Nanoarchitectonics For Brain Drug Delivery

Author : Anurag Kumar Singh,Vivek K. Chaturvedi,Jay Singh
Publisher : CRC Press
Page : 381 pages
File Size : 43,5 Mb
Release : 2024-02-22
Category : Technology & Engineering
ISBN : 9781003851844

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Nanoarchitectonics for Brain Drug Delivery by Anurag Kumar Singh,Vivek K. Chaturvedi,Jay Singh Pdf

This book discusses basics of brain diseases and the role of nanobiotechnology in existing treatment options for neurodegenerative disorders. It begins with an overview of brain diseases and the need for novel drug-delivery approaches. It highlights the current route for the intranasal advanced drug-delivery systems for brain diseases. It also discusses innovative categories of drug-delivery systems, including mesoporous silica nanoparticles, polymeric nanocarriers, and lipid-based nanocarriers through multi-responsive DDSs and their implications in brain disorders. Features: Includes an overview of brain diseases and highlights the need for novel drug-delivery approaches Focuses on theoretical aspects of advanced drug-delivery systems for brain diseases including challenges and progress in nose-to-brain delivery Provides an overview of technological approaches and their implications for neurodegenerative disorders, central nervous system (CNS), and brain drug delivery in brain cancer Discusses key advances in the development of polymer nanoparticles for drug delivery to the CNS Reviews the role of herbal medicines and naturally derived polymeric nanoparticle for the treatment of neurodegenerative disorders This book is aimed at graduate students and researchers in biomedical engineering, biotechnology, drug delivery, and neurology.

Author : Carla Vitorino,Andreia Jorge,Alberto A.C.C. Pais
Publisher : CRC Press
Page : 518 pages
File Size : 46,6 Mb
Release : 2021-03-15
Category : Medical
ISBN : 9781000245592

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Nanoparticles for Brain Drug Delivery by Carla Vitorino,Andreia Jorge,Alberto A.C.C. Pais Pdf

In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. The book encompasses general aspects pertaining to fundamental development, including tripartite in silico–in vitro–in vivo approaches. It also covers a diversity of nanomedicines applied in treatment and/or diagnosis and monitoring of CNS disorders. Aspects concerning their translation from the bench to clinical practice are also seamlessly discussed. This book will inspire readers to discover possible approaches to holistically delivering drugs into the brain. Edited by Carla Vitorino, Andreia Jorge and Alberto Pais, this book will appeal to anyone involved in nanomedicine, pharmaceutics, neurological and cancer therapies, drug delivery research and computational and regulatory sciences.

Author : Javier O. Morales,Pieter J. Gaillard
Publisher : Unknown
Page : 128 pages
File Size : 53,7 Mb
Release : 2021
Category : Blood-brain barrier
ISBN : 107160838X

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Nanomedicines for Brain Drug Delivery by Javier O. Morales,Pieter J. Gaillard Pdf

Author : Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani
Publisher : CRC Press
Page : 567 pages
File Size : 52,5 Mb
Release : 2019-08-05
Category : Medical
ISBN : 9780429877537

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Nanocarriers for Brain Targeting by Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani Pdf

This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more. The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.

Author : Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne
Publisher : Springer Science & Business Media
Page : 731 pages
File Size : 55,8 Mb
Release : 2013-12-03
Category : Medical
ISBN : 9781461491057

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Drug Delivery to the Brain by Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne Pdf

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. ​

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Page : 720 pages
File Size : 52,5 Mb
Release : 2019-03-20
Category : Medical
ISBN : 9780128172612

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Nanoarchitectonics in Biomedicine by Alexandru Mihai Grumezescu Pdf

