Multiple Sclerosis Therapeutics

Author : Jeffrey A. Cohen,Richard A. Rudick
Publisher : Cambridge University Press
Page : 128 pages
File Size : 43,5 Mb
Release : 2011-10-20
Category : Medical
ISBN : 9781139502375

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Multiple Sclerosis Therapeutics by Jeffrey A. Cohen,Richard A. Rudick Pdf

This book comprehensively reviews the current state of clinical trial methods in multiple sclerosis treatment, providing investigators, sponsors and specialists with current knowledge of outcome measures and study designs for disease and symptom management. The status of the rapidly evolving field of disease-modifying drugs is presented, with emphasis on the most promising therapies currently being tested. Experts discuss disease and symptom management for MS subtypes, including neuromyelitis optica and pediatric MS. In addition, key scientific advances in MS pathology, genetics, immunology and epidemiology are presented. The fourth edition has been extensively revised, featuring more than 50% new material. All chapters have been substantially updated to provide current information on rapidly evolving topics and this volume contains 15 new chapters, reflecting the growth of the field in recent years. This book is an essential reference for practitioners caring for MS patients, investigators planning or conducting clinical trials, and clinical trial sponsors.

Author : Eli Minkoff,Eli Baker
Publisher : CRC Press
Page : 928 pages
File Size : 46,5 Mb
Release : 2007-03-06
Category : Medical
ISBN : 9780203012055

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Multiple Sclerosis Therapeutics by Eli Minkoff,Eli Baker Pdf

Since the publication of the previous edition of this volume, there has been substantial progress in a number of areas of multiple sclerosis (MS) research. Although immunosuppressive treatments continue to be developed and refined, more targeted immunomodulatory therapies are surfacing as we learn more about how the immune system works in health an

Author : Richard Rudick
Publisher : CRC Press
Page : 598 pages
File Size : 55,5 Mb
Release : 1999-09-01
Category : Medical
ISBN : 0415805821

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Multiple Sclerosis Therapeutics by Richard Rudick Pdf

This textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies and on patient care. The international team of contributors discuss the clinical course of multiple sclerosis, its clinical heterogeneity, the presence of subclinical disease activity which occurs during the early stages of the disease. Multiple sclerosis presents clinical challenges: from unexpected and irregular relapses to profressive deterioration.

Author : Institute of Medicine,Board on Neuroscience and Behavioral Health,Committee on Multiple Sclerosis: Current Status and Strategies for the Future
Publisher : National Academies Press
Page : 457 pages
File Size : 43,9 Mb
Release : 2001-08-10
Category : Medical
ISBN : 9780309072854

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Multiple Sclerosis by Institute of Medicine,Board on Neuroscience and Behavioral Health,Committee on Multiple Sclerosis: Current Status and Strategies for the Future Pdf

Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.

Author : Richard A. Rudick,Jeffrey A. Cohen
Publisher : CRC Press
Page : 784 pages
File Size : 44,8 Mb
Release : 2003-01-16
Category : Medical
ISBN : 1841842265

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Multiple Sclerosis Therapeutics, Second Edition by Richard A. Rudick,Jeffrey A. Cohen Pdf

This revised textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies, and, most importantly, on patient care. An international team of contributors discusses the clinical course of multiple sclerosis, its clinical heterogeneity, and the presence of subclinical disease activity which occurs during the early stages of the disease. There have been substantial advances in the field since the first edition was published in 1999. There are new chapters on functional imaging, the issues involved in long-term follow-up studies, cyclophosphamide, sex hormones and pregnancy-related factors, complementary and alternative treatments, management of cognitive impairment, treatment of pain, and rehabilitative approaches. Chapters on MS pathogenesis, imaging, the interferons, glatiramer acetate, mitoxantrone, IVIg, plasma exchange, stem cell transplantation, combination therapies, and newly-emerging treatments have been updated. This book is essential for any clinician who works with MS patients.

