Neuroimmunology Research Focus

Author : Paulo V. Broglio
Publisher : Nova Publishers
Page : 240 pages
File Size : 48,9 Mb
Release : 2007
Category : Nervous system
ISBN : 1600215319

Get Book

Neuroimmunology Research Focus by Paulo V. Broglio Pdf

Neuroimmunology is a rapidly-growing branch of biomedical science that studies of all aspects of the interactions between the immune system and nervous system. It deals with, among other things, the physiological functioning of the neuroimmune system in states of both health and disease; malfunctions of the neuroimmune system in disorders (autoimmune diseases, hypersensitivities, immune deficiency), the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo. Despite the brain's status as an immune privileged site, an extensive bi-directional communication takes place between the nervous and the immune system in both health and disease. Immune cells and neuroimmune molecules such as cytokines, chemokines, and growth factors modulate brain function through multiple signalling pathways throughout the lifespan. Immunological, physiological and psychological stressors engage cytokines and other immune molecules as mediators of interactions with neuroendocrine, neuropeptide, and neurotransmitter systems. For example, brain cytokine levels increase following stress exposure, while treatments designed to alleviate stress reverse this effect. This book presents leading research in the field.

Author : Allan Siegel,Steven S. Zalcman
Publisher : Springer Science & Business Media
Page : 437 pages
File Size : 50,7 Mb
Release : 2008-11-09
Category : Medical
ISBN : 9780387848518

Get Book

The Neuroimmunological Basis of Behavior and Mental Disorders by Allan Siegel,Steven S. Zalcman Pdf

For many years, the immune and central nervous systems were thought to function independently with little or no interaction between the two. This view has und- gone dramatic changes over the past three decades. Indeed, we now know that there exists various feedback loops between the brain and immune systems that impact signi cantly upon different behavioral processes, including normal behavior and mental disorders. Pioneering efforts in generating this change were initiated by a number of early investigators. Included were those whose efforts were directed at establishing neuroimmune connections as well as others whose research focused upon the relationship between immunity, cytokines, and behavior. This book brings together outstanding scientists and clinicians who have made major contributions to the rapidly developing eld investigating the relationship between immunity and behavior. The book is divided into three parts. The rst part describes pathways by which the brain and immune systems communicate and int- act with each other. In the chapter “Cytokines and the Blood–Brain Barrier” p- vides insight into interactions between the blood–brain barrier and cytokines. Such interactions underlie basic communication between the immune system and brain that are present in normal as well as in disease conditions. In the chapter “Neu- chemical and Endocrine Responses to Immune Activation: The Role of Cytokines,” the neurochemical and endocrine consequences of immune challenge and cytokine administration on central neurotransmitter activity are discussed.

Author : Ruth Arnon,Ariel Miller
Publisher : Academic Press
Page : 504 pages
File Size : 45,7 Mb
Release : 2016-05-10
Category : Science
ISBN : 9780128020074

Get Book

Translational Neuroimmunology in Multiple Sclerosis by Ruth Arnon,Ariel Miller Pdf

Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the localization and amount of the damage induced by combined inflammatory, demyelinating, and neurodegenerative processes. Although a cure for MS does not currently exist, therapies can help treat MS attacks, attenuate disease activity, reduce progress of the disease, and manage symptoms. Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis, from experimental models and the human disease to the translation of this research to immunotherapeutic strategies. Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers of disease activity, pharmacogenetics, and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon—such as neuroprotective strategies, stem cells, and repair promotion—are discussed. Contributed by renowned leaders in the field, this cross-disciplinary volume is a great resource for basic scientists and clinical practitioners in neuroscience, neurology, immunology, pharmacology, and in-drug development. Provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis and the translation of this research to immunotherapy treatment Edited by renowned leaders in the field of neuroimmunology and multiple sclerosis Contains the latest resource material for basic and clinical scientists and practitioners in neuroscience, neurology, immunology, and pharmacology

Author : Anonim
Publisher : Unknown
Page : 96 pages
File Size : 44,9 Mb
Release : 1994
Category : Government publications
ISBN : UCR:31210023565425

