Molecular Immunological Considerations In Malaria Vaccine Development

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Molecular Immunological Considerations in Malaria Vaccine Development

Michael F. Good,Allan J. Saul
Molecular Immunological Considerations in Malaria Vaccine Development Book PDF

Author : Michael F. Good,Allan J. Saul
Publisher : CRC Press
Page : 282 pages
File Size : 42,8 Mb
Release : 1993-10-13
Category : Medical
ISBN : 0849352584

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Molecular Immunological Considerations in Malaria Vaccine Development by Michael F. Good,Allan J. Saul Pdf

Some of the world's leading research scientists in the field have contributed to this new book on malaria vaccine development. The book examines various strategies being pursued against the different stages of the parasite (the sporozoite, asexual erythrocytic stages, and sexual stages). It describes vaccines that combat the parasite directly, vaccines aimed at preventing disease, vaccines based on attenuated parasites, and vaccines based on small, carefully defined synthetic peptides. The book provides a compendium of current approaches, lists of preferred antigens, and the results of vaccine trials to date. Molecular immunology involved with both the natural immune response to parasites and with the constraints on inducing immunity are emphasized throughout the book. Views on how vaccines may be tested and then integrated into malaria control programs are also discussed. Molecular Immunological Considerations in Malaria Vaccine Development will be useful for researchers and students in immunology, parasitology, biotechnology, vaccine design, and tropical and public health.

Adverse Effects of Vaccines

Institute of Medicine,Board on Population Health and Public Health Practice,Committee to Review Adverse Effects of Vaccines
Adverse Effects of Vaccines Book PDF

Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee to Review Adverse Effects of Vaccines
Publisher : National Academies Press
Page : 894 pages
File Size : 49,5 Mb
Release : 2012-04-26
Category : Medical
ISBN : 9780309214353

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Adverse Effects of Vaccines by Institute of Medicine,Board on Population Health and Public Health Practice,Committee to Review Adverse Effects of Vaccines Pdf

In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

Opportunities in Biotechnology for Future Army Applications

National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Opportunities in Biotechnology for Future Army Applications
Opportunities in Biotechnology for Future Army Applications Book PDF

Author : National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Opportunities in Biotechnology for Future Army Applications
Publisher : National Academies Press
Page : 118 pages
File Size : 50,9 Mb
Release : 2001-07-11
Category : Science
ISBN : 9780309075558

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Opportunities in Biotechnology for Future Army Applications by National Research Council,Division on Engineering and Physical Sciences,Board on Army Science and Technology,Committee on Opportunities in Biotechnology for Future Army Applications Pdf

This report surveys opportunities for future Army applications in biotechnology, including sensors, electronics and computers, materials, logistics, and medical therapeutics, by matching commercial trends and developments with enduring Army requirements. Several biotechnology areas are identified as important for the Army to exploit, either by direct funding of research or by indirect influence of commercial sources, to achieve significant gains in combat effectiveness before 2025.

Science, Medicine, and Animals

National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research
Science Medicine and Animals Book PDF

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research
Publisher : National Academies Press
Page : 23 pages
File Size : 46,9 Mb
Release : 2006-02-19
Category : Science
ISBN : 9780309101172

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Science, Medicine, and Animals by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research Pdf

Science, Medicine, and Animals explains the role that animals play in biomedical research and the ways in which scientists, governments, and citizens have tried to balance the experimental use of animals with a concern for all living creatures. An accompanying Teacher's Guide is available to help teachers of middle and high school students use Science, Medicine, and Animals in the classroom. As students examine the issues in Science, Medicine, and Animals, they will gain a greater understanding of the goals of biomedical research and the real-world practice of the scientific method in general. Science, Medicine, and Animals and the Teacher's Guide were written by the Institute for Laboratory Animal Research and published by the National Research Council of the National Academies. The report was reviewed by a committee made up of experts and scholars with diverse perspectives, including members of the U.S. Department of Agriculture, National Institutes of Health, the Humane Society of the United States, and the American Society for the Prevention of Cruelty to Animals. The Teacher's Guide was reviewed by members of the National Academies' Teacher Associates Network. Science, Medicine, and Animals is recommended by the National Science Teacher's Association NSTA Recommends.