Author : Richard A. Rudick,Jeffrey A. Cohen
Publisher : CRC Press
Page : 784 pages
File Size : 40,7 Mb
Release : 2004-06-02
Category : Medical
ISBN : 1135414025

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Multiple Sclerosis Therapeutics, Second Edition by Richard A. Rudick,Jeffrey A. Cohen Pdf

This revised textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies, and, most importantly, on patient care. An international team of contributors discusses the clinical course of multiple sclerosis, its clinical heterogeneity, and the presence of subclinical disease activity which occurs during the early stages of the disease. There have been substantial advances in the field since the first edition was published in 1999. There are new chapters on functional imaging, the issues involved in long-term follow-up studies, cyclophosphamide, sex hormones and pregnancy-related factors, complementary and alternative treatments, management of cognitive impairment, treatment of pain, and rehabilitative approaches. Chapters on MS pathogenesis, imaging, the interferons, glatiramer acetate, mitoxantrone, IVIg, plasma exchange, stem cell transplantation, combination therapies, and newly-emerging treatments have been updated. This book is essential for any clinician who works with MS patients.

Author : Ian S. Zagon,Patricia J. McLaughlin
Publisher : Unknown
Page : 137 pages
File Size : 40,7 Mb
Release : 2017
Category : Electronic
ISBN : 0994438133

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Multiple Sclerosis by Ian S. Zagon,Patricia J. McLaughlin Pdf

Author : Jeffrey A. Cohen,Richard A. Rudick
Publisher : Informa Healthcare
Page : 32 pages
File Size : 52,9 Mb
Release : 2007-10
Category : Medical
ISBN : 1841846600

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Multiple Sclerosis Therapeutics, Third Edition (PBK) by Jeffrey A. Cohen,Richard A. Rudick Pdf

This textbook provides a comprehensive update of clinical trial methodology and current therapeutic modalities in multiple sclerosis.

Author : Stella E. Hughes,Gabrielle Macaron
Publisher : Karger Medical and Scientific Publishers
Page : 166 pages
File Size : 52,7 Mb
Release : 2021-05-19
Category : Medical
ISBN : 9783318067972

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Fast Facts: Multiple Sclerosis by Stella E. Hughes,Gabrielle Macaron Pdf

Multiple sclerosis (MS) is a leading cause of disability in young adults, carrying a considerable individual and societal economic burden. The development of disease-modifying therapies and updates to diagnostic criteria are leading us into a new era for MS management, both in the earliest disease phases and progressive MS. In this completely revised/fully updated edition of Fast Facts: Multiple Sclerosis, we present the most recent evidence on disease pathogenesis and all clinical aspects of the condition, as well as the latest on disease-modifying therapies and other potential treatments. Given the need for multidisciplinary management of MS, we have written this resource for the benefit of all health professionals involved in MS care. Table of Contents: • Epidemiology and genetics • Pathology • The clinical picture • Treatment of relapses and symptoms • Disease-modifying treatment • Emerging therapies • Special MS populations • Lifestyle considerations and the multidisciplinary team • Advanced MS

Author : Dr. T. Jock Murray, MS,Allen C. Bowling, MD, PhD,Chris Polman, MD, PhD,Alan Thompson, MD, FRCP, FRCPI,John Noseworthy, MD
Publisher : Demos Health
Page : 197 pages
File Size : 44,8 Mb
Release : 2006-03-01
Category : Health & Fitness
ISBN : 1932603514

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Multiple Sclerosis by Dr. T. Jock Murray, MS,Allen C. Bowling, MD, PhD,Chris Polman, MD, PhD,Alan Thompson, MD, FRCP, FRCPI,John Noseworthy, MD Pdf

