Molecular Genetics Of Sex Determination

Author : Derek J. Chadwick,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 286 pages
File Size : 42,8 Mb
Release : 2002-04-26
Category : Science
ISBN : 0470843462

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The Genetics and Biology of Sex Determination by Derek J. Chadwick,Jamie A. Goode Pdf

Nature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels. A major landmark was the discovery in 1990 of the SRY gene and the subsequent demonstration of its key role in triggering male sex determination in transgenic mice. This book reviews and discusses our current understanding of the molecular genetic pathways of sex determination, with special emphasis on vertebrates. It features comparisons with other modes of sex determination, consideration of the biology of sexual development and discussion of the evolution of sex-determining mechanisms. By bringing together an international and interdisciplinary group of experts who study many different aspects of the problem, the book highlights much new and exciting work in this area and serves to identify and stimulate promising new research directions.

Author : Stephen S. Wachtel
Publisher : Academic Press
Page : 518 pages
File Size : 50,6 Mb
Release : 2014-07-23
Category : Science
ISBN : 9781483295589

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Molecular Genetics of Sex Determination by Stephen S. Wachtel Pdf

In this era of accelerated discovery and prolific output, Molecular Genetics of Sex Determination keeps readers abreast of this fields fast-moving biology. Its chapters were completed by experts in eacharea only months before publication. The text is organized into two parts. First, it reviews the basic biology of sex determination and summarizes ground-breaking work in mouse, marsupial, and Drosophila systems. Second, it covers current human genetics, clinical studies, and the syndromes of abnormal sex differentiation. With chapters by preeminent reproductive biologists, this is a capital work. Ohno's law is described by Ohno; the Lyon hypothesis, by Lyon; Sinclair tells how he cloned the testis-determining gene; and so on. Molecular Genetics of Sex Determination is authoritative, comprehensive, and current. It is prime reading for geneticists, developmental biologists, graduate students in these and related fields, clinical researchers, physicians, and medical students. Reviews the genetics of sex determination in 19 up-to-date chapters Features research on sex chromosomes and sex-determining genes Includes abnormalities of sex determination and clinical genetics Written by scientists who pioneered work in this field

Author : R.S. Verma
Publisher : Elsevier
Page : 368 pages
File Size : 55,6 Mb
Release : 1996-04-23
Category : Science
ISBN : 0080526179

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Genetics of Sex Determination by R.S. Verma Pdf

The Genetical Theory of Natural Selection by R.A. Fisher (1930) dictated that sexual dimorphisms may depend upon a single medelian factor. This could be true for some species but his suggestion could not take off the ground as gender in Drosophila is determined by the number of X chromosomes. Technical advances in molecular biology have revived the initial thinking of Fisher and dictate that TDF or SRY genes in humans or Tdy in mice are sex determining genes. The fortuitous findings of XX males and XY female, which are generally termed sex reversal phenomenon, are quite bewildering traits that have caused much amazement concerning the pairing mechanism(s) of the pseudoautosomal regions of human X and Y chromosomes at meiosis. These findings have opened new avenues to explore further the genetic basis of sex determination at the single gene level. The aim of the fourth volume, titled Genetics of Sex Determination is to reflect on the latest advances and future investigative directions, encompassing 10 chapters. Commissioned several distinguished scientists, all pre-eminent authorities in each field to shed their thoughts concisely but epitomise their chapters with an extended bibliography. Obviously, during the past 60 years, the metoric advances are voluminous and to cover every account of genes, chromosomes, and sex in a single volume format would be a herculean task. Therefore, a few specific topics are chosen, which may be of great interest to scientists and clinicians. The seasoned scientists who love to inquire about the role of genes in sex determination should find the original work of these notable contributors very enlightening. This volume is intended for advanced students who want to keep abreast as well as for those who indulge in the search for genes of sex determination.

Author : Derek'' J. Chadwic'k,Jamie' A. Good'e,Novarti's Foundatio'n
Publisher : Unknown
Page : 275 pages
File Size : 40,9 Mb
Release : 2021-04-29
Category : Electronic
ISBN : 9798745958816

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The Genetics and Biology of Sex Determination (Novartis Foundation Symposia Book 244) by Derek'' J. Chadwic'k,Jamie' A. Good'e,Novarti's Foundatio'n Pdf

Nature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels. A major landmark was the discovery in 1990 of the SRY gene and the subsequent demonstration of its key role in triggering male sex determination in transgenic mice. This book reviews and discusses our current understanding of the molecular genetic pathways of sex determination, with special emphasis on vertebrates. It features comparisons with other modes of sex determination, consideration of the biology of sexual development and discussion of the evolution of sex-determining mechanisms.By bringing together an international and interdisciplinary group of experts who study many different aspects of the problem, the book highlights much new and exciting work in this area and serves to identify and stimulate promising new research directions.

