Molecular Mechanisms For Repair Of Dna

Author : Philip Hanawalt
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 50,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468428957

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Molecular Mechanisms for Repair of DNA by Philip Hanawalt Pdf

An "age" has passed in the 40 years since we first observed recovery from radiation damage in irradiated bacteria. During the early 1930s, we had been discussing the possibility of rapid changes after radiation exposure with Farring ton Daniels, Benjamin Duggar, John Curtis, and others at the University of Wisconsin. After working with living cells, we had concluded that organisms receiving massive insults must have a wide variety of repair mechanisms available for restoration of at least some of the essential properties of the cell. The problem was how to fmd and identify these recovery phenomena. At that time I was working on a problem considered to be of great importance-the existence of the so-called mitogenetic rays. Several hundred articles and a score of books had already appeared dealing with mitogenetic rays, a type of radiation that was thought to exist in the shorter ultraviolet region. Our search for mitogenetic rays necessitated the design of experiments of greatest sensitivity for the detection of ultraviolet. It was vital that conditions be kept as constant as possible during exposure. All the work was done at icewater temperature (3-5°C) during and after exposure. We knew that light was an important factor for cell recovery, so all our experiments were done in dim light, with the plated-out cells being covered with dark cloth. Our statements on the effect of visible light stimulated Kelner to search for "photoreactivation' (as it was later called).

Author : Philip Hanawalt,Richard Burton Setlow
Publisher : Springer
Page : 456 pages
File Size : 51,8 Mb
Release : 1975-10
Category : Science
ISBN : UOM:39015000821127

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Molecular Mechanisms for Repair of DNA by Philip Hanawalt,Richard Burton Setlow Pdf

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 46,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Philip C. Hanawalt,Richard Burton Setlow
Publisher : Unknown
Page : 843 pages
File Size : 51,6 Mb
Release : 1975
Category : DNA repair
ISBN : LCCN:75017731

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Molecular Mechanisms for Repair of DNA by Philip C. Hanawalt,Richard Burton Setlow Pdf

Author : Fumio Hanaoka,Kaoru Sugasawa
Publisher : Springer
Page : 555 pages
File Size : 52,9 Mb
Release : 2016-01-22
Category : Science
ISBN : 9784431558736

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DNA Replication, Recombination, and Repair by Fumio Hanaoka,Kaoru Sugasawa Pdf

This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.

Author : Philip Hanawalt
Publisher : Elsevier
Page : 832 pages
File Size : 42,7 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323142328

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DNA Repair Mechanisms by Philip Hanawalt Pdf

DNA Repair Mechanisms is an account of the proceedings at a major international conference on DNA Repair Mechanisms held at Keystone, Colorado on February 1978. The conference discusses through plenary sessions the overall standpoint of DNA repair. The papers presented and other important documents, such as short summaries by the workshop session conveners, comprise this book. The compilation describes the opposing views, those that agree and dispute about certain topic areas. This book, divided into 15 parts, is arranged according to the proceedings in the conference. The plenary sessions are grouped with the related workshop and poster manuscripts. The first two parts generally tackle repair in terms of its identification and quantification, as well as the models, systems, and perspectives it utilizes. The following parts discuss the various types of repair including base excision, nucleotide excision repair in bacteria, excision repair in mammalian cells, inducible/error-prone repair in prokaryotes, and strand break repair in mammalian cells among others. This reference material looks into the replicative bypass mechanisms in mammalian cells, viral probes, and hereditary repair defects. It explains repair deficiency and human disease, as well as mutagenesis and carcinogenesis. The last part of this book deals with the consequences and effects of DNA repair. This volume is a helpful source of reference for students, teachers, scientists, and researchers in the different fields of genetics, radiology, biochemistry, and environmental biology.

Author : Paul Doetsch
Publisher : Academic Press
Page : 354 pages
File Size : 55,6 Mb
Release : 2012-07-17
Category : Medical
ISBN : 9780123876652

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Mechanisms of DNA Repair by Paul Doetsch Pdf

Mechanisms of DNA Repair.

Author : Philip C. Hanawalt,Richard Burton Setlow
Publisher : Unknown
Page : 0 pages
File Size : 51,5 Mb
Release : 1975
Category : Electronic
ISBN : OCLC:38053738

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Molecular Mechanisms for Repair of DNA by Philip C. Hanawalt,Richard Burton Setlow Pdf

Author : Payam Behzadi
Publisher : BoD – Books on Demand
Page : 235 pages
File Size : 43,5 Mb
Release : 2021-05-19
Category : Medical
ISBN : 9781838810931

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DNA by Payam Behzadi Pdf

DNA is the most important biomolecule ever discovered. Indeed, this molecule bears genetic information from one generation to another. In this regard, DNA bases have a key role in transferring genetic information and data safely. However, there are cellular, genetic, and environmental factors that may damage the different parts of DNA molecules. These damages may result in mutations and cell death. As such, several DNA repair mechanisms have evolved. Over three sections, this book examines many of these mechanisms.

