Monte Carlo In Heavy Charged Particle Therapy

Author : Pablo Cirrone,Giada Petringa
Publisher : CRC Press
Page : 528 pages
File Size : 43,9 Mb
Release : 2023-11-08
Category : Science
ISBN : 9781000987652

Get Book

Monte Carlo in Heavy Charged Particle Therapy by Pablo Cirrone,Giada Petringa Pdf

This book explores the current difficulties and unsolved problems in the field of particle therapy and, after analysing them, discusses how (and if) innovative Monte Carlo approaches can be used to solve them. Each book chapter is dedicated to a different sub-discipline, including multi-ion treatments, flash-radiotherapy, laser-accelerated beams, nanoparticles effects, binary reactions to enhance radiobiology, and space-related issues. This is the first book able to provide a comprehensive insight into this exciting field and the growing use of Monte Carlo in medical physics. It will be of interest to graduate students in medicine and medical physics, in addition to researchers and clinical staff. Key Features: Explores the exciting and interdisciplinary topic of Monte Carlo in particle therapy and medicine. Addresses common challenges in the field. Edited by an authority on the subject, with chapter contributions from specialists. Pablo Cirrone is a medical physicist and researcher at the Laboratori Nazionali del Sud of INFN, Italy, where he supports and coordinates various experimental groups. Dr. Cirrone is an expert in the use of proton and ion in radiation treatment and of absolute and relative dosimetry in electron, photon and ion beam. He is an expert in the development and test of detectors for medical applications, of the production and use of laser-driven beams for medical and multidisciplinary applications and recipient of the Michael Gotein Award. He is active on many scientific committees and organizes national and international conferences. Giada Petringa is a researcher at the Laboratori Nazionali del Sud of INFN, Italy. Dr. Petringa has a professional experience in the field of Monte Carlo simulations for medical applications, dosimetry, microdosimetry, and diagnostics with conventional and laser-driven proton beams. In 2019 she had a MSCA-IF-2019 (Marie Sklodowska-Curie Actions-Individual Fellowship) grant funded by the European Community in the framework of the H2020 program. She is a member of the Editorial Board of the international journal Physica Medica - European Journal of Medical. She organized more than fifteen international Geant4 Schools. She is an official member of the Geant4 code Collaboration at CERN since 2019. She is a code developer, and she collaborates to maintain two of the official examples of the code.

Author : Pablo Cirrone,Giada Petringa
Publisher : CRC Press
Page : 350 pages
File Size : 55,8 Mb
Release : 2024-01-26
Category : Science
ISBN : 9781000987614

Get Book

Monte Carlo in Heavy Charged Particle Therapy by Pablo Cirrone,Giada Petringa Pdf

This book explores the current difficulties and unsolved problems in the field of particle therapy and, after analysing them, discusses how (and if) innovative Monte Carlo approaches can be used to solve them. Each book chapter is dedicated to a different sub-discipline, including multi-ion treatments, flash-radiotherapy, laser-accelerated beams, nanoparticles effects, binary reactions to enhance radiobiology, and space-related issues. This is the first book able to provide a comprehensive insight into this exciting field and the growing use of Monte Carlo in medical physics. It will be of interest to graduate students in medicine and medical physics, in addition to researchers and clinical staff. Key Features: Explores the exciting and interdisciplinary topic of Monte Carlo in particle therapy and medicine Addresses common challenges in the field Edited by an authority on the subject, with chapter contributions from specialists

Author : AAPM Radiation Therapy Committee. Task Group 20
Publisher : Unknown
Page : 55 pages
File Size : 53,7 Mb
Release : 1986
Category : Radiation dosimetry
ISBN : 0883185008

Get Book

Protocol for Heavy Charged-particle Therapy Beam Dosimetry by AAPM Radiation Therapy Committee. Task Group 20 Pdf

Author : Marco Durante,Francis A. Cucinotta,Jay S. Loeffler
Publisher : Frontiers Media SA
Page : 650 pages
File Size : 49,6 Mb
Release : 2018-01-31
Category : Electronic
ISBN : 9782889453917

Get Book

Charged Particles in Oncology by Marco Durante,Francis A. Cucinotta,Jay S. Loeffler Pdf

High-energy charged particles represent a cutting-edge technique in radiation oncology. Protons and carbon ions are used in several centers all over the world for the treatment of different solid tumors. Typical indications are ocular malignancies, tumors of the base of the skull, hepatocellular carcinomas and various sarcomas. The physical characteristics of the charged particles (Bragg peak) allow sparing of much more normal tissues than it is possible using conventional X-rays, and for this reason all pediatric tumors are considered eligible for protontherapy. Ions heavier than protons also display special radiobiological characteristics, which make them effective against radioresistant and hypoxic tumors. On the other hand, protons and ions with high charge (Z) and energy (HZE particles) represent a major risk for human space exploration. The main late effect of radiation exposure is cancer induction, and at the moment the dose limits for astronauts are based on cancer mortality risk. The Mars Science Laboratory (MSL) measured the dose on the route to Mars and on the planet’s surface, suggesting that a human exploration missions will exceed the radiation risk limits. Notwithstanding many studies on carcinogenesis induced by protons and heavy ions, the risk uncertainty remains very high. In this research topic we aim at gathering the experiences and opinions of scientists dealing with high-energy charged particles either for cancer treatment or for space radiation protection. Clinical results with protons and heavy ions, as well as research in medical physics and pre-clinical radiobiology are reported. In addition, ground-based and spaceflight studies on the effects of space radiation are included in this book. Particularly relevant for space studies are the clinical results on normal tissue complications and second cancers. The eBook nicely demonstrates that particle therapy in oncology and protection of astronauts from space radiation share many common topics, and can learn from each other.

