Neural And Synaptic Defects In Autism Spectrum Disorders

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Neural and Synaptic Defects in Autism Spectrum Disorders

Hansen Wang,Laurie C. Doering
Neural and Synaptic Defects in Autism Spectrum Disorders Book PDF

Author : Hansen Wang,Laurie C. Doering
Publisher : Frontiers Media SA
Page : 287 pages
File Size : 48,5 Mb
Release : 2015-07-07
Category : Electronic book
ISBN : 9782889196289

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Neural and Synaptic Defects in Autism Spectrum Disorders by Hansen Wang,Laurie C. Doering Pdf

Autism spectrum disorders (ASDs) are a group of genetically and clinically heterogeneous neurodevelopmental disorders characterized by impaired reciprocal social interactions and communication, and restricted and repetitive patterns of behaviors and interests. Studies in genetics, neurobiology and systems biology are providing insights into the pathogenesis of ASDs. Investigation of neural and synaptic defects in ASDs not only sheds light on the molecular and cellular mechanisms that govern the function of the central nervous system, but may lead to the discovery of potential therapeutic targets for autism and other cognitive disorders. Our Research Topic which constitutes this e-book documents the recent development and ideas in the study of pathogenesis and treatment of ASDs, with an emphasis on syndromic disorders such as fragile X and Rett syndromes. In addition, model systems and methodological approaches with translational relevance to autism are covered herein. We hope that the Research Topic will enhance the global knowledge base in the autism research community and foster new research directions in autism related biology.

Neural and Synaptic Defects in Autism Spectrum Disorders

Anonim
Neural and Synaptic Defects in Autism Spectrum Disorders Book PDF

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 54,8 Mb
Release : 2015
Category : Electronic
ISBN : OCLC:1368444572

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Neural and Synaptic Defects in Autism Spectrum Disorders by Anonim Pdf

Autism spectrum disorders (ASDs) are a group of genetically and clinically heterogeneous neurodevelopmental disorders characterized by impaired reciprocal social interactions and communication, and restricted and repetitive patterns of behaviors and interests. Studies in genetics, neurobiology and systems biology are providing insights into the pathogenesis of ASDs. Investigation of neural and synaptic defects in ASDs not only sheds light on the molecular and cellular mechanisms that govern the function of the central nervous system, but may lead to the discovery of potential therapeutic targets for autism and other cognitive disorders. Our Research Topic which constitutes this e-book documents the recent development and ideas in the study of pathogenesis and treatment of ASDs, with an emphasis on syndromic disorders such as fragile X and Rett syndromes. In addition, model systems and methodological approaches with translational relevance to autism are covered herein. We hope that the Research Topic will enhance the global knowledge base in the autism research community and foster new research directions in autism related biology.

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Carlo Sala,Chiara Verpelli
Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability Book PDF

Author : Carlo Sala,Chiara Verpelli
Publisher : Academic Press
Page : 394 pages
File Size : 50,5 Mb
Release : 2016-04-30
Category : Medical
ISBN : 9780128005330

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Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability by Carlo Sala,Chiara Verpelli Pdf

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities Describes the genes implicated in autistic spectrum disorders and their function Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture

Autism Spectrum Disorders

Andreas M. Grabrucker
Autism Spectrum Disorders Book PDF

Author : Andreas M. Grabrucker
Publisher : Unknown
Page : 117 pages
File Size : 50,8 Mb
Release : 2021
Category : Electronic
ISBN : OCLC:1280592589

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Autism Spectrum Disorders by Andreas M. Grabrucker Pdf

Autism spectrum disorders are developmental disorders. Individuals with autism spectrum disorders develop differently. These differences are usually present in social interaction, communication, and sensory processing, and become visible through a wide variety of behavioral responses that differ from individuals without autism spectrum disorders. Despite significant research efforts, the exact causes of autism spectrum disorders remain poorly understood; however, researchers have gained extensive insights into possible pathomechanisms, even at the molecular level of cells. Many diagnostic criteria have been developed, adapted, and improved. The eight chapters in this book highlight the current state-of-the-art in many areas of autism spectrum disorders. Chapter 1 provides an overview of the epidemiology of autism spectrum disorders and the current knowledge of the underlying pathogenic mechanisms. Chapter 2 summarizes the diagnostic criteria and procedures and highlights present and upcoming therapeutic strategies. Chapter 3 reviews the adverse events and trauma in people with autism spectrum disorders. Chapters 4 and 5 focus on atypical sensory processing, and Chapter 6 discusses the genetic overlap of autism spectrum disorders with other neuropsychiatric disorders such as attention deficit hyperactivity disorder (ADHD), depression, and schizophrenia. Chapter 7 focuses on the contribution of abnormalities in mitochondria, and chapter 8 discusses gut-brain interactions and a potential role for microbiota in autism spectrum disorders. This book is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson.