Nanoarchitectonics in Biomedicine describes this new area of nanoscience that has emerged as a major branch of nanoscience. The book brings together recent applications and discusses the advantages and disadvantages of each process, offering international perspectives on the technologies based on these findings. It offers new insights for nanoarchitectonics, starting with the currently used methods of synthesis and characterization of such materials, along with their biomedical applications. Authored by a wide range of international scientists, this volume shows how nanoarchitectonics is being used to create more efficient medical treatment solutions. Users will find this to be an important research resource for those wanting to learn more on the emerging topic of nanoarchitectonics in biomedical science. Explores how design aspects, smart materials and personalized materials are used in biomedicine today Offers global perspectives on how nanoarchitectonics is used in different regions Presents an important research resource for those wanting to learn more on the emerging topic of nanoarchitectonics in biomedical science

Author : Alina Maria Holban,Alexandru Mihai Grumezescu
Publisher : William Andrew
Page : 970 pages
File Size : 44,5 Mb
Release : 2016-07-12
Category : Technology & Engineering
ISBN : 9780323477222

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Nanoarchitectonics for Smart Delivery and Drug Targeting by Alina Maria Holban,Alexandru Mihai Grumezescu Pdf

Nanoarchitectonics for Smart Delivery and Drug Targeting is one of the first books on the market to exclusively focus on the topic of nanoarchitectonics, a rapidly developing area of nanotechnology which allows scientists to arrange nanoscale structural units, typically a group of atoms or molecules, in an intended configuration. This book assesses novel applications of nanomaterials in the areas of smart delivery and drug targeting using nanoarchitectonics and discusses the advantages and disadvantages of each application. Provides a scholarly introduction to the uses of nanoarchitectonics in drug delivery and targeting Explores novel opportunities and ideas for developing and improving nanoscale drug delivery systems through the use of nanoarchitectonics, allowing scientists to see how this exciting new technology is used in practice Assesses the pros and cons of each application, allowing readers to assess when it is most appropriate to use nanoarchitectonics in drug delivery

Author : Mahendra Rai,Mrunali Patel,Rashmin Patel
Publisher : John Wiley & Sons
Page : 448 pages
File Size : 50,5 Mb
Release : 2021-10-19
Category : Science
ISBN : 9781119769880

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Nanotechnology in Medicine by Mahendra Rai,Mrunali Patel,Rashmin Patel Pdf

NANOTECHNOLOGY IN MEDICINE Discover thorough insights into the toxicology of nanomaterials used in medicine In Nanotechnology in Medicine: Toxicity and Safety, an expert team of nanotechnologists delivers a robust and up-to-date review of current and future applications of nanotechnology in medicine with a special focus on neurodegenerative diseases, cancer, diagnostics, nano-nutraceuticals, dermatology, and gene therapy. The editors offer resources that address nanomaterial safety, which tends to be the greatest hurdle to obtaining the benefits of nanomedicine in healthcare. The book is a one-stop resource for recent and comprehensive information on the toxico logical and safety aspects of nanotechnology used in human health and medicine. It provides readers with cutting-edge techniques for delivering therapeutic agents into targeted cellular compartments, cells, tissues, and organs by using nanoparticulate carriers. The book also offers methodological considerations for toxicity, safety, and risk assessment. Nanotechnology in Medicine: Toxicity and Safety also provides readers with: A thorough introduction to the nanotoxicological aspects of nanomedicine, including translational nanomedicine and nanomedicine personalization Comprehensive introductions to nanoparticle toxicity and safety, including selenium nanoparticles and metallic nanoparticles Practical discussions of nanotoxicology and drug delivery, including gene delivery using nanocarriers and the use of nanomaterials for ocular delivery applications In-depth examinations of nanotechnology ethics and the regulatory framework of nanotechnology and medicine Perfect for researchers, post-doctoral candidates, and specialists in the fields of nanotechnology, nanomaterials, and nanocarriers, Nanotechnology in Medicine: Toxicity and Safety will also prove to be an indispensable part of the libraries of nanoengineering, nanomedicine, and biopharmaceutical professionals and nanobiotechnologists.

