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Molecular Neurobiology of Addiction Recovery by Kenneth Blum,John Femino,Scott Teitelbaum,John Giordano,Marlene Oscar-Berman,Mark Gold Pdf
Humans are biologically programmed to seek out pleasurable experiences. These experiences are processed in the mesolimbic system, also referred to as the "reward center" of the brain, where a number of chemical messengers work in concert to provide a net release of dopamine in the Nucleus Accumbens. In some genetically predisposed individuals, addiction occurs when the mechanisms of the mesolimbic system are disrupted by the use of various drugs of abuse. Since Alcoholics Anonymous was founded in 1935, it's 12 step program of spiritual and character development has helped countless alcoholics and drug addicts curb their self-destructive behaviors. However, the program was developed at a time when comparatively little was known about the function of the brain and it has never been studied scientifically. This is the first book to take a systematic look at the molecular neurobiology associated with each of the 12 steps and to review the significant body of addiction research literature that is pertinent to the program.
The Neurobiology of Addiction by Trevor W. Robbins,Barry J. Everitt,David J. Nutt Pdf
In the past two decades, there have been astonishing advances in our understanding of the neurobiological basis and nature of drug addiction. We now know the initial molecular sites of action, at identified receptors, of virtually all of the major drugs of abuse including cocaine, heroin, and amphetamine, as well as legal drugs such as nicotine and alcohol. We also understand the main components of a 'reward system' and its connections to major brain regions involved in motivation and emotion, such as the amygdala, hippocampus, and prefrontal cortex. The Neurobiology of Addiction describes the latest advances in our understanding of addiction. It brings together world class researchers to debate the nature and extent of addiction, as well as its causes, consequences, and treatment. The focus of the book is on the brain processes underlying addiction, in terms of neural systems, neurochemical basis, and molecular changes. Several types of addiction are discussed ranging from illicit drugs - cocaine, amphetamine, and heroin to legal drugs - alcohol and nicotine. In addition, it explores increasingly common behavioural addictions such as gambling and obesity. Included are chapters on vulnerability to addiction, genetic factors, opponent motivational processes, animal models, relapse, cognitive deficits associated with drug abuse, new pharmacological treatments, and current controversies concerning different neuropsychological theories of addiction. Throughout, it reports on cutting edge research using brain imaging, and state of the art molecular methodology. The book will make fascinating reading for students and teachers in the field of neuroscience, pharmacology and psychology, as well as experts in the field.
Neurobiology of Addiction by George F. Koob,Michel Le Moal Pdf
Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. · Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching
Author : George F. Koob,Michael A. Arends,Michel Le Moal Publisher : Academic Press Page : 351 pages File Size : 43,5 Mb Release : 2014-07-12 Category : Medical ISBN : 9780123869593
Drugs, Addiction, and the Brain by George F. Koob,Michael A. Arends,Michel Le Moal Pdf
Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain. Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle Actual data figures from original sources illustrating key concepts and findings Introduction to basic neuropharmacology terms and concepts Introduction to numerous animal models used to study diverse aspects of drug use. Thorough review of extant work on the neurobiology of addiction
Institute of Medicine,Committee to Identify Strategies to Raise the Profile of Substance Abuse and Alcoholism Research
Author : Institute of Medicine,Committee to Identify Strategies to Raise the Profile of Substance Abuse and Alcoholism Research Publisher : National Academies Press Page : 236 pages File Size : 48,6 Mb Release : 1997-11-10 Category : Medical ISBN : 9780309174596
Dispelling the Myths About Addiction by Institute of Medicine,Committee to Identify Strategies to Raise the Profile of Substance Abuse and Alcoholism Research Pdf
Every year about half a million men, women, and children in the United States die from the effects of using nicotine, alcohol, and illegal drugs: one of every four American deaths. Yet research to solve this terrible problem is often perceived as less important than other types of biomedical investigation. Focusing on four major classes of drugs with the greatest social and economic impactâ€"nicotine, alcohol, opioids, and stimulantsâ€"Dispelling the Myths About Addiction examines what is known about addiction and what is needed to develop a talented cadre of investigators and to educate the public about addiction research. The committee explores these areas: Economic costs of addiction. What has been learned about addiction from research into basic neurobiology and the brain, psychosocial and behavioral factors, and epidemiology. Education and training of researchers and the research infrastructure. Public perceptions and their impact on public policy in this field. This volume outlines the challenges and opportunities in addiction research today and makes recommendations to educators, treatment professionals, public and private institutions, and others for how to build support for addiction research and treatment.
