Neoadjuvant Chemotherapy

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Preoperative (Neoadjuvant) Chemotherapy

Joseph Ragaz,Pierre R. Band,James H. Goldie
Preoperative Neoadjuvant Chemotherapy Book PDF

Author : Joseph Ragaz,Pierre R. Band,James H. Goldie
Publisher : Springer Science & Business Media
Page : 172 pages
File Size : 45,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642826719

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Preoperative (Neoadjuvant) Chemotherapy by Joseph Ragaz,Pierre R. Band,James H. Goldie Pdf

Despite recent advances in adjuvant therapies of cancer, the regi mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing of chemotherapy before definitive sur gery is not a minor change in the therapy of cancer. To be successful, large numbers of practitioners and their patients must participate. Substantial alterations of many aspects of the present management of cancer will have to follow. Therefore, before such therapy can be fully and routinely implemented, results of the novel treatment and its rationale have to be carefully evaluated. In preoperative treatment, other features will likely gain impor tance. For the first time, clinicians have a chance to follow the in vivo response of the tumor exposed to preoperative chemotherapy. The subsequent histological assessment of the tumor sample may likely become an important prognostic guide, permitting more re fined individual approaches to the planning of postoperative adju vant treatment. The value of such a treatment strategy can already be appreciated in the clinical setting, as seen from the therapy of osteosarcoma. Furthermore, preoperative chemotherapy might render previously inoperable tumors operable and hence resectable with a curative intention. The preoperative reduction of tumor bulk may also effectively decrease the need for more radical operations, permitting a more uniform adoption of conservative surgery.

Neoadjuvant Chemotherapy

Maurie Markman
Neoadjuvant Chemotherapy Book PDF

Author : Maurie Markman
Publisher : BoD – Books on Demand
Page : 116 pages
File Size : 43,6 Mb
Release : 2013-05-22
Category : Medical
ISBN : 9789535111399

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Neoadjuvant Chemotherapy by Maurie Markman Pdf

In the chapters of this excellent text, the authors have described advances in the neoadjuvant chemotherapeutic management of a number of tumor types. Based on the extensive experience with this management concept in breast cancer, several chapters are devoted to this important topic (Section 1). Section 2 deals with the administration of neoadjuvant chemotherapy in non-breast malignancies. Those who read and study the content of the chapters in this book will come away with a far greater understanding of the rationale supporting neoadjuvant chemotherapy, the existing evidence-based data regarding its use, limitations of the approach, and required future investigative efforts to learn how to optimize the benefits of this innovative management concept.

Surgery for Ovarian Cancer

Robert E. Bristow,Beth Y. Karlan,Dennis S. Chi
Surgery for Ovarian Cancer Book PDF

Author : Robert E. Bristow,Beth Y. Karlan,Dennis S. Chi
Publisher : CRC Press
Page : 437 pages
File Size : 49,7 Mb
Release : 2019-02-21
Category : Medical
ISBN : 9780429578854

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Surgery for Ovarian Cancer by Robert E. Bristow,Beth Y. Karlan,Dennis S. Chi Pdf

Updated and expanded, the third edition of Surgery for Ovarian Cancer focuses on essential techniques for the effective management of ovarian cancer. It reflects the most contemporary science and surgical applications for the management of patients with ovarian cancer and related peritoneal surface malignancies. This new edition takes a step-by-step approach and includes new intraoperative photographs and videos illustrating surgical procedures. It is principally devoted to the technical aspects of cytoreductive surgery, with chapters divided according to anatomic region. The chapters cover relevant anatomical considerations, surgical challenges specific to each region, and operative approaches and techniques favored by the authors. The list of contributing authors has been expanded from the previous edition and includes international and world-renowned experts from the fields of gynecologic oncology and surgical oncology. The topics of minimally invasive surgery, secondary cytoreduction, palliative surgery, and postoperative care are also covered in detail. New to the third edition are chapters on preoperative risk stratification, regional therapeutics and peritonectomy procedures, and quality assurance relating to ovarian cancer surgery. This comprehensive text is essential reading for all practitioners working with patients with ovarian cancers.

