Molecular Mechanisms In Visual Transduction

Author : D.G. Stavenga,W.J. de Grip,E.N. Pugh
Publisher : Elsevier
Page : 596 pages
File Size : 50,6 Mb
Release : 2000-11-30
Category : Science
ISBN : 0080536778

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Molecular Mechanisms in Visual Transduction by D.G. Stavenga,W.J. de Grip,E.N. Pugh Pdf

Molecular mechanisms in visual transduction is presently one of the most intensely studied areas in the field of signal transduction research in biological cells. Because the sense of vision plays a primary role in animal biology, and thus has been subject to long evolutionary development, the molecular and cellular mechanisms underlying vision have a high degree of sensitivity and versatility. The aims of visual transduction research are first to determine which molecules participate, and then to understand how they act in concert to produce the exquisite electrical responses of the photoreceptor cells. Since the 1940s [1] we have known that rod vision begins with the capture of a quantum of energy, a photon, by a visual pigment molecule, rhodopsin. As the function of photon absorption is to convert the visual pigment molecule into a G-protein activating state, the structural details of the visual pigments must be explained from the perspective of their role in activating their specific G-proteins. Thus, Chapters 1-3 of this Handbook extensively cover the physico-chemical molecular characteristics of the vertebrate rhodopsins. Following photoconversion and G-protein activation, the phototransduction cascade leads to modifications of the population of closed and open ion channels in the photoreceptor plasma membrane, and thereby to the electrical response. The nature of the channels of vertebrate photoreceptors is examined in Chapter 4, and Chapter 5 integrates the present body of knowledge of the activation steps in the cascade into a quantitative framework. Once the phototransduction cascade is activated, it must be subsequently silenced. The various molecular mechanisms participating in inactivation are treated in Chapters 1-4 and especially Chapter 5. Molecular biology is now an indispensable tool in signal transduction studies. Numerous vertebrate (Chapter 6) and invertebrate (Chapter 7) visual pigments have been characterized and cloned. The genetics and evolutionary aspects of this great subfamily of G-protein activating receptors are intriguing as they present a natural probe for the intimate relationship between structure and function of the visual pigments. Understanding the spectral characteristics from the molecular composition can be expected to

Author : Ikuo Takeuchi,Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 316 pages
File Size : 46,6 Mb
Release : 2008-04-30
Category : Medical
ISBN : 9780470515709

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Rhodopsins and Phototransduction by Ikuo Takeuchi,Gregory R. Bock,Jamie A. Goode Pdf

Brings together key new results of interdisciplinary collaborations among various research fields on rhodopsin including the photoreceptive mechanism of rhodopsins, the molecular mechanism of the visual transduction process, visual processes in the retina and other transduction processes in the retina and brain. The structures of the rhodopsin molecule are studied in the fields of protein chemistry, molecular biology, organic chemistry and structural biology; the ultra fast reactions of the retinal protein are studied in physics, biophysics, physical chemistry, organic chemistry and photobiology; the phototransduction in retinal proteins and visual cells are studied in biophysics, biochemistry, biophysical chemistry and photobiology; and the localization in the tissues is studied in anatomy and histochemistry. The diversity of visual systems in various animals is studied in zoology and comparative biochemistry.

Author : Joyce Tombran-Tink,Colin J. Barnstable
Publisher : Springer Science & Business Media
Page : 504 pages
File Size : 40,6 Mb
Release : 2008-08-11
Category : Medical
ISBN : 9781597453745

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Visual Transduction And Non-Visual Light Perception by Joyce Tombran-Tink,Colin J. Barnstable Pdf

This book reveals not only how the eye evolved into an organ of vision, but also describes how molecular mechanisms of key molecules operate in the phototransduction cascade. In this groundbreaking text, experts also explain mechanisms for sensing radiation outside of the visible wavelengths. Comprehensive and penetrating, the book brings together the mechanisms of the visual transduction cascade and is an invaluable text for everyone conducting research in the visual system.