The huge expansion of information available about MS, especially through the Internet, has put the individual with MS in a position to take increasing responsibility for her or his own care. There is thus a need for a comprehensive, readily accessible guide to the present therapeutic options, which will give the inquirer a balanced guide to the relative effectiveness of individual treatments. This book is designed to do just that. This bestselling title is a unique compendium of the most frequently used treatments for multiple sclerosis, an authoritative reference for all physicians, and a factual guide for patients who need information about therapies. This new edition has been extensively revised both in content and format from previous editions. Its organization into sections dealing with the treatment of acute exacerbations, disease-modifying therapies, symptom management, and alternative therapies makes the book much more accessible to the reader. The title has been changed from "Therapeutic Claims in Multiple Sclerosis" to reflect the major restructuring of this edition and to better describe the range and focus of the content.The authors have included the original data underlying the conclusions reached by the Therapeutic Claims Committee of the International Federation of Multiple Sclerosis Societies, providing for a greater understanding of how those conclusions were reached. The addition of references at the end of each chapter will be especially useful for physicians and other health care professionals, but will also be of interest to those lay readers who want more detail about the therapies discussed.

Author : Barbara S. Giesser
Publisher : Oxford University Press
Page : 613 pages
File Size : 40,9 Mb
Release : 2016
Category : Medical
ISBN : 9780199341016

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Primer on Multiple Sclerosis by Barbara S. Giesser Pdf

This text provides a comprehensive overview of the clinical and basic science aspects of MS. It is designed to be of practical use to clinical neurologists, and addresses all of the major issues that may occur in the management of persons with MS.

Author : Jeffrey A. Cohen
Publisher : Unknown
Page : 128 pages
File Size : 43,8 Mb
Release : 2002
Category : Electronic
ISBN : OCLC:1099326413

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Multiple Sclerosis Therapeutics by Jeffrey A. Cohen Pdf

This revised textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies, and, most importantly, on patient care. An international team of contributors discusses the clinical course of multiple sclerosis, its clinical heterogeneity, and the presence of subclinical disease activity which occurs during the early stages of the disease. There have been substantial advances in the field since the first edition was published in 1999. There are new chapters on functional imaging, the issues involved in long-term.

Author : Anthony Reder
Publisher : CRC Press
Page : 574 pages
File Size : 48,8 Mb
Release : 1997-01-28
Category : Medical
ISBN : 0824797647

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Interferon Therapy of Multiple Sclerosis by Anthony Reder Pdf

This reference presents cutting-edge basic and clinical research on all forms of interferon (IFN) involvement in the management of multiple sclerosis (MS)-detailing topics from IFN-receptor molecular interactions to synergy and interference with other agents such as cytotoxic drugs and chemotherapy. Features detailed research findings on IFN ß -1a (Avonex) and IFN -1b (Betaseron).

Author : Walter George Bradley
Publisher : Unknown
Page : 1672 pages
File Size : 52,7 Mb
Release : 2004
Category : Medical
ISBN : 0750674695

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Neurology in Clinical Practice by Walter George Bradley Pdf

New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.

Author : Fred F. Ferri
Publisher : Elsevier Health Sciences
Page : 7409 pages
File Size : 53,7 Mb
Release : 2018-05-26
Category : Medical
ISBN : 9780323550765

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Ferri's Clinical Advisor 2019 E-Book by Fred F. Ferri Pdf

Updated annually with the latest developments in diagnosis and treatment recommendations, Ferri’s Clinical Advisor uses the popular "5 books in 1" format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on more than 900 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all updated by experts in key clinical fields. Updated algorithms and current clinical practice guidelines help you keep pace with the speed of modern medicine. Contains significant updates throughout, with more than 500 new figures, tables, and boxes added to this new edition. Features 17 all-new topics including opioid overdose, obesity-Hypoventilation syndrome, acute pelvic pain in women, new-onset seizures, and eosinophilic esophagitis, among many others. Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. Includes cross-references, outlines, bullets, tables, boxes, and algorithms to help you navigate a wealth of clinical information. Offers access to exclusive online content: more than 90 additional topics; new algorithms, images, and tables; EBM boxes; patient teaching guides, color images, and more.