Neuroanatomy And Pathology Of Sporadic Alzheimer S Disease

Author : Heiko Braak,Kelly Del Tredici
Publisher : Springer
Page : 162 pages
File Size : 52,7 Mb
Release : 2015-01-10
Category : Medical
ISBN : 3319126806

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Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by Heiko Braak,Kelly Del Tredici Pdf

As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail

Author : Heiko Braak,Kelly Del Tredici
Publisher : Springer Science & Business Media
Page : 127 pages
File Size : 43,7 Mb
Release : 2008-11-27
Category : Medical
ISBN : 9783540798507

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Neuroanatomy and Pathology of Sporadic Parkinson's Disease by Heiko Braak,Kelly Del Tredici Pdf

The synucleinopathy sporadic Parkinson’s disease (sPD) is the second most frequent degenerative disorder of the human nervous system after Alzheimer’s disease. The propensity for developing sPD exists in all ethnic groups worldwide, and the prevalence of the disorder increases considerably with age, thereby imposing an enormous social and economic burden on societies with increased life expectancy. The sPD-associated pathological process is progressive, does not go into remission, and can take decades to reach its culmination if it is not be terminated prematurely by death owing to other causes. Against the background of the normal morphology and anatomy, the authors analyze the pathoanatomy of sPD in the nervous system at various neuropathological stages and summarize the potential functional consequences of the lesions.

Author : Heiko Braak,Kelly Del Tredici
Publisher : Springer
Page : 162 pages
File Size : 40,8 Mb
Release : 2014-12-11
Category : Medical
ISBN : 9783319126791

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Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by Heiko Braak,Kelly Del Tredici Pdf

As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail

Author : Margaret M. Esiri,Virginia M. -Y. Lee,John Q. Trojanowski
Publisher : Cambridge University Press
Page : 600 pages
File Size : 50,8 Mb
Release : 2004-07-22
Category : Medical
ISBN : 0521819156

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The Neuropathology of Dementia by Margaret M. Esiri,Virginia M. -Y. Lee,John Q. Trojanowski Pdf

Completely rewritten and updated, this new edition is almost twice the size of its predecessor. Illustrated in colour throughout, and with contributions from the world's leading authorities, it is the definitive reference on the neuropathology of dementia. It gives practical guidance to pathologists, describes the contribution of neuroimaging to diagnosis, and surveys the clinical features of dementia. New material includes: Three entirely new chapters on neuroimaging, molecular diagnostics, and transgenic models. Two chapters on tauopathies under new authorship. A chapter under new authorship on synucleinopathies, which includes multiple system atrophy.

Author : Rudy Castellani,George Perry
Publisher : Biota Publishing
Page : 93 pages
File Size : 49,6 Mb
Release : 2013-10-01
Category : Health & Fitness
ISBN : 9781615046393

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Molecular Pathology of Alzheimer's Disease by Rudy Castellani,George Perry Pdf

Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.

Author : Peter Riederer,Heinz Reichmann,Moussa B. H. Youdim,Manfred Gerlach
Publisher : Springer Science & Business Media
Page : 484 pages
File Size : 40,5 Mb
Release : 2006-11-23
Category : Medical
ISBN : 9783211452950

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Parkinson's Disease and Related Disorders by Peter Riederer,Heinz Reichmann,Moussa B. H. Youdim,Manfred Gerlach Pdf

This book gives a comprehensive overview on current clinical and basic research issues related to Parkinson’s disease and its related disorders. The book is the result of the 16th International Congress of Parkinson’s Disease and Related disorders congress 2005. Its contents are suitable for neurologists, psychiatrists, neurosurgeons, basic researchers, geneticians and patients as well as their relatives.

Author : Hanna Falk Erhag,Ulrika Lagerlöf Nilsson,Therese Rydberg Sterner,Ingmar Skoog
Publisher : Springer Nature
Page : 254 pages
File Size : 40,9 Mb
Release : 2022-01-10
Category : Social Science
ISBN : 9783030780630

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A Multidisciplinary Approach to Capability in Age and Ageing by Hanna Falk Erhag,Ulrika Lagerlöf Nilsson,Therese Rydberg Sterner,Ingmar Skoog Pdf

This open access book provides insight on how to interpret capability in ageing – one’s individual ability to perform actions in order to reach goals one has reason to value – from a multidisciplinary approach. With for the first time in history there being more people in the world aged 60 years and over than there are children below the age of 5, the book describes this demographic trends as well as the large global challenges and important societal implications this will have such as a worldwide increase in the number of persons affected with dementia, and in the ratio of retired persons to those still in the labor market. Through contributions from many different research areas, it discussed how capability depends on interactions between the individual (e.g. health, genetics, personality, intellectual capacity), environment (e.g. family, friends, home, work place), and society (e.g. political decisions, ageism, historical period). The final chapter summarizes the differences and similarities in these contributions. As such this book provides an interesting read for students, teachers and researchers at different levels and from different fields interested in capability and multidisciplinary research.

