Induced Mutagenesis

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Mutagenesis: exploring genetic diversity of crops

Author : N.B. Tomlekova,M.I. Kozgar,M.R. Wani
Publisher : BRILL
Page : 394 pages
File Size : 41,9 Mb
Release : 2023-09-04
Category : Technology & Engineering
ISBN : 9789086867967

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Mutagenesis: exploring genetic diversity of crops by N.B. Tomlekova,M.I. Kozgar,M.R. Wani Pdf

In the present era various international organizations, such as FAO, UNO, IAEA, FNCA, etc., have unanimously agreed that millions of people in both developing and developed countries are not only facing a shortage of food, but also non-availability of nutrients. The main reason put forward by these agencies is that there is less genetic diversity prevalent in the major crops, which has been further diminished since the inception of conventional plant breeding. Since the first decade of the last century the mutation breeding approach has been pivotal in enhancing the genetic diversity of crops, thereby enriching the genetic pool. ‘Mutagenesis: exploring genetic diversity of crops’ describes the latest achievements in mutation breeding, with a particular focus on the development of novel mutant varieties and F1 hybrids of crops highly superior to the parental ones. The book details experimental as well as literary studies of induced mutagenesis and its role in developing the new potent varieties. The book will be useful for agricultural policy making authorities in countries of agricultural importance, scientific researchers, breeders, teachers and students keen to use mutation breeding and to explore its hidden potential to secure food and nutrient availability for the growing world population.

Stress-Induced Mutagenesis

Author : David Mittelman
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 48,7 Mb
Release : 2013-03-12
Category : Medical
ISBN : 9781461462804

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Stress-Induced Mutagenesis by David Mittelman Pdf

The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes. This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.

Induced Mutagenesis

Author : Christopher W. Lawrence
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 46,7 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781468443820

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Induced Mutagenesis by Christopher W. Lawrence Pdf

Concern is often expressed that our environment may include an increasingly large variety of mutagens, but the extent of the potential hazard they pose has yet to be fully evaluated. A variety of empirical procedures has been devised with which to estimate the mutagenic potency of suspect agents, and the relative merits of different tests are currently under debate. Although such tests are of great value, and are indeed indispensable, they are not, nevertheless, sufficient. In the long term, accurate estimation of hazard will also require a better understanding of the various mechanisms of mutagenesis, and in many instances these remain remarkably elusive. Our knowledge and appreciation of the problem has increased substantially over the last few years, but the precise way in which many mutagens cause mutations is not yet known. The aims of this conference were therefore two-fold. The first was to survey present information about mutagenic mechanisms, drawing together data from work with various experimental approaches and organisms, in order to discern the principles governing the action of different mutagens. The second was to examine the implications of such principles for the execution and evaluation of test procedures, and critically assess the research areas that need further attention in order to improve the interpretation of test results. Chris Lawrence v ACKNOWLEDGEMENT We gratefully acknowledge the support provided for this Conference by the U.,S. Department of Energy, The Foundation for Microbiology, Exxon Corporation and the University of Rochester.

The Handbook of Plant Mutation Screening

Author : Khalid Meksem,Guenter Kahl
Publisher : John Wiley & Sons
Page : 460 pages
File Size : 45,9 Mb
Release : 2009-12-21
Category : Science
ISBN : 3527629408

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The Handbook of Plant Mutation Screening by Khalid Meksem,Guenter Kahl Pdf

Induced mutagenesis is a common and promising method for screening for new crops with improved properties. This title introduces the different methods and then focuses on the screening, detection and analysis of the novel mutations. Written by a global team of authors the book is an indispensable tool for all scientists working on crop breeding in industry and academia.

