Natural Small Molecule Drugs From Plants

Author : Guan-Hua Du
Publisher : Springer
Page : 741 pages
File Size : 43,7 Mb
Release : 2018-11-19
Category : Medical
ISBN : 9789811080227

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Natural Small Molecule Drugs from Plants by Guan-Hua Du Pdf

This book discusses 120 types of natural, small-molecule drugs derived from plants. They are grouped into 7 parts according their clinical uses, such as drugs for cardiovascular diseases, for metabolic diseases, for neuropsychiatric diseases, for immune-mediated inflammatory diseases, anti-tumor drugs, and drugs for parasites and bacterial infection. Each chapter systematically summarizes one drug, including its physicochemical properties, sources, pharmacological effects and clinical applications. To help readers understand the drug better, the research and pharmacological activity for each drug is also described, which serves as a salutary lesson for future drug development. Written by frontline researchers, teachers and clinicians working in field of pharmacy and pharmacology it provides an overview of natural, small-molecule drugs derived from plants for researchers in the field.

Author : Lixin Zhang,Arnold L. Demain
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 42,7 Mb
Release : 2007-11-17
Category : Medical
ISBN : 9781592599769

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Natural Products by Lixin Zhang,Arnold L. Demain Pdf

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Author : Mayuri Napagoda,Lalith Jayasinghe
Publisher : Walter de Gruyter GmbH & Co KG
Page : 302 pages
File Size : 54,5 Mb
Release : 2022-04-19
Category : Science
ISBN : 9783110593655

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Chemistry of Natural Products by Mayuri Napagoda,Lalith Jayasinghe Pdf

Plants produce secondary metabolites that humans harness for their own benefit. About half of drugs currently in clinical use are based on these chemicals found in nature. Chemistry of Natural Products covers secondary metabolites present in medicinal plants and their biosynthesis, biological activities, and isolation and separation techniques. This book is ideal for researchers in the areas of biochemistry, medicine, and pharmacology.

Author : George E. Barreto,Amirhossein Sahebkar
Publisher : Springer Nature
Page : 603 pages
File Size : 40,8 Mb
Release : 2021-04-16
Category : Medical
ISBN : 9783030648725

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Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health by George E. Barreto,Amirhossein Sahebkar Pdf

Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal is to present a comprehensive collection on most of the therapeutic aspects of plant-derived natural products and molecular mechanisms thereof.

Author : Subhash C. Mandal,Amit Kumar Nayak,Amal Kumar Dhara
Publisher : Academic Press
Page : 752 pages
File Size : 45,5 Mb
Release : 2021-10-05
Category : Medical
ISBN : 9780323900805

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Herbal Biomolecules in Healthcare Applications by Subhash C. Mandal,Amit Kumar Nayak,Amal Kumar Dhara Pdf

Herbal Biomolecules in Healthcare Applications presents extensive detailed information on all the vital principles, basics and fundamental aspects of multiple herbal biomolecules in the healthcare industry. This book examines important herbal biomolecules including alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, terpenes, fats and waxes, proteins and peptides, and vitamins. These herbal biomacromolecules are responsible for different bioactivities as well as pharmacological potentials. A systematic understanding of the extraction, purification, characterization, applications of these herbal biomolecules and their derivatives in healthcare fields is developed in this comprehensive book. Chapters explore the key topics along with an emphasis on recent research and developments in healthcare fields by leading experts. They include updated literature review of the relevant key topics, good quality illustrations, chemical structures, flow charts, well-organized tables and case studies. Herbal Biomolecules in Healthcare Applications will be useful for researchers working on natural products and biomolecules with bioactivity and nutraceutical properties. Professionals specializing in scientific areas such as biochemistry, pharmacology, analytical chemistry, organic chemistry, clinics, or engineering focused on bioactive natural products will find this book useful. Provides a study of different type of biomolecules from herbal extracts and their bioactivities as well as their application in the healthcare industry Contributions by global leaders and experts from academia, industry and regulatory agencies, who have been considered as pioneers in the application of herbal biomolecules in the diverse healthcare fields Includes updated literature review along with practical examples and research case studies

Author : Hildebert Wagner,Peter Maria Wolff
Publisher : Springer
Page : 312 pages
File Size : 41,7 Mb
Release : 1977
Category : Drugs
ISBN : UOM:39015010199688

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New Natural Products and Plant Drugs with Pharmacological, Biological Or Therapeutical Activity by Hildebert Wagner,Peter Maria Wolff Pdf

Author : J. Mulzer,R. Bohlmann
Publisher : Springer Science & Business Media
Page : 363 pages
File Size : 43,6 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9783662040423

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The Role of Natural Products in Drug Discovery by J. Mulzer,R. Bohlmann Pdf

Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Author : Ramarao Poduri
Publisher : Springer Nature
Page : 522 pages
File Size : 40,9 Mb
Release : 2021-02-15
Category : Medical
ISBN : 9789811555343

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Drug Discovery and Development by Ramarao Poduri Pdf

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Author : Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi
Publisher : Elsevier
Page : 776 pages
File Size : 51,9 Mb
Release : 2018-02-16
Category : Science
ISBN : 9780081021040

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Natural Products and Drug Discovery by Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi Pdf

Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout

Author : Anne E. Osbourn,Virginia Lanzotti
Publisher : Springer Science & Business Media
Page : 588 pages
File Size : 45,6 Mb
Release : 2009-07-07
Category : Science
ISBN : 9780387854984

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Plant-derived Natural Products by Anne E. Osbourn,Virginia Lanzotti Pdf

Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.

