Molecular Oncology Of Breast Cancer

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Molecular Oncology of Breast Cancer

Jeffrey Stuart Ross,Gabriel N. Hortobagyi
Molecular Oncology of Breast Cancer Book PDF

Author : Jeffrey Stuart Ross,Gabriel N. Hortobagyi
Publisher : Jones & Bartlett Learning
Page : 642 pages
File Size : 46,6 Mb
Release : 2005
Category : Medical
ISBN : 0763748102

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Molecular Oncology of Breast Cancer by Jeffrey Stuart Ross,Gabriel N. Hortobagyi Pdf

The first comprehensive reference to focus on the molecular development and treatment of the disease, Molecular Oncology of Breast Cancer provides authoritative information across the spectrum of modern breast cancer research and clinical care. Edited by two world-class experts in cancer pathology, drug development, and patient management, with contributions from over 50 experts, this ground-breaking text describes the genes, proteins, and biologic pathways that are being evaluated today and will be tested in the future to derive the molecular signature of each newly diagnosed breast cancer. For the first time, readers can now obtain, in a single volume, up-to-date information on how molecular-based tests are being used to identify predisposition, provide earliest detection, decide classification based on genetic fingerprint and predict therapy-specific outcomes. MOBC includes unique chapters on functional imaging and the impact of targeted therapies on the FDA approval process. This book gives readers vital, up-to-date information on important molecular discoveries that affect the everyday management of the breast cancer patient.

Principles of Molecular Oncology

Miguel H. Bronchud
Principles of Molecular Oncology Book PDF

Author : Miguel H. Bronchud
Publisher : Springer Science & Business Media
Page : 716 pages
File Size : 43,7 Mb
Release : 2003-12-03
Category : Medical
ISBN : 9781592596645

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Principles of Molecular Oncology by Miguel H. Bronchud Pdf

At the midpoint of the 20th century, our knowledge of cancer was based on epide- ology and pathology, and treatment consisted of surgery and radiation therapy. At mid-century, Medawar and colleagues initiated the understanding of transplantation immunology, Farber described the first use of an antifolic drug to treat leukemia, and Jacobson and coworkers described the irradiation-protection effect of spleen cells. These observations opened the door to the development of chemotherapy and tra- plantation in the treatment of cancer. Despite the rapid development of these new disciplines, progress was usually based on empiric observations and clinical trials. The rapid advances in molecular biology at the end of the 20th century mark a new era in our knowledge of cancer. Molecular immunology, molecular genetics, mole- lar pharmacology, and the Human Genome Project are in the process of providing a level of understanding of cancer undreamed of in the past. Optimism is based on the firm belief that understanding at the molecular level will lead to better and earlier di- nosis, to new forms of treatment, and, most importantly, eventually to prevention of many types of cancer.

Genes, Oncogenes, and Hormones

Robert B. Dickson,Marc E. Lippman
Genes Oncogenes and Hormones Book PDF

Author : Robert B. Dickson,Marc E. Lippman
Publisher : Springer Science & Business Media
Page : 478 pages
File Size : 55,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461535003

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Genes, Oncogenes, and Hormones by Robert B. Dickson,Marc E. Lippman Pdf

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current di agnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Molecular Basis of Breast Cancer

Jose Russo,Irma H. Russo
Molecular Basis of Breast Cancer Book PDF

Author : Jose Russo,Irma H. Russo
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 42,9 Mb
Release : 2011-06-28
Category : Medical
ISBN : 9783642187360

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Molecular Basis of Breast Cancer by Jose Russo,Irma H. Russo Pdf

This richly-illustrated atlas-like book provides a foundation for the biological and molecular understanding of how the mammary gland develops and how breast cancer originates. The main goal is to comprehensively review in ten chapters fundamental knowledge in breast cancer. New paradigms are described in which induction of differentiation in the mammary gland can promote prevention and cure of breast cancer. The text is extremely helpful both for clinicians treating patients and researchers looking for new avenues of development.