Author : Helga Kolb,Eduardo Fernandez,Ralph Nelson
Publisher : Unknown
Page : 128 pages
File Size : 42,5 Mb
Release : 2007
Category : Electronic
ISBN : OCLC:503519994

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Webvision by Helga Kolb,Eduardo Fernandez,Ralph Nelson Pdf

Author : Henning Stieve,H. Stieve
Publisher : Springer Science & Business Media
Page : 510 pages
File Size : 51,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642704444

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The Molecular Mechanism of Photoreception by Henning Stieve,H. Stieve Pdf

very important, especially the comparison of vertebrate and invertebrate transduction mechanisms. The workshop was very successful and the outcome of the discussions proved it worth the effort. To no small extent has that success been made possible by Dr. Silke Bernhard who with a combination of authority and charm together with her extremely efficient and dedicated staff organized this workshop, providing the conditions and framework for a scientific debate of outstanding quality in a friendly and pleasant atmosphere. The great majority of participants were also very committed to making this workshop successful. Besides the reports of the four discussion groups, this publication contains the background papers which were revised by the authors partly as a result of suggestions of some participants. I hope this book will give a fair overview of the state of our knowledge of research in visual transduction. It was a pleasure to edit, especially because of the friendly and very efficient commitment of K. Geue, J. Lupp, and A. Eckert and the cooperativeness of most of the contributors. Particularly I would like to acknowledge gratefully the extensive efforts and patience of the four rapporteurs, M.L. Applebury, W.H. Miller, W.G. Owen, and E.N. Pugh, Jr., in compiling, writing, and revising the group reports. REFERENCES (1) Altman, J. 1985. Sensory transduction, new visions in photoreception. Nature 313: 264-265. (2) Hagins, W.A. 1972. The visual process: Excitatory mechanisms in the primary receptor cells. Ann. Rev. Biophys. Bioeng. 1: 131-158.

Author : P. Christen,E. Hofmann
Publisher : Springer
Page : 0 pages
File Size : 55,9 Mb
Release : 2011-12-08
Category : Science
ISBN : 3642751911

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EJB Reviews 1989 by P. Christen,E. Hofmann Pdf

EJB Reviews 1989 offer the collection of all reviews published in the European Journal of Biochemistry in one handy volume. This series of review articles by leading scientists covers emerging and rapidly growing fields of research in fundamental as well as in applied areas of biochemistry, such as medicine, biotechnology, agriculture and nutrition. Novel methodological and technological approaches which stimulate biochemical research are also included. All authors review their field in a very critical, selective, evaluative manner, with emphasis on interdisciplinary aspects wherever possible.

Author : William Hughes Miller
Publisher : Unknown
Page : 452 pages
File Size : 46,7 Mb
Release : 1981
Category : Science
ISBN : 0121533158

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Molecular Mechanisms of Photoreceptor Transduction by William Hughes Miller Pdf

Author : Steven J. Fliesler,Oleg G. Kisselev
Publisher : CRC Press
Page : 408 pages
File Size : 52,9 Mb
Release : 2007-12-26
Category : Science
ISBN : 1420007165

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Signal Transduction in the Retina by Steven J. Fliesler,Oleg G. Kisselev Pdf

In the twenty-first century, we are just beginning to understand more clearly the enormous diversity and complexity of signaling processes in the retina. Integrating advances in the biochemistry, cell biology, physiology, and physics of phototransduction, Signal Transduction in the Retina presents the methodologies and experimental approaches that yield key information on the mechanisms underlying normal retinal physiology. This in-depth work discusses the latest techniques and applications for understanding retinal function and degradation, developing novel therapeutic strategies, and promoting cellular survival and functional retention. Drawing contributions from experts in a range of disciplines, each chapter presents a brief overview of the area discussed along with specific methodology for obtaining the primary data to understand the cellular and molecular process. Given the dominance and wealth of information on rhodopsin-based phototransduction, the book devotes substantial attention to this topic, but also evaluates a diversity of signaling mechanisms. Beginning with the molecular mechanisms of vertebrate phototransduction, this volume presents the structure of phototransduction cascade components at atomic resolution, as well as molecular interactions in multi-protein complexes and novel cell-based strategies for understanding signal shut-off and light adaptation. It discusses non-visual phototransduction and the role of melanopsin in adaptive photoresponses and circadian clock regulation. The book also compares the visual signaling processes of vertebrates and invertebrates. It examines experimental studies of insulin-based signaling in the inner and outer retina; investigates retinal development including signaling in progenitor cells, cell-cell communication in developing cells, and neovascularization; and studies lipid-derived mediators such as neuroprotectins and discusses the participation of retinal pigment epithelium in neuronal survival.