Somaclonal Variation and Induced Mutations in Crop Improvement

Author : S.M. Jain,D.S. Brar,B.S. Ahloowalia
Publisher : Springer Science & Business Media
Page : 615 pages
File Size : 53,7 Mb
Release : 2013-03-14
Category : Science
ISBN : 9789401591256

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Somaclonal Variation and Induced Mutations in Crop Improvement by S.M. Jain,D.S. Brar,B.S. Ahloowalia Pdf

Genetic variability is an important parameter for plant breeders in any con ventional crop improvement programme. Very often the desired variation is un available in the right combination, or simply does not exist at all. However, plant breeders have successfully recombined the desired genes from cultivated crop gerrnplasm and related wild species by sexual hybridization, and have been able to develop new cultivars with desirable agronomie traits, such as high yield, disease, pest, and drought resistance. So far, conventional breeding methods have managed to feed the world's ever-growing population. Continued population growth, no further scope of expanding arable land, soil degradation, environ mental pollution and global warrning are causes of concern to plant biologists and planners. Plant breeders are under continuous pressure to improve and develop new cultivars for sustainable food production. However, it takes several years to develop a new cultivar. Therefore, they have to look for new technologies, which could be combined with conventional methods to create more genetic variability, and reduce the time in developing new cultivars, with early-maturity, and improved yield. The first report on induced mutation of a gene by HJ. Muller in 1927 was a major mi1estone in enhancing variation, and also indicated the potential applica tions of mutagenesis in plant improvement. Radiation sources, such as X-rays, gamma rays and fast neutrons, and chemical mutagens (e. g. , ethyl methane sulphonate) have been widely used to induce mutations.

Induced Mutations in Plant Breeding

Author : W. Gottschalk,G. Wolff
Publisher : Springer Science & Business Media
Page : 250 pages
File Size : 50,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642819971

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Induced Mutations in Plant Breeding by W. Gottschalk,G. Wolff Pdf

Mutation breeding has been introduced into modern plant breeding in the early 1940's. In spite of pessimistic predictions, the application of experimental mutagenesis has led to encouraging results demonstrating that mutation breeding is a well-functioning method in many crops. So far, more than 500 varieties, developed by means of induced mutations, have been officially released; others have been approved for registration. Many mutants with characters of agronomic interest cannot be utilized directly because of their unsatisfying yielding capacities, or of other negative traits which are partly due to the pleiotropic action of the mutant genes. Sometimes their negative selection value can be overcome by transferring them into the genomes of other varieties. According to experience available, the efficiency of mutant genes can conSiderably vary depending on the genotypic background in which they become effective. The interactions between mutant genes and genotypic back ground cannot be predicted. Therefore, mutants with valuable traits should be crossed with many varieties and strains in order to discern positive and negative interactions. In this way, genotypes can be selected in which the mutant gene is able to express its action without showing negative by-effects. This procedure has been used for about 10 years by combining the methods of mutation and crossbreeding. Mutation breeding is predominantly used in annual diploid and allo polyploid self-fertilizing crops, while it causes much more difficulties in cross-pollinating species.

Chemically-Induced DNA Damage, Mutagenesis, and Cancer

Author : Ashis K. Basu, Takehiko Nohmi
Publisher : MDPI
Page : 275 pages
File Size : 50,9 Mb
Release : 2018-08-27
Category : Electronic
ISBN : 9783038971290

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Chemically-Induced DNA Damage, Mutagenesis, and Cancer by Ashis K. Basu, Takehiko Nohmi Pdf

This book is a printed edition of the Special Issue " Chemically-Induced DNA Damage, Mutagenesis, and Cancer" that was published in IJMS

Plant Mutagenesis and Crop Improvement

Author : Nitish Kumar
Publisher : CRC Press
Page : 302 pages
File Size : 51,6 Mb
Release : 2024-02-23
Category : Science
ISBN : 9781003834243

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Plant Mutagenesis and Crop Improvement by Nitish Kumar Pdf