Management of the Breast and Axilla in the Neoadjuvant Setting

Atilla Soran,Faina Nakhlis
Management of the Breast and Axilla in the Neoadjuvant Setting Book PDF

Author : Atilla Soran,Faina Nakhlis
Publisher : Springer Nature
Page : 375 pages
File Size : 44,8 Mb
Release : 2021-12-14
Category : Medical
ISBN : 9783030880200

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Management of the Breast and Axilla in the Neoadjuvant Setting by Atilla Soran,Faina Nakhlis Pdf

Over the last several decades breast cancer management has made great strides in the improvement of oncologic treatment outcomes, particularly so in patients with early stage disease. While wide-spread access to screening resulting in early detection is undoubtedly to be credited for this trend, at the same time, the management of breast cancer has evolved to be an intricate multidisciplinary collaboration between breast imagers, surgeons, medical oncologists and radiation oncologist. As a result, with better mutual understanding of multidisplinary goals and challenges, the treatment strategies have become more individualized, with a great emphasis being placed on the intrinsic disease biology. Furthermore, the indications for neoadjuvant systemic therapy have significantly broadened, with a substantial number of patients with early stage breast cancer being able to take advantage of this strategy to decrease the extent of breast surgery they would undergo at its completion. As such, the management of the axilla in these patients has presented with new challenges as well as with new opportunities to scale down on the extent of local therapy and, consequently, its toxicity. This text will provide a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians (surgeons, medical oncologists, radiation oncologists) and researchers with an interest in breast cancer. The book will review novel and evoling strategies in neoadjuvant systemic therapy forn early stage breast cancer, provide new perspectives about appropriate axillary imaging in anticipation of neoadjuvant systemic therapy, and describe new data on innovative surgical techniques and Radiation Oncology concepts designed to deescalate the extent and toxicity of local therapy while insuring oncologic safety. Several landmark clinical trials have been published in the last few years and will be placed in context with respect to current management. Integration of novel diagnostic and interventional breast imaging, local therapy (surgery and radiation) with contemporary systemic therapy will also be discussed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in, this challenging field. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Neoadjuvant Chemotherapy

Oliver Bathe
Neoadjuvant Chemotherapy Book PDF

Author : Oliver Bathe
Publisher : BoD – Books on Demand
Page : 272 pages
File Size : 44,5 Mb
Release : 2012-02-01
Category : Medical
ISBN : 9789533079943

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Neoadjuvant Chemotherapy by Oliver Bathe Pdf

The most significant advances in cancer therapy in recent years have involved the development of systemic therapeutics. With improvements in response rates in solid tumors, opportunities have arisen to enhance the effectiveness of surgery. Administration of systemic therapy prior to surgery - neoadjuvant chemotherapy - represents one approach by which clinicians have successfully reduced the extent of surgery and, in some instances, positively impacted on clinical outcomes. This collection of works by expert clinicians from a variety of disciplines represents an exploration of the current knowledge of the role of neoadjuvant chemotherapy in diverse tumor types.

Adjuvant Therapy of Breast Cancer

I. Craig Henderson
Adjuvant Therapy of Breast Cancer Book PDF

Author : I. Craig Henderson
Publisher : Springer
Page : 488 pages
File Size : 53,7 Mb
Release : 1992-08-31
Category : Health & Fitness
ISBN : UOM:39015025380216

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Adjuvant Therapy of Breast Cancer by I. Craig Henderson Pdf

The results of randomized trials evaluating the use of early or adjuvant systemic treatment for patients with resectable breast cancer provide an eloquent rebuttal to those who would argue that we have made no progress in the treatment of cancer. Many of the tumors that we have been most successful in curing with chemotherapy and other newer forms of treatment are relatively uncommon. In contrast, breast cancer continues to be the single most common malignancy among women in the western world, is increasingly a cause of death throughout Asia and Third-World countries, and remains one of the most substantial causes of cancer mortality world wide. The use of mammography as a means of early detection has been shown to reduce breast cancer mortality by 25-35% among those popu lations in which it is utilized. The use of adjuvant systemic treatment in appropriate patients provides a similar (and additional) reduction in breast cancer mortality. Few subjects have been so systematically studied in the history of medicine, and it seems fair to conclude that the value to adjuvant systemic therapy in prolonging the lives of women with breast cancer is more firmly supported by empirical evidence than even the more conventional or primary treatments using various combinations ofsurgery and radiotherapy.

Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers

Andrea Necchi,Philippe E. Spiess
Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers Book PDF

Author : Andrea Necchi,Philippe E. Spiess
Publisher : Springer Nature
Page : 312 pages
File Size : 43,9 Mb
Release : 2022-01-03
Category : Medical
ISBN : 9783030805463

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Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers by Andrea Necchi,Philippe E. Spiess Pdf

This book aims to provide readers with a current overview of enrolling trials with immune-checkpoint inhibitors in the preoperative setting of localized bladder cancer, renal cell carcinoma, and prostate cancer. The advent of immunotherapy has revolutionized treatments of genitourinary malignancy and evolved strategies for multidisciplinary management. This book explains neoadjuvant checkpoint inhibitors in localized genitourinary cancers, providing insights into the mechanisms of response and development of resistance of cancer cells to immunotherapy. It debates optimal trial design of preoperative checkpoint inhibitors in GU tumors, including optimal endpoints and the role of pathologic response as a surrogate endpoint of survival. It also illuminates clinical management of patients with organ-confined GU tumors, such as side effect management and perioperative safety, before providing an overview of biomarker use for patient selection across the early-stage GU malignancies. Lastly, the book provides the reader with the most up-to-date data emerging from clinical trials involving immunotherapy in early-stage GU malignancies. Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers: Multidisciplinary Management provides a comprehensive review of the field, serving as a valuable resource for urologists, medical oncologists, pathologists, fellows in urologic oncology, upper-level residents training in urology and medical oncology, as well as pharmacists interested in RCC clinicians.

