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Author : Anders Björklund,Ulf Stenevi
Publisher : Elsevier Publishing Company
Page : 746 pages
File Size : 50,7 Mb
Release : 1985
Category : Brain
ISBN : UOM:39015010651803
Author : United States. Congress. Office of Technology Assessment
Publisher : Unknown
Page : 210 pages
File Size : 53,5 Mb
Release : 1990
Category : Central nervous system
ISBN : MINN:31951P00890384X
Author : Congress of the United States Office of
Publisher : The Minerva Group, Inc.
Page : 208 pages
File Size : 53,7 Mb
Release : 2002-06
Category : Medical
ISBN : 0898759072
Author : United States. Congress. Office of Technology Assessment
Publisher : Unknown
Page : 208 pages
File Size : 41,7 Mb
Release : 1990
Category : Central nervous system
ISBN : UCR:31210024829739
Author : Anonim
Publisher : DIANE Publishing
Page : 193 pages
File Size : 52,7 Mb
Release : 2024-06-03
Category : Electronic
ISBN : 9781428921962
Author : William J. Freed
Publisher : MIT Press
Page : 590 pages
File Size : 47,6 Mb
Release : 2000
Category : Central nervous system
ISBN : 0262062089
After providing basic background on transplantation, brain structure, and development, the book discusses Parkinson's disease, the use of transplants to influence localized brain functions, circuit reconstruction, and genetic engineering and other future technologies.
Author : Anonim
Publisher : Newnes
Page : 408 pages
File Size : 54,6 Mb
Release : 2012-12-31
Category : Science
ISBN : 9780444595454
This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Author : R.B. Wallace,G.D. Das
Publisher : Springer Science & Business Media
Page : 250 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461255390
During the last decade research on neural transplantation in mammals has grown extensively, and has attracted the attention of many young inquisitive scientists. This growth, as the critics point out, has been somewhat random, and has resulted neither in the formulation of basic concepts nor in any other significant achievement. For instance, they question-how is it possible to jump into functional research with clinical bearing when the basic morphological work has not yet been conducted? The criticism, objectively speaking, is valid and is supported by the fact that every investigator who has stepped into this unex plored field of neurosciences has formulated questions in his own way, has followed his own "model" oftransplantation, and has arrived at his own unique conclusions. The potential danger, as the critics emphasize, in this type of approach lies in that instead of evolving into a scientifically solid and valuable field of research, it may end in a confusing and conflicting mass of questionable claims and subjective opinions. The present situation, very likely, is a reflection of unrestrained enthusiasm and imaginativeness of the investigators, and the demands of the times for the so-called "newsworthy" and "breakthrough" publications. Despite these limitations, two important facts have been estab lished in this field. First, as far as transplantation of neural tissues per se is concerned, what was considered impossible by some critics about 10-12 years ago has been shown to be possible.
Author : John R. Sladek
Publisher : Springer Science & Business Media
Page : 468 pages
File Size : 52,7 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781468446852
The story of mammalian neural transplantation really begins eighty-one years ago. In Chicago in December of 1903, a 34-year-old physician, Elizabeth Hopkins Dunn, working as a research assistant in neurology, initiated a series of experiments to examine the ability of neonatal rat cerebral tissue to survive transplantation into the brain of matched littermates. Out of 46 attempts, four clearly successful grafts were identified. The publication of Dunn's results in 1917, the first credible report to demonstrate the feasibility of mammalian CNS transplants, generated little interest. In fact, the next significant experiment in this field did not appear until 1930. The field continued to grow slowly and quietly as investigators gradually realized the value of neural trans plantation to study problems of development and plasticity in the mammalian nervous system. With the discovery in 1979 that grafted neurons were capable of appropriate and functional interactions with the host brain, interest in neural transplantation esca lated sharply. The extraordinary opportunities created by using functional neural trans plants in investigating basic issues in neurobiology, as well as the clinical implications, excited both scientists and the public. The popularity of neural transplantation has been growing rapidly in the past five years and shows no signs of abating. The present volume was designed to meet two needs created by the rapid growth of this subdiscipline of neurobiology. The first was to provide a thorough review of the experimental foundations of neural transplantation.