A Time for Metabolism and Hormones

Paolo Sassone-Corsi,Yves Christen
A Time for Metabolism and Hormones Book PDF

Author : Paolo Sassone-Corsi,Yves Christen
Publisher : Springer
Page : 132 pages
File Size : 46,8 Mb
Release : 2016-04-04
Category : Medical
ISBN : 9783319270692

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A Time for Metabolism and Hormones by Paolo Sassone-Corsi,Yves Christen Pdf

Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

Cognitive Plasticity in Neurologic Disorders

Joseph I. Tracy,Benjamin M. Hampstead,K. Sathian
Cognitive Plasticity in Neurologic Disorders Book PDF

Author : Joseph I. Tracy,Benjamin M. Hampstead,K. Sathian
Publisher : Oxford University Press, USA
Page : 433 pages
File Size : 45,7 Mb
Release : 2014-12-02
Category : Medical
ISBN : 9780199965243

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Cognitive Plasticity in Neurologic Disorders by Joseph I. Tracy,Benjamin M. Hampstead,K. Sathian Pdf

This volume makes clear that the cognitive and behavioural symptoms of neurologic disorders and syndromes are dynamic and changing. Each chapter describes the neuroplastic processes at work in a particular condition, giving rise to these ongoing cognitive changes.

Jasper's Basic Mechanisms of the Epilepsies

Jeffrey L. Noebels,Massimo Avoli
Jasper s Basic Mechanisms of the Epilepsies Book PDF

Author : Jeffrey L. Noebels,Massimo Avoli
Publisher : OUP USA
Page : 1258 pages
File Size : 42,8 Mb
Release : 2012-06-29
Category : Medical
ISBN : 9780199746545

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Jasper's Basic Mechanisms of the Epilepsies by Jeffrey L. Noebels,Massimo Avoli Pdf

Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Autism Spectrum Disorder

Michael Fitzgerald
Autism Spectrum Disorder Book PDF

Author : Michael Fitzgerald
Publisher : BoD – Books on Demand
Page : 380 pages
File Size : 51,7 Mb
Release : 2015-04-02
Category : Science
ISBN : 9789535120377

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Autism Spectrum Disorder by Michael Fitzgerald Pdf

This book starts with a new sub category of Autism Criminal Autistic Psychopathy and school shootings. It focuses on a number of interventions, including speech and language pathology, speech and language assessment instruments, occupational therapy, improving functional language development in autism with natural gestures, communication boards etc as well as helping people with autism using the pictorial support, training of concepts of significant others, theory of mind, social concepts and a conceptual model for empowering families of children with autism cross culturally. It also examines the issue of hyperandrogenism and evidence-based treatments of autism. In terms of assessment, it focuses on psychological and biological assessment including neurotransmitters systems, structural and functional brain imaging, coping strategies of parents, examines the intertwining of language impairment, specific language impairment and ASD, as well as implicit and spontaneous Theory of Mind reading in ASD. In terms of aetiology, it focuses on genetic factors, epigenetics, synaptic vesicles, toxicity during neurodevelopment, immune system and sex differences. It also examines the link between social cognitive anatomical and neurophysiologic biomarkers and candidate genes. This book will be relevant to all mental health professionals because autism occurs in all the different areas of psychiatry and professionals who will find it helpful will be psychiatrists, psychologists, social workers, nurses, teachers and all those working with persons with Autism including parents who nowadays are interested in knowing more and more, at a detailed level about their children or adults with autism.