Breast Cancer

Anne M. Bowcock
Breast Cancer Book PDF

Author : Anne M. Bowcock
Publisher : Springer Science & Business Media
Page : 593 pages
File Size : 42,9 Mb
Release : 1999-01-11
Category : Medical
ISBN : 9781592594566

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Breast Cancer by Anne M. Bowcock Pdf

A comprehensive state-of-the-art summary of breast cancer research and treatment by leading authorities. The book's many distinguished contributors illuminate the biology and genetics of breast cancer, including what is known about the hereditary breast cancer genes, BRCA1 and 2, the cutting-edge cytogenic approaches, and the biology of breast cancer metastasis. In addition, the authors describe current and future methods of breast cancer treatment in depth, and discuss environment and diet as risk factors for the disease. Breast Cancer: Molecular Genetics, Pathogenesis, and Therapeutics constitutes an excellent reference and resource for all those clinical and experimental oncologists, as well as genetic counselors nurses, who need to understand the latest developments in breast cancer biology, risk, and treatment.

Breast Cancer: Cellular and Molecular Biology

Marc E. Lippman,Robert B. Dickson
Breast Cancer Cellular and Molecular Biology Book PDF

Author : Marc E. Lippman,Robert B. Dickson
Publisher : Springer Science & Business Media
Page : 406 pages
File Size : 54,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461317333

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Breast Cancer: Cellular and Molecular Biology by Marc E. Lippman,Robert B. Dickson Pdf

Where do you begin to look for a recent, authoritative article on the diagnosis or management of particular malignancy? The few general oncology text books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals fre quently publish good in-depth reviews of cancer topics, and published sym posium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by divid ing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Molecular Oncology: Underlying Mechanisms and Translational Advancements

Ammad Ahmad Farooqi,Muhammad Ismail
Molecular Oncology Underlying Mechanisms and Translational Advancements Book PDF

Author : Ammad Ahmad Farooqi,Muhammad Ismail
Publisher : Springer
Page : 302 pages
File Size : 42,7 Mb
Release : 2017-03-29
Category : Medical
ISBN : 9783319530826

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Molecular Oncology: Underlying Mechanisms and Translational Advancements by Ammad Ahmad Farooqi,Muhammad Ismail Pdf

Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.

Molecular Pathology of Breast Cancer

Sunil Badve,Yesim Gökmen-Polar
Molecular Pathology of Breast Cancer Book PDF

Author : Sunil Badve,Yesim Gökmen-Polar
Publisher : Springer
Page : 428 pages
File Size : 45,9 Mb
Release : 2016-11-26
Category : Medical
ISBN : 9783319417615

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Molecular Pathology of Breast Cancer by Sunil Badve,Yesim Gökmen-Polar Pdf

The complex landscape of breast cancer requires distinct strategies for the management of various molecular subtypes of this disease. Rapid advances in the field of molecular biology have been bewildering for those involved in its study and management. “Molecular Pathology of Breast Cancer” aims to close this knowledge gap by discussing comprehensively the evolution, biological basis and clinical applications with a focus on the “what, when, and how” of the most significant molecular markers known to date. These markers are evaluated in the context of genomic, transcriptomic and proteomic profiles, which is integral to the practice of precision medicine. The application of next generation sequencing (NGS) has provided new insights in the regulation of genomic and transcriptomic structure and function. Alterations in DNA such as mutations and single nucleotide polymorphisms (SNPs) have been correlated with outcomes and provide for novel therapeutic approaches. These NGS analyses have also revealed the extensive contributions of epigenetic mechanisms such as histone modifications, non-coding RNA and alternative splicing. All of these changes together contribute to alterations in proteome. Newer assays that allow greater stability and analytical consistency are emerging. These alterations in tumor profiles can be also now detected by imaging techniques. The heterogeneity of both tumor and tumor microenvironment, an inevitable reality, is discussed in detail with particular focus on cancer stem cells and immune signaling. A chapter is dedicated to the emerging technology of “liquid biopsy”, which opens a novel approach for “continuous” monitoring of cancer that might be superior to conventional diagnostics, “Molecular Pathology of Breast Cancer” provides a quick and easy, not to mention essential, tour for clinicians, pathologists and scientists who are seeking to understand the integration of molecular biology into the diagnosis, prognosis and management of breast cancer.

