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Author : Jie Yan,Jianfeng Liu,Qian Ren,Qi Wang
Publisher : Frontiers Media SA
Page : 215 pages
File Size : 49,5 Mb
Release : 2023-01-13
Category : Science
ISBN : 9782832511411
Author : Sayed Ali,Francesce Fornai,Yossef Itzhak
Publisher : Wiley-Blackwell
Page : 552 pages
File Size : 48,5 Mb
Release : 2006-08-23
Category : Medical
ISBN : 1573316296
Methamphetamine, MDMA, cocaine, PMA , GHB, and various solvents are the most widely abused drugs in Europe, the United States, Central America, South America, and Asia; and their use has dramatically increased over the last two decades. These drugs of abuse are known to cause neurotoxicity in several species, including not only rodents, dogs, and nonhuman primates, but also humans. The precise neurochemical mechanisms underlying this drug-induced neurotoxicity remain unclear. This volume explores this question, specifically addressing the following aspects: (1) the role of genomics and proteomics in drug-induced neurotoxicity, (2) drugs of abuse and medication development, (3) molecular biology and free radicals in drug-induced neurotoxicity, (4) substituted amphetamine-induced neurochemical changes and relationship to neurotoxicity, (5) drugs of abuse and imaging brain structure and function. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member
Author : Syed F. Ali,Toshitaka Nabeshima,Tomoji Yanagita
Publisher : Unknown
Page : 664 pages
File Size : 46,9 Mb
Release : 2004
Category : Medical
ISBN : UVA:X004846766
This volume brings together basic and clinical investigators for the purpose of deepening our understanding of drugs of abuse and treatment of drug addiction. Methamphetamine, MDMA, PMA, and various solvents are the most widely abused drugs in the world; and their use has dramatically increased over the last two decades. These drugs of abuse are known to be neurotoxic in several species, including rodents, dogs, nonhuman primates, and humans. Nevertheless, the precise neurochemical mechanisms underlying this drug-induced neurotoxicity remain unclear. This volume will serve as a useful source of information not only for neurochemists, but also for investigators from many other disciplines.
Author : Sherrel Howard
Publisher : John Wiley & Sons
Page : 0 pages
File Size : 48,7 Mb
Release : 2014-05-05
Category : Medical
ISBN : 1118288459
Drug abuse has been, and continues to be, a global societal issue with diverse sets of impacts. Drugs of Abuse: Pharmacology and Molecular Mechanisms introduces the basic principles of pharmacology and neuroscience of drug abuse. Understanding the chemistry of commonly abused drugs and their impact on brain function will provide students and researchers with a more profound understanding of the molecular basis of drug abuse and addiction. Drugs of Abuse: Pharmacology and Molecular Mechanisms opens with a brief history of drug use and abuse. Subsequent sections look at specific families of drugs, including stimulants, depressants, and hallucinogens among others, and explore how their chemical make-up interacts with brain function. The final chapter provides a brief overview of clinical substance abuse treatment. Providing a concise, accessible introductory overview of the topic, Drugs of Abuse: Pharmacology and Molecular Mechanisms will be a valuable resource for students, researchers, and others interested in how drugs interact with the brain. Introduces readers to the basic principles of neuroscience and pharmacology as related to drug use and abuse. Explores how the chemical make-up of drugs interact with the brain and can lead to addiction Includes coverage of a wide array of commonly abused families of drugs, including stimulants, depressants, hallucinogens, and others. Provides an essential introduction to the chemical and molecular underpinnings of drug use and abuse
Author : Sherrel G. Howard
Publisher : Unknown
Page : 210 pages
File Size : 50,7 Mb
Release : 2014
Category : Central nervous system stimulants
ISBN : 1118850041
Drug abuse has been, and continues to be, a global societal issue with diverse sets of impacts. Drugs of Abuse: Pharmacology and Molecular Mechanisms introduces the basic principles of pharmacology and neuroscience of drug abuse. Understanding the chemistry of commonly abused drugs and their impact on brain function will provide students and researchers with a more profound understanding of the molecular basis of drug abuse and addiction. Drugs of Abuse: Pharmacology and Molecular Mechanisms opens with a brief history of drug use and abuse.
Author : Institute of Medicine,Committee on Opportunities in Drug Abuse Research
Publisher : National Academies Press
Page : 330 pages
File Size : 47,7 Mb
Release : 1996-11-01
Category : Medical
ISBN : 9780309055338
Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.
