Molecular Biology Of Alzheimer S Disease

Author : Christian Haass
Publisher : CRC Press
Page : 350 pages
File Size : 55,7 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203303610

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Molecular Biology of Alzheimer's Disease by Christian Haass Pdf

Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.

Author : Sangram S. Sisodia,Rudolph E. Tanzi
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 55,7 Mb
Release : 2007-02-16
Category : Medical
ISBN : 9780387351353

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Alzheimer's Disease by Sangram S. Sisodia,Rudolph E. Tanzi Pdf

This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.

Author : Rudy Castellani,George Perry
Publisher : Biota Publishing
Page : 93 pages
File Size : 42,7 Mb
Release : 2013-10-01
Category : Health & Fitness
ISBN : 9781615046393

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Molecular Pathology of Alzheimer's Disease by Rudy Castellani,George Perry Pdf

Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.

Author : Robert Becker,Ezio Giacobini
Publisher : Springer Science & Business Media
Page : 571 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461241164

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Alzheimer Disease by Robert Becker,Ezio Giacobini Pdf

Author : Dennis J. Selkoe,David Michael Holtzman,Eckhard Mandelkow
Publisher : Cold Spring Harbor Perspective
Page : 0 pages
File Size : 40,6 Mb
Release : 2012
Category : Medical
ISBN : 1936113449

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The Biology of Alzheimer Disease by Dennis J. Selkoe,David Michael Holtzman,Eckhard Mandelkow Pdf

Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in the brain as the disease progressesincluding the accumulation of amyloid plaques and neurofibrillary tanglesis critical for the development of successful therapeutic approaches. Written and edited by leading experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Contributors discuss the biochemistry and cell biology of amyloid -protein precursor (APP), tau, presenilin, -secretase, and apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its causation and pathogenesis. This comprehensive volume, which includes discussions of therapeutic strategies that are currently used or under development, is a vital reference for neurobiologists, cell biologists, pathologists, and other scientists pursuing the biological basis of Alzheimer disease, as well as investigators, clinicians, and students interested in its pathogenesis, treatment, and prevention.

Author : Anonim
Publisher : Academic Press
Page : 408 pages
File Size : 54,8 Mb
Release : 2019-11-05
Category : Science
ISBN : 9780128178751

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Molecular Biology of Neurodegenerative Diseases: Visions for the Future by Anonim Pdf

Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Volume 168 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, Propagation and removal of cerebral amyloid angiopathy, and much more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Author : Robert Becker,Ezio Giacobini
Publisher : Unknown
Page : 632 pages
File Size : 51,8 Mb
Release : 1996-12-01
Category : Electronic
ISBN : 1461241170

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Alzheimer Disease by Robert Becker,Ezio Giacobini Pdf

Author : Anonim
Publisher : Academic Press
Page : 222 pages
File Size : 53,9 Mb
Release : 2021-01-14
Category : Science
ISBN : 9780128241448

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Molecular Biology of Neurodegenerative Diseases: Visions for the Future - Part B by Anonim Pdf

Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Part B, Volume 177 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, and more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Author : G. Lubec
Publisher : Springer Science & Business Media
Page : 362 pages
File Size : 50,8 Mb
Release : 2013-12-01
Category : Medical
ISBN : 9783709163801

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The Molecular Biology of Down Syndrome by G. Lubec Pdf

This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology.

Author : Roger N. Rosenberg,A. E. Harding
Publisher : Butterworth-Heinemann
Page : 277 pages
File Size : 43,7 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483163307

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The Molecular Biology of Neurological Disease by Roger N. Rosenberg,A. E. Harding Pdf

The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

Author : Wilma Wasco,Rudolph Tanzi
Publisher : Springer Science & Business Media
Page : 313 pages
File Size : 43,9 Mb
Release : 1996-11-01
Category : Medical
ISBN : 9781592594719

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Molecular Mechanisms of Dementia by Wilma Wasco,Rudolph Tanzi Pdf

The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.