Neural Mechanisms of Addiction by Mary Torregrossa Pdf
Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field. Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research. Transcends multiple neural, neurochemical and behavioral domains Summarizes advances in the field of addiction research since the advent of optogenetics Discusses the most current, leading theories of addiction, including molecular mechanisms and dopamine mechanisms
A NEW YORK TIMES BESTSELLER From a renowned behavioral neuroscientist and recovering addict, a rare page-turning work of science that draws on personal insights to reveal how drugs work, the dangerous hold they can take on the brain, and the surprising way to combat today's epidemic of addiction. Judith Grisel was a daily drug user and college dropout when she began to consider that her addiction might have a cure, one that she herself could perhaps discover by studying the brain. Now, after twenty-five years as a neuroscientist, she shares what she and other scientists have learned about addiction, enriched by captivating glimpses of her personal journey. In Never Enough, Grisel reveals the unfortunate bottom line of all regular drug use: there is no such thing as a free lunch. All drugs act on the brain in a way that diminishes their enjoyable effects and creates unpleasant ones with repeated use. Yet they have their appeal, and Grisel draws on anecdotes both comic and tragic from her own days of using as she limns the science behind the love of various drugs, from marijuana to alcohol, opiates to psychedelics, speed to spice. With more than one in five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide, and Grisel delves with compassion into the science of this scourge. She points to what is different about the brains of addicts even before they first pick up a drink or drug, highlights the changes that take place in the brain and behavior as a result of chronic using, and shares the surprising hidden gifts of personality that addiction can expose. She describes what drove her to addiction, what helped her recover, and her belief that a “cure” for addiction will not be found in our individual brains but in the way we interact with our communities. Set apart by its color, candor, and bell-clear writing, Never Enough is a revelatory look at the roles drugs play in all of our lives and offers crucial new insight into how we can solve the epidemic of abuse.
Institute of Medicine,Committee on Opportunities in Drug Abuse Research
Author : Institute of Medicine,Committee on Opportunities in Drug Abuse Research Publisher : National Academies Press Page : 330 pages File Size : 55,9 Mb Release : 1996-11-01 Category : Medical ISBN : 9780309055338
Pathways of Addiction by Institute of Medicine,Committee on Opportunities in Drug Abuse Research Pdf
Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.
Office of the Surgeon General,U.s. Department of Health and Human Services
Author : Office of the Surgeon General,U.s. Department of Health and Human Services Publisher : Createspace Independent Publishing Platform Page : 420 pages File Size : 51,6 Mb Release : 2017-08-15 Category : Electronic ISBN : 1974580628
Facing Addiction in America by Office of the Surgeon General,U.s. Department of Health and Human Services Pdf
All across the United States, individuals, families, communities, and health care systems are struggling to cope with substance use, misuse, and substance use disorders. Substance misuse and substance use disorders have devastating effects, disrupt the future plans of too many young people, and all too often, end lives prematurely and tragically. Substance misuse is a major public health challenge and a priority for our nation to address. The effects of substance use are cumulative and costly for our society, placing burdens on workplaces, the health care system, families, states, and communities. The Report discusses opportunities to bring substance use disorder treatment and mainstream health care systems into alignment so that they can address a person's overall health, rather than a substance misuse or a physical health condition alone or in isolation. It also provides suggestions and recommendations for action that everyone-individuals, families, community leaders, law enforcement, health care professionals, policymakers, and researchers-can take to prevent substance misuse and reduce its consequences.
Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol addiction and its effects on the brain. Offering thorough coverage of all aspects of alcohol research, treatment and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of alcohol misuse. Alcohol is one of the world’s most common addictive substances, with about two billion individuals worldwide consuming it in one form or another and three million annual deaths that are associated with alcohol misuse. Alcohol alters a variety of neurological processes, from molecular biology, to cognition. Moreover, addiction to alcohol can lead to numerous other health concerns and damage virtually every organ system in the body, making diagnosis and treatment of individuals addicted to alcohol of critical importance. Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of alcohol use, along with its effects on neurobiological function Discusses alcohol use as a component of dual-use and poly addictions Outlines numerous screening and treatment strategies for alcohol misuse Covers both the physical and psychological effects of alcohol use and withdrawals to provide a fully-formed view of alcohol dependency and its effects
A Clinical Guide to Treating Behavioral Addictions by Amanda L. Giordano, PhD, LPC Pdf
Giordano, an established scholar in behavioral addictions, has provided a landmark clinical reference book. This text provides the quintessential guide to understanding process addictions with detailed attention to assessment and treatment that is unparalleled in the literature. This is a must-have book for every clinician. - Craig S. Cashwell, Ph.D., LPC, NCC, ACS, CSAT-S, Professor, William & Mary ”This groundbreaking text, A Clinical Guide to Treating Behavioral Addictions, is a must-read for counselors and educators alike. As a former addictions counselor, now counselor educator, I found the information in this text timely, relevant, and instrumental to the work of treating persons with behavioral addictions. This go-to resource will prove to be invaluable for years to come!” --Michael K. Schmit, PhD, LPC, Hazelden Betty Ford Graduate School of Addiction Studies An innovative new text addressing 11 behavioral addictions in detail with a focus on recent neuroscience. This practical, approachable guide for clinicians comprehensively covers an array of behavioral addictions ranging from internet gaming addiction and sex addiction, to social media addiction and food addiction. Each chapter answers foundational questions to inform clinical practice including: How do I conceptualize it?, How do I identify it?, How do I assess it?, How do I treat it?, and How do I learn more? &Through this innovative resource, clinicians will gain valuable knowledge regarding the conceptualization, identification, assessment, and treatment of behavioral addictions. Each chapter highlights the most current research related to specific behavioral addictions, provides a synthesis of recent neuroscience, and examines diverse treatment approaches to fit the widest range of clinical styles. In addition, this book describes the evolving definition of addiction, provides examples of how to advocate for clients with behavioral addictions, and devotes an entire chapter to understanding the neuroscience of addiction. This clinical reference book will help counselors provide compassionate, effective services to clients with a variety of behavioral addictions. Purchase includes digital access for use on most mobile devices or computers. Key Features: Offers “Voices from the Field” sections in which clinicians describe their experiences working with each behavioral addiction Includes a chapter completely devoted to the neuroscience of addiction in addition to a synthesis of recent neuroscience in each chapter Synthesizes current research to aid in clinical conceptualizations Describes useful assessment instruments and how to access them Presents a wide range of treatment approaches and 12-step program options Provides abundant resources for further study
Neurobiology of Alcohol Dependence by Antonio Noronha,Changhai Cui,Robert Adron Harris,John C. Crabbe Pdf
Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence. Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence Chapters authored by leaders in the field around the globe — the broadest, most expert coverage available
Integrative Addiction and Recovery by Shahla Modir,George Munoz Pdf
