The Neurobiology Of Addiction

Author : George F. Koob,Michel Le Moal
Publisher : Elsevier
Page : 503 pages
File Size : 55,8 Mb
Release : 2005-11-11
Category : Psychology
ISBN : 9780080497372

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Neurobiology of Addiction by George F. Koob,Michel Le Moal Pdf

Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. · Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching

Author : Francesca Mapua Filbey
Publisher : Cambridge University Press
Page : 209 pages
File Size : 55,5 Mb
Release : 2019-03-14
Category : Medical
ISBN : 9781107127982

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The Neuroscience of Addiction by Francesca Mapua Filbey Pdf

Combines classic theories with current neuroscientific studies to explain the addiction cycle, focusing on neuroimaging studies and applications.

Author : Carlton K. Erickson
Publisher : W. W. Norton & Company
Page : 312 pages
File Size : 40,7 Mb
Release : 2007-02-17
Category : Psychology
ISBN : 0393076229

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The Science of Addiction: From Neurobiology to Treatment by Carlton K. Erickson Pdf

Runner-up winner of the Hamilton Book Author Award, this book is a comprehensive overview of the neurobiology behind addictions. Neuroscience is clarifying the causes of compulsive alcohol and drug use––while also shedding light on what addiction is, what it is not, and how it can best be treated––in exciting and innovative ways. Current neurobiological research complements and enhances the approaches to addiction traditionally taken in social work and psychology. However, this important research is generally not presented in a forthright, jargon-free way that clearly illustrates its relevance to addiction professionals. The Science of Addiction presents a comprehensive overview of the roles that brain function and genetics play in addiction. It explains in an easy-to-understand way changes in the terminology and characterization of addiction that are emerging based upon new neurobiological research. The author goes on to describe the neuroanatomy and function of brain reward sites, and the genetics of alcohol and other drug dependence. Chapters on the basic pharmacology of stimulants and depressants, alcohol, and other drugs illustrate the specific and unique ways in which the brain and the central nervous system interact with, and are affected by, each of these substances Erickson discusses current and emerging treatments for chemical dependence, and how neuroscience helps us understand the way they work. The intent is to encourage an understanding of the body-mind connection. The busy clinical practitioner will find the chapter on how to read and interpret new research findings on the neurobiological basis of addiction useful and illuminating. This book will help the almost 21.6 million Americans, and millions more worldwide, who abuse or are dependent on drugs by teaching their caregivers (or them) about the latest addiction science research. It is also intended to help addiction professionals understand the foundations and applications of neuroscience, so that they will be able to better empathize with their patients and apply the science to principles of treatment.

Author : Judith Grisel
Publisher : Anchor
Page : 258 pages
File Size : 43,6 Mb
Release : 2020-01-14
Category : Psychology
ISBN : 9780525434900

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Never Enough by Judith Grisel Pdf

A NEW YORK TIMES BESTSELLER From a renowned behavioral neuroscientist and recovering addict, a rare page-turning work of science that draws on personal insights to reveal how drugs work, the dangerous hold they can take on the brain, and the surprising way to combat today's epidemic of addiction. Judith Grisel was a daily drug user and college dropout when she began to consider that her addiction might have a cure, one that she herself could perhaps discover by studying the brain. Now, after twenty-five years as a neuroscientist, she shares what she and other scientists have learned about addiction, enriched by captivating glimpses of her personal journey. In Never Enough, Grisel reveals the unfortunate bottom line of all regular drug use: there is no such thing as a free lunch. All drugs act on the brain in a way that diminishes their enjoyable effects and creates unpleasant ones with repeated use. Yet they have their appeal, and Grisel draws on anecdotes both comic and tragic from her own days of using as she limns the science behind the love of various drugs, from marijuana to alcohol, opiates to psychedelics, speed to spice. With more than one in five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide, and Grisel delves with compassion into the science of this scourge. She points to what is different about the brains of addicts even before they first pick up a drink or drug, highlights the changes that take place in the brain and behavior as a result of chronic using, and shares the surprising hidden gifts of personality that addiction can expose. She describes what drove her to addiction, what helped her recover, and her belief that a “cure” for addiction will not be found in our individual brains but in the way we interact with our communities. Set apart by its color, candor, and bell-clear writing, Never Enough is a revelatory look at the roles drugs play in all of our lives and offers crucial new insight into how we can solve the epidemic of abuse.