Crop improvement using classically induced mutagenesis is now well standardized. Many new promising varieties of different crops have been successfully developed worldwide using both physical and chemical mutagens. Voluminous literature is now available on basic and applied aspects of mutagenesis. The mutation technique has been refined and holds the promise of generating much wider and more desirable variability than classical breeding. Recent advances in technology combined with classical mutation breeding offer new and exciting challenges for the development of new varieties. A global inventory of induced mutagenesis activities for crop improvement is requried. This book covers both basic and applied aspects of mutation and its impact on various crops: it is extremely well prepared and contains a huge volume of information accumulated using classically induced mutagenesis on different crops in different countries. Three key features: Describes the importance of induced mutation in crop plant research and its application to production Highlights new advances in the understanding of plant mutagenesis in crop improvement Contains contributions from major leaders in the field of plant mutation research This volume brings together all the important and relevant literature in the field. It provides a complete account of the mutation breeding of crops, presenting conclusions about the value of the method, its possibilities, limitations, and shortcomings, and the possible difficulties of further application in various crops. The initial chapters deal with the interactions between mutagenic treatment and plant material, such as aspects of mutagenic treatment, postirradiation behavior of shoot apices, and adventitious bud techniques. All available literature is then discussed crop by crop and critically evaluated. This will serve as an extremely comprehensive guide for researchers, teachers, students, and individuals who are interested in using induced mutagenesis as a tool for crop improvement.

Plant Cell Culture

Author : Michael R. Davey,Paul Anthony
Publisher : John Wiley & Sons
Page : 358 pages
File Size : 49,9 Mb
Release : 2010-05-20
Category : Science
ISBN : 0470686510

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Plant Cell Culture by Michael R. Davey,Paul Anthony Pdf

The ability to culture cells is fundamental for mass propagation and as a baseline for the genetic manipulation of plant nuclei and organelles. The introduction to Plant Cell Culture: Essential Methods provides a general background to plant cell culture, including basic principles, technologies and laboratory practices that underpin the more detailed techniques described in subsequent chapters. Whilst each chapter provides a background to the topic area and methodology, a crucial aspect is the provision of detailed protocols with emphasis on trouble shooting, describing common problems and detailed advice for their avoidance. Plant Cell Culture: Essential Methods provides the reader with a concise overview of these techniques, including micropropagation, mutagenesis, cryopreservation, genetic and plastid transformation and somatic cell technologies. This book will be an essential addition to any plant science laboratory's bookshelf. Highlights the best and most up-to-date techniques for working on plant cell culture Explains clearly and precisely how to carry out selected techniques in addition to background information on the various approaches Chapters are written by leading international authorities in the field and cover both well-known and new, tried and tested, methods for working in plant cell culture An essential laboratory manual for students and early-career researchers.

Mutagenesis

Author : Rajnikant Mishra
Publisher : BoD – Books on Demand
Page : 260 pages
File Size : 49,7 Mb
Release : 2012-08-17
Category : Science
ISBN : 9789535107071

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Mutagenesis by Rajnikant Mishra Pdf

The complexity of problem understanding biochemical and molecular basis of healthy life, and eagerness to find simple solution necessitate evolution of technology like mutagenesis. The chapters of this book contain experiences of scientists working in the area of mutagenesis. It describes suitable experimental models (microorganism, plants or animals) for testing spontaneous and induced mutations which are useful for basic and translational research. It includes methods towards gene targeting, developing disease and pest resistant plants, creating temperature sensitive molecular machines, understanding mitochondrial mutagenesis, detecting anti-mutagens, improving genetic insight into impaired immunity and disease. It also describes mutagenesis induced by DNA damage. It has also provided advantage of in vitro transcription and translation to yield proteins with point mutations, deletions or insertions for studying stability, DNA-protein or protein-protein interaction. Trust, it will serve readers as valuable integrated resources emphasizing methods of mutagenesis, and understanding mechanism of variable penetrance or expressivity of mutations.

Biotechnologies for Plant Mutation Breeding

Author : Joanna Jankowicz-Cieslak,Thomas H. Tai,Jochen Kumlehn,Bradley J. Till
Publisher : Springer
Page : 343 pages
File Size : 47,5 Mb
Release : 2016-12-08
Category : Science
ISBN : 9783319450216

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Biotechnologies for Plant Mutation Breeding by Joanna Jankowicz-Cieslak,Thomas H. Tai,Jochen Kumlehn,Bradley J. Till Pdf

This book is open access under a CC BY-NC 2.5 license. This book offers 19 detailed protocols on the use of induced mutations in crop breeding and functional genomics studies, which cover topics including chemical and physical mutagenesis, phenotypic screening methods, traditional TILLING and TILLING by sequencing, doubled haploidy, targeted genome editing, and low-cost methods for the molecular characterization of mutant plants that are suitable for laboratories in developing countries. The collection of protocols equips users with the techniques they need in order to start a program on mutation breeding or functional genomics using both forward and reverse-genetic approaches. Methods are provided for seed and vegetatively propagated crops (e.g. banana, barley, cassava, jatropha, rice) and can be adapted for use in other species.

