,7 Mb
Release : 2016-04-15
Category : Science
ISBN : 9780128018279

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Molecular Basis of Nutrition and Aging by Marco Malavolta,Eugenio Mocchegiani Pdf

Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging Explores how nutritional factors are involved in the pathogenesis of aging across body systems Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition

Lifespan

David A. Sinclair,Matthew D. LaPlante
Lifespan Book PDF

Author : David A. Sinclair,Matthew D. LaPlante
Publisher : Unknown
Page : 406 pages
File Size : 41,5 Mb
Release : 2019
Category : Aging
ISBN : 0008380325

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Lifespan by David A. Sinclair,Matthew D. LaPlante Pdf

From an acclaimed Harvard professor and one of Time's most influential people, this paradigm-shifting book shows how almost everything we think we know about aging is wrong, offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls readers to consider a future where aging can be treated. For decades, experts have believed that we are at the mercy of our genes, and that natural damage to our genes--the kind that inevitably happens as we get older--makes us become sick and grow old. But what if everything you think you know about aging is wrong? What if aging is a disease--and that disease is treatable? In Lifespan, one of the world's foremost experts on aging and genetics reveals a groundbreaking new theory that will forever change the way we think about why we age and what we can do about it. Aging isn't immutable; we can have far more control over it than we realize. This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs--many from Dr. David Sinclair's own lab--that demonstrate how we can slow down, or even reverse, the genetic clock. The key is activating newly discovered vitality genes--the decedents of an ancient survival circuit that is both the cause of aging and the key to reversing it. Dr. Sinclair shares the emerging technologies and simple lifestyle changes--such as intermittent fasting, cold exposure, and exercising with the right intensity--that have been shown to help lead to longer lives. Lifespan provides a roadmap for taking charge of our own health destiny and a bold new vision for the future when humankind is able to live to be 100 years young.

Clinical Genetics and Genomics of Aging

Juan Carlos Gomez-Verjan,Nadia Alejandra Rivero-Segura
Clinical Genetics and Genomics of Aging Book PDF

Author : Juan Carlos Gomez-Verjan,Nadia Alejandra Rivero-Segura
Publisher : Springer
Page : 0 pages
File Size : 44,7 Mb
Release : 2021-04-14
Category : Medical
ISBN : 3030409570

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Clinical Genetics and Genomics of Aging by Juan Carlos Gomez-Verjan,Nadia Alejandra Rivero-Segura Pdf

The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research.