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Page : 574 pages
File Size : 42,5 Mb
Release : 2017-06-22
Category : Technology & Engineering
ISBN : 9780323527347

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Antimicrobial Nanoarchitectonics by Alexandru Mihai Grumezescu Pdf

Antimicrobial Nanoarchitectonics: From Synthesis to Applications brings together recent research in antimicrobial nanoparticles, specifically in the sustained and controlled delivery of antimicrobials. Particular attention is given to i) reducing the side effects of antibiotics, ii) increasing the pharmacological effect, and iii) improving aqueous solubility and chemical stability of different antimicrobials. In addition, antimicrobial nanoparticles in drug delivery are discussed extensively. The book also evaluates the pros and cons of using nanostructured biomaterials in the prevention and eradication of infections. It is an important reference resource for materials scientists and bioengineers who want to learn how nanomaterials are used in antimicrobial therapy. Provides readers with the information necessary to select the appropriate bionanomaterial to solve particular infection problems Includes case studies, showing how particular bionanomaterials have been used to cure infections Explains the central role that nanotechnology plays in modern antimicrobial therapy Evaluates the pros and cons of using nanostructured biomaterials in the prevention and eradication of infections

Author : Omar Azzaroni,Katsuhiko Ariga
Publisher : Royal Society of Chemistry
Page : 521 pages
File Size : 41,5 Mb
Release : 2022-02-16
Category : Science
ISBN : 9781788018029

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Concepts and Design of Materials Nanoarchitectonics by Omar Azzaroni,Katsuhiko Ariga Pdf

This book covers introductory features underlying the field of nanoarchitectonices, presenting a unifying overview of the theoretical aspects and emerging applications that are changing the capability to understand and design advanced functional materials.

Author : Vivek Mishra,Syed Sibtay Razi,Ajit Kumar
Publisher : CRC Press
Page : 347 pages
File Size : 47,7 Mb
Release : 2024-06-17
Category : Technology & Engineering
ISBN : 9781040036778

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Functional Fluorescent Materials by Vivek Mishra,Syed Sibtay Razi,Ajit Kumar Pdf

Functional Fluorescent Materials: Applications in Sensing, Bioimaging, and Optoelectronics explains functional molecular probes (organic/inorganic materials, polymers, nanomaterials), with a focus on those that represent spectroscopic properties with detection of different analytes and specific roles in molecular recognition and their applications. It broadly covers molecular recognition to applications of fluorescence reporters, starting from optoelectronic properties of materials, detection of heavy metals, through biological macromolecules, and further to a living cell, tissue imaging, and theranostics. Features: • Covers different aspects of fluorescence spectroscopy ranging from chemical, physical, and biological aspects along with optoelectronic properties, mechanisms, and applications. • Describes all types of chemical and functionalized fluorescent nanomaterials. • Provides additional information on different kinds of fluorescence reporters. • Explains the concept of fluorescence spectroscopy and its role in human health care. • Discusses changes in static and dynamic properties of fluorescent probes and molecular recognitions. This book is aimed at graduate students and researchers in materials, chemical engineering, and engineering physics.

Author : Mahendra Rai,Mehdi Razzaghi-Abyaneh,Avinash P. Ingle
Publisher : John Wiley & Sons
Page : 416 pages
File Size : 40,7 Mb
Release : 2020-11-17
Category : Science
ISBN : 9781119671862

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Nanobiotechnology in Diagnosis, Drug Delivery and Treatment by Mahendra Rai,Mehdi Razzaghi-Abyaneh,Avinash P. Ingle Pdf