Author : Juan I. Castrillo,Stephen G. Oliver
Publisher : Humana
Page : 0 pages
File Size : 51,5 Mb
Release : 2016-10-15
Category : Medical
ISBN : 1493947036

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Systems Biology of Alzheimer's Disease by Juan I. Castrillo,Stephen G. Oliver Pdf

Alzheimer’s disease (AD) and many other neurodegenerative disorders are multifactorial in nature, involving a combination of genomic, epigenomic, network dynamic and environmental factors. A proper investigation requires new integrative Systems Biology approaches, at both the experimental and computational level. The interplay of disease mechanisms and homeostatic networks will underlie the time of onset and rate of progression of the disease. This book addresses such an integrated approach to AD. It aims to present Systems Biology, including both experimental and computational approaches, as a new strategy for the study of AD and other multifactorial diseases, with the hope that the results will translate into more effective diagnosis and treatment, as well as improved public health policies. Written for the highly successful Methods in Molecular Biology series, practical and cutting-edge, Systems Biology of Alzheimer’s Disease is intended for post-graduate students, post-doctoral researchers and experts in different fields with an interest in comprehensive Systems Biology strategies applicable to AD and other complex multifactorial diseases (including other neurodegenerative diseases and cancers). This book aims to complement other excellent volumes and monographs on AD that cover fundamental, physiological or medical aspects of the disease.

Author : Anonim
Publisher : Academic Press
Page : 498 pages
File Size : 48,6 Mb
Release : 2012-05-22
Category : Science
ISBN : 9780123858849

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Molecular Biology of Neurodegenerative Diseases by Anonim Pdf

Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells which leads to problems with movement and mental functioning. Examples include Parkinson’s, Alzheimer’s and Huntington’s disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases. Contributions from leading authorities Informs and updates on all the latest developments in the field

Author : Robert Perneczky
Publisher : Springer Nature
Page : 345 pages
File Size : 55,5 Mb
Release : 2024
Category : Alzheimer's disease
ISBN : 9781071637746

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Biomarkers for Alzheimer's Disease Drug Development by Robert Perneczky Pdf

Zusammenfassung: This fully updated volume provides an up-to-date and comprehensive overview of the current state of technologies helping to accelerate Alzheimer's disease drug development. Addressing the latest advances in preclinical and clinical research, including new insights into the molecular mechanisms and emerging therapeutic strategies, the book continues by exploring digital biomarkers and advanced neuroimaging analysis which will transform how clinical trials in the Alzheimer's disease field are performed. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice that leads to greater success in the lab or clinic. Authoritative and practical, Biomarkers for Alzheimer's Disease Drug Development, Second Edition seeks to inspire and inform future efforts to develop effective treatments for this devastating disease

Author : Avril D. Woodhead,Anthony D. Blackett,Alexander Hollaender
Publisher : Springer Science & Business Media
Page : 485 pages
File Size : 43,8 Mb
Release : 2013-11-22
Category : Psychology
ISBN : 9781489922182

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Molecular Biology of Aging by Avril D. Woodhead,Anthony D. Blackett,Alexander Hollaender Pdf

It is delightful but humbling to find my face at the start of these Proceedings--there are innumerable other faces which could equally weIl stand there, from among the band who have fore gathered at every gerontology conference since the subject was launched in its present form; but I deeply appreciate being there. Gerontology d. id not grow by accident. Its present standing is the fruit of careful planning, undertaken by European and American scientists back in the 1950's. In those days it was still a "fringe" science, and the conspirators had much the standing of the 1920's Interplanetary Society. The United States itself is the offspring of conspiracy, for when the results of conspiracy are beneficent, the conspirators become Founding Fathers. This has been the case with gerontology. The present meeting is especially gratifying because the papers have been recitals of normal, hard-science investigation. We had to get through the rigors of a long period of semantic argument and a long period of one-shot general theories before this kind of meeting, normal in all other research fields, could take place. It was also necesssary to breed in the menagerie a generation of excellent investigators aware of the theoretical background but unintimidated by it, who share our conviction that human aging is comprehensible and probably controllable, and who go into the laboratory to attack specifics.