Myocardial Protection

Author : Tomas A. Salerno,Marco Ricci
Publisher : John Wiley & Sons
Page : 344 pages
File Size : 40,7 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9781405178433

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Myocardial Protection by Tomas A. Salerno,Marco Ricci Pdf

Myocardial protection is regarded as one of the most important, yet also most controversial aspects of cardiac surgery. There has been considerable improvement in myocardial protection strategies over recent years, utilising a variety of new approaches to treat cardiac diseases, and this text is intended to embrace the state of the art in this field. The book summarises the state of knowledge on all aspects of myocardial protection, including the latest in the treatment of cardiac diseases, robotics, pediatric surgery and the treatment of cardiac failure. Robotic surgery, valvular surgery, pediatric surgery and coronary surgery are all covered by renowned experts, producing a comprehensive, forward-looking view of the field of myocardial protection. This book should function to update physicians and surgeons interested in the field of cardiac surgery on the current state of knowledge on myocardial protection.

Author : Edmo Atique Gabriel,Tomas Salerno
Publisher : Springer Science & Business Media
Page : 453 pages
File Size : 53,5 Mb
Release : 2010-10-05
Category : Medical
ISBN : 9781849963084

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Principles of Pulmonary Protection in Heart Surgery by Edmo Atique Gabriel,Tomas Salerno Pdf

Over the past ?fty years, advanced techniques and strategies have arisen in the ?eld of myocardial protection. Meticulous trials, focusing on pulmonary protection during heart surgery requiring cardiopulmonary bypass (CPB), have been missing. This te- book is intended to serve as a useful tool to spread information on strategies for lung protection during heart surgery with CPB. Emphasis on pulmonary protection will be turned to lung perfusion as an adjunct for minimizing the deleterious effects of pulmonary ischemia-reperfusion injury in heart surgery. Many renowned authors have contributed by presenting their expe- ence on lung perfusion in basic research and clinical trials. Furthermore, they have enlightened the quality of this textbook with new ideas, concepts, and future perspectives. The scope of this textbook is of interest to different professionals, such as card- vascular surgeons, pulmonary surgeons, transplantation physicians, cardiothoracic anesthesiologists, intensive care physicians, cardiothoracic fellows, radiologists, basic sciences physicians, cardiologists, pulmonary medicine physicians, perfusi- ists, nurses, students, and researchers. This textbook has 7 sections, aimed at addressing general and speci?c aspects of pulmonary protection during heart surgery with CPB. The ?rst section on general concepts provides information about anatomic, physiologic, histologic, molecular, and radiologic considerations regarding the lungs. The second section focuses on ischemia-reperfusion injury and is composed of several interesting chapters, addressing the basic science aspects of pulmonary p- tection, as well as experimental and clinical experiences from different heart surgery centers worldwide.

Author : David Yuh,Luca Vricella,Stephen Yang,John R. Doty
Publisher : McGraw Hill Professional
Page : 1312 pages
File Size : 55,7 Mb
Release : 2014-02-05
Category : Medical
ISBN : 9780071714938

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Johns Hopkins Textbook of Cardiothoracic Surgery, Second Edition by David Yuh,Luca Vricella,Stephen Yang,John R. Doty Pdf

THE LANDMARK GUIDE TO ADULT CARDIAC, CONGENITAL CARDIAC, AND GENERAL THORACIC SURGERY--COMPLETELY UPDATED AND REVISED IN FULL COLOR An essential guide for daily clinical practice and a thorough review for the cardiothoracic boards, Johns Hopkins Textbook of Cardiothoracic Surgery is filled with authoritative guidance on surgical techniques and pre- and postoperative strategies for managing cardiothoracic disease. The content of this trusted classic reflects the rapidly changing field of cardiothoracic surgery. In addition to the basic curriculum required for certification, you will find coverage of advanced concepts, controversial issues, and new technologies. Johns Hopkins Textbook of Cardiothoracic Surgery provides an in-depth look at the full-spectrum of disorders and their surgical and medical management options, including congenital, acquired, and neoplastic diseases. Supporting this detailed coverage is an easy-to-navigate design and step-by-step explanations of the most complex operations. THE SECOND EDITION IS HIGHLIGHTED BY: NEW board review Q&A Ten NEW chapters including: Surgical Therapies for Atrial Fibrillation, Management of Adults with Congenital Heart Disease, and Stem Cells for Cardiac Surgical Disease NEW full-color illustrations An increased number of decision-making flow charts that will prove valuable when preparing for cases and examinations Key Concepts that highlight epidemiology, pathophysiology, clinical features, diagnostic and treatment strategies, and outcomes for each topic NOTE: This book was previously known as the Johns Hopkins Manual of Cardiothoracic Surgery but the second edition has been renamed to better reflect its scope and comprehensive nature.