Author : Richard J. Wurtman
Publisher : Unknown
Page : 460 pages
File Size : 50,7 Mb
Release : 1996
Category : Medical
ISBN : UVA:X004080894

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The Neurobiology of Alzheimer's Disease by Richard J. Wurtman Pdf

The overall goal of the International Study Group on the Pharmacology of Memory Disorders Associated with Ageing is to point out discoveries that shed light on the potential causes of Alzheimer's disease, its pathogenesis, and the biological mechanisms that could underlie its cure. This eighth meeting in the series, aims to stimulate research in dementia and increase the transfer of information from the basic sciences to physicians and the pharmaceutical industry."

Author : Jonas H. Ellenberg,William C. Koller,James William Langston
Publisher : CRC Press
Page : 600 pages
File Size : 47,8 Mb
Release : 1995-03-01
Category : Medical
ISBN : 0824788230

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Etiology of Parkinson's Disease by Jonas H. Ellenberg,William C. Koller,James William Langston Pdf

This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.

Author : Maria A. Patestas,Leslie P. Gartner
Publisher : John Wiley & Sons
Page : 544 pages
File Size : 44,7 Mb
Release : 2016-02-17
Category : Medical
ISBN : 9781118677353

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A Textbook of Neuroanatomy by Maria A. Patestas,Leslie P. Gartner Pdf

Newly revised and updated, A Textbook of Neuroanatomy, Second Edition is a concise text designed to help students easily master the anatomy and basic physiology of the nervous system. Accessible and clear, the book highlights interrelationships between systems, structures, and the rest of the body as the chapters move through the various regions of the brain. Building on the solid foundation of the first edition, A Textbook of Neuroanatomy now includes two new chapters on the brainstem and reflexes, as well as dozens of new micrographs illustrating key structures. Throughout the book the clinical relevance of the material is emphasized through clinical cases, questions, and follow-up discussions in each chapter, motivating students to learn the information. A companion website is also available, featuring study aids and artwork from the book as PowerPoint slides. A Textbook of Neuroanatomy, Second Edition is an invaluable resource for students of general, clinical and behavioral neuroscience and neuroanatomy.

Author : Bradford Dickerson,Alireza Atri
Publisher : Oxford University Press
Page : 400 pages
File Size : 53,5 Mb
Release : 2014-08-01
Category : Medical
ISBN : 9780199928460

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Dementia by Bradford Dickerson,Alireza Atri Pdf

Dementia: Comprehensive Principles and Practice is a clinically-oriented book designed for clinicians, scientists, and other health professionals involved in the diagnosis, management, and investigation of disease states causing dementia. A "who's who" of internationally-recognized experts contribute chapters emphasizing a multidisciplinary approach to understanding dementia. The organization of the book takes an integrative approach by providing three major sections that (1) establish the neuroanatomical and cognitive framework underlying disorders of cognition, (2) provide fundamental as well as cutting-edge material covering specific diseases associated with dementia, and (3) discuss approaches to the diagnosis and treatment of dementing illnesses.

Author : Mathias Jucker,Konrad Beyreuther,Christian Haass,Roger M. Nitsch
Publisher : Springer Science & Business Media
Page : 541 pages
File Size : 45,7 Mb
Release : 2006-11-22
Category : Medical
ISBN : 9783540376521

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Alzheimer: 100 Years and Beyond by Mathias Jucker,Konrad Beyreuther,Christian Haass,Roger M. Nitsch Pdf

Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tübingen. The celebratory event "Alzheimer 100 Years and Beyond" was organized through the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen. This volume, a collection of articles by the invited speakers and of a few other prominent researchers, is published as a record of those events.

Author : Alireza Minagar
Publisher : Academic Press
Page : 360 pages
File Size : 41,9 Mb
Release : 2009-06-04
Category : Science
ISBN : 008088878X

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Neurobiology of Dementia by Alireza Minagar Pdf

With recent advances of modern medicine, more people reach the “elderly age around the globe, and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians’ and neuroscientists’ interest to carry out more research projects into the pathogenesis of this devastating group of diseases.

Author : Ines Moreno-Gonzalez,Rodrigo Morales,David Baglietto-Vargas,Raquel Sanchez-Varo
Publisher : Frontiers Media SA
Page : 156 pages
File Size : 40,7 Mb
Release : 2020-07-14
Category : Electronic
ISBN : 9782889638550

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Risk Factors for Alzheimer’s Disease by Ines Moreno-Gonzalez,Rodrigo Morales,David Baglietto-Vargas,Raquel Sanchez-Varo Pdf

Author : Jiehui Jiang,Kuangyu Shi,Fangyu Peng,Chih-Yu Hsu,Woon-Man Kung
Publisher : Frontiers Media SA
Page : 845 pages
File Size : 54,8 Mb
Release : 2022-07-05
Category : Science
ISBN : 9782889763719

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Translational Advances in Alzheimer's, Parkinson's, and Other Neurodegenerative Dementias by Jiehui Jiang,Kuangyu Shi,Fangyu Peng,Chih-Yu Hsu,Woon-Man Kung Pdf