Molecules Of Death

Author : Rosemary H. Waring,Glyn B. Steventon,Steve C. Mitchell
Publisher : Imperial College Press
Page : 455 pages
File Size : 54,5 Mb
Release : 2007
Category : Medical
ISBN : 9781860948145

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Molecules of Death by Rosemary H. Waring,Glyn B. Steventon,Steve C. Mitchell Pdf

This book has been developed over many years from several popular courses taught to students at both Birmingham and London universities. It provides an important step in introducing principles and concepts within the field of toxicology. The underlying mechanisms of toxicity are highlighted through examples taken from gases, minerals, plants, fungi, bacteria, marine creatures, industrial chemicals and pharmacological agents.In this second edition, the text has been completely revised and expanded with the addition of six new chapters ? carbon monoxide, hydrofluoric acid, lead, mushroom, toxins, paracetamol, paraquat and diquat. Each chapter is self-sufficient, enabling readers to dip into chapters of interest at random without any lack of understanding. The book is informative, with numerous clinical details, and will appeal to those who wish to delve into this fascinating subject.

Author : Steven C Mitchell,Glyn B Steventon,Rosemary H Waring
Publisher : World Scientific Publishing Company
Page : 456 pages
File Size : 44,8 Mb
Release : 2007-08-06
Category : Medical
ISBN : 9781911298441

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Molecules Of Death (2nd Edition) by Steven C Mitchell,Glyn B Steventon,Rosemary H Waring Pdf

This book has been developed over many years from several popular courses taught to students at both Birmingham and London universities. It provides an important step in introducing principles and concepts within the field of toxicology. The underlying mechanisms of toxicity are highlighted through examples taken from gases, minerals, plants, fungi, bacteria, marine creatures, industrial chemicals and pharmacological agents.In this second edition, the text has been completely revised and expanded with the addition of six new chapters — carbon monoxide, hydrofluoric acid, lead, mushroom, toxins, paracetamol, paraquat and diquat. Each chapter is self-sufficient, enabling readers to dip into chapters of interest at random without any lack of understanding. The book is informative, with numerous clinical details, and will appeal to those who wish to delve into this fascinating subject./a

Author : Rick Strassman
Publisher : Simon and Schuster
Page : 384 pages
File Size : 46,9 Mb
Release : 2000-12-01
Category : Body, Mind & Spirit
ISBN : 9781594779732

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DMT: The Spirit Molecule by Rick Strassman Pdf

A clinical psychiatrist explores the effects of DMT, one of the most powerful psychedelics known. • A behind-the-scenes look at the cutting edge of psychedelic research. • Provides a unique scientific explanation for the phenomenon of alien abduction experiences. From 1990 to 1995 Dr. Rick Strassman conducted U.S. Government-approved and funded clinical research at the University of New Mexico in which he injected sixty volunteers with DMT, one of the most powerful psychedelics known. His detailed account of those sessions is an extraordinarily riveting inquiry into the nature of the human mind and the therapeutic potential of psychedelics. DMT, a plant-derived chemical found in the psychedelic Amazon brew, ayahuasca, is also manufactured by the human brain. In Strassman's volunteers, it consistently produced near-death and mystical experiences. Many reported convincing encounters with intelligent nonhuman presences, aliens, angels, and spirits. Nearly all felt that the sessions were among the most profound experiences of their lives. Strassman's research connects DMT with the pineal gland, considered by Hindus to be the site of the seventh chakra and by Rene Descartes to be the seat of the soul. DMT: The Spirit Molecule makes the bold case that DMT, naturally released by the pineal gland, facilitates the soul's movement in and out of the body and is an integral part of the birth and death experiences, as well as the highest states of meditation and even sexual transcendence. Strassman also believes that "alien abduction experiences" are brought on by accidental releases of DMT. If used wisely, DMT could trigger a period of remarkable progress in the scientific exploration of the most mystical regions of the human mind and soul.

Author : John Emsley
Publisher : Royal Society of Chemistry
Page : 278 pages
File Size : 55,9 Mb
Release : 2008
Category : Law
ISBN : 9780854049653

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Molecules of Murder by John Emsley Pdf

The book looks at 10 toxic molecules and discusses their chemistry and effects in humans, followed by a re-examination of their deliberate misuse in high profile murder cases.