Neo-adjuvant Chemotherapy

Claude Jacquillat,Cl Jacquillat,Marise Weil,David Khayat,Institut national de la santé et de la recherche médicale (France)
Neo adjuvant Chemotherapy Book PDF

Author : Claude Jacquillat,Cl Jacquillat,Marise Weil,David Khayat,Institut national de la santé et de la recherche médicale (France)
Publisher : John Libbey Eurotext
Page : 1066 pages
File Size : 41,8 Mb
Release : 1988
Category : Medical
ISBN : 0861961501

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Neo-adjuvant Chemotherapy by Claude Jacquillat,Cl Jacquillat,Marise Weil,David Khayat,Institut national de la santé et de la recherche médicale (France) Pdf

This book presents the Proceedings of the Second International Congress on Neo-Adjuvant Chemotherapy which took place on 19 to 21 February 1988 in Paris.

Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy

Pierre Banzet,James F. Holland,David Khayat,Marise Weil
Proceedings of the 3rd International Congress on Neo Adjuvant Chemotherapy Book PDF

Author : Pierre Banzet,James F. Holland,David Khayat,Marise Weil
Publisher : Springer Science & Business Media
Page : 474 pages
File Size : 49,6 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9782817807829

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Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy by Pierre Banzet,James F. Holland,David Khayat,Marise Weil Pdf

This book includes some selected presentations given at the 3rd International Congress on Neo-Adjuvant Chemotherapy which was held in Paris from February 6th to February 9th, 1991. It was attended by over 2000 physicians from around the world and by 700 nurses. Its organisation was saddened by the untimely death of Professor Claude Jacquillat on October 12th, 1990. It was further complicated in January and February 1991 by the gulf events which led some guests to cancel their participation. However with the outstanding help of the two presidents cho sen by Claude Jacquillat before his death, Pierre Banzet from Paris and James F. Holland from New York, the organizers could set up an exciting meeting confirming the impact of neo-adjuvant chemotherapy on relatively new indi cations such as non-small lung cancers, bladder cancer, esophagal cancer, cer vix cancer, etc ... It is noteworthy that a contradictory debate on primary chemotherapy in non-small lung cancer turned into a consensus conference. In breast cancer, the downstaging induced by primary chemotherapy is ack nowledged by all and the conviction that Jacquillat defended so heartily that breast preservation should be proposed to all patients with breast cancer what ever their tumour size is shared now by more and more people. A special emphasis was given to new drugs, new combination, new access (locoregional therapy) and new developments such as that of growth factors and of interleukin 2.

Advanced Therapy of Breast Disease

S. Eva Singletary,Geoffrey L. Robb,Gabriel N. Hortobagyi
Advanced Therapy of Breast Disease Book PDF

Author : S. Eva Singletary,Geoffrey L. Robb,Gabriel N. Hortobagyi
Publisher : PMPH-USA
Page : 902 pages
File Size : 40,5 Mb
Release : 2004
Category : Breast
ISBN : 1550092626

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Advanced Therapy of Breast Disease by S. Eva Singletary,Geoffrey L. Robb,Gabriel N. Hortobagyi Pdf

The information surveyed in this volulme is designed to provide the clinician with an expert overview of the current state of the art in breast cancer management. It should provide at least a flavor of the major paradigm shift that is occurring in this rapidly evolving field. Breast cancer management is moving away from a "kill or cure" model and advancing toward a model focused on strategies of prevention and of long-term management of breast cancer as a chronic disease. The acceptance of this new paradigm by patients and clinicians alike will represent a major focus for the twenty-first century.

