Mycobacterium Tuberculosis

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Mycobacterium Tuberculosis Pathogenesis, Infection Prevention and Treatment

Davide Maria Ferraris,Riccardo Miggiano,Menico Rizzi
Mycobacterium Tuberculosis Pathogenesis Infection Prevention and Treatment Book PDF

Author : Davide Maria Ferraris,Riccardo Miggiano,Menico Rizzi
Publisher : Unknown
Page : 128 pages
File Size : 46,9 Mb
Release : 2020
Category : Electronic
ISBN : 3039366599

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Mycobacterium Tuberculosis Pathogenesis, Infection Prevention and Treatment by Davide Maria Ferraris,Riccardo Miggiano,Menico Rizzi Pdf

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB) and it represents a persistent public health threat for a number of complex biological and sociological reasons. According to the most recent Global Tuberculosis Report (2019) edited by the World Health Organization (WHO), TB is considered the ninth cause of death worldwide and the leading cause of mortality by a single infectious agent, with the highest rate of infections and death toll rate mostly concentrated in developing and low-income countries. We present here the editorial section to the Special Issue entitled “Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment” that includes 7 research articles and a review. The scientific contributions included in the Special Issue mainly focus on the characterization of MTB strains emerging in TB endemic countries as well as on multiple mechanisms adopted by the bacteria to resist and to adapt to antitubercular therapies.

Disease Control Priorities, Third Edition (Volume 6)

King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha
Disease Control Priorities Third Edition Volume 6 Book PDF

Author : King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha
Publisher : World Bank Publications
Page : 506 pages
File Size : 53,9 Mb
Release : 2017-11-06
Category : Medical
ISBN : 9781464805257

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Disease Control Priorities, Third Edition (Volume 6) by King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha Pdf

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Tuberculosis in Adults and Children

Dorothee Heemskerk,Maxine Caws,Ben Marais,Jeremy Farrar
Tuberculosis in Adults and Children Book PDF

Author : Dorothee Heemskerk,Maxine Caws,Ben Marais,Jeremy Farrar
Publisher : Springer
Page : 66 pages
File Size : 51,6 Mb
Release : 2015-07-17
Category : Medical
ISBN : 9783319191324

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Tuberculosis in Adults and Children by Dorothee Heemskerk,Maxine Caws,Ben Marais,Jeremy Farrar Pdf

This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control

Sebastien Gagneux
Strain Variation in the Mycobacterium tuberculosis Complex Its Role in Biology Epidemiology and Control Book PDF

Author : Sebastien Gagneux
Publisher : Springer
Page : 314 pages
File Size : 53,5 Mb
Release : 2018-08-31
Category : Science
ISBN : 3319877763

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Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control by Sebastien Gagneux Pdf

Until about 10 years ago, the general view in the field was that Mycobacterium tuberculosis, the causative agent of human tuberculosis was a “clone” with insufficient natural sequence variation between clinical strains to be considered biologically and epidemiologically “relevant”. This view has now changed quite dramatically thanks to the –omics revolution, particularly the advent of next generation DNA sequencing. Large-scale comparative genomic studies over the last few years have revealed that M. tuberculosis clinical strains are more genetically diverse than appreciated previously. Moreover, an increasing number of experimental and epidemiological studies are showing that this genetic diversity also translates into important phenotypic variation. Taken together, these findings have led to a paradigm shift, such that currently phylogenetic diversity among M. tuberculosis clinical strains is being considered in the development of new tools to combat tuberculosis. The purpose of this book is to bring together a series of contributions from some of the most influential groups working on various aspects of M. tuberculosis diversity, and which through their work have contributed to the this paradigm shift. This includes authors focusing on the evolution of M. tuberculosis in relation to other members of the M. tuberculosis complex adapted to animals, the co-evolution between M. tuberculosis and humans, the phenotypic consequences of strains diversity both from an experimental and epidemiological point of view, the ecology and evolution of drug resistant tuberculosis, the diversity and evolution of the BCG vaccine strains, and the use of mathematical modelling to study strain diversity and drug resistance in human tuberculosis. No such book has ever been published, and given the paradigm shift described above, this book will be a valuable resource both for established researchers as well as new scientists, clinicians and public health officials joining the growing field of tuberculosis research.