Author : Shamim Ahmad,Fumio Hanaoka
Publisher : Springer Science & Business Media
Page : 191 pages
File Size : 52,8 Mb
Release : 2008-11-30
Category : Science
ISBN : 9780387095998

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Molecular Mechanisms of Xeroderma Pigmentosum by Shamim Ahmad,Fumio Hanaoka Pdf

Xeroderma pigmentosum (XP), meaning parchment skin and pigmentary dist- bance, is a rare and mostly autosomal recessive genetic disorder that was originally named by two dermatologists, the Austrian Ferdinand Ritter von Hebra and his H- garian son in law Moritz Kaposi in 1874i and 1883. 2 The earliest published record (PubMed) available on the internet is a publication in 1949 by Ulicna Zapletalova under the title, "Contribution to the pathogenesis of xeroderma pigmentosum". It was in the late 1960s when James Cleaver (contributor of Chapter 1 of this book), at the University of California, San Francisco, while working on nucleotide excision repair (NER), read an article in a local newspaper about XP and soon after obtained a skin biopsy from a patient suffering from XP that showed that cells from it were deficient in NER. Thus, his studies led to the discovery that indeed this genetic defect was due to mutations in DNA repair genes that imbalance the NER pathway. . s The discovery paved the way for further exploration of the link between DNA damage, mutagenesis, neoplastic transformation and DNA repair diseases. Since then, 4,088 papers, incl- ing excellent reviews, on XP are listed on the internet (PubMed data, February 2008), and an XP Society has been established in the USA (http://www. xps. org) and an XP Support Group in the United Kingdom (www. xpsupportgroup. org. uk)

Author : Wilson Iii David M
Publisher : World Scientific
Page : 824 pages
File Size : 43,8 Mb
Release : 2016-12-08
Category : Science
ISBN : 9789814719742

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Base Excision Repair Pathway, The: Molecular Mechanisms And Role In Disease Development And Therapeutic Design by Wilson Iii David M Pdf

This book will serve as the preeminent text book on the topic of "base excision repair", a key DNA repair pathway that protects cells from most spontaneous forms of DNA damage, including oxidative lesions that arise both in the nuclear and mitochondrial genomes. The book, which includes contributions from many of the world leaders in the field, provides a detailed description of the molecular mechanisms of base excision repair, as well as its emerging relationship to epigenetic regulation, the aging process and human disease, such as cancer susceptibility, immunological defects and neurological disorders. The book will also cover the state-of-the-art technologies being developed to assess base excision repair capacity among individuals in the population, in addition to the strategies being employed to target base excision repair as part of therapeutic paradigms to eradicate disease, namely cancer. This book represents one of the most extensive efforts to date to cover the topic of "base excision repair". It includes chapters by many of the most established investigators in the field, from all over the world.

Author : Michael G. Simic,Lawrence Grossman,Arthur C. Upton,David S. Bergtold
Publisher : Springer Science & Business Media
Page : 567 pages
File Size : 49,8 Mb
Release : 2013-11-21
Category : Science
ISBN : 9781461594628

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Mechanisms of DNA Damage and Repair by Michael G. Simic,Lawrence Grossman,Arthur C. Upton,David S. Bergtold Pdf

This book is based on the papers presented at the conference on "Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.

Author : Christopher W. Lawrence
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 54,5 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781468443820

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Induced Mutagenesis by Christopher W. Lawrence Pdf

Concern is often expressed that our environment may include an increasingly large variety of mutagens, but the extent of the potential hazard they pose has yet to be fully evaluated. A variety of empirical procedures has been devised with which to estimate the mutagenic potency of suspect agents, and the relative merits of different tests are currently under debate. Although such tests are of great value, and are indeed indispensable, they are not, nevertheless, sufficient. In the long term, accurate estimation of hazard will also require a better understanding of the various mechanisms of mutagenesis, and in many instances these remain remarkably elusive. Our knowledge and appreciation of the problem has increased substantially over the last few years, but the precise way in which many mutagens cause mutations is not yet known. The aims of this conference were therefore two-fold. The first was to survey present information about mutagenic mechanisms, drawing together data from work with various experimental approaches and organisms, in order to discern the principles governing the action of different mutagens. The second was to examine the implications of such principles for the execution and evaluation of test procedures, and critically assess the research areas that need further attention in order to improve the interpretation of test results. Chris Lawrence v ACKNOWLEDGEMENT We gratefully acknowledge the support provided for this Conference by the U.,S. Department of Energy, The Foundation for Microbiology, Exxon Corporation and the University of Rochester.

Author : Errol C. Friedberg,Graham C. Walker,Wolfram Siede,Richard D. Wood
Publisher : American Society for Microbiology Press
Page : 2587 pages
File Size : 44,6 Mb
Release : 2005-11-22
Category : Science
ISBN : 9781555813192

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DNA Repair and Mutagenesis by Errol C. Friedberg,Graham C. Walker,Wolfram Siede,Richard D. Wood Pdf

An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.

Author : J. Lemontt,W. M. Generoso
Publisher : Springer
Page : 420 pages
File Size : 55,8 Mb
Release : 1982-07
Category : Science
ISBN : UOM:39015003226761

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Molecular and Cellular Mechanisms of Mutagenesis by J. Lemontt,W. M. Generoso Pdf

It has been nearly 35 years since the peacetime Biology Division of Oak Ridge National Laboratory was started, born of rather inauspicious conditions. Virtually no facilities were available and most of the wartime scientists had left. So, when we started out, it was obvious to me that something had to be done to reestab lish research. Even more, because Oak Ridge was not known at that time for its biological work but rather for the separation of Uranium 235, nuclear reactor development, and radioisotope produc tion, a new tradition had to be promoted. Although good biological work had been done at Oak Ridge during the war to protect the workers and the results of this work were quite excellent, very few installations remained. When we started the work of the Biology Division, it became essential to make it part of the flow of mod~rn biology allover the world. As Director, I had to do more than just attract promising scientists. We created an atmosphere conducive to creative research and nurtured all of the other aspects of a productive laboratory. Of course, we carefully prepared the results of our work in publish able form. We made a sincere effort to invite seminar speakers and lecturers to come to Oak Ridge despite the sacrifices this presented to our early budget. We also had to do something more, and here I "cashed in" on my experience of the previous 15 years.