Author : Steven J. Fliesler,Oleg G. Kisselev
Publisher : CRC Press
Page : 408 pages
File Size : 40,8 Mb
Release : 2007-12-26
Category : Science
ISBN : 0849373158

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Signal Transduction in the Retina by Steven J. Fliesler,Oleg G. Kisselev Pdf

In the twenty-first century, we are just beginning to understand more clearly the enormous diversity and complexity of signaling processes in the retina. Integrating advances in the biochemistry, cell biology, physiology, and physics of phototransduction, Signal Transduction in the Retina presents the methodologies and experimental approaches that yield key information on the mechanisms underlying normal retinal physiology. This in-depth work discusses the latest techniques and applications for understanding retinal function and degradation, developing novel therapeutic strategies, and promoting cellular survival and functional retention. Drawing contributions from experts in a range of disciplines, each chapter presents a brief overview of the area discussed along with specific methodology for obtaining the primary data to understand the cellular and molecular process. Given the dominance and wealth of information on rhodopsin-based phototransduction, the book devotes substantial attention to this topic, but also evaluates a diversity of signaling mechanisms. Beginning with the molecular mechanisms of vertebrate phototransduction, this volume presents the structure of phototransduction cascade components at atomic resolution, as well as molecular interactions in multi-protein complexes and novel cell-based strategies for understanding signal shut-off and light adaptation. It discusses non-visual phototransduction and the role of melanopsin in adaptive photoresponses and circadian clock regulation. The book also compares the visual signaling processes of vertebrates and invertebrates. It examines experimental studies of insulin-based signaling in the inner and outer retina; investigates retinal development including signaling in progenitor cells, cell-cell communication in developing cells, and neovascularization; and studies lipid-derived mediators such as neuroprotectins and discusses the participation of retinal pigment epithelium in neuronal survival.

Author : Carlo Musio
Publisher : World Scientific
Page : 510 pages
File Size : 55,7 Mb
Release : 2001
Category : Medical
ISBN : 9789812799975

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Vision by Carlo Musio Pdf

The light sense is conceivably the key sense in both the animal and the plant kingdom. Vision research, undoubtedly a fast-growing field, is providing impressive results OCo thanks to modern theoretical and methodological advances. The approach of biophysics and neuroscience seems to be of great benefit and, for this reason, the present book gives an outline of recent acquisitions and updated advanced methods concerning this approach. Visual mechanisms and processes are analysed at several (molecular, cellular, integrative, computational and cognitive) levels by different methodologies (from molecular biology to computation) applied to different living models (from protists to humans, via invertebrates and lower vertebrates). Contents: The Optics of Animal Eyes (M F Land); Rhodopsin-Like Proteins: The Universal and Probably Unique Proteins for Vision (P Gualtieri); The Molecular Design of a Visual Cascade: Molecular Stages of Phototransduction in Drosophila (R Paulsen et al.); Molecular Changes During Primary Visual Pathway Development (K L Moya et al.); Color Vision and Retinal Randomness of the Japanese Yellow Swallowtail Butterfly, Papilio Xuthus (K Arikawa et al.); Patch-Clamping Solitary Visual Cells to Understand the Cellular Mechanisms of Invertebrate Phototransduction (C Musio); Phototransduction in Retinal Rods and Cones (Y Koutalos et al.); Formation of OC ONOCO and OC OFFOCO Ganglion Cell Mosaics (L M Chalupa); Endogenous Nitric Oxide Modulates Signal Transmission from Photoreceptors to On-Center Bipolar Cells in the Rabbit Retina (B Lei & I Perlman); Now You See It, Now You Don't: Shunting Inhibition in Early Vision (L Borg-Graham et al.); Visual Perceptual Learning (N Berardi & A Fiorentini); Functions of the Primate Temporal Lobe Cortical Visual Areas in Invariant Visual Object and Face Recognition (E T Rolls); Vector Code in Neuronal Networks (E N Sokolov); and other papers. Readership: Scientists and postdoctoral students in neurosciences, biophysics and physiology."