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Understanding the Biology of Sex and Gender Differences
Publisher : National Academies Press
Page : 288 pages
File Size : 55,5 Mb
Release : 2001-07-02
Category : Medical
ISBN : 0309132975

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Exploring the Biological Contributions to Human Health by Institute of Medicine,Board on Health Sciences Policy,Committee on Understanding the Biology of Sex and Gender Differences Pdf

It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Author : Alberto J. Solari
Publisher : CRC Press
Page : 340 pages
File Size : 40,7 Mb
Release : 1993-10-22
Category : Nature
ISBN : 0849345715

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Sex Chromosomes and Sex Determination in Vertebrates by Alberto J. Solari Pdf

The cloning of the SRY gene and the attainment of XX mice transgenic for the Sry gene opened a new era in research on sex determination. This book surveys current knowledge of sex chromosomes and sex determination in all vertebrate classes, relying on the restriction of genetic recombination in sex chromosomes as the unifying concept of this subject. The book's interdisciplinary approach integrates contributions from the fields of cytogenetics, molecular biology, developmental biology, and evolutionary genetics. A detailed treatment of the meiotic behavior of sex chromosomes is featured, and the entire text is supplemented by numerous schemes, drawings, and electron micrographs. The book will be valuable to general cytogeneticists, vertebrate zoologists, and veterinarian and medical practitioners interested in the foundations of sex determination and the current knowledge of sex chromosomes. It will also interest students in advanced undergraduate and graduate courses in these areas.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 40,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Aleksandr F. Smirnov,A. V. Trukhina
Publisher : Scientific Research Publishing, Inc. USA
Page : 118 pages
File Size : 45,8 Mb
Release : 2024-06-11
Category : Science
ISBN : 9781618963901

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Molecular-Genetic Mechanisms of Sex Determination in Animals by Aleksandr F. Smirnov,A. V. Trukhina Pdf

Gender (sex) is a set of morphological and physiological characteristics of the organism underlying sexual reproduction, the essence of which is reduced to fertilization, i.e. the fusion of male and female gametes (gametes) zygote, which develops into a new organism.Sexual reproduction of a species is considered as one of the mechanisms of its homeostasis. Thanks to this mechanism, numerous species have an evolutionary advantage. In the book, two authors will discuss the types of genetic sex determination and differentiation, mostly in multicellular animal organisms. Sex determination is both genetic and environmental process, the sex of an individual being established through an alternative physiological solution. There are two main postulated mechanisms of sex determination: genetic (GSD, Genetical Sex Determination) and environmental (ESD, Environmental Sex Determination).

Author : R. H. F. Hunter
Publisher : Cambridge University Press
Page : 360 pages
File Size : 49,6 Mb
Release : 1995-03-09
Category : Science
ISBN : 0521462185

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Sex Determination, Differentiation and Intersexuality in Placental Mammals by R. H. F. Hunter Pdf

How do males become male and females become female? And what are the consequences if the decision is not incisive? Drawing upon interests in animal genetics and molecular biology, the author endeavours to answer these difficult yet fascinating questions. Originally published in 1995, this book describes the genetic determination of sex and examines how sexual organs are differentiated. Using examples of intersexuality, chimaeras and asymmetries, the book describes the underlying molecular basis of sex determination and sexual differentiation, and focuses on the critical role of the rate of embryonic development in these vital processes. Male precocity is a recurrent theme, as is the involvement of Sertoli cells and their secretion of anti-Müllerian hormone. An invaluable book for reproductive physiologists, geneticists and developmental biologists whose interests may extend from animal science through veterinary medicine to human clinical medicine.

Author : Leo Beukeboom,Nicolas Perrin
Publisher : OUP Oxford
Page : 240 pages
File Size : 50,9 Mb
Release : 2014-06-12
Category : Science
ISBN : 9780191631399

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The Evolution of Sex Determination by Leo Beukeboom,Nicolas Perrin Pdf

Sexual reproduction is a fundamental aspect of life. It is defined by the occurrence of meiosis and the fusion of two gametes of different sexes or mating types. Sex-determination mechanisms are responsible for the sexual fate and development of sexual characteristics in an organism, be it a unicellular alga, a plant, or an animal. In many cases, sex determination is genetic: males and females have different alleles or different genes that specify their sexual morphology. In animals, this is often accompanied by chromosomal differences. In other cases, sex may be determined by environmental (e.g. temperature) or social variables (e.g. the size of an organism relative to other members of its population). Surprisingly, sex-determination mechanisms are not evolutionarily conserved but are bewilderingly diverse and appear to have had rapid turnover rates during evolution. Evolutionary biologists continue to seek a solution to this conundrum. What drives the surprising dynamics of such a fundamental process that always leads to the same outcome: two sex types, male and female? The answer is complex but the ongoing genomic revolution has already greatly increased our knowledge of sex-determination systems and sex chromosomes in recent years. This novel book presents and synthesizes our current understanding, and clearly shows that sex-determination evolution will remain a dynamic field of future research. The Evolution of Sex Determination is an advanced, research level text suitable for graduate students and researchers in genetics, developmental biology, and evolution.

