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Functional Neural Transplantation III by Anonim Pdf
This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Functional Neural Transplantation III by Anonim Pdf
This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.
Functional Neural Transplantation IV by Anonim Pdf
Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides a survey of the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science to an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair. Selected chapters review the latest advances in translating the new technologies to a broader range of neurodegenerative diseases, stroke, spinal cord injury, glial and retinal disease and pain than had hitherto been considered possible, with the realization that the opportunities of off-the-shelf cell therapy may fast be approaching a plausible reality. Comprehensive set of critical reviews covering the field Presents state-of-the-art topics in science and translational medicine Written by international leaders in the field of neural transplantation
Functional Neural Transplantation III by Stephen B. Dunnett,Anders Björklund Pdf
"This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery."--Publisher's website
Author : John R. Sladek Publisher : Springer Science & Business Media Page : 468 pages File Size : 51,9 Mb Release : 2013-11-11 Category : Medical ISBN : 9781468446852
The story of mammalian neural transplantation really begins eighty-one years ago. In Chicago in December of 1903, a 34-year-old physician, Elizabeth Hopkins Dunn, working as a research assistant in neurology, initiated a series of experiments to examine the ability of neonatal rat cerebral tissue to survive transplantation into the brain of matched littermates. Out of 46 attempts, four clearly successful grafts were identified. The publication of Dunn's results in 1917, the first credible report to demonstrate the feasibility of mammalian CNS transplants, generated little interest. In fact, the next significant experiment in this field did not appear until 1930. The field continued to grow slowly and quietly as investigators gradually realized the value of neural trans plantation to study problems of development and plasticity in the mammalian nervous system. With the discovery in 1979 that grafted neurons were capable of appropriate and functional interactions with the host brain, interest in neural transplantation esca lated sharply. The extraordinary opportunities created by using functional neural trans plants in investigating basic issues in neurobiology, as well as the clinical implications, excited both scientists and the public. The popularity of neural transplantation has been growing rapidly in the past five years and shows no signs of abating. The present volume was designed to meet two needs created by the rapid growth of this subdiscipline of neurobiology. The first was to provide a thorough review of the experimental foundations of neural transplantation.
Functional Neural Transplantation IV by Anonim Pdf
Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science, providing an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.
Functional Neural Transplantation IV by Anonim Pdf
Functional Neural Transplantation IV: Translation to Clinical Application, Part B, Volume 231 provides the current status of cell transplantation in the nervous system, focusing on the conditions for achieving structural repair and functional recovery after brain damage or disease. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments in cellular and molecular science, providing the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair. Selected chapters review the latest advances in translating new technologies to a broader range of neurodegenerative diseases, stroke, spinal cord injury, glial and retinal disease and pain than had hitherto been considered impossible, with a realization that the opportunities of off-the-shelf cell therapy may fast be approaching a plausible reality. Provides a comprehensive set of critical reviews covering the field Presents state-of-the-art topics in science and translational medicine Written by international leaders in the field of neural transplantation
Functional Neural Transplantation IV by Anonim Pdf
Functional Neural Transplantation IV: Translation to Clinical Application, Part B, Volume 231 provides the current status of cell transplantation in the nervous system, focusing on the conditions for achieving structural repair and functional recovery. New to this edition are chapters on Plasticity and Regeneration in the Injured Spinal Cord After Cell Transplantation Therapy, Transplantation of GABAergic Interneurons for Cell-Based Therapy, Rebuilding CNS Inhibitory Circuits to Control Chronic Neuropathic Pain and Itch, From Transplanting Schwann Cells in Experimental Rat Spinal Cord Injury to their Transplantation into Human Injured Spinal Cord in Clinical Trials, and the Recruitment of Endogenous CNS Stem Cells for Regeneration in Demyelinating Disease. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments in cellular and molecular science, providing the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, while also addressing the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.
Functional Neural Transplantation II. Novel Cell Therapies for CNS Disorders by S.B. Dunnett,A. Björklund Pdf
The first edition of Functional Neural Transplantation, appearing in 1994, was commissioned to provide a systematic overview of the main areas of active research into the use of neural transplantation for functional repair at that time. There have though been major developments in the field over the last decade. First, whereas many of the model systems are the same, the sophistication of the research has developed dramatically. Secondly, there has been a major change in focus related to the nature of the optimal reparative process, moving away from a primary goal involving repair by replacement of lost cells, to strategies based on halting or reversing the disease process itself. Thirdly, the last decade has (not surprisingly) seen an expansion in the breadth of clinical applications for transplantation not only of primary embryonic neural tissues but also the initial applications of cells and cell lines. In order to address these recent developments as we enter the 21st century, 10 years after conception and 6 years after the publication of Functional Neural Transplantation, the Editors have now sought to co-ordinate and edit an updated version, Functional Neural Transplantation II. Functional Neural Transplantation II is not just a revised edition of the previous volume, but an entirely new and complementary second volume to update the field to 'state of the art' for the new millennium. For many major topic areas (such as functional repair in neurodegenerative disorders of the basal ganglia) there has been a continual flow of significant advances. Although these topics are covered in both volumes, the Editors have sought to avoid duplication by requiring that the present coverage emphasises the major developments over the last decade while relying on the first volume for the background overviews. Other topics though are entirely new in the present volume, such as novel applications of neural transplantation to other major clinical relevance such as retinal repair or alleviation of pain. A key departure of the present volume is the addition of several early chapters addressing the technical and developmental issues associated with identification of alternative sources of cells for transplantation - cell lines, immortalised cells, precursor/stem cells and xenotransplantation.
Institute of Medicine,Board on Neuroscience and Behavioral Health,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Biological and Biomedical Applications of Stem Cell Research
Author : Institute of Medicine,Board on Neuroscience and Behavioral Health,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Biological and Biomedical Applications of Stem Cell Research Publisher : National Academies Press Page : 112 pages File Size : 54,7 Mb Release : 2002-01-25 Category : Science ISBN : 9780309170420
Stem Cells and the Future of Regenerative Medicine by Institute of Medicine,Board on Neuroscience and Behavioral Health,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Biological and Biomedical Applications of Stem Cell Research Pdf
Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
Jasper's Basic Mechanisms of the Epilepsies by Jeffrey L. Noebels,Massimo Avoli Pdf
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Neural Stem Cells for Brain and Spinal Cord Repair by Tanja Zigova Pdf
Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.