Author : Trevor W. Robbins,Barry J. Everitt,David J. Nutt
Publisher : Unknown
Page : 327 pages
File Size : 41,9 Mb
Release : 2010
Category : Medical
ISBN : 9780199562152

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The Neurobiology of Addiction by Trevor W. Robbins,Barry J. Everitt,David J. Nutt Pdf

In the past two decades, there have been astonishing advances in our understanding of the neurobiological basis and nature of drug addiction. We now know the initial molecular sites of action, at identified receptors, of virtually all of the major drugs of abuse including cocaine, heroin, and amphetamine, as well as legal drugs such as nicotine and alcohol. We also understand the main components of a 'reward system' and its connections to major brain regions involved in motivation and emotion, such as the amygdala, hippocampus, and prefrontal cortex. The Neurobiology of Addiction describes the latest advances in our understanding of addiction. It brings together world class researchers to debate the nature and extent of addiction, as well as its causes, consequences, and treatment. The focus of the book is on the brain processes underlying addiction, in terms of neural systems, neurochemical basis, and molecular changes. Several types of addiction are discussed ranging from illicit drugs - cocaine, amphetamine, and heroin to legal drugs - alcohol and nicotine. In addition, it explores increasingly common behavioural addictions such as gambling and obesity. Included are chapters on vulnerability to addiction, genetic factors, opponent motivational processes, animal models, relapse, cognitive deficits associated with drug abuse, new pharmacological treatments, and current controversies concerning different neuropsychological theories of addiction. Throughout, it reports on cutting edge research using brain imaging, and state of the art molecular methodology. The book will make fascinating reading for students and teachers in the field of neuroscience, pharmacology and psychology, as well as experts in the field.

Author : Adrian Carter,Wayne Hall
Publisher : Cambridge University Press
Page : 365 pages
File Size : 40,9 Mb
Release : 2011-11-17
Category : Medical
ISBN : 9781139504676

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Addiction Neuroethics by Adrian Carter,Wayne Hall Pdf

Addiction is a significant health and social problem and one of the largest preventable causes of disease globally. Neuroscience promises to revolutionise our ability to treat addiction, lead to recognition of addiction as a 'real' disorder in need of medical treatment and thereby reduce stigma and discrimination. However, neuroscience raises numerous social and ethical challenges: • If addicted individuals are suffering from a brain disease that drives them to drug use, should we mandate treatment? • Does addiction impair an individual's ability to consent to research or treatment? • How will neuroscience affect social policies towards drug use? Addiction Neuroethics addresses these challenges by examining ethical implications of emerging neurobiological treatments, including: novel psychopharmacology, neurosurgery, drug vaccines to prevent relapse, and genetic screening to identify individuals who are vulnerable to addiction. Essential reading for academics, clinicians, researchers and policy-makers in the fields of addiction, mental health and public policy.

Author : George F. Koob,Michael A. Arends,Mandy L McCracken,Michel Le Moal
Publisher : Academic Press
Page : 402 pages
File Size : 41,9 Mb
Release : 2021-07-07
Category : Psychology
ISBN : 9780128167946

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Alcohol by George F. Koob,Michael A. Arends,Mandy L McCracken,Michel Le Moal Pdf

A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. Alcohol, Volume 3 in the series, explores the molecular, cellular, and neurocircuitry systems in the brain responsible for alcohol addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. Outlines the history and behavioral mechanism of action of alcohol relevant to the neurobiology of alcohol addiction Includes neurocircuitry, cellular, and molecular neurobiological mechanisms of alcohol addiction in each stage of the addiction cycle Explores evolving areas of research associated with all three stages of the alcohol addiction cycle, including neurobiological studies of neurodevelopmental effects of early exposure to alcohol, sleep disturbances caused by alcohol, pain interactions with alcohol, sex differences in the response to alcohol, and epigenetic/genetic interactions with alcohol

