Molecular Pharmacology

Author : John Dickenson,Fiona Freeman,Chris Lloyd Mills,Christian Thode,Shiva Sivasubramaniam
Publisher : John Wiley & Sons
Page : 675 pages
File Size : 53,6 Mb
Release : 2012-11-30
Category : Medical
ISBN : 9781118451953

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Molecular Pharmacology by John Dickenson,Fiona Freeman,Chris Lloyd Mills,Christian Thode,Shiva Sivasubramaniam Pdf

This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.

Author : Francesco Clementi,Guido Fumagalli
Publisher : John Wiley & Sons
Page : 784 pages
File Size : 41,9 Mb
Release : 2015-07-01
Category : Medical
ISBN : 9781118768594

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General and Molecular Pharmacology by Francesco Clementi,Guido Fumagalli Pdf

With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book

Author : Stefan Offermanns,W. Rosenthal
Publisher : Springer Science & Business Media
Page : 1515 pages
File Size : 47,9 Mb
Release : 2008-08-14
Category : Medical
ISBN : 9783540389163

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Encyclopedia of Molecular Pharmacology by Stefan Offermanns,W. Rosenthal Pdf

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Author : Amteshwar Singh Jaggi,Jasleen Kaur Virdi,Anjana Bali
Publisher : Unknown
Page : 384 pages
File Size : 42,5 Mb
Release : 2021-02
Category : Medical
ISBN : 9389974348

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Cellular and Molecular Pharmacology by Amteshwar Singh Jaggi,Jasleen Kaur Virdi,Anjana Bali Pdf

Author : J. B. Stenlake
Publisher : A&C Black
Page : 336 pages
File Size : 50,9 Mb
Release : 1979-01-01
Category : Medical
ISBN : 0485111721

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Foundations of Molecular Pharmacology by J. B. Stenlake Pdf

Author : Angel Catala,Usama Ahmad
Publisher : BoD – Books on Demand
Page : 168 pages
File Size : 40,5 Mb
Release : 2020-12-16
Category : Medical
ISBN : 9781839629310

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Molecular Pharmacology by Angel Catala,Usama Ahmad Pdf

This book concentrates on recent developments related to the application of original structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology as well as basic pharmacological problems that offer mechanistic insights that are generally significant for the field of pharmacology. Written by experts, chapters cover such topics as drug transport mechanisms and drug–receptor complexes. This volume offers up-to-date, expert reviews of the fast-moving field of molecular pharmacology.

Author : Joen-Rong Sheu,Howard Prentice
Publisher : MDPI
Page : 153 pages
File Size : 49,6 Mb
Release : 2019-02-11
Category : Biochemistry
ISBN : 9783038975410

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Molecular Pharmacology and Pathology of Strokes by Joen-Rong Sheu,Howard Prentice Pdf

This book is a printed edition of the Special Issue "Molecular Pharmacology and Pathology of Strokes" that was published in IJMS

Author : Stefan Offermanns,Walter Rosenthal
Publisher : Unknown
Page : 1152 pages
File Size : 46,6 Mb
Release : 2004
Category : Encyclopedias and dictionaries
ISBN : UOM:39015052659656

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Encyclopedic Reference of Molecular Pharmacology by Stefan Offermanns,Walter Rosenthal Pdf

Presents current information on the molecular mechanisms of drug action. Provides 159 essays describing groups of drugs and drug targets. Several essays deal with general principles of pharmacology, such as drug tolerance, drug addiction, or drug metabolism.

Author : Robert A. Meyers
Publisher : John Wiley & Sons
Page : 1100 pages
File Size : 42,7 Mb
Release : 2018-03-02
Category : Science
ISBN : 9783527687190

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Translational Medicine by Robert A. Meyers Pdf

This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.

Author : Robert M. Featherstone
Publisher : Unknown
Page : 416 pages
File Size : 49,8 Mb
Release : 1973
Category : Biological transport
ISBN : UOM:39015009564561

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A Guide to Molecular Pharmacology-toxicology by Robert M. Featherstone Pdf

Author : Terry Kenakin
Publisher : Wiley-Blackwell
Page : 256 pages
File Size : 54,5 Mb
Release : 1997-02-25
Category : Medical
ISBN : 086542540X

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Molecular Pharmacology by Terry Kenakin Pdf

This text provides a brief introduction to general pharmacological principles and their use as experimental tools. By using receptor theory and molecular models, this text explores the mechanisms of drug responses in body systems without using the body itself. It also discusses biostatistics as related to drug-response quantification and optimization.

Author : E.J. Ariens
Publisher : Elsevier
Page : 526 pages
File Size : 51,6 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323147149

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Molecular Pharmacology V3 by E.J. Ariens Pdf

Molecular Pharmacology: The Model of Action of Biologically Active Compounds, Volume 1 discusses the mode of action of bioactive compounds on a molecular level. This book reviews the processes that control the uptake of drugs, their diffusion through tissues, as well as their metabolism and excretion. Comprised of three sections, this volume starts with an overview of the different aspects of drug distribution and metabolism. This text then examines the totality of intermolecular processes or reactions between drug and receptor molecules, which is known as drug-receptor interaction. Other chapters explore the actions of various pharmacodynamic agents, including hormones and substances with selective toxicity, auxins, and odorants. This book discusses as well the ways in which the actions of drugs combine with the tissues and act upon themselves. The final chapter deals with the complicated types of relations between stimulus and effect. Pharmacologists and researchers will find this book useful.

Author : Bryan L. Roth
Publisher : Springer Science & Business Media
Page : 628 pages
File Size : 40,9 Mb
Release : 2008-08-17
Category : Medical
ISBN : 9781597450805

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The Serotonin Receptors by Bryan L. Roth Pdf

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

Author : Francesco Clementi,Guido Fumagalli
Publisher : John Wiley & Sons
Page : 784 pages
File Size : 47,8 Mb
Release : 2015-08-10
Category : Medical
ISBN : 9781118768570

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General and Molecular Pharmacology by Francesco Clementi,Guido Fumagalli Pdf

With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book

Author : Gerard Marshall Raj,Ramasamy Raveendran
Publisher : Springer Nature
Page : 410 pages
File Size : 54,8 Mb
Release : 2019-11-16
Category : Medical
ISBN : 9789813297791

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Introduction to Basics of Pharmacology and Toxicology by Gerard Marshall Raj,Ramasamy Raveendran Pdf

This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.