Author : Jane E. Bottenstein
Publisher : Springer Science & Business Media
Page : 473 pages
File Size : 49,8 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9780306483561
Neural Stem Cells: Development and Transplantation provides comprehensive, critical and insightful reviews by leading experts in this exciting field of research. This volume will provide the latest data on neural stem cell properties and their therapeutic applications. This volume will be particularly useful for students, basic scientists, and clinicians in the academic or industrial sectors who have an interest in understanding neural development and its application to repairing the nervous system.
Author : Anonim
Publisher : Academic Press
Page : 382 pages
File Size : 54,7 Mb
Release : 2017-05-25
Category : Medical
ISBN : 9780128118139
Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides a survey of the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science to an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair. Selected chapters review the latest advances in translating the new technologies to a broader range of neurodegenerative diseases, stroke, spinal cord injury, glial and retinal disease and pain than had hitherto been considered possible, with the realization that the opportunities of off-the-shelf cell therapy may fast be approaching a plausible reality. Comprehensive set of critical reviews covering the field Presents state-of-the-art topics in science and translational medicine Written by international leaders in the field of neural transplantation
Author : Antal Nogradi
Publisher : Springer Science & Business Media
Page : 158 pages
File Size : 41,5 Mb
Release : 2007-06-30
Category : Medical
ISBN : 9780387326337
The book gives an account of results obtained from experiments where grafts of neuronal, glial and other tissues as well as artificial materials were placed into the spinal cord. It attempts to evaluate the contributions made by these studies to our understanding of basic neurobiologies questions. These include factors that regulate neuronal growth during development as well as regenera tion following injury to the nervous system. The model of neural transplanta tion is also useful for the study of cell-to-cell interactions, and this applies to interactions between glial cells and neurones, between various populations of neuronal cells and finally between axons and skeletal muscle fibres. The mecha nisms involved in the establishment of specific synaptic connections between neurones can also be investigated in this experimental paradigm. Important in formation regarding this issue was also obtained on systems other than the spinal cord, i. e. the cerebellum, hippocampus and striatum. Although such in formation of precise connections between the host and the grafted embryonic tissue is still lacking in the spinal cord, there is much information on the re sponse of the host nervous system to the grafted embryonic tissue, and that of the graft to its new host environment. It appears that embryonic grafts are able to induce repair processes follow ing injury to the nervous system.
Author : Derek J. Chadwick,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 334 pages
File Size : 42,5 Mb
Release : 2003-10-31
Category : Medical
ISBN : 9780470870822
The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed. This timely book brings together leading neuroscientists, clinicians, and cell and developmental biologists to discuss the use of neural transplants in neurodegenerative disorders, such as Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential alternatives to freshly derived fetal tissue as the source of transplants, for example xenografts, encapsulated cells and immortalized stem cells. With authoritative contributions and lively discussion sections, this book presents much new and exciting work in this field and identifies promising new research directions.
Author : Martyn Berry,Society for Neuroscience
Publisher : Springer-Verlag
Page : 334 pages
File Size : 51,7 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9783662252642
Author : Stephen B. Dunnett,Alan A. Boulton,Glen B. Baker
Publisher : Springer Science & Business Media
Page : 554 pages
File Size : 46,7 Mb
Release : 1999-10-20
Category : Medical
ISBN : 9780896037939
we might seek alternative sources of donor tissues. Genetic en- neering, expansion of precursor cells, generation of immortalized cell lines, and transplantation between species are all under active investigation. Although significant difficulties remain for each of these alternatives, the problems appear soluble and relevant knowledge is expanding rapidly. As we enter the twenty-first century, the place of neural tra- plantation in experimental neuroscience is continuing to evolve. Rather than being a topic in its own right, neural transplantation increasingly serves as just another technique in the researcher's armory--alongside lesions, pharmaceuticals, gene transfer, and a variety of other techniques--for the experimental manipulation of brain structure and function. This is particularly true for studies of degeneration, plasticity, regeneration, and recovery of function in the nervous system, topics of increasing importance as experimental neurobiology is required to serve the higher needs of neurological and mental health in aging societies. Within this evolving context, Neural Transplantation Methods seeks to serve a particular need: to provide experimental neu- scientists with a source book of information to enable them to select and adapt transplantation techniques to their own expe- mental programs. All authors have been asked to address prac- cal issues, to enable the reader to assess what is available, what are the alternatives, what are the practical issues to be resolved in applying a particular protocol and getting it to work reliably in their unique experimental context.