Author : Harald Paganetti
Publisher : CRC Press
Page : 691 pages
File Size : 44,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439836453

Get Book

Proton Therapy Physics by Harald Paganetti Pdf

Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.

Author : Frank Verhaegen,Joao Seco
Publisher : CRC Press
Page : 291 pages
File Size : 40,5 Mb
Release : 2021-11-29
Category : Medical
ISBN : 9781000455557

Get Book

Monte Carlo Techniques in Radiation Therapy by Frank Verhaegen,Joao Seco Pdf

Targets both students or professionals, both novice and experienced, in medical radiotherapy physics. Combines overviews of development, methods and references to facilitate Monte Carlo studies. Focuses on applications in radiotherapy.

Author : C-M Charlie Ma,Tony Lomax
Publisher : CRC Press
Page : 254 pages
File Size : 54,8 Mb
Release : 2012-10-09
Category : Medical
ISBN : 9781439816080

Get Book

Proton and Carbon Ion Therapy by C-M Charlie Ma,Tony Lomax Pdf

Proton and Carbon Ion Therapy is an up-to-date guide to using proton and carbon ion therapy in modern cancer treatment. The book covers the physics and radiobiology basics of proton and ion beams, dosimetry methods and radiation measurements, and treatment delivery systems. It gives practical guidance on patient setup, target localization, and trea

Author : Joao Seco,Frank Verhaegen
Publisher : CRC Press
Page : 344 pages
File Size : 46,8 Mb
Release : 2013-03-25
Category : Medical
ISBN : 9781466507920

Get Book

Monte Carlo Techniques in Radiation Therapy by Joao Seco,Frank Verhaegen Pdf

Modern cancer treatment relies on Monte Carlo simulations to help radiotherapists and clinical physicists better understand and compute radiation dose from imaging devices as well as exploit four-dimensional imaging data. With Monte Carlo-based treatment planning tools now available from commercial vendors, a complete transition to Monte Carlo-based dose calculation methods in radiotherapy could likely take place in the next decade. Monte Carlo Techniques in Radiation Therapy explores the use of Monte Carlo methods for modeling various features of internal and external radiation sources, including light ion beams. The book—the first of its kind—addresses applications of the Monte Carlo particle transport simulation technique in radiation therapy, mainly focusing on external beam radiotherapy and brachytherapy. It presents the mathematical and technical aspects of the methods in particle transport simulations. The book also discusses the modeling of medical linacs and other irradiation devices; issues specific to electron, photon, and proton ion beams and brachytherapy; and the optimization of treatment planning, radiation dosimetry, and quality assurance. Useful to clinical physicists, graduate students, and researchers, this book provides a detailed, state-of-the-art guide to the fundamentals, application, and customization of Monte Carlo techniques in radiotherapy. Through real-world examples, it illustrates the use of Monte Carlo modeling and simulations in dose calculation, beam delivery, kilovoltage and megavoltage imaging, proton radiography, device design, and much more.

Author : Matthias Würl
Publisher : Springer
Page : 86 pages
File Size : 54,9 Mb
Release : 2016-05-30
Category : Science
ISBN : 9783658131685

Get Book

Towards Offline PET Monitoring at a Cyclotron-Based Proton Therapy Facility by Matthias Würl Pdf

Matthias Würl presents two essential steps to implement offline PET monitoring of proton dose delivery at a clinical facility, namely the setting up of an accurate Monte Carlo model of the clinical beamline and the experimental validation of positron emitter production cross-sections. In the first part, the field size dependence of the dose output is described for scanned proton beams. Both the Monte Carlo and an analytical computational beam model were able to accurately predict target dose, while the latter tends to overestimate dose in normal tissue. In the second part, the author presents PET measurements of different phantom materials, which were activated by the proton beam. The results indicate that for an irradiation with a high number of protons for the sake of good statistics, dead time losses of the PET scanner may become important and lead to an underestimation of positron-emitter production yields.