Mycobacterium Tuberculosis Protocols

Tanya Parish,Neil G. Stoker
Mycobacterium Tuberculosis Protocols Book PDF

Author : Tanya Parish,Neil G. Stoker
Publisher : Springer Science & Business Media
Page : 403 pages
File Size : 47,7 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9781592591473

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Mycobacterium Tuberculosis Protocols by Tanya Parish,Neil G. Stoker Pdf

The aim of this book is to provide detailed protocols for studying the molecular biology of the pathogen Mycobacterium tuberculosis, and its int- actions with host cells. As established mycobacterial laboratories move - wards exploiting the genome, and laboratories with expertise in other fields apply them to mycobacteria, both traditional and novel methodologies need to be reviewed. Thus the chapters in Mycobacterium tuberculosis Protocols range from perspectives on storage of strains and safety issues to the application of the latest functional genomics technologies. The last few years have been remarkable ones for research into M. tuber- losis. The most important landmark by far has been the completion of the genome sequence of the widely studied H37Rv strain (1). We can now predict every protein and RNA molecule made by the pathogen. This information is or will soon be enriched by the addition of genome sequences of other strains from the M. tuberculosis complex: a second strain of M. tuberculosis, My- bacterium bovis, and the vaccine strain, M. bovis BCG. Valuable comparative data will also be provided by the genome sequences of Mycobacterium leprae, Mycobacterium avium, and Streptomyces coelicolor. Another recent milestone for M. tuberculosis has been the development of efficient mutagenesis me- odologies, the lack of which has been a major handicap in functional studies.

Tuberculosis in the Workplace

Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee on Regulating Occupational Exposure to Tuberculosis
Tuberculosis in the Workplace Book PDF

Author : Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee on Regulating Occupational Exposure to Tuberculosis
Publisher : National Academies Press
Page : 334 pages
File Size : 45,6 Mb
Release : 2001-05-15
Category : Medical
ISBN : 9780309171250

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Tuberculosis in the Workplace by Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee on Regulating Occupational Exposure to Tuberculosis Pdf

Before effective treatments were introduced in the 1950s, tuberculosis was a leading cause of death and disability in the United States. Health care workers were at particular risk. Although the occupational risk of tuberculosis has been declining in recent years, this new book from the Institute of Medicine concludes that vigilance in tuberculosis control is still needed in workplaces and communities. Tuberculosis in the Workplace reviews evidence about the effectiveness of control measuresâ€"such as those recommended by the Centers for Disease Control and Preventionâ€"intended to prevent transmission of tuberculosis in health care and other workplaces. It discusses whether proposed regulations from the Occupational Safety and Health Administration would likely increase or sustain compliance with effective control measures and would allow adequate flexibility to adapt measures to the degree of risk facing workers.

Zoonotic Tuberculosis

Charles O. Thoen,James H. Steele,John B. Kaneene
Zoonotic Tuberculosis Book PDF

Author : Charles O. Thoen,James H. Steele,John B. Kaneene
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 52,6 Mb
Release : 2014-02-12
Category : Medical
ISBN : 9781118474280

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Zoonotic Tuberculosis by Charles O. Thoen,James H. Steele,John B. Kaneene Pdf

Zoonotic Tuberculosis: Mycobacterium bovis and OtherPathogenic Mycobacteria, Third Edition is a comprehensivereview of the state of the art in the control and elimination ofinfections caused by Mycobacterium tuberculosis complex inanimals and humans. This update to the most complete and currentreference available on Mycobacterium bovis includes newcoverage of the latest molecular techniques; more information onhuman infection and One Health; updates to the information on theInternational Union Against Tuberculosis and Lung Disease (IUATLD),the World Health Organization (WHO), Pan American HealthOrganization (PAHO), and the United States Department ofAgriculture’s (USDA) National Tuberculosis EradicationProgram; and coverage of additional African countries. TheThird Edition upholds the book’s reputation as a truly globalresource on M. bovis. Written by an international list of tuberculosis experts,chapters cover the status of tuberculosis in many regionsthroughout the world and deal with issues related to the detection,spread, and control of Mycobacterium bovis, as well as theeconomic impact of outbreaks. Zoonotic Tuberculosis:Mycobacterium bovis and Other Pathogenic Mycobacteria offersvaluable information for public health officials, medical doctors,state and federal regulatory veterinarians, veterinarypractitioners, and animal caretakers.

Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism

Jean Pieters,John D. McKinney
Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism Book PDF

Author : Jean Pieters,John D. McKinney
Publisher : Springer
Page : 0 pages
File Size : 55,8 Mb
Release : 2016-08-23
Category : Medical
ISBN : 3662521423

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Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism by Jean Pieters,John D. McKinney Pdf

Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.

Tuberculosis

David Schlossberg
Tuberculosis Book PDF

Author : David Schlossberg
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 40,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468403053

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Tuberculosis by David Schlossberg Pdf

Completely revised and updated, this comprehensive resource covers the epidemiology, pathogenesis, varied clinical manifestations, treatment and prevention of tuberculosis. All of the extra-pulmonary as well as pulmonary manifestations of tuberculosis are covered. Atypical mycobacterial infection is detailed. A special feature of this second edition is the new material on AIDS, which is now known to be complicated by tuberculosis infection.

Atlas of Mycobacterium Tuberculosis

Ali Akbar Velayati,Parissa Farnia
Atlas of Mycobacterium Tuberculosis Book PDF

Author : Ali Akbar Velayati,Parissa Farnia
Publisher : Academic Press
Page : 226 pages
File Size : 43,8 Mb
Release : 2016-09-30
Category : Medical
ISBN : 9780128038802

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Atlas of Mycobacterium Tuberculosis by Ali Akbar Velayati,Parissa Farnia Pdf

Atlas of Mycobacterium Tuberculosis reveals in-depth information about mycobacterium tuberculosis which has never before been reported. Using atomic force microscopy (AFM), the in-depth phenotypic interaction that occurs in different stages of the tuberculosis lifecycle is illustrated, including resting, exponential, and dormant states. Coverage also includes the macroscopic and microscopic anatomy of mycobacterium, including pigmentation, morphology of colonies, size and shape, and the phenotypic changes from susceptible to resistant, all shown with images from electronic and atomic force microscopes. This book will open a new window into the results of molecular changes at the cellular level, guiding researchers and scientists to think in new ways about the area of cell wall and the reproductive and drug resistance phenomena surrounding tuberculosis. Identifies the different stages and morphological aspects of mycobacterium tuberculosis with the use of new microscopy techniques Includes never-before-seen photographs from the personal collection and scientific achievement of the authors Outlines the nature of the lifecycle of mycobacterium tuberculosis in relation to adaptation in humans

Mycobacterium tuberculosis

Mauro Bendinelli,Herman Friedman
Mycobacterium tuberculosis Book PDF

Author : Mauro Bendinelli,Herman Friedman
Publisher : Springer Science & Business Media
Page : 438 pages
File Size : 55,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468454185

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Mycobacterium tuberculosis by Mauro Bendinelli,Herman Friedman Pdf

Tuberculosis once again occupies a special position in the areas of infec tious diseases and microbiology. This disease has been important to mankind since even before biblical times. Tuberculosis has been a major cause of morbidity and mortality in humans, especially in highly ur banized Europe, until a few decades ago. Indeed, this disease became a center of many novels, plays, and operas, since it appeared to be quite popular to have the heroine dying of "consumption. " Most importantly, tuberculosis also became the focus of attention for many investigations during the 19th and even the 20th centuries. Major advances were made in the areas of isolation and identification of M. tuberculosis and related microorganisms. The discovery, by Robert Koch, that tuberculosis was caused by an infectious agent revolutionized our thinking about dis eases. Koch's postulates were developed with tuberculosis in mind and became a focal point for many advances in microbiology and medicine. Studies with mycobacteria as a central focus have also led to revolu tionary new concepts about immunology in general. Koch himself showed that those exposed to M. tuberculosis develop a skin hypersen sitivity or allergy to the microorganism's antigens, an observation which was the starting point for many important developments. Indeed, imme diate-type hypersensitivity and atopic or IgE-mediated allergy were de fined in relation to the delayed-type cutaneous hypersensitivity evi denced with the tubercle bacillus.

