Molecular Pathology Of Alzheimer S Disease

Author : Rudy Castellani,George Perry
Publisher : Biota Publishing
Page : 113 pages
File Size : 40,9 Mb
Release : 2013-10-31
Category : Health & Fitness
ISBN : 9781615047413

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Molecular Pathology of Alzheimer's Disease by Rudy Castellani,George Perry Pdf

Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.

Author : David Dawbarn,Shelley J. Allen
Publisher : Oxford University Press
Page : 128 pages
File Size : 55,7 Mb
Release : 2007-05-03
Category : Medical
ISBN : 9780191034589

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Neurobiology of Alzheimer's Disease by David Dawbarn,Shelley J. Allen Pdf

Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associated proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.

Author : Dennis Dickson,Roy O. Weller
Publisher : John Wiley & Sons
Page : 497 pages
File Size : 46,6 Mb
Release : 2011-09-09
Category : Medical
ISBN : 9781444341232

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Neurodegeneration by Dennis Dickson,Roy O. Weller Pdf

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Author : Paul A. Adlard,Roger Chung
Publisher : Frontiers Media SA
Page : 177 pages
File Size : 55,5 Mb
Release : 2016-02-02
Category : Electronic book
ISBN : 9782889197200

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The Molecular Pathology of Cognitive Decline: Focus on Metals by Paul A. Adlard,Roger Chung Pdf

In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.

Author : David Dawbarn,Shelley J. Allen
Publisher : Oxford University Press, USA
Page : 444 pages
File Size : 51,5 Mb
Release : 2001
Category : Medical
ISBN : UVA:X004551396

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Neurobiology of Alzheimer's Disease by David Dawbarn,Shelley J. Allen Pdf

This revised edition of a book first published in 1995, presents an accessible overview of Alzheimer's disease, with an emphasis on research into the molecular mechanisms of neuronal degeneration. International experts have provided in-depth reviews of their areas of expertise, including coverage of the key molecules known to be involved, such as Ab, tau, apolipoprotein E and the presenilins. Other areas covered include neuropathology, genetics, neurochemical pathology, inflammation, diagnosis, models of the disease and opportunities for treatment, employing both existing and emerging drug therapies. The book will provide a readable introduction for those new to the subject, as well as covering a wide range of specialist topics for more experienced researchers and those interested in the overlap with other related specialist areas. Also included are appendices detailing gene and protein information on APP, tau, the presenilins, apolipoprotein E and the newly cloned therapeutic target, BACE.

Author : Masatoshi Takeda,Toshihisa Tanaka,Ramón Cacabelos
Publisher : Karger Medical and Scientific Publishers
Page : 312 pages
File Size : 50,6 Mb
Release : 2004
Category : Medical
ISBN : 9783805576031

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Molecular Neurobiology of Alzheimer Disease and Related Disorders by Masatoshi Takeda,Toshihisa Tanaka,Ramón Cacabelos Pdf

Alzheimers disease affects 6-10% of the elderly population, causing impairment in cognitive functions and significant disability in daily living for more than ten years. Neurofibrillary tangles, amyloid deposits and neuronal loss are the three hallmarks of Alzheimers disease. Due to insolubility of these unique structures in Alzheimer brain tissue, they were very difficult to study by usual biochemical methods in the past. Active research is now going on to elucidate the pathogenesis of Alzheimers disease. Major topics of neurobiological study of Alzheimers disease include the unraveling of the molecular mechanism of neurofibrillary tangle formation in neuronal and glial cells, the molecular processing of amyloid precursor protein in intracellular organella and in extra-cellular space, and the molecular mechanism of neuronal loss. The articles in this book were selected from contributions presented by leading scientists in this field at the international symposium which took place in Osaka in 2002. This publication is essential reading for all researchers, clinicians, basic and social scientists, neurologists and psychiatrists to promote the understanding of this formidable disease.

Author : Patrick A. Lewis,Jennifer E. Spillane
Publisher : Academic Press
Page : 274 pages
File Size : 44,6 Mb
Release : 2018-11-16
Category : Science
ISBN : 9780128110706

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The Molecular and Clinical Pathology of Neurodegenerative Disease by Patrick A. Lewis,Jennifer E. Spillane Pdf

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

Author : Harry F. Baker
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 48,5 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781592591343

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Molecular Pathology of the Prions by Harry F. Baker Pdf

Internationally recognized investigators review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level. Utilizing a variety of cutting-edge techniques, these distinguished scientists seek to define the normal function of a prion protein, to detect and measure the early immune response to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological investigations to elucidate the pathogenetic mechanisms involved in prion diseases. State-of-the-art and richly insightful, Molecular Pathology of the Prions captures for basic and clinical neuropathologists the latest developments and approaches to understanding the pathogenesis of prion diseases, and by analogy suggests possible research techniques for the more common proteinopthies, such as Alzheimer's and Parkinson's diseases.

Author : Gareth W. Roberts,Julia M. Polak
Publisher : Cambridge University Press
Page : 204 pages
File Size : 51,5 Mb
Release : 1995-06-08
Category : Medical
ISBN : 0521425581

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Molecular Neuropathology by Gareth W. Roberts,Julia M. Polak Pdf

This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.

Author : K. Beyreuther,Daniel M. Michaelson,Ûnîversîṭā George S. Wise Faculty of Life Sciences
Publisher : Unknown
Page : 50 pages
File Size : 48,8 Mb
Release : 2002
Category : Electronic
ISBN : OCLC:255339654

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Cellular and Animal Models of Alzheimer's Disease Molecular Pathology by K. Beyreuther,Daniel M. Michaelson,Ûnîversîṭā George S. Wise Faculty of Life Sciences Pdf

Author : Christian Haass
Publisher : CRC Press
Page : 350 pages
File Size : 52,5 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203303610

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Molecular Biology of Alzheimer's Disease by Christian Haass Pdf

Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.

Author : J. Robin Harris,Falk Fahrenholz
Publisher : Springer Science & Business Media
Page : 409 pages
File Size : 52,9 Mb
Release : 2006-11-22
Category : Science
ISBN : 9780387232263

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Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta by J. Robin Harris,Falk Fahrenholz Pdf

To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.

Author : Ian Macreadie
Publisher : MDPI
Page : 228 pages
File Size : 51,8 Mb
Release : 2019-10-25
Category : Science
ISBN : 9783039214075

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Molecular Mechanism of Alzheimer's Disease by Ian Macreadie Pdf

Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.

Author : Gary Miner
Publisher : Marcel Dekker
Page : 450 pages
File Size : 49,6 Mb
Release : 1989
Category : Medical
ISBN : UOM:39015018863624

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Familial Alzheimer's Disease by Gary Miner Pdf

Author : Sangram S. Sisodia,Rudolph E. Tanzi
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 40,7 Mb
Release : 2007-02-16
Category : Medical
ISBN : 9780387351353

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Alzheimer's Disease by Sangram S. Sisodia,Rudolph E. Tanzi Pdf

This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.