Author : Stephen J. Wilson
Publisher : John Wiley & Sons
Page : 552 pages
File Size : 40,5 Mb
Release : 2015-07-07
Category : Psychology
ISBN : 9781118472248

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The Wiley Handbook on the Cognitive Neuroscience of Addiction by Stephen J. Wilson Pdf

This volume provides a thorough and up-to-date synthesis of the expansive and highly influential literature from the last 30 years by bringing together contributions from leading authorities in the field, with emphasis placed on the most commonly investigated drugs of abuse. Emphasises the most commonly investigated drugs of abuse, including alcohol, cocaine, nicotine, and opiates Brings together the work of the leading authorities in all major areas of the field Provides novel coverage of cutting-edge methods for using cognitive neuroscience to advance the treatment of addiction, including real-time neurofeedback and brain stimulation methods Includes new material on emerging themes and future directions in the use of cognitive neuroscience to advance addiction science

Author : George F. Koob,Michael A. Arends,Michel Le Moal
Publisher : Academic Press
Page : 351 pages
File Size : 41,7 Mb
Release : 2014-07-12
Category : Medical
ISBN : 9780123869593

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Drugs, Addiction, and the Brain by George F. Koob,Michael A. Arends,Michel Le Moal Pdf

Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain. Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle Actual data figures from original sources illustrating key concepts and findings Introduction to basic neuropharmacology terms and concepts Introduction to numerous animal models used to study diverse aspects of drug use. Thorough review of extant work on the neurobiology of addiction

Author : W.W. Fleischhacker,D.J. Brooks
Publisher : Springer Science & Business Media
Page : 136 pages
File Size : 52,9 Mb
Release : 2003-09-04
Category : Medical
ISBN : 3211013156

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Addiction Mechanisms, Phenomenology and Treatment by W.W. Fleischhacker,D.J. Brooks Pdf

Substance-related disorders pose an increasing challenge not only to the field of psychiatry but also to public health. The rapid development of our society has also changed the face of substance use and abuse, both quantitatively and qualitatively. In this volume international experts present reviews of the latest research covering many areas ranging from neurobiology to psychological management, as well as different drugs, from alcohol to ecstasy.

Author : Anonim
Publisher : Unknown
Page : 76 pages
File Size : 50,8 Mb
Release : 2007
Category : Brain
ISBN : MINN:31951D025861296

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Drugs, Brains, and Behavior by Anonim Pdf

Author : Marc Lewis
Publisher : Doubleday Canada
Page : 320 pages
File Size : 44,6 Mb
Release : 2015-08-04
Category : Self-Help
ISBN : 9780385682299

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The Biology of Desire by Marc Lewis Pdf

Through the vivid, true stories of five people who journeyed into and out of addiction, a renowned neuroscientist explains why the “disease model” of addiction is wrong and illuminates the path to recovery. The psychiatric establishment and rehab industry in the Western world have branded addiction a brain disease, based on evidence that brains change with drug use. But in The Biology of Desire, cognitive neuroscientist and former addict Marc Lewis makes a convincing case that addiction is not a disease, and shows why the disease model has become an obstacle to healing. Lewis reveals addiction as an unintended consequence of the brain doing what it’s supposed to do—seek pleasure and relief—in a world that’s not cooperating. Brains are designed to restructure themselves with normal learning and development, but this process is accelerated in addiction when highly attractive rewards are pursued repeatedly. Lewis shows why treatment based on the disease model so often fails, and how treatment can be retooled to achieve lasting recovery, given the realities of brain plasticity. Combining intimate human stories with clearly rendered scientific explanation, The Biology of Desire is enlightening and optimistic reading for anyone who has wrestled with addiction either personally or professionally.