Comprehensive Guide to Autism

Vinood B. Patel,Victor R. Preedy,Colin R. Martin
Comprehensive Guide to Autism Book PDF

Author : Vinood B. Patel,Victor R. Preedy,Colin R. Martin
Publisher : Springer
Page : 0 pages
File Size : 41,8 Mb
Release : 2013-10-15
Category : Psychology
ISBN : 1461447879

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Comprehensive Guide to Autism by Vinood B. Patel,Victor R. Preedy,Colin R. Martin Pdf

Autism is a complex multifaceted disorder affecting neurodevelopment during the early years of life and, for many, throughout the life span. Inherent features include difficulties or deficits in communication, social interaction, cognition, and interpersonal behavioral coordination, to name just a few. Autism profoundly impacts the affected individual, the family, and, in many cases, the localized communities. The increased prevalence of childhood autism has resulted in rapid developments in a wide range of disciplines in recent years. Nevertheless, despite intensive research, the cause(s) remain unresolved and no single treatment strategy is employed. To address these issues, Comprehensive Guide to Autism is an all-embracing reference that offers analyses and discussions of contemporary issues in the field of autism. The work brings together scientific material from leading experts in the field relating to a wide range of important current topics, such as the early identification and treatment of children with autism, pertinent social and behavioral studies, recent developments in genetics and immunology, the influence of diet, models of autism, and future treatment prospects. Comprehensive Guide to Autism contains essential readings for behavioral science researchers, psychologists, physicians, social workers, parents, and caregivers.

The Neuroscience of Autism Spectrum Disorders

Joseph D. Buxbaum,Patrick R. Hof
The Neuroscience of Autism Spectrum Disorders Book PDF

Author : Joseph D. Buxbaum,Patrick R. Hof
Publisher : Academic Press
Page : 494 pages
File Size : 55,5 Mb
Release : 2012-10-25
Category : Medical
ISBN : 9780123919243

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The Neuroscience of Autism Spectrum Disorders by Joseph D. Buxbaum,Patrick R. Hof Pdf

Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available

Reviews of Physiology, Biochemistry and Pharmacology

Bernd Nilius,Susan G. Amara,Thomas Gudermann,Reinhard Jahn,Roland Lill,Stefan Offermanns,Ole H. Petersen
Reviews of Physiology Biochemistry and Pharmacology Book PDF

Author : Bernd Nilius,Susan G. Amara,Thomas Gudermann,Reinhard Jahn,Roland Lill,Stefan Offermanns,Ole H. Petersen
Publisher : Springer Science & Business Media
Page : 126 pages
File Size : 44,6 Mb
Release : 2012-05-30
Category : Medical
ISBN : 9783642292569

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Reviews of Physiology, Biochemistry and Pharmacology by Bernd Nilius,Susan G. Amara,Thomas Gudermann,Reinhard Jahn,Roland Lill,Stefan Offermanns,Ole H. Petersen Pdf

Cardiac ion channels and mechanisms for protection against atrial fibrillation. Intrinsically photosensitive retinal ganglion cells. Quantifying and modeling the temperature-dependent gating of TRP channels.

Homeostatic Control of Brain Function

Detlev Boison,Susan Masino
Homeostatic Control of Brain Function Book PDF

Author : Detlev Boison,Susan Masino
Publisher : Oxford University Press
Page : 657 pages
File Size : 40,9 Mb
Release : 2016
Category : Medical
ISBN : 9780199322299

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Homeostatic Control of Brain Function by Detlev Boison,Susan Masino Pdf

Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

The Neurobiology of Autism

Margaret L. Bauman,Thomas L. Kemper
The Neurobiology of Autism Book PDF

Author : Margaret L. Bauman,Thomas L. Kemper
Publisher : JHU Press
Page : 428 pages
File Size : 43,8 Mb
Release : 2005
Category : Medical
ISBN : 0801880475

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The Neurobiology of Autism by Margaret L. Bauman,Thomas L. Kemper Pdf