Author : Florence P. Haseltine,Michael E. McClure,Ellen H. Goldberg
Publisher : Springer Science & Business Media
Page : 174 pages
File Size : 41,8 Mb
Release : 2013-11-22
Category : Psychology
ISBN : 9781489919656

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Genetic Markers of Sex Differentiation by Florence P. Haseltine,Michael E. McClure,Ellen H. Goldberg Pdf

Author : Anonim
Publisher : Academic Press
Page : 336 pages
File Size : 41,7 Mb
Release : 1995-11-14
Category : Science
ISBN : 0080568203

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Advances in Genetics by Anonim Pdf

Advances in Genetics increases its focus on modern human genetics and its relation to medicine with Volume 33 of this long-standing serial. The recent merger of Molecular Genetic Medicine with Advances in Genetics affirms the Academic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. In this volume, Petes and Pukkila synthesize the latest research on meiotic recombination, with specific reference to crossover and gene conversions. The "absurd size and complex" structure of the Dystrophin gene is considered in another chapter, with discussions of strategies for future diagnosis and treatment of muscular dystrophy. Two chapters also examine the molecular genetics of sex determination, including the influence of maternal age and resulting chromosomal aberrations. Volume 33 also includes a review of the PAX and HOX gene families and their links to the developmental process, cellular growth control, and forms of cancer. Case studies of thrombophilia, Menkes, and Wilson diseases are used to exemplify the genetic disorders of blood clotting, copper deficiency, and toxicity, respectively. Triman takes a genetic approach to understanding the function of ribosomal RNA using E. coli as the model best able to reveal the inherent complications of the translation process. Leach and O'Connell describe the use of radiation hybrids for constructing high-resolution maps of the human genome. With these reviews the alliance of Molecular Genetic Medicine with Advances in Genetics is completed under the banner of Advances in Genetics. Key Features * Presents technical and historical overviews of molecular biology applied to disease detection, diagnosis, and treatment * Chronicles the continuing explosion of knowledge in molecular genetic medicine by highlighting current approaches to understanding human illness * Documents the revolution in human and molecular genetics leading to a new field of medicine * This volume highlights Analysis of human chromosomes with chapters on pathology of sex determination and numerical chromosomal abnormalities Molecular and genetic bases of muscular dystrophy and Menkes and Wilson diseases Techniques including FISH, IRS-PCR, and radiation hybrids

Author : Anonim
Publisher : Academic Press
Page : 394 pages
File Size : 46,8 Mb
Release : 2019-04-16
Category : Science
ISBN : 9780128115046

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Sex Determination in Vertebrates by Anonim Pdf

Sex Determination, Volume 134, the latest release in the Current Topics in Developmental Biology series, contains current reviews in the field of vertebrate sex determination. It covers molecular pathways of sex determination in genetic and environmental species and encompasses both sex determination of somatic lineages and commitment of germ cells to male or female fate. Chapters in this new release cover, amongst other topics, Mapping the Sox9 Enhancer Elements, Epigenetic Regulation of Sex Determination, Evolution and Management of Sex Chromosomes, Regulation of Germ Cell Sex Identity in Medaka, Control of Sex Determination in Zebrafish, Sexually Dimorphic Germ Cell Identity in Mammals, and more. Contains reviews written by leading experts in each field Includes informative figures that illustrate principle points that are useful for teaching Written in a style that is clear and simple

Author : Ken Reed,Jennifer A. Marshall Graves
Publisher : Unknown
Page : 410 pages
File Size : 44,5 Mb
Release : 1993
Category : Mammals
ISBN : OCLC:1288479825

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Sex Chromosomes and Sex-determining Genes by Ken Reed,Jennifer A. Marshall Graves Pdf

Author : Sarah S. Richardson
Publisher : University of Chicago Press
Page : 320 pages
File Size : 44,9 Mb
Release : 2013-12-13
Category : Science
ISBN : 9780226084718

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Sex Itself by Sarah S. Richardson Pdf

Human genomes are 99.9 percent identical—with one prominent exception. Instead of a matching pair of X chromosomes, men carry a single X, coupled with a tiny chromosome called the Y. Tracking the emergence of a new and distinctive way of thinking about sex represented by the unalterable, simple, and visually compelling binary of the X and Y chromosomes, Sex Itself examines the interaction between cultural gender norms and genetic theories of sex from the beginning of the twentieth century to the present, postgenomic age. Using methods from history, philosophy, and gender studies of science, Sarah S. Richardson uncovers how gender has helped to shape the research practices, questions asked, theories and models, and descriptive language used in sex chromosome research. From the earliest theories of chromosomal sex determination, to the mid-century hypothesis of the aggressive XYY supermale, to the debate about Y chromosome degeneration, to the recent claim that male and female genomes are more different than those of humans and chimpanzees, Richardson shows how cultural gender conceptions influence the genetic science of sex. Richardson shows how sexual science of the past continues to resonate, in ways both subtle and explicit, in contemporary research on the genetics of sex and gender. With the completion of the Human Genome Project, genes and chromosomes are moving to the center of the biology of sex. Sex Itself offers a compelling argument for the importance of ongoing critical dialogue on how cultural conceptions of gender operate within the science of sex.