Mycobacterium bovis Infection in Animals and Humans

Charles O. Thoen,James H. Steele,Michael J. Gilsdorf
Mycobacterium bovis Infection in Animals and Humans Book PDF

Author : Charles O. Thoen,James H. Steele,Michael J. Gilsdorf
Publisher : John Wiley & Sons
Page : 356 pages
File Size : 54,5 Mb
Release : 2008-02-28
Category : Medical
ISBN : 9780470344156

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Mycobacterium bovis Infection in Animals and Humans by Charles O. Thoen,James H. Steele,Michael J. Gilsdorf Pdf

Written by tuberculosis specialists from around the world, Mycobacterium Bovis Infection in Animals and Humans, Second Edition remains the most comprehensive collection of timely information regarding Mycobacterium bovis in any single source. The chapters are organized for quick access to well-indexed topics, and extensive reference lists are included to aid infectious disease specialists, regulatory officials, diagnosticians, researchers or public health workers interested in M bovis. This international reference includes the most current information on mechanisms of virulence of tubercle bacilli and immunologic and biochemical responses of the host involved in resistance. The book includes information on the diagnosis and application of the latest molecular techniques in epidemiologic investigations. Included are chapters on the economic impact of outbreaks of M. bovis in alternate species on control programs in domestic animals. There are also contributions by representatives of the International Union Against Tuberculosis and Lung Disease, PAHO of the World Health Organization, The Centers for Disease Control, and The University of Texas Health Center. This excellent reference is an invaluable aid to clinicians dealing directly with tuberculosis, as well as to government regulatory personnel, professional and graduate students, and instructors in basic and allied health sciences

CDC Yellow Book 2018: Health Information for International Travel

Centers for Disease Control and Prevention CDC
CDC Yellow Book 2018 Health Information for International Travel Book PDF

Author : Centers for Disease Control and Prevention CDC
Publisher : Oxford University Press
Page : 672 pages
File Size : 52,6 Mb
Release : 2017-04-17
Category : Medical
ISBN : 9780190628635

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CDC Yellow Book 2018: Health Information for International Travel by Centers for Disease Control and Prevention CDC Pdf

THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

Tuberculosis and the Tubercle Bacillus

William R. Jacobs, Jr.,Helen McShane,Valerie Mizrahi,Ian M. Orme
Tuberculosis and the Tubercle Bacillus Book PDF

Author : William R. Jacobs, Jr.,Helen McShane,Valerie Mizrahi,Ian M. Orme
Publisher : John Wiley & Sons
Page : 1379 pages
File Size : 49,9 Mb
Release : 2017-09-01
Category : Medical
ISBN : 9781683673057

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Tuberculosis and the Tubercle Bacillus by William R. Jacobs, Jr.,Helen McShane,Valerie Mizrahi,Ian M. Orme Pdf

Can today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035. This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs. Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB. Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against "persisters" and those that act on the electron transport complex and ATP synthase of M. tuberculosis. Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF. Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated. The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.

Mycobacteria and TB

Stefan H. E. Kaufmann,Helmut Hahn
Mycobacteria and TB Book PDF

Author : Stefan H. E. Kaufmann,Helmut Hahn
Publisher : Karger Medical and Scientific Publishers
Page : 165 pages
File Size : 54,5 Mb
Release : 2003
Category : Medical
ISBN : 9783805574594

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Mycobacteria and TB by Stefan H. E. Kaufmann,Helmut Hahn Pdf

Tuberculosis remains one of the main fatal infections in humans. With annual morbidity and mortality rates worldwide of 8 and 2 million cases respectively, the disease is far from being eradicated. In fact, the dangerous liaison between TB and HIV, and the increasing incidences of multidrug resistant strains of Mycobacterium tuberculosis are aggravating the problem. The latest epidemiological data indicate that new drugs and a novel vaccine are urgently needed to control TB adequately. This volume summarizes the state of the art in the prevention, diagnosis and therapy of TB. In addition, the molecular biology of M. tuberculosis and the immunology of the host response are presented. Researchers are beginning to understand how the immune response controls the pathogen quite efficiently, yet fails to eradicate it completely in the 2 billion people worldwide who are infected but do not develop the disease. Finally, recent strategies towards the development of new vaccines are reviewed. Scientists investigating the epidemiology, immunology and molecular biology of TB or engaged in vaccine and drug development as well as physicians and social workers treating TB patients will benefit from this timely overview.