Treatment of Soft Tissue Sarcomas

H.M. Pinedo,J. Verweij
Treatment of Soft Tissue Sarcomas Book PDF

Author : H.M. Pinedo,J. Verweij
Publisher : Springer Science & Business Media
Page : 143 pages
File Size : 40,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461317579

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Treatment of Soft Tissue Sarcomas by H.M. Pinedo,J. Verweij Pdf

One of the major advances of the last decade concerning the treatment of patients with soft tissue sarcomas is that an increased number of patients are being discussed in multidisciplinary teams prior to the initial treatment. The present volume on soft tissue sarcomas in the series Cancer Treatment and Research reflects the multidisciplinary approach with a focus on recent developments. The availability of new histopathologic techniques has reduced the number of unclassified sarcomas and has furhter increased the importance of the histo pathologist in providing estimates of the prognosis of the patient as well as data for the planning of treatment strategy. Further data for this strategy will be provided by diagnostic imaging. In this field, the role of magnetic reson ance imaging has been further defined. Of utmost importance is the recent trend toward consensus in staging. The modification of the staging system of the American Joint Commission for Cancer Staging and End Results Report ing brings the possibility of a single staging system within reach in the next decade. As surgery still provides the only chance for cure, the importance of being the most sparing as possible is obvious. For this reason, radiotherapy has been applied with success. The introduction of relatively new radiation tech niques is therefore being observed with interest.

Rectal Cancer Treatment

M.W. Büchler,R. J. Heald,B. Ulrich,J. Weitz
Rectal Cancer Treatment Book PDF

Author : M.W. Büchler,R. J. Heald,B. Ulrich,J. Weitz
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 40,8 Mb
Release : 2005-10-11
Category : Medical
ISBN : 9783540274490

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Rectal Cancer Treatment by M.W. Büchler,R. J. Heald,B. Ulrich,J. Weitz Pdf

Rectal cancer is one of the most prevalent cancers world-wide. It is also a paradigm for multimodal management, as the combination of surgery, chemotherapy and radiotherapy is often necessary to achieve the optimal outcome. Recently, international experts met in Heidelberg, Germany to discuss the latest developments in the management of rectal cancer, including the anatomic and pathologic basis, staging tools, surgical concepts including fast-track surgery and laparoscopic resection, functional outcome after surgery and the role of radio- and chemotherapy. This monograph summarizes this meeting and gives an extensive overview of the current concepts in management of rectal cancer.

Anterior Skull Base Tumors

P. Nicolai,P.J. Bradley
Anterior Skull Base Tumors Book PDF

Author : P. Nicolai,P.J. Bradley
Publisher : Karger Medical and Scientific Publishers
Page : 266 pages
File Size : 45,6 Mb
Release : 2020-07-30
Category : Medical
ISBN : 9783318066708

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Anterior Skull Base Tumors by P. Nicolai,P.J. Bradley Pdf

In recent years, interest in the management of anterior skull base tumors has been fostered by the introduction and subsequent rapid expansion of indications of transnasal endoscopic techniques. In parallel, extraordinary progress has been made in all the other disciplines which are involved in the complex process of managing anterior skull base tumors, leading to substantial improvements in diagnosis and treatment. The anterior skull base can be involved in a large variety of tumors of a varying nature and histology, which in the majority of cases originate from adjacent anatomic sites. In fact, primary lesions of the anterior skull base mainly include osteoma and other tumors originating from bone and cartilage. Tumors involving the anterior skull base have their origin prevalently in the sinonasal tract, but lesions developing on the intracranial site, such as meningiomas, may also extend caudally to encroach upon this area. All these lesions are rare, which means that the pertinent literature does not include prospective studies or treatment guidelines based on a high level of evidence. In view of the extreme histological variability of lesions involving the anterior skull base, much emphasis has been placed on addressing the different nuances of treatment in relation to histology, especially for malignant tumors. The chapters focusing on surgery provide divergent views on selection criteria for a specific surgical technique, which is the aim of this publication.

Adjuvant Therapy for Breast Cancer

Monica Castiglione,Martine J. Piccart
Adjuvant Therapy for Breast Cancer Book PDF

Author : Monica Castiglione,Martine J. Piccart
Publisher : Springer Science & Business Media
Page : 483 pages
File Size : 43,8 Mb
Release : 2009-07-11
Category : Medical
ISBN : 9780387751153

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Adjuvant Therapy for Breast Cancer by Monica Castiglione,Martine J. Piccart Pdf

Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.

Perez and Brady's Principles and Practice of Radiation Oncology

Edward C. Halperin,Carlos A. Perez,Luther W. Brady
Perez and Brady s Principles and Practice of Radiation Oncology Book PDF

Author : Edward C. Halperin,Carlos A. Perez,Luther W. Brady
Publisher : Lippincott Williams & Wilkins
Page : 2152 pages
File Size : 44,7 Mb
Release : 2008
Category : Medical
ISBN : 078176369X

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Perez and Brady's Principles and Practice of Radiation Oncology by Edward C. Halperin,Carlos A. Perez,Luther W. Brady Pdf

The thoroughly updated fifth edition of this landmark work has been extensively revised to better represent the rapidly changing field of radiation oncology and to provide an understanding of the many aspects of radiation oncology. This edition places greater emphasis on use of radiation treatment in palliative and supportive care as well as therapy.