Author : Rohit Dutt,Anil K Sharma,Raj K Keservani,Vandana Garg
Publisher : Apple Academic Press
Page : 480 pages
File Size : 42,6 Mb
Release : 2022-06
Category : Electronic
ISBN : 1774638940

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Promising Drug Molecules of Natural Origin by Rohit Dutt,Anil K Sharma,Raj K Keservani,Vandana Garg Pdf

This new volume, Promising Drug Molecules of Natural Origin, explores potential beneficial drug substances derived from nature. It presents the general principles, characteristics, evaluation techniques, and applications involved in drug molecules from natural sources, such as plants and marine life. With chapters from renowned experts from around the world, the chapters in this volume address the challenges of standardization of herbal medicines, methods of characterization of natural medicines and phyto-constituents, and quality control methods for herbal medicines. Several chapters in the book focus on the evolution of phyto-constituents in cancer therapeutics, while others deal with applications for other diseases, such as diabetes and neuroinflammatory disorders. The volume also specifically reviews heterocyclic drugs from plants. This volume will be a valuable resource for faculty and advanced students in pharmaceutics as well as researchers, scientists, and industry professionals in medicine and drug development.

Author : National Academy of Sciences/Smithsonian Institution,Division on Earth and Life Studies,Commission on Life Sciences,E.O. Wilson
Publisher : National Academies Press
Page : 535 pages
File Size : 44,5 Mb
Release : 1988-01-01
Category : Science
ISBN : 9780309037396

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Biodiversity by National Academy of Sciences/Smithsonian Institution,Division on Earth and Life Studies,Commission on Life Sciences,E.O. Wilson Pdf

This important book for scientists and nonscientists alike calls attention to a most urgent global problem: the rapidly accelerating loss of plant and animal species to increasing human population pressure and the demands of economic development. Based on a major conference sponsored by the National Academy of Sciences and the Smithsonian Institution, Biodiversity creates a systematic framework for analyzing the problem and searching for possible solutions.

Author : Subramayam Vemulpad,Joanne Jamie
Publisher : CRC Press
Page : 398 pages
File Size : 48,8 Mb
Release : 2014-02-24
Category : Medical
ISBN : 9781482243598

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Recent Advances in Plant-Based, Traditional, and Natural Medicines by Subramayam Vemulpad,Joanne Jamie Pdf

The purpose of this book is to discuss several medicinal plants to find wider application in the domain of medicinal, clinical, and pharmaceutical treatment. Recent Advances in Plant-Based, Traditional, and Natural Medicines serves as a useful source of ideas and an inspiration for further cell and molecular biology research toward developing drugs and treatments from these traditional and plant-based remedies. The book covers a variety of topics and: • Considers the current state of research of traditional and plant-based medicines • Covers the current status of ethnomedicine and medicinal plant discovery • Presents the clinical applications of traditional and plant-based medicines

Author : Dipesh Dhakal,Eung-Soo Kim,Mattheos Koffas
Publisher : Frontiers Media SA
Page : 222 pages
File Size : 54,5 Mb
Release : 2019-12-23
Category : Electronic
ISBN : 9782889632534

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Engineering the Microbial Platform for the Production of Biologics and Small-Molecule Medicines by Dipesh Dhakal,Eung-Soo Kim,Mattheos Koffas Pdf

Author : Ho John Wing Shing
Publisher : World Scientific
Page : 172 pages
File Size : 40,9 Mb
Release : 2019-04-23
Category : Medical
ISBN : 9789814525640

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Naturally Occurring Small Molecules For Disease And Cancer Treatment: Therapeutic Benefits In Combination Therapy by Ho John Wing Shing Pdf

Western drugs and target medicines for disease treatment come with undesirable side effects that have limited their use in patients for an extended period of time. It is warranted to develop a treatment strategy with alternative medicines to reduce toxicity relating to drugs, in particular, cancer drugs. Thus, a combination therapy with herbal medicines provides a more effective treatment method for hard-to-treat diseases. The recent breakthroughs in naturally occurring small molecules from herbal medicines have provided experimental evidence and are clinically significant in treatment strategies.This unique volume presents the recent developments in the field of herbal medicines for the treatment of diseases and cancer. Recent progress on small molecules isolated from herbal medicines that exhibit therapeutic benefits in humans is highlighted. The book provides an overview of the significant discoveries and pioneering contributions of herbal medicines in combination with other drugs; the author's evaluation of the combination therapy in cancer treatment; and a recent discovery of crocodile tissue extract with pharmacological properties.