Molecular Oncology Principles and Recent Advances

Javier Camacho
Molecular Oncology Principles and Recent Advances Book PDF

Author : Javier Camacho
Publisher : Bentham Science Publishers
Page : 237 pages
File Size : 55,5 Mb
Release : 2012-02-07
Category : Medical
ISBN : 9781608050161

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Molecular Oncology Principles and Recent Advances by Javier Camacho Pdf

"Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials currently in progress for cancer patients, the success rate is still very low. Understanding the molecular aspects of cancer development, the discovery of new molecu"

Molecular Oncology

Frank Joseph Rauscher (III)
Molecular Oncology Book PDF

Author : Frank Joseph Rauscher (III)
Publisher : Cambridge University Press
Page : 985 pages
File Size : 48,8 Mb
Release : 2014
Category : Medical
ISBN : 9780521876629

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Molecular Oncology by Frank Joseph Rauscher (III) Pdf

Reviews the origins of molecular oncology, including technologies for cancer analysis, key pathways in human malignancies, and available pharmacologic therapies.

Introduction to Oncogenes and Molecular Cancer Medicine

Dennis W. Ross
Introduction to Oncogenes and Molecular Cancer Medicine Book PDF

Author : Dennis W. Ross
Publisher : Springer Science & Business Media
Page : 188 pages
File Size : 50,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461216629

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Introduction to Oncogenes and Molecular Cancer Medicine by Dennis W. Ross Pdf

Providing the physician with a solid understanding of molecular biology and its applications for the diagnosis and treatment of cancer, this book reviews the basic molecular and other principles of cancer medicine, including controls of cell growth and senescence, carcinogenesis, tumorogenesis, and epidemiology. The second part of the book gives clinical examples to demonstrate the basic science principles, including chapters on leukaemia, colon cancer, and breast cancer. A chapter on molecular diagnostics and screening plus a chapter on new molecular anti-cancer therapies allow readers an insight into current therapies as well as the future of molecular cancer medicine. A useful glossary defines new terminology at-a-glance. Written in a user-friendly, conversational format, this text will be welcomed by all physicians eager to sharpen their own understanding of molecular cancer medicine as well as to help them provide patients with balanced information on the advances and limitations of current treatment options.

Molecular Oncology and Clinical Applications

CITTADINI,BASERGA,PINEDO,GALEOTTI,CORDA
Molecular Oncology and Clinical Applications Book PDF

Author : CITTADINI,BASERGA,PINEDO,GALEOTTI,CORDA
Publisher : Birkhäuser
Page : 425 pages
File Size : 47,9 Mb
Release : 2013-11-21
Category : Science
ISBN : 9783034856638

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Molecular Oncology and Clinical Applications by CITTADINI,BASERGA,PINEDO,GALEOTTI,CORDA Pdf