Author : Hugo J. Bellen
Publisher : Unknown
Page : 466 pages
File Size : 41,5 Mb
Release : 1999
Category : Cellular signal transduction
ISBN : UOM:39015048547338

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Neurotransmitter Release by Hugo J. Bellen Pdf

Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons thatcommunicate with each other and their targets. This fast and accurate intercellular signalling most occurs at synapses, specialized processes of neurons that release chemical signals, called neurotransmitters. Neurotransmitters: Frontiers in Molecular Biology will provide the reader withextensive background information on neurotransmitter release. It takes a multidisciplinary approach, but does not assume previous knowledge having basic introductions to most topics. Topics however are covered in enough detail to be of interest to experts in the field. Throughout, emphasis is placedon the rationale by which proteins are assigned specific functions rather than just providing facts about function. The first chapter provides an introduction to the basic features and properties of the synapse and is followed by a chapter detailing several important techniques used to elucidatevarious aspects of release. Chapters 3 describes many of the biochemical approaches used to identify proteins involved in neurotransmitter release and then chapters 4 and 5 focus on more specific aspects of synaptic transmission: the proteins that transport neurotransmitters and the role ofphosphlipids in the process. The next five chapters concentrate on approaches to unravel the function of many proteins in vivo by using toxins, giant squid axons, C. elegans, Drosophila, and mice. The final chapter summarizes current knowledge on endocytosis and recycling. Knowledge of themolecular mechanisms underlying neurotransmitter release has expanded tremendously over the last 10 years. Many of the proteins involved have been isolated, but their roles have yet to be determined. These discoveries will be a major challenge and it is therefore the major aim of this book not onlyto provide information but also to generate excitement.

Author : Maria A. Livrea
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 48,5 Mb
Release : 2000
Category : Health & Fitness
ISBN : 3764358823

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Vitamin A and Retinoids by Maria A. Livrea Pdf

Rapid progress has been made in our understanding of the molecular mechanisms of cell growth and oncogenesis during the past decade. Special attention has been given to the presentation of the frequently neglected close correlation between changes in signal transduction and metabolic pathways during oncogenesis. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on the clinical efficiency of retinoids in skin disorders and cancer. The book presents recent findings on the regulation of cell growth in normal and neoplastic tissues by growth factors including hormones, and by the activation and inactivation of oncogenes and tumor suppressor genes, respectively. It also offers a survey of the molecular and cell biochemistry of retinoids. Basic researchers in biochemistry, pharmacology and cell biology as well as clinicians will find this book very informative and up-to-date. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on clinical efficiency of retinoids in skin disorders and cancer. Basic researchers in biochemistry, pharmacology, cell biology, and clinicians will find this book very informative and up-to-date. The chapters, organized in six sections, are contributed by leading scientists who have been working in the retinoid field for decades. Their experience and competence is aknowledged worldwide.

Author : Paul A. Hargrave,Klaus P. Hofmann,U. Benjamin Kaupp
Publisher : Springer Science & Business Media
Page : 317 pages
File Size : 44,8 Mb
Release : 2013-04-09
Category : Science
ISBN : 9783642764820

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Signal Transduction in Photoreceptor Cells by Paul A. Hargrave,Klaus P. Hofmann,U. Benjamin Kaupp Pdf

This book deals with the mechanism of signal transduction in vertebrate and invertebrate photoreceptors. It contains contributions on the structure and function of rhodopsin or other G-coupled receptors, on the regulation of second messengers by enzyme cascade, the role of Ca2+ in light adaptation, control of ionic channels in photoreceptor cells.

Author : Bastien D. Gomperts,Ijsbrand M. Kramer,Peter E.R. Tatham
Publisher : Gulf Professional Publishing
Page : 444 pages
File Size : 55,9 Mb
Release : 2003-10-15
Category : Medical
ISBN : 0122896327

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Signal Transduction by Bastien D. Gomperts,Ijsbrand M. Kramer,Peter E.R. Tatham Pdf

Signal Transduction is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particularly cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources, key observations and experiments that set the scene for recent and current work.

Author : Glenn Prazere Lobo,Manas R. Biswal,Altaf A. Kondkar
Publisher : Frontiers Media SA
Page : 162 pages
File Size : 51,6 Mb
Release : 2021-04-21
Category : Science
ISBN : 9782889667024

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Molecular Mechanisms of Retinal Cell Degeneration and Regeneration by Glenn Prazere Lobo,Manas R. Biswal,Altaf A. Kondkar Pdf