Author : Anwar-Saad A. Abd-Elfattah,Andrew S. Wechsler
Publisher : Springer Science & Business Media
Page : 565 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461304555

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Purines and Myocardial Protection by Anwar-Saad A. Abd-Elfattah,Andrew S. Wechsler Pdf

A critical review of the most up-to-date research on purines and myocardial protection. The role of purines in reversible `myocardial stunning' and irreversible (myocardial infarction) ischemic injury, ventricular arrhythmias, and ischemic preconditioning is discussed in detail, by experts. All reviews address recent and rather controversial issues on purines and myocardial protection. Mechanisms of cardioprotection of exogenous versus endogenous purines are discussed in detail. The contribution of internationally recognized experts in the field of purines and cardiovascular physiology and in myocardial protection makes this a unique and interesting book for clinicians, basic scientists and students.

Author : Shahzad G. Raja
Publisher : Springer Nature
Page : 1089 pages
File Size : 41,5 Mb
Release : 2020-02-11
Category : Medical
ISBN : 9783030241742

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Cardiac Surgery by Shahzad G. Raja Pdf

This textbook provides a succinct overview of cardiac surgery, with key concepts being emphasized throughout. An abundance of illustrations, intra-operative photographs, tables as well as information boxes, aids the reader to visualise, grasp and retain difficult concepts. The inclusion of evidence-based approaches to the management of a range of cardiac surgical conditions equips the reader with an understanding of how to overcome a variety of potentially tough clinical challenges. Concise Cardiac Surgery: A Complete Guide comprehensively covers a range of techniques used in cardiac surgery. It is therefore, an ideal resource for the trainee and practising cardiac surgeon seeking a practically focused text detailing how to apply the latest techniques and evidence-based approaches in their day-to-day practice.

Author : Ravi Pillai,John E. C. Wright
Publisher : Unknown
Page : 328 pages
File Size : 52,7 Mb
Release : 1999
Category : Medical
ISBN : UOM:39015048939352

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Surgery for Ischaemic Heart Disease by Ravi Pillai,John E. C. Wright Pdf

Ischaemic heart disease remains the most important cause of death in most developed countries. Alongside preventive measures the advent of coronary artery surgery has improved the symptomatic status and long-term survival in patients suffering from coronary artery disease and myocardial infarction. This book brings together developments in the field that have occurred in the last ten years including advances in surgical techniques, protection of the heart and post-operative care, and it introduces the link with molecular biology.

Author : Bruno K. Podesser,David J. Chambers
Publisher : Springer Science & Business Media
Page : 287 pages
File Size : 49,7 Mb
Release : 2010-10-28
Category : Medical
ISBN : 9783211855485

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New Solutions for the Heart by Bruno K. Podesser,David J. Chambers Pdf

Although cardiac surgery has made an enormous progress during the last decades, the discipline has to cope with essential changes: Patients are increasingly cared for by cardiologists and therefore referred to the surgeon in a later stage of disease. Consequently, they are more often in an increasingly serious state or in advanced age with significant comorbidities. In order to meet the requirements of these different patient groups, cardiosurgical treatments require special protectional strategies for the heart in order to perform the planned operations safely. This book presents the latest knowledge of modern techniques of myocardial protection taking into consideration the different patient groups and current scientific strategies. Furthermore, it discusses present and future scientific approaches in myocardial protection and preservation.