Get Book

Neuroimmunology & Mental Health by Anonim Pdf

Author : Robert M. Coleman
Publisher : Nova Publishers
Page : 270 pages
File Size : 44,9 Mb
Release : 2005
Category : Central nervous system
ISBN : 1594544174

Get Book

Focus on Neurochemistry Research by Robert M. Coleman Pdf

The brain is an enormously dynamic organ. Even when we sleep connections are made, signals sent and messages delivered. One of the key ways that the brain operates is via chemical stimuli which permits different parts of the brain to communicate between themselves and with the rest of the body. Determining what these chemicals, proteins and molecules are is an important way to not only discover how the brain works, but provide novel targets that may be useful in the treatment of disease, for instance in dealing with memory loss in dementia. This new book brings together international research in a broad range of topics, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of CNS function, neuroimmunology, metabolism, as well as the neurochemistry of neurological and psychiatric disorders of the CNS.

Author : Nima Rezaei,Niloufar Yazdanpanah
Publisher : Elsevier
Page : 542 pages
File Size : 52,5 Mb
Release : 2023-06-16
Category : Medical
ISBN : 9780323900713

Get Book

Translational Neuroimmunology, Volume 7 by Nima Rezaei,Niloufar Yazdanpanah Pdf

Translational NeuroImmunology: Neuroinflammation updates on bench to bedside studies on neurological disorders that have immunological etiologies. The book covers neuroimmunology and the principles of autoimmune and autoinflammatory neurological disorders, with multiple sclerosis as the main focus. The immunopathology, genetics and epigenetics, microbiome, diagnosis and treatment of multiple sclerosis will be explained in ten chapters. A chapter also examines distinct aspects of pericytes, with final discussions on the neurologic manifestations, diagnostic approaches and treatments of the various neuroimmune disorders and lessons learned from translational research on non-human primates and zebrafish. All sections are presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research. Gives an introduction on neuroimmunological diseases, from bench to bedside Encourages the development of immunologic approaches to analyze the interaction and specific properties of nervous tissue elements during development and disease Focuses on understanding and therapeutically manipulating immunological responses to injury, degeneration and autoimmunity in the central nervous system Proves changes in relevant immune and inflammatory reactions at the cellular and molecular level during the development of nervous system diseases

Author : Cris S. Constantinescu,Rāzvan I. Arsenescu,Violeta Arsenescu
Publisher : Springer
Page : 337 pages
File Size : 43,9 Mb
Release : 2016-05-24
Category : Medical
ISBN : 9783319286099

Get Book

Neuro-Immuno-Gastroenterology by Cris S. Constantinescu,Rāzvan I. Arsenescu,Violeta Arsenescu Pdf

This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.

Author : Michal Schwartz,Anat London
Publisher : Yale University Press
Page : 316 pages
File Size : 49,7 Mb
Release : 2015-01-01
Category : Medical
ISBN : 9780300203479

Get Book

Neuroimmunity by Michal Schwartz,Anat London Pdf

Pathbreaking research offers new hope for treating brain diseases and injuries and for maintaining brain health even into old age In the past, the brain was considered an autonomous organ, self-contained and completely separate from the body's immune system. But over the past twenty years, neuroimmunologist Michal Schwartz, together with her research team, not only has overturned this misconception but has brought to light revolutionary new understandings of brain health and repair. In this book Schwartz describes her research journey, her experiments, and the triumphs and setbacks that led to the discovery of connections between immune system and brain. Michal Schwartz, with Anat London, also explains the significance of the findings for future treatments of brain disorders and injuries, spinal cord injuries, glaucoma, depression, and other conditions such as brain aging and Alzheimer's and Parkinson's diseases. Scientists, physicians, medical students, and all readers with an interest in brain function and its relationship to the immune system in health and disease will find this book a valuable resource. With general readers in mind, the authors provide a useful primer to explain scientific terms and concepts discussed in the book.

Author : Amanda L. Piquet,Enrique Alvarez
Publisher : Springer Nature
Page : 536 pages
File Size : 48,5 Mb
Release : 2021-03-08
Category : Medical
ISBN : 9783030618834

Get Book

Neuroimmunology by Amanda L. Piquet,Enrique