Author : Kenneth Blum,John Femino,Scott Teitelbaum,John Giordano,Marlene Oscar-Berman,Mark Gold
Publisher : Springer Science & Business Media
Page : 98 pages
File Size : 51,8 Mb
Release : 2013-05-27
Category : Medical
ISBN : 9781461472308

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Molecular Neurobiology of Addiction Recovery by Kenneth Blum,John Femino,Scott Teitelbaum,John Giordano,Marlene Oscar-Berman,Mark Gold Pdf

Humans are biologically programmed to seek out pleasurable experiences. These experiences are processed in the mesolimbic system, also referred to as the "reward center" of the brain, where a number of chemical messengers work in concert to provide a net release of dopamine in the Nucleus Accumbens. In some genetically predisposed individuals, addiction occurs when the mechanisms of the mesolimbic system are disrupted by the use of various drugs of abuse. Since Alcoholics Anonymous was founded in 1935, it's 12 step program of spiritual and character development has helped countless alcoholics and drug addicts curb their self-destructive behaviors. However, the program was developed at a time when comparatively little was known about the function of the brain and it has never been studied scientifically. This is the first book to take a systematic look at the molecular neurobiology associated with each of the 12 steps and to review the significant body of addiction research literature that is pertinent to the program.​

Author : David W. Self,Julie K. Staley Gottschalk
Publisher : Springer Science & Business Media
Page : 392 pages
File Size : 42,6 Mb
Release : 2009-12-18
Category : Medical
ISBN : 9783642030017

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Behavioral Neuroscience of Drug Addiction by David W. Self,Julie K. Staley Gottschalk Pdf

Drug addiction is a chronically relapsing mental illness involving severe motivational disturbances and loss of behavioral control leading to personal dev- tation. The disorder af?icts millions of people, often co-occurring with other mental illnesses with enormous social and economic costs to society. Several decades of research have established that drugs of abuse hijack the brain’s natural reward substrates, and that chronic drug use causes aberrant alterations in these rewa- processing systems. Such aberrations may be demonstrated at the cellular, neu- transmitter, and regional levels of information processing using either animal models or neuroimaging in humans following chronic drug exposure. Behaviorally, these neural aberrations manifest as exaggerated, altered or dysfunctional expr- sion of learned behavioral responses related to the pursuit of drug rewards, or to environmental factors that precipitate craving and relapse during periods of drug withdrawal. Current research efforts are aimed at understanding the associative and causal relationships between these neurobiological and behavioral events, such that treatment options will ultimately employ therapeutic amelioration of neural de?cits and restoration of normal brain processing to promote efforts to abstain from further drug use. The Behavioral Neuroscience of Drug Addiction, part of the Springer series on Current Topics in Behavioral Neurosciences, contains scholarly reviews by noted experts on multiple topics from both basic and clinical neuroscience ?elds.

Author : Institute of Medicine,Committee to Identify Strategies to Raise the Profile of Substance Abuse and Alcoholism Research
Publisher : National Academies Press
Page : 236 pages
File Size : 48,7 Mb
Release : 1997-11-10
Category : Medical
ISBN : 9780309174596

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Dispelling the Myths About Addiction by Institute of Medicine,Committee to Identify Strategies to Raise the Profile of Substance Abuse and Alcoholism Research Pdf

Every year about half a million men, women, and children in the United States die from the effects of using nicotine, alcohol, and illegal drugs: one of every four American deaths. Yet research to solve this terrible problem is often perceived as less important than other types of biomedical investigation. Focusing on four major classes of drugs with the greatest social and economic impactâ€"nicotine, alcohol, opioids, and stimulantsâ€"Dispelling the Myths About Addiction examines what is known about addiction and what is needed to develop a talented cadre of investigators and to educate the public about addiction research. The committee explores these areas: Economic costs of addiction. What has been learned about addiction from research into basic neurobiology and the brain, psychosocial and behavioral factors, and epidemiology. Education and training of researchers and the research infrastructure. Public perceptions and their impact on public policy in this field. This volume outlines the challenges and opportunities in addiction research today and makes recommendations to educators, treatment professionals, public and private institutions, and others for how to build support for addiction research and treatment.