Advances in Mutagenesis Research

Author : Günter Obe
Publisher : Springer Science & Business Media
Page : 250 pages
File Size : 47,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642774669

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Advances in Mutagenesis Research by Günter Obe Pdf

Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity and cancerogenicity of chemicals and other agents. Permanent mutation in genes and chromosomes, can be induced by aplethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Among the aspects discused by Advances in Mutagenesis Research are (1) the understanding of the molecular mechanisms leading to mutations, and (2) the prevention of a thoughtless introduction of mutagenic agents into the environment. Contents: Nikolay W. Timofeeff-Ressovsky (1900-1981): An Essay on his Life and Scientific Achievements. - Arylnitrenium Ions and the Genotoxic Potency of Aromatic Amines and Nitro Compounds. - Analysisof Mutagenicity and Chemical Structure in Various Series of Related Compounds. - Formation of 8-Hydroxyguanine by Oxidative DNA Damage, its Repair and its Mutagenic Effects. - Exploring Genetic and Non-Genetic Relationships: The Induction of Micronuclei. - Mechanisms of Induced Mutagenesis by Ultraviolet Light in Escherichia coli. - Polytene Chromosomes in Mutagenesis. Three-Way Differential Stainingof Chromosomes for the Identification of SCEs per Cell Cycle: Fundamentals and Applications. - The Mammalian Centromere: Centromere Separation, Kinetochore Proteins and Aneuploidy. - Chorionic Villi Analysis. - ExploringGenetic and Non-Genetic Relationships: The Induction of Micronuclei.

Induced Mutagenesis

Author : Christopher W. Lawrence
Publisher : Springer
Page : 0 pages
File Size : 48,5 Mb
Release : 1983-01-01
Category : Medical
ISBN : 0306411636

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Induced Mutagenesis by Christopher W. Lawrence Pdf

Concern is often expressed that our environment may include an increasingly large variety of mutagens, but the extent of the potential hazard they pose has yet to be fully evaluated. A variety of empirical procedures has been devised with which to estimate the mutagenic potency of suspect agents, and the relative merits of different tests are currently under debate. Although such tests are of great value, and are indeed indispensable, they are not, nevertheless, sufficient. In the long term, accurate estimation of hazard will also require a better understanding of the various mechanisms of mutagenesis, and in many instances these remain remarkably elusive. Our knowledge and appreciation of the problem has increased substantially over the last few years, but the precise way in which many mutagens cause mutations is not yet known. The aims of this conference were therefore two-fold. The first was to survey present information about mutagenic mechanisms, drawing together data from work with various experimental approaches and organisms, in order to discern the principles governing the action of different mutagens. The second was to examine the implications of such principles for the execution and evaluation of test procedures, and critically assess the research areas that need further attention in order to improve the interpretation of test results. Chris Lawrence v ACKNOWLEDGEMENT We gratefully acknowledge the support provided for this Conference by the U.,S. Department of Energy, The Foundation for Microbiology, Exxon Corporation and the University of Rochester.

C. Elegans II

Author : Donald L. Riddle
Publisher : Firefly Books
Page : 1252 pages
File Size : 53,7 Mb
Release : 1997
Category : Medical
ISBN : 0879695323

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C. Elegans II by Donald L. Riddle Pdf

Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR

Health Effects of Exposure to Low Levels of Ionizing Radiation

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V)
Publisher : National Academies
Page : 436 pages
File Size : 54,8 Mb
Release : 1990-02-01
Category : Science
ISBN : 9780309039956

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Health Effects of Exposure to Low Levels of Ionizing Radiation by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V) Pdf

This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.