Malaria Immunology

Peter Perlmann,Marita Troye-Blomberg
Malaria Immunology Book PDF

Author : Peter Perlmann,Marita Troye-Blomberg
Publisher : Karger Medical and Scientific Publishers
Page : 422 pages
File Size : 49,5 Mb
Release : 2002-01-01
Category : Medical
ISBN : 9783805573764

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Malaria Immunology by Peter Perlmann,Marita Troye-Blomberg Pdf

Despite extensive efforts to control it, malaria is still one of the most devastating infectious diseases worldwide. This book, now in its second edition, provides a broad and up-to-date overview of the rapidly expanding field of malaria immunology and its importance in the control of this disease. The first section deals with the malaria parasite and its interactions with both the vertebrate host and the mosquitoes which transmit the disease. In the second part, the mechanisms of immunity and their regulation by environmental and genetic factors are discussed. Finally, this volume contains several chapters on malaria vaccine development, describing the application of the most recent vaccine technologies as well as ongoing and planned vaccine trials. Authored by well-recognized experts, this volume not only demonstrates the rapid progress being made in the search for vaccines against malaria, but also broadens our understanding of immunity to infection in general. It is therefore highly recommended reading for all scientists and professionals in the fields of immunology, infection and vaccine development.

Chimpanzees in Biomedical and Behavioral Research

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Institute of Medicine,Board on Health Sciences Policy,Committee on the Use of Chimpanzees in Biomedical and Behavioral Research
Chimpanzees in Biomedical and Behavioral Research Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Institute of Medicine,Board on Health Sciences Policy,Committee on the Use of Chimpanzees in Biomedical and Behavioral Research
Publisher : National Academies Press
Page : 200 pages
File Size : 41,6 Mb
Release : 2012-01-05
Category : Science
ISBN : 9780309220392

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Chimpanzees in Biomedical and Behavioral Research by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Institute of Medicine,Board on Health Sciences Policy,Committee on the Use of Chimpanzees in Biomedical and Behavioral Research Pdf

For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.

Infectious Disease and Host-Pathogen Evolution

Krishna R. Dronamraju
Infectious Disease and Host Pathogen Evolution Book PDF

Author : Krishna R. Dronamraju
Publisher : Cambridge University Press
Page : 394 pages
File Size : 50,9 Mb
Release : 2004-04-05
Category : Science
ISBN : 9781139451697

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Infectious Disease and Host-Pathogen Evolution by Krishna R. Dronamraju Pdf

This book, originally published in 2004, is concerned with the links between human evolution and infectious disease. It has long been recognised that an important factor in human evolution has been the struggle against infectious disease and, more recently, it was revealed that complex genetic polymorphisms are the direct result of that struggle.

Pharmaceutical Biotechnology

Daan J. A. Crommelin,Robert D. Sindelar
Pharmaceutical Biotechnology Book PDF

Author : Daan J. A. Crommelin,Robert D. Sindelar
Publisher : CRC Press
Page : 456 pages
File Size : 48,7 Mb
Release : 2002-11-14
Category : Medical
ISBN : 0415285011

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Pharmaceutical Biotechnology by Daan J. A. Crommelin,Robert D. Sindelar Pdf

The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.

The Science and Applications of Synthetic and Systems Biology

Institute of Medicine,Board on Global Health,Forum on Microbial Threats
The Science and Applications of Synthetic and Systems Biology Book PDF

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 570 pages
File Size : 53,8 Mb
Release : 2011-12-30
Category : Science
ISBN : 9780309219396

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The Science and Applications of Synthetic and Systems Biology by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Progress in Immunology Vol. VIII

M. Benczur,Anna Erdei,A. Falus,G. Füst,G.A. Medgyesi,G.G. Petranyi,Eva Rajnavölgyi
Progress in Immunology Vol VIII Book PDF

Author : M. Benczur,Anna Erdei,A. Falus,G. Füst,G.A. Medgyesi,G.G. Petranyi,Eva Rajnavölgyi
Publisher : Springer
Page : 926 pages
File Size : 53,9 Mb
Release : 2013-12-21
Category : Medical
ISBN : 9783642514791