In the decade since the first edition of The Neurobiology of Autism was published, research has revealed valuable new information about the nature and origins of autism, including genetics and abnormalities in such neurotransmitters as acetylcholine and serotonin. For this long-anticipated new edition, neurologists Margaret L. Bauman and Thomas L. Kemper bring together leading researchers and clinicians to present the most current scientific knowledge and theories about autism. The contributors cover genetics, imaging studies, physiology, neuroanatomy and neurochemistry, immunology, brain function, the epidemiology of the disease, and related disorders. Thoroughly updated, The Neurobiology of Autism remains the best single-volume work on the wide array of research being conducted into the causes, characteristics, and treatment of autism. Contributors: George M. Anderson, Yale Child Study Center; Tara L. Arndt, University of Rochester Medical Center (URMC); Trang Au, University of Massachusetts Medical School (UMMC); Jocelyne Bachevalier, University of Texas Health Science Center; Irina N. Bespalova, Seaver Autism Research Center, Mt. Sinai School of Medicine (SARC); Gene J. Blatt, Boston University School of Medicine (BUSM); Susan E. Bryson, IWK Health Centre–Dalhousie University; Timothy M. Buie, Massachusetts General Hospital (MGH); Joseph D. Buxbaum, SARC; Kathryn M. Carbone, The Johns Hopkins University School of Medicine (JHUSM); Diane C. Chugani, Wayne State University; Daniel F. Connor, UMMC; Edwin H. Cook, Jr., University of Chicago; S. Hossein Fatemi, University of Minnesota Medical School; Susan E. Folstein, Tufts University School of Medicine; Eric Fombonne, McGill University; Randi Jenssen Hagerman, UC Davis Medical Center; Elizabeth Petri Henske, Fox Chase Cancer Center, Philadelphia; Jeannette J. A. Holden, Queen's University; Ronald J. Killiany, BUSM; Omanand Koul, UMMC; Mandy Lee, Newcastle General Hospital, U.K.; Xudong Liu, Queen's University; Tara L. Moore, BUSM; Mark B. Moss, BUSM; Karin B. Nelson, National Institute of Neurological Disorders and Stroke; Phillip G. Nelson, National Institute of Child Health and Human Development; Elaine Perry, Newcastle General Hospital; Jonathan Pevsner, JHUSM; Mikhail V. Pletnikov, JHUSM; Stephen W. Porges, University of Illinois at Chicago; Lucio Rehbein, Universidad de la Frontera, Chile; Jennifer Reichert, SARC; Patricia M. Rodier, URMC; Beth Rosen-Sheidley, MGH; Susan L. Smalley, UCLA Neuropsychiatric Research Institute; Ronald J. Steingard, UMMC; Helen Tager-Flusberg, BUSM; Gary L. Wenk, University of Arizona; Andrew W. Zimmerman, JHUSM

Excitatory-Inhibitory Balance

Takao K. Hensch,Michela Fagiolini
Excitatory Inhibitory Balance Book PDF

Author : Takao K. Hensch,Michela Fagiolini
Publisher : Springer Science & Business Media
Page : 286 pages
File Size : 50,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461500391

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Excitatory-Inhibitory Balance by Takao K. Hensch,Michela Fagiolini Pdf

A new perspective on brain function depends upon an understanding of the interaction and integration of excitation and inhibition. A recent surge in research activity focused on inhibitory interneurons now makes a more balanced view possible. Technological advances such as improved imaging methods, visualized patch-clamp recording, multiplex single-cell PCR, and gene-targeted deletion or knock-in mice are some of the novel tools featured in this book. This book will provide an integrated view of neuron function, operating in a balanced regime of excitation and inhibition. It is a timely contribution emphasizing how this balance is established, maintained, and modified from the molecular to system levels. The broad spectrum of topics from molecular to cellular and system/computational neuroscience will appeal to a wide audience of advanced graduate students, post-docs, and faculty. Moreover, this book this book features active young researchers from around the world, who are currently educating the brain scientists of tomorrow.

Sleep, Neuronal Plasticity and Brain Function

Peter Meerlo,Ruth M. Benca,Ted Abel
Sleep Neuronal Plasticity and Brain Function Book PDF

Author : Peter Meerlo,Ruth M. Benca,Ted Abel
Publisher : Springer
Page : 559 pages
File Size : 53,5 Mb
Release : 2015-05-18
Category : Medical
ISBN : 9783662468784

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Sleep, Neuronal Plasticity and Brain Function by Peter Meerlo,Ruth M. Benca,Ted Abel Pdf

This book reviews current knowledge on the importance of sleep for brain function, from molecular mechanisms to behavioral output, with special emphasis on the question of how sleep and sleep loss ultimately affect cognition and mood. It provides an extensive overview of the latest insights in the role of sleep in regulating gene expression, synaptic plasticity and neurogenesis and how that in turn is linked to learning and memory processes. In addition, readers will learn about the potential clinical implications of insufficient sleep and discover how chronically restricted or disrupted sleep may contribute to age-related cognitive decline and the development of psychiatric disorders such as schizophrenia and depression. The book consists of 19 chapters, written by experts in basic sleep research and sleep medicine, which together cover a wide range of topics on the importance of sleep and consequences of sleep disruption. This book will be of interest to students, researchers and clinicians with a general interest in brain function or a specific interest in sleep.