Integrative Addiction and Recovery offers an authentic model of comprehensive integrative modalities germane and specific to the field of addiction and recovery treatment. Although many treatment services for addiction include "holistic," "alternative," or "integrative" in their descriptions, they contain no substantive programs or services consistent with the mind, body, spirit paradigm contained within the integrative approach to health and healing. Consequently, many patients do not have the opportunity to benefit from the true spirit of an integrative approach within the discipline of addition and recovery medicine. This book sets the standard for a bona fide integrative approach for others to follow, providing information that is immediately useful in clinical practice and rigorously evidence-based. Authored by world-class experts in the field of addiction medicine, Integrative Addiction and Recovery presents both scientific and holistic data regarding a wide variety of holistic and conventional approaches to the treatment of substance abuse and behavioral addictions. Its chapters cover both conventional and holistic treatment and provide background for each of the major classes of drugs of abuse, including opiates, alcohol, tobacco, stimulants, sedative-hypnotics, hallucinogens and marijuana. It also includes chapters on the topics of food addiction and behavioral addictions such as gambling and shopping. The authors explore the major holistic modalities, providing background and theory in areas like acupuncture, Traditional Chinese Medicine, Homeopathy, Aromatherapy, and Ayurvedic Medicine, while at the same time providing spiritual approach chapters on Shamanism and Ibogaine, as well as more conventional issues with a holistic view including Co-Occurring Disorders and Psychosocial Treatment, and Group Support. The very complex issue of chronic pain and addiction is also addressed, along with relapse prevention strategies.
Neurocircuitry of Addiction by Nicholas W. Gilpin Pdf
People use drugs for many different reasons, including the pursuit of "high," social factors and self-medication of other conditions. Many millions of people are addicted to at least one substance, and the cost of addiction is immense, at both the individual and societal levels. Neurocircuitry of Addiction is the first book of its kind, with a focus on addiction neuroscience from a neural circuit perspective. This book begins with a primer on circuit-based neuroscience that equips the reader with an understanding of the applications described throughout the book. Each subsequent chapter positions a different brain region at the "center" of addiction neurocircuitry and goes on to describe the anatomical connectivity of that brain region, how those circuits are affected by drug exposure, and the role of those circuits in controlling addiction-related behaviors. All chapters of this book are written by content experts for a target audience that has some basic neuroscience background, but no prior in-depth knowledge regarding the neurocircuitry of addiction. Reviews the circuit-based tools that are used by scientists to investigate neural circuit function Describes how acute and chronic alcohol and drug exposure affect neural circuit function Describes the state of the science regarding the role of specific neural circuis in drug addiction Chapters include data from both human neuroscience and animal models
Overcoming Your Alcohol or Drug Problem by Dennis C. Daley,G. Alan Marlatt Pdf
This expanded edition of the successful Graywind title, Managing Your Drug and Alcohol Problem: Therapist Guide provides an evidence-based treatment protocol for all types of substance use disorders. Designed to accompany the Managing Your Addictive Behavior: Workbook, Second Edition, this guide provides clinicians with valuable strategies for working with substance use disorders by focusing on specific issues involved in both stopping substance abuse and changing behaviors or lifestyle aspects that contribute to continued substance abuse. In addition to addressing professional approaches/attitudes toward the substance abusing client, assessment, psychosocial and pharamacotherapeutic treatment, and self-help programs, this expanded edition also includes a new chapter on the management of a co-occurring psychiatric disorder. TreatmentsThatWorkTM represents the gold standard of behavioral healthcare interventions! · All programs have been rigorously tested in clinical trials and are backed by years of research · A prestigious scientific advisory board, led by series Editor-In-Chief David H. Barlow, reviews and evaluates each intervention to ensure that it meets the highest standard of evidence so you can be confident that you are using the most effective treatment available to date · Our books are reliable and effective and make it easy for you to provide your clients with the best care available · Our corresponding workbooks contain psychoeducational information, forms and worksheets, and homework assignments to keep clients engaged and motivated · A companion website (www.oup.com/us/ttw) offers downloadable clinical tools and helpful resources · Continuing Education (CE) Credits are now available on select titles in collaboration with PsychoEducational Resources, Inc. (PER)