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Progress in Immunology Vol. VIII by M. Benczur,Anna Erdei,A. Falus,G. Füst,G.A. Medgyesi,G.G. Petranyi,Eva Rajnavölgyi Pdf

At this congress there were again numereous reports of progress in immunology. The new technologies are continuing to have an immense impact: gene isolation, mutation, transfection and expression, protein structure andpeptide synthesis, cell cloning, hybridization and monoclonal antibodies, CD serology, SCID and transgenic mice, modern immunomodulation and vaccines. A trmendous mass of data has accumulated over the last years. The reports are up-to-date and outstanding,to a degree no journal will ever achieve, and the results are presented in a concise and lucid way. This report will serve as a guideline for the years to came, because it is a treasure trove of explorations, making it exciting reading. This progress presents outstanding contributions. Immunology is exhibited at its best: an exciting research area and a rewarding subject to study for the benefit of mankind - today more than ever.

Medical Microbiology

S. Rajan
Medical Microbiology Book PDF

Author : S. Rajan
Publisher : MJP Publisher
Page : 682 pages
File Size : 43,6 Mb
Release : 2019-06-11
Category : Medical
ISBN : 8210379456XXX

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Medical Microbiology by S. Rajan Pdf

PART I GENERAL ASPECTS OF MEDICAL MICROBIOLOGY Introduction and Historical Developments in Microbiology Normal Flora of the Healthy Human Host Non-specific Defence Mechanisms Host–Microbe Interactions Infective Syndrome and Diagnostic Procedure Antimicrobial Chemotherapy Epidemiology and Control of Community Infections Collection of Various Specimens for Diagnosis Selective Cum Differential Media used for the Isolation of Bacteria PART II BACTERIOLOGY General Characteristics of Bacteria Classification of Pathogenic Bacteria Staphylococcal Infections Streptococcal Infections Dental Caries Pneumonia Diphtheria Meningitis Whooping Cough Tuberculosis Leprosy Diarrhoea Cholera Gastroenteritis Typhoid Fever Gonorrhoea Syphilis Gas Gangrene Tetanus Leptospira Borrelia Helicobacter pylori Campylobacter Pseudomonas aeruginosa Chlamydia Rickettsiae Brucella Bacillus anthracis Actinomyces PART III VIROLOGY Characteristic Features of Viruses Classification of Animal Viruses Diagnosis of Viral Infections Smallpox Common Cold Influenza Measles Mumps Rubella Arbovirus Infections Polio Rabies Hepatitis AIDS Herpesvirus Infections Treatment of Viral Infections PART IV MYCOLOGY Introduction to Fungi Mycoses Laboratory Diagnosis of Fungal Infections Superficial Mycoses Subcutaneous Mycoses Systemic Mycoses PART V PARASITOLOGY General Characteristics of Parasites Classification of Pathogenic Protozoa and Helminthes Nematodes Protozoan Infections Nematode Infections Trematode Infections PART VI MYCOPLASMA AND OTHER INFECTIONS Mycoplasma Zoonotic Infections Nosocomial Infections Appendix-I Appendix-II Model Questions Glossary Index

Immunization Safety Review

Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee
Immunization Safety Review Book PDF

Author : Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee
Publisher : National Academies Press
Page : 152 pages
File Size : 47,8 Mb
Release : 2002-07-02
Category : Medical
ISBN : 9780309169882

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Immunization Safety Review by Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee Pdf

By two years of age, healthy infants in the United States can receive up to 20 vaccinations to protect against 11 diseases. Although most people know that vaccines effectively protect against serious infectious diseases, approximately one-quarter of parents in a recent survey believe that infants get more vaccines than are good for them, and that too many immunizations could overwhelm an infant's immune system. The Immunization Safety Review Committee reviewed the evidence regarding the hypothesis that multiple immunizations increase the risk for immune dysfunction. Specifically, the committee looked at evidence of potential biological mechanisms and at epidemiological evidence for or against causality related to risk for infections, the autoimmune disease type 1 diabetes, and allergic disorders.