The basic knowledge of cell biology and molecular genetics in oncology is increasingly attracting the interest of clinical oncologists and is close to reaching a helpful application at the bedside. At present, it seems clear that the solution of the cancer problem lies within the comprehension of the intimate mechanisms leading to cell transformation and tumor progression as weIl as of the cancer-host relationship. According to this rationale every achievement in this context could drastically improve both diagnosis and therapy of neoplastic diseases. This={)ook represents the proceedings of the International Conference o~ Cancer: Biological Mechanisms and Clinical Applications, held in Rome on November 16-18, 1992. The meeting was organized by the Centro di Ricerche Oncologiche "Giovanni XXIII" of the Catholic University of Rome and the Consorzio Mario Negri Sud of S. M. Imbaro in collaboration with other colleagues from the Universities of Napoli and Bologna. As organizers and pmticipants to the Conference we think the meeting was a success, as was confirmed by the great interest raised in scientific and academic circles. The book collects contributions from leading scientists in all oncological m·eas ranging from molecular biology to immunology, diagnosis and therapy. The papers are organized into four sections: I - Molecular aspects of cell transformation and growth; II - Membrane receptors and signal transduction; III - Models for new therapeutical strategies; IV - Clinical Applications, following the strategy that chm·acterized the entire meeting: from molecule to bedside.

Precision Molecular Pathology of Breast Cancer

Ashraf Khan,Ian O. Ellis,Andrew M. Hanby,Ediz F. Cosar,Emad A. Rakha,Dina Kandil
Precision Molecular Pathology of Breast Cancer Book PDF

Author : Ashraf Khan,Ian O. Ellis,Andrew M. Hanby,Ediz F. Cosar,Emad A. Rakha,Dina Kandil
Publisher : Springer
Page : 338 pages
File Size : 46,7 Mb
Release : 2015-08-12
Category : Medical
ISBN : 9781493928866

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Precision Molecular Pathology of Breast Cancer by Ashraf Khan,Ian O. Ellis,Andrew M. Hanby,Ediz F. Cosar,Emad A. Rakha,Dina Kandil Pdf

This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2. Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.

Molecular Oncology Testing for Solid Tumors

Michael Ola Idowu,Catherine Isabelle Dumur,Carleton Theodore Garrett
Molecular Oncology Testing for Solid Tumors Book PDF

Author : Michael Ola Idowu,Catherine Isabelle Dumur,Carleton Theodore Garrett
Publisher : Springer
Page : 742 pages
File Size : 45,6 Mb
Release : 2015-08-18
Category : Medical
ISBN : 9783319163048

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Molecular Oncology Testing for Solid Tumors by Michael Ola Idowu,Catherine Isabelle Dumur,Carleton Theodore Garrett Pdf

Familiarity with and understanding molecular testing is becoming imperative for practicing physicians, especially pathologists and oncologists given the current explosion of molecular tests for diagnostic, prognostic and predictive indications. Molecular Oncology Testing for Solid Tumors is designed to present an up to date practical approach to molecular testing in a easy to understand format. Emphasis is placed on quality assurance (pre-analytic, analytic and post-analytic) and test interpretation, including but not limited to: the important role of pathologists in ensuring specimen adequacy for molecular testing; factors to consider in choosing platforms for molecular assays; advantages and limitations inherent to common assays/platforms that pathologists need to communicate effectively with clinicians; the importance of required quality assurance measures to ensure accurate / reproducible results; pitfalls in test interpretation (including different types of artifacts that may lead to False Positive or False Negative interpretations); test reporting using standard nomenclature; review of the current and future potential utility of next-generation sequencing in oncology. All chapters are written by pathologists and clinicians experienced in practical applications of molecular tests for solid tumors. The uniqueness of this textbook is the use of a standardized template for each of the molecular tests being discussed followed by a discussion of relevant quality assurance issues to ensure focused and efficient presentation of information. This will enable readers to easily understand the Order, Report and Evaluate (ORE) process of molecular tests. Lastly, summary tables of all the molecular assays and mutations discussed in the text are provided as an appendix for quick reference. For readers interested in more detailed information, a link to websites where additional information can be obtained is provided.

Molecular Mechanisms of Cancer

Georg F. Weber
Molecular Mechanisms of Cancer Book PDF

Author : Georg F. Weber
Publisher : Springer Science & Business Media
Page : 643 pages
File Size : 43,8 Mb
Release : 2007-09-12
Category : Medical
ISBN : 9781402060168

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Molecular Mechanisms of Cancer by Georg F. Weber Pdf

This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.