Author : John Emsley
Publisher : Royal Society of Chemistry
Page : 251 pages
File Size : 54,9 Mb
Release : 2017-06-23
Category : Molecular toxicology
ISBN : 9781788011037

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More Molecules of Murder by John Emsley Pdf

How can a plant as beautiful as the foxglove be so deadly and yet for more than a century be used to treat heart disease? The same is true of other naturally occurring molecules as will be revealed in this current book by award-winning author and chemist, John Emsley. More Molecules of Murder follows on from his highly-acclaimed earlier book Molecules of Murder, and again it deals with 14 potential poisons; seven of which are man-made and seven of which are natural. It investigates the crimes committed with them, not from the point of view of the murderers, their victims, or the detectives, but from the poison used. In so doing it throws new light on how these crimes were carried out and ultimately how the perpetrators were uncovered and brought to justice. Each chapter starts by looking at the target molecule itself, its discovery, its chemistry, its often-surprising use in medicine, its effects on the human body, and its toxicology. The rest of the chapter is devoted to murders and attempted murders in which it has been used. But, be reassured that murder by poison is not the threat it once was, thanks to laws which restrict access to such materials and to the skills of analytical chemists in detecting their presence in incredibly tiny amounts.

Author : Anthony R Butler,Rosslyn Nicholson
Publisher : Royal Society of Chemistry
Page : 168 pages
File Size : 48,8 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847551238

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Life, Death and Nitric Oxide by Anthony R Butler,Rosslyn Nicholson Pdf

Designated 'Molecule of the Year' in 1992 in recognition of its many biological roles, nitric oxide has wide significance in the world around us and the story of nitric oxide is still unfolding. This small and seemingly innocent molecule has for many years been known to play a significant role in both the creation of photochemical smogs and in the nitrogen cycle. It has an interesting chemistry as a metal ligand, and the bonding within the nitric oxide molecule has been extensively studied. More recently, the molecule has been in the spotlight for the role it plays in controlling blood flow, in the immune system and in brain activity. Life, Death and Nitric Oxide covers many of the topics relating to nitric oxide, from smog and catalytic converters to tumour growth, blood flow and Viagra, with the aim of finding out why such a simple molecule can do so much.

Author : Neil Bradbury, Ph.D.
Publisher : St. Martin's Press
Page : 234 pages
File Size : 49,6 Mb
Release : 2022-02-01
Category : True Crime
ISBN : 9781250270764

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A Taste for Poison by Neil Bradbury, Ph.D. Pdf

“A fascinating tale of poisons and poisonous deeds which both educates and entertains.” --Kathy Reichs A brilliant blend of science and crime, A TASTE FOR POISON reveals how eleven notorious poisons affect the body--through the murders in which they were used. As any reader of murder mysteries can tell you, poison is one of the most enduring—and popular—weapons of choice for a scheming murderer. It can be slipped into a drink, smeared onto the tip of an arrow or the handle of a door, even filtered through the air we breathe. But how exactly do these poisons work to break our bodies down, and what can we learn from the damage they inflict? In a fascinating blend of popular science, medical history, and true crime, Dr. Neil Bradbury explores this most morbidly captivating method of murder from a cellular level. Alongside real-life accounts of murderers and their crimes—some notorious, some forgotten, some still unsolved—are the equally compelling stories of the poisons involved: eleven molecules of death that work their way through the human body and, paradoxically, illuminate the way in which our bodies function. Drawn from historical records and current news headlines, A Taste for Poison weaves together the tales of spurned lovers, shady scientists, medical professionals and political assassins to show how the precise systems of the body can be impaired to lethal effect through the use of poison. From the deadly origins of the gin & tonic cocktail to the arsenic-laced wallpaper in Napoleon’s bedroom, A Taste for Poison leads readers on a riveting tour of the intricate, complex systems that keep us alive—or don’t.