Molecular Vaccines

Matthias Giese
Molecular Vaccines Book PDF

Author : Matthias Giese
Publisher : Springer Science & Business Media
Page : 460 pages
File Size : 43,5 Mb
Release : 2013-10-16
Category : Medical
ISBN : 9783709114193

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Molecular Vaccines by Matthias Giese Pdf

This book gives a comprehensive overview to all aspects of global molecular vaccine research. It introduces concepts of vaccine immunology and molecular vaccine development for viral, bacterial, parasitic and fungal infections. Furthermore, the broad field of research and development in molecular cancer vaccines is discussed in detail. This book is a must have for scientists and clinicians interested in new developments in molecular vaccine research and application in infections and cancer.

Towards Malaria Elimination

Sylvie Manguin,Vas Dev
Towards Malaria Elimination Book PDF

Author : Sylvie Manguin,Vas Dev
Publisher : BoD – Books on Demand
Page : 454 pages
File Size : 53,9 Mb
Release : 2018-07-18
Category : Medical
ISBN : 9781789235500

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Towards Malaria Elimination by Sylvie Manguin,Vas Dev Pdf

Towards Malaria Elimination - A Leap Forward was started to mark the occasion for renewed commitment to end malaria transmission for good (the WHO's call for "Malaria Free World" by 2030). This book is dedicated for the benefit of researchers, scientists, program and policy managers, students and anyone interested in malaria and other mosquito-borne diseases with the goal of sharing recent information on success stories, innovative control approaches and challenges in different regions of the world. Some main issues that emerged included multidrug-resistant malaria and pandemic risk, vaccines, cross-border malaria, asymptomatic parasite reservoir, the threat of Plasmodium vivax and Plasmodium knowlesi, insecticide resistance in Anopheles vectors and outdoor malaria transmission. This book is one little step forward to bring together in 17 chapters the experiences of malaria-expert researchers from five continents to present updated information on disease epidemiology and control at the national/regional level, highlighting the constraints, challenges, accomplishments and prospects of malaria elimination.

The Neutrophils

Dmitry Gabrilovich
The Neutrophils Book PDF

Author : Dmitry Gabrilovich
Publisher : World Scientific
Page : 448 pages
File Size : 50,6 Mb
Release : 2013-03-20
Category : Medical
ISBN : 9781783262915

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The Neutrophils by Dmitry Gabrilovich Pdf

This is a third edition of the popular book, which presents an overview of the most recent findings in the biology of neutrophils. These cells are critically important for protection against bacterial and viral infections and have been recently demonstrated to be a major contributor to tumor associated immune suppression. In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This monograph provides a detailed description of signal transduction, generation of reactive oxygen, and mechanisms of migration and death of these cells. Besides that, it contains unique information regarding neutrophils' role in cancer. Finally, this monograph describes recent advances in attempts to improve neutrophil function and use these cells in the treatment of diseases. Contents:Molecular Regulation of Granulopoiesis (Sachin Kumar and Marie-Dominique Filippi)The Neutrophil Respiratory Burst Oxidase (Mark T Quinn)Novel Neutrophil Receptors and Their Signal Transduction (Nicole R Fortenbery, Xianhong Chen and Sheng Wei)Mechanisms of Neutrophil Migration (Fong W Lam, Rolando E Rumbaut and Alan R Burns)Cytokine Production by Neutrophils (Luc de Chaisemartin, Marco Cassatella and Sylvie Chollet-Martin)Neutrophils and Apoptosis (Christopher D Lucas and Adriano G Rossi)Regulation of Neutrophil Functions by Long Chain Fatty Acids (Antonio Ferrante, Charles S Hii and Bernadette Boog)S100 Calgranulins in Inflammation (Carolyn L Geczy, Phillipe A Tessier and Lincoln Gomes)Neutrophils and Myeloid-Derived Suppressor Cells in Cancer (Je-In Youn, Alex Corzo and Dmitry Gabrilovich)Colony-Stimulating Factors for Prevention and Treatment of Neutropenia and Infectious Diseases (David C Dale, Lee J Quinton and Steve Nelson) Readership: Students, professionals, cancer researchers, medical practitioners. Key Features:Comprehensive nature of the reviews of different aspects of neutrophil biologyFocus on cutting-edge discoveries in the fieldReview of neutrophils function in cancerKeywords:Neutrophils;Infection Diseases;Cancer;Cytokines;Apoptosis;Fatty Acids;Myeloid-Derived Suppressor Cells