Author : Rakesh C. Kukreja
Publisher : CRC Press
Page : 115 pages
File Size : 52,8 Mb
Release : 2000-08-01
Category : Science
ISBN : 9781498712668

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Heat Shock Proteins in Myocardial Protection by Rakesh C. Kukreja Pdf

Myocardial ischemic syndromes pose a major medical problem and a significant economic health care concern. Reperfusion, although used in the clinical arena as essential to the survival of acutely ischemic heart muscle carries with it the risk of "reperfusion injury". Therefore the salvage of additional myocardium is highly desirable. Over a decade ago, it was shown that whole body heat shock activated a powerful endogenous protective mechanism that significantly improved myocardial salvage following prolonged ischemia and reperfusion injury in the heart. A characteristic feature of this heat shock response was the expression of a family of proteins known as heat shock proteins. Many of these proteins function as molecular chaperones, helping to refold proteins denatured as a consequence of lethal injuries and facilitating the synthesis of new proteins to replace those irreparably damaged. Altered expression of these proteins has been extensively documented in association with a diverse array of diseases such as ischemia and perfusion injury, cardiac hypertrophy, fever, inflammation, metabolic diseases, infection, cell and tissue trauma, aging, and cancer. Interestingly, some studies have now shown a direct correlation of the heat shock proteins produced and the degree of myocardial protection. This book is a thorough description of the current state of knowledge of the mechanisms of heat shock proteins induced cardiac protection at the cellular and molecular level, the controversies in this growing field and the potential of treating ischemic heart disease with overexpression of heat shock proteins in patients. The book will be especially useful for investigators interested in studying tissue injury and its protection with the overexpression of heat shock proteins.

Author : Lionel H. Opie
Publisher : John Wiley & Sons
Page : 220 pages
File Size : 41,9 Mb
Release : 1994-08-16
Category : Medical
ISBN : 0471076694

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Myocardial Protection by Calcium Antagonists by Lionel H. Opie Pdf

About the Book There are vast amounts of new data emerging in the study of calcium antagonist drugs. The major issues involved are no longer just the effects of calcium antagonist drugs in angina or hypertension but their possible postinfarct protective effects, both to provide prophylaxis and to improve left ventricular function. New trials have also changed our thinking. One major trial suggested that the use of one of these agents in postinfarct patients with no history of heart failure in the acute infarct stage was not only safe but could confer positive protection from reinfarction and possibly from sudden death. Another study, also in postinfarct patients but with a different agent, has drawn attention to a further unexpected benefit, namely improvement of mechanical diastolic function. In the area of hypertension, the emphasis has shifted to the regression of left ventricular hypertrophy, now recognized as an independent risk factor for cardiovascular mortality, and to diastolic dysfunction. Looking to the future, calcium antagonists may exert protection against end-stage heart failure by limiting left ventricular hypertrophy and by vascular beneficial effects. There is emerging interest that the combination with ACE inhibitors may exert additive effects on control of hypertension and on diabetic hypertensive renal lesions. Reviews of Other Books by the Author Drugs for the Heart--"A gem" (New England Journal of Medicine) The Heart--"The subjects are brilliantly illuminated and made exciting by excellent line diagrams" (The Lancet) Angiotensin-Converting Enzyme Inhibitors: Scientific Basis for Clinical Use--"A milestone" (British Medical Journal)

Author : Derek Yellon,Garrett J. Gross
Publisher : Springer Science & Business Media
Page : 232 pages
File Size : 45,7 Mb
Release : 1995-12-31
Category : Medical
ISBN : 0792337913

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Myocardial Protection and the KATP Channel by Derek Yellon,Garrett J. Gross Pdf

The ATP-sensitive potassium channel (KATP) was discovered in 1983. Since then, an enormous amount of research has been undertaken to characterize it in detail. This volume consolidates both the current knowledge and most recent advances on the subject, and its relationship to myocardial protection. To this end, the editors have assembled investigators at the forefront of ongoing basic and clinical research to provide scholarly and candid comments concerning each of the pertinent issues, including: a comprehensive review of the biology of the channel with respect to the structure-activity relationship as well as overall chemistry of the channel; the role of opening this channel and its effect on smooth muscle (covering both the effects on myocardial stunning and its ability to protect against myocardial infarction); the relationship of KATP channel opening and the protection to the myocardium afforded by the phenomenon of ischemic preconditioning; the relationship between the KATP channel and electrophysiological consequences with specific reference to arrhythmogenicity; and the clinical implications of the use of agents that mimic the opening of this channel, with reference to its protective nature and its use in the treatment of angina. Audience: Clinicians and basic scientists who have a direct interest in the KATP channel as well as those groups who are interested in the entire concept of myocardial protection and its relationship to academic and clinical medicine.