Author : Harald Paganetti
Publisher : CRC Press
Page : 772 pages
File Size : 40,5 Mb
Release : 2018-11-19
Category : Science
ISBN : 9781351855754

Get Book

Proton Therapy Physics, Second Edition by Harald Paganetti Pdf

Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature. After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed. This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics. Features: Updated with the latest technologies and methods in the field, covering all delivery methods of proton therapy, including beam scanning and passive scattering Discusses clinical aspects, such as treatment planning and quality assurance Offers insight on the past, present, and future of proton therapy from a physics perspective

Author : Faiz M. Khan,John P. Gibbons (Jr.)
Publisher : Lippincott Williams & Wilkins
Page : 584 pages
File Size : 43,7 Mb
Release : 2014
Category : Medical
ISBN : 9781451182453

Get Book

Khan's The Physics of Radiation Therapy by Faiz M. Khan,John P. Gibbons (Jr.) Pdf

This classic full-color text helps the entire radiation therapy team--radiation oncologists, medical physicists, dosimetrists, and radiation therapistsdevelop a thorough understanding of 3D conformal radiotherapy (3D-CRT), stereotactic radiosurgery (SRS), high dose-rate remote afterloaders (HDR), intensity modulated radiation therapy (IMRT), image-guided radiation therapy (IGRT), Volumetric Modulated Arc Therapy (VMAT), and proton beam therapy, as well as the physical concepts underlying treatment planning, treatment delivery, and dosimetry.

Author : Ute Linz
Publisher : Springer Science & Business Media
Page : 728 pages
File Size : 44,7 Mb
Release : 2011-12-09
Category : Science
ISBN : 9783642214141

Get Book

Ion Beam Therapy by Ute Linz Pdf

The book provides a detailed, up-to-date account of the basics, the technology, and the clinical use of ion beams for radiation therapy. Theoretical background, technical components, and patient treatment schemes are delineated by the leading experts that helped to develop this field from a research niche to its current highly sophisticated and powerful clinical treatment level used to the benefit of cancer patients worldwide. Rather than being a side-by-side collection of articles, this book consists of related chapters. It is a common achievement by 76 experts from around the world. Their expertise reflects the diversity of the field with radiation therapy, medical and accelerator physics, radiobiology, computer science, engineering, and health economics. The book addresses a similarly broad audience ranging from professionals that need to know more about this novel treatment modality or consider to enter the field of ion beam therapy as a researcher. However, it is also written for the interested public and for patients who might want to learn about this treatment option.

Author : Anonim
Publisher : Academic Press
Page : 483 pages
File Size : 54,9 Mb
Release : 2012-12-31
Category : Science
ISBN : 9780123964793

Get Book

Theory of Heavy Ion Collision Physics in Hadron Therapy by Anonim Pdf

Advances in Quantum Chemistry presents surveys of current topics in this rapidly developing field that has emerged at the cross section of the historically established areas of mathematics, physics, chemistry, and biology. It features detailed reviews written by leading international researchers. This volume focuses on the theory of heavy ion physics in medicine. Presents surveys of current topics in this rapidly developing field Features detailed reviews written by leading international researchers Focuses on the theory of heavy ion physics in medicine

Author : Arabinda Kumar Rath,Narayan Sahoo
Publisher : Springer
Page : 194 pages
File Size : 45,5 Mb
Release : 2016-03-10
Category : Medical
ISBN : 9788132226222

Get Book

Particle Radiotherapy by Arabinda Kumar Rath,Narayan Sahoo Pdf

The results of decades of research and development are providing compelling evidence about the efficacy of radiation therapy with proton and carbon ion beams to achieve superior complication free tumor control leading to a world-wide rapid growth in their clinical use. This book contains comprehensive reviews of the state of the art of the technology and physics of heavy charge particle therapy by the experts from the leading cancer centers of world that will be valuable as a practical guide for radiation therapy professionals interested in these modalities.

Author : Charles M. Washington,Dennis T. Leaver
Publisher : Elsevier Health Sciences
Page : 939 pages
File Size : 53,7 Mb
Release : 2015-04-01
Category : Medical
ISBN : 9780323287524

Get Book

Principles and Practice of Radiation Therapy by Charles M. Washington,Dennis T. Leaver Pdf

The only radiation therapy text written by radiation therapists, Principles and Practice of Radiation Therapy, 4th Edition helps you understand cancer management and improve clinical techniques for delivering doses of radiation. A problem-based approach makes it easy to apply principles to treatment planning and delivery. New to this edition are updates on current equipment, procedures, and treatment planning. Written by radiation therapy experts Charles Washington and Dennis Leaver, this comprehensive text will be useful throughout your radiation therapy courses and beyond. Comprehensive coverage of radiation therapy includes a clear introduction and overview plus complete information on physics, simulation, and treatment planning. Spotlights and shaded boxes identify the most important concepts. End-of-chapter questions provide a useful review. Chapter objectives, key terms, outlines, and summaries make it easier to prioritize, understand, and retain key information. Key terms are bolded and defined at first mention in the text, and included in the glossary for easy reference. UPDATED chemotherapy section, expansion of What Causes Cancer, and inclusions of additional cancer biology terms and principles provide the essential information needed for clinical success. UPDATED coverage of post-image manipulation techniques includes new material on Cone beam utilization, MR imaging, image guided therapy, and kV imaging. NEW section on radiation safety and misadministration of treatment beams addresses the most up-to-date practice requirements. Content updates also include new ASRT Practice Standards and AHA Patient Care Partnership Standards, keeping you current with practice requirements. UPDATED full-color insert is expanded to 32 pages, and displays images from newer modalities.