Author : Sungchul Ji,University of Medicine and Dentistry of New Jersey
Publisher : Unknown
Page : 552 pages
File Size : 42,5 Mb
Release : 1991
Category : Cell death
ISBN : UCAL:B4344049

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Molecular Theories of Cell Life and Death by Sungchul Ji,University of Medicine and Dentistry of New Jersey Pdf

Most of the chapters were written on the basis of lectures delivered at the International Colloquium on title] held in Piscataway, New Jersey, May 1986; but some were solicited and submitted as late as mid-1989. The long delay in publication does not diminish the value here; in fact, some authors (

Author : Vittorio de Franciscis
Publisher : Nova Publishers
Page : 258 pages
File Size : 44,5 Mb
Release : 2007
Category : Health & Fitness
ISBN : 1600212433

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Signalling Molecules as Targets in Cancer Therapy by Vittorio de Franciscis Pdf

This book presents state-of-the-art information on the molecules of cell signalling pathways that represent actual or future targets for cancer therapy. By giving an update of the most promising approaches in this rapidly evolving field, the book contributes to the translation of the recent advances in the knowledge of intracellular signalling into the generation of innovative biomolecules as specific tools to target the most promising tumour-specific candidates. The book begins logically with the molecules first encountered along the signalling pathways, the membrane receptors for growth factors (Part I). Next, Part II presents several examples of intracellular molecular targets that are situated one step beyond in the pathways, while Part III addresses the difficult task of tuning the delicate balance between cell death and survival. In Part IV, the reader is taken into the practical problems raised by the therapy of specific cancers (glioma, childhood leukaemia), and into an original strategy from the field of nuclear medicine with the potential to generate innovative molecular-targeted cancer therapies.

Author : J.L. VanLancker
Publisher : Springer Science & Business Media
Page : 325 pages
File Size : 49,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461394181

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Molecules, Cells, and Disease by J.L. VanLancker Pdf

In tracing their origin and their fate, the beginning and the end of their environment, humans have often been guided by curiosity. Such concern has helped man to discover, among other things, the structure of the universe from star to atom and the evolution of life from unicellular organism to human being. The study of disease is unique. Although it may have been in spired by the curiosity of a few, it has always been the concern of all, because preventing or curing disease has meant survival not only of individuals, but of entire nations, not only of humans, but of fellow living creatures. If greed, force, religion, and language have been major causes of wars, diseases, more than arms, have often decided the outcome of battles and thereby have woven the pattern of history. For millennia, a large fraction of the human race believed that disease expressed the wrath of God(s) against individuals or societies. Therefore, only priests or priestesses, kings, and queens were endowed with the power of healing. In the West, Hippocrates is credited for exorcising this concept of disease and for objectively describing and cataloguing them. The contributions of Greek physicians to Western medicine made possible more accurate diagnoses and prognoses.

Author : L. Aloe,L. Calza
Publisher : Elsevier
Page : 570 pages
File Size : 41,6 Mb
Release : 2003-12-10
Category : Science
ISBN : 9780080497501

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NGF and Related Molecules in Health and Disease by L. Aloe,L. Calza Pdf

The book highlights different aspects of current understanding of neurotrophin-receptor signal transduction pathways, including the signaling endosome hypothesis. Findings on the synaptotrophic potential of NGF and related neurotrophins, neurotrophin involvement in neuronal stem cell biology, biological activity of the NGF precursor proNGF, and nociception- and antinociception-associated activity of NGF and/or BDNF are also presented and discussed. Several chapters deal with the involvement of various neurotrophins in the control of different nonneuronal processes, such as immune, inflammatory and allergic reactions, tissue repair and wound healing. The findings showed that neurotrophins play important roles in the pathobiology of a surprising variety of seemingly unrelated non-neurological diseases, including bronchial asthma, rheumatoid arthritis, systemic sclerosis, hair growth disorders, psoriasis, corneal and skin ulcers, atherosclerosis, metabolic syndrome, crush syndrome, and Behçet's disease. There are also chapters on the involvement of NGF and related molecules in neurological diseases, including Huntington's disease, the multiple sclerosis-like model of experimental allergic encephalomyelitis, peripheral neuropathies, neuroblastoma, Parkinson's disease, Alzheimer's disease, and even motion sickness syndrome, also psychiatric disorders, including depression and schizophrenia. Finally, potential important therapeutic benefits are presented, for diabetic neuropathy, gastrointestinal dysmotility, CNS neurodegenerative disease, spinal cord injuries, cutaneous and corneal ulcers, as well as peripheral ischemic vasculopathy.