Presents nanobiotechnology in drug delivery and disease management Featuring contributions from noted experts in the field, this book highlights recent advances in the nano-based drug delivery systems. It also covers the diagnosis and role of various nanomaterials in the management of infectious diseases and non-infectious disorders, such as cancers and other malignancies and their role in future medicine. Nanobiotechnology in Diagnosis, Drug Delivery and Treatment starts by introducing how nanotechnology has revolutionized drug delivery, diagnosis, and treatments of diseases. It then focuses on the role of various nanocomposites in diagnosis, drug delivery, and treatment of diseases like cancer, Alzheimer's disease, diabetes, and many others. Next, it discusses the application of a variety of nanomaterials in the diagnosis and management of gastrointestinal tract disorders. The book explains the concept of nanotheranostics in detail and its role in effective monitoring of drug response, targeted drug delivery, enhanced drug accumulation in the target tissues, sustained as well as triggered release of drugs, and reduction in adverse effects. Other chapters cover aptamer-incorporated nanoparticle systems; magnetic nanoparticles; theranostics and vaccines; toxicological concerns of nanomaterials used in nanomedicine; and more. Provides a concise overview of state-of-the-art nanomaterials and their application like drug delivery in infectious diseases and non-infectious disorders Highlights recent advances in the nano-based drug delivery systems and role of various nanomaterials Introduces nano-based sensors which detect various pathogens Covers the use of nanodevices in diagnostics and theranostics Nanobiotechnology in Diagnosis, Drug Delivery and Treatment is an ideal book for researchers and scientists working in various disciplines such as microbiology, biotechnology, nanotechnology, pharmaceutical biotechnology, pharmacology, pharmaceutics, and nanomedicine.

Author : Katsuhiko Ariga,Mitsuhiro Ebara
Publisher : John Wiley & Sons
Page : 328 pages
File Size : 49,5 Mb
Release : 2018-01-15
Category : Technology & Engineering
ISBN : 9783527808281

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Materials Nanoarchitectonics by Katsuhiko Ariga,Mitsuhiro Ebara Pdf

A unique overview of the manufacture of and applications for materials nanoarchitectonics, placing otherwise hard-to-find information in context. Edited by highly respected researchers from the most renowned materials science institute in Japan, the first part of this volume focuses on the fabrication and characterization of zero to three-dimensional nanomaterials, while the second part presents already existing as well as emerging applications in physics, chemistry, biology, and biomedicine.

Author : Awanish Mishra
Publisher : Springer Nature
Page : 457 pages
File Size : 42,7 Mb
Release : 2024-06-02
Category : Electronic
ISBN : 9789819968077

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Drug Delivery Strategies in Neurological Disorders: Challenges and Opportunities by Awanish Mishra Pdf

Author : Wing-Fu Lai
Publisher : Springer Nature
Page : 511 pages
File Size : 54,7 Mb
Release : 2020-10-19
Category : Medical
ISBN : 9783030544904

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Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications by Wing-Fu Lai Pdf

This book presents a multidisciplinary assessment of the state of science in the use of systemic delivery technologies to deliver anti-aging therapeutics now under development. There is a gap between basic aging research and the development of intervention technologies. This major obstacle must be overcome before biogerontological interventions can be put into clinical practice. As biogerontology comes to understand aging as a systemic degenerative process, it is clear that there is a pressing need for technologies that enable cells and tissues in a fully developed adult body to be manipulated systemically to combat aging. The authors review advances in the chemistry and engineering of systemic delivery methods and analyze the strengths and limitations of each. The book is organized into six sections. The first offers an overview of the need for systemic delivery technologies alongside the development of anti-aging therapies and describes approaches that will be required for studying the properties and efficiency of carriers for systemic delivery. Sections II, III and IV describe recent advances in a range of strategies that may enable systemic delivery to help combat aging conditions ranging from cell senescence to decline in immune function and hormonal secretion. Section V discusses practical strategies to engineer and optimize the performance of delivery technologies for applications in systemic delivery, along with their working principles. The final section discusses technical and biological barriers that must be overcome as systemic delivery technologies move from research laboratory to clinical applications aimed at tackling aging and age-associated diseases. Benefiting scholars, students and a broader audience of interested readers, the book includes helpful glossary sections in each chapter, as well as sidebars that highlight important notes, and questions for future research.