Author : Robert Vink,Mihai Nechifor
Publisher : University of Adelaide Press
Page : 354 pages
File Size : 55,6 Mb
Release : 2011
Category : Medical
ISBN : 9780987073051
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Neurotoxicology and Models for Assessing Risk
Publisher : National Academies Press
Page : 167 pages
File Size : 43,8 Mb
Release : 1992-02-01
Category : Science
ISBN : 9780309045315
Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Author : Victor R. Preedy
Publisher : Academic Press
Page : 1182 pages
File Size : 42,5 Mb
Release : 2016-03-25
Category : Psychology
ISBN : 9780128003756
Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader’s knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 2 addresses stimulants, club and dissociative drugs, hallucinogens, and inhalants and solvents. Each section provides data on the general, molecular and cellular, and structural and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention, and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad material and substances. Offers a modern approach to understanding the pathology of substances of abuse, offering an evidence-based ethos for understanding the neurology of addictions Fills an existing gap in the literature by serving as a “one-stop-shopping synopsis of everything to do with the neuropathology of drugs of addiction and substance misuse Includes in each chapter: list of abbreviations, abstract, introduction, applications to other addictions and substance misuse, mini-dictionary of terms, summary points, 6+ figures and tables, and full references Offers coverage of preclinical, clinical, and population studies, from the cell to whole organs, and from the genome to whole body
Author : Ralph E. Tarter,Robert T. Ammerman,Peggy J. Ott
Publisher : Springer Science & Business Media
Page : 582 pages
File Size : 47,7 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781475729139
A review of the literature pertaining to the neurobehavioral pharmacology of abusable drugs, this is the only book to survey each of the eleven classes of addictive drugs from the perspectives of neurological, behavioral, and clinical pharmacology. Designed to serve as a companion text to the DSM-IV manual, the Handbook provides comprehensive information about each drug and drug class having abuse potential with respect to their pharmaceutical mechanisms and actions.
Author : United Nations Office on Drugs and Crime
Publisher : United Nations
Page : 128 pages
File Size : 54,6 Mb
Release : 2007-06-27
Category : Political Science
ISBN : 9789211554014
This report offers one of the most comprehensive insights into global trends in international culture, production, seizure and price of illicit drugs. It examines trends in the world's four major markets: opium and heroin, coca and cocaine, cannabis, and amphetamine-type stimulants. This edition provides an in-depth examination of the link between transnational organized crime and drug trafficking. A detailed statistical appendix on production, prices and consumption completes this book, which gives the reader a comprehensive picture of the world's drug problem.
Author : National Institute on Drug Abuse
Publisher : Unknown
Page : 40 pages
File Size : 45,6 Mb
Release : 2000
Category : Drug abuse
ISBN : MINN:31951D01962761Y
Author : Antonius M. VanDongen
Publisher : CRC Press
Page : 350 pages
File Size : 40,8 Mb
Release : 2008-10-29
Category : Science
ISBN : 142004415X
The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world’s leading authorities on NMDA receptors, Biology of the NMDA Receptor brings together virtually all the players in this important field.
Author : Niamh Nic Daeid,Max Houck
Publisher : CRC Press
Page : 798 pages
File Size : 54,8 Mb
Release : 2017-08-09
Category : Law
ISBN : 9781439826591
Every three years, worldwide forensics experts gather at the Interpol Forensic Science Symposium to exchange ideas and discuss scientific advances in the field of forensic science and criminal justice. Drawn from contributions made at the latest gathering in Lyon, France, Interpol's Forensic Science Review is a one-source reference providing a comp
Author : Anonim
Publisher : Elsevier
Page : 348 pages
File Size : 55,8 Mb
Release : 2016-01-21
Category : Medical
ISBN : 9780444635440
Neuroscience for Addiction Medicine: From Prevention to Rehabilitation: Constructs and Drugs is the latest volume from Progress in Brain Research focusing on new trends and developments in addiction research. This established international series examines major areas of basic and clinical research within neuroscience, as well as popular emerging subfields such as addiction. This volume takes an integrated approach to review and summarize some of the most recent progress from the subfield of addiction research, with particular emphasis on potential applications in a clinical setting. Explores new trends and developments in basic and clinical research in the addiction subfield of neuroscience Uses an integrated approach to review and summarize recent progress Emphasizes potential applications in a clinical setting Enhances the literature of neuroscience by further expanding the established international series Progress in Brain Research