Author : Wen-Xing Ding,Xiao-Ming Yin
Publisher : Springer
Page : 290 pages
File Size : 47,7 Mb
Release : 2017-08-02
Category : Science
ISBN : 9783319581064

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Molecules, Systems and Signaling in Liver Injury by Wen-Xing Ding,Xiao-Ming Yin Pdf

This essential volume presents comprehensive information on cell death and autophagy in liver diseases, including the role and molecular signaling pathways of cell death in alcohol and non-alcoholic fatty liver disease, bile acids, hepatitis C virus and drug-induced liver injury. The book starts with a discussion of lipotoxicity in non-parenchymal cells, followed by a discussion of cell death and autophagy in cholangiocytes, hepatic stellate cells and Kupffer cells in hepatic biliary diseases, fibrosis and liver inflammation. The book also covers Bcl-2 family proteins, beta-catenin and HMGB1 signaling in regulating cell death in the liver as well as mitochondria, ER stress and gut microbiota on liver injury. The Cell Death in Biology and Diseases series has recruited world experts ranging from basic scientists to clinicians on cell death in liver diseases. Likewise the contributors of this volume are leaders in their fields with worldwide expertise and perspective. Molecul es, Systems and Signaling in Liver Injury is an essential companion to Hepatocytes and Non-Parenchymal Cells and Diseases. It is beneficial for both clinicians and basic scientists and is relevant to those working on drug discovery for preventing and treating liver diseases by targeting cell death and autophagy pathways.

Author : David Stephen Pisetsky,Reinhard Edmund Voll,Edit I. Buzás
Publisher : Frontiers Media SA
Page : 214 pages
File Size : 55,6 Mb
Release : 2021-10-29
Category : Medical
ISBN : 9782889714117

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The Role of Extracellular Nuclear Molecules in the Pathogenesis of Autoimmune Disease by David Stephen Pisetsky,Reinhard Edmund Voll,Edit I. Buzás Pdf

Author : Ho John Wing Shing
Publisher : World Scientific
Page : 172 pages
File Size : 52,6 Mb
Release : 2019-04-23
Category : Medical
ISBN : 9789814525640

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Naturally Occurring Small Molecules For Disease And Cancer Treatment: Therapeutic Benefits In Combination Therapy by Ho John Wing Shing Pdf

Western drugs and target medicines for disease treatment come with undesirable side effects that have limited their use in patients for an extended period of time. It is warranted to develop a treatment strategy with alternative medicines to reduce toxicity relating to drugs, in particular, cancer drugs. Thus, a combination therapy with herbal medicines provides a more effective treatment method for hard-to-treat diseases. The recent breakthroughs in naturally occurring small molecules from herbal medicines have provided experimental evidence and are clinically significant in treatment strategies.This unique volume presents the recent developments in the field of herbal medicines for the treatment of diseases and cancer. Recent progress on small molecules isolated from herbal medicines that exhibit therapeutic benefits in humans is highlighted. The book provides an overview of the significant discoveries and pioneering contributions of herbal medicines in combination with other drugs; the author's evaluation of the combination therapy in cancer treatment; and a recent discovery of crocodile tissue extract with pharmacological properties.

Author : Heddy Zola
Publisher : John Wiley & Sons
Page : 595 pages
File Size : 45,8 Mb
Release : 2007-02-02
Category : Medical
ISBN : 9780471701323

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Leukocyte and Stromal Cell Molecules by Heddy Zola Pdf

Offers comprehensive coverage of all known CD molecules based on the results of the latest Human Leukocyte Differentiation Antigen (HLDA) Workshops. It begins with an historical introduction, followed by a concise summary of the structure, function, and applications in research, diagnosis and therapy. Next, overviews for each section discuss latest developments, methodologies, and conclusions. The core chapters then offer one-page CD summaries in a standardized format. The summaries present salient features for each molecule, including its structure (accompanied by a diagram), cell and tissue distribution, function, clinical applications, available reagents, and sources for additional information.