Author : Sunit Ghosh,Florian Falter,Albert C. Perrino, Jr
Publisher : Cambridge University Press
Page : 271 pages
File Size : 45,7 Mb
Release : 2015-11-26
Category : Medical
ISBN : 9781107428256

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Cardiopulmonary Bypass by Sunit Ghosh,Florian Falter,Albert C. Perrino, Jr Pdf

A complete clinically orientated guide to cardiopulmonary bypass and extracorporeal support for trainee medical and technical personnel in cardiac surgery.

Author : David J. Hearse,M. V. Braimbridge,Per Jynge
Publisher : Unknown
Page : 440 pages
File Size : 53,6 Mb
Release : 1981
Category : Cardiac arrest, Induced
ISBN : UOM:39015000316235

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Protection of the Ischemic Myocardium by David J. Hearse,M. V. Braimbridge,Per Jynge Pdf

Author : Jonathan H. Mackay,Joseph E. Arrowsmith
Publisher : Cambridge University Press
Page : 0 pages
File Size : 47,7 Mb
Release : 2012-03-15
Category : Medical
ISBN : 052119685X

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Core Topics in Cardiac Anesthesia by Jonathan H. Mackay,Joseph E. Arrowsmith Pdf

Since the publication of the first edition of Core Topics in Cardiac Anaesthesia, the clinical landscape has undergone significant change. Recent developments include the increased use of electrophysiology, the resurgence of primary percutaneous intervention in acute coronary syndromes, the use of percutaneous devices in patients previously considered inoperable, and the withdrawal of aprotinin. Against this landscape, this invaluable resource has been fully updated. New chapters are dedicated to right heart valves, pulmonary vascular disease, cardiac tumours and cardiac trauma. All other chapters have been updated according to the latest international guidelines. Written and edited by an international author team with a wealth of expertise in all aspects of the perioperative care of cardiac patients, topics are presented in an easy to digest and a readily accessible manner. Core Topics in Cardiac Anaesthesia, Second Edition is essential reading for residents and fellows in anaesthesia and cardiac surgery and clinical perfusionists.

Author : Morris Karmazyn
Publisher : Birkhäuser
Page : 508 pages
File Size : 47,5 Mb
Release : 2013-03-12
Category : Medical
ISBN : 9783034889889

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Myocardial Ischemia: Mechanisms, Reperfusion, Protection by Morris Karmazyn Pdf

Myocardial ischemia and subsequent reperfusion of the ischemic myocardium represent complex phenomena encompassing numerous physiological processes. This book aims at enhancing our understanding of these processes and stresses recent important developments in this very active area of research. The concise, state-of-the-art reviews cover recent advances in many fields important to the area of myocardial ischemia and reperfusion including physiology, pathology, pharmacology, biochemistry and molecular biology with reference to clinical relevance and applicability of these findings. Major areas which are highlighted include vascular mechanisms resulting in myocardial ischemia, cellular events in the ischemic, postinfarcted and reperfused myocardium as well as new exciting developments in cardiac protection that involve both novel pharmacological approaches as well as endogenous cardioprotective mechanisms such as preconditioning. Aimed at both the basic and clinical cardiovascular investigator, the book comprehensively reviews the rapid progress made in recent years in understanding the etiology of myocardial ischemia and reperfusion. It will further serve as an authoritative reference for all those interested in learning about the important developments in the treatment of myocardial ischemic and reperfusion disorders.

Author : Akio Suzuki,Tei Haku
Publisher : Ishiyaku EuroAmerica, Incorporated
Page : 78 pages
File Size : 53,8 Mb
Release : 1985
Category : Cardiac arrest, Induced
ISBN : UOM:39015009564504

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Myocardial Protection and Cardioplegia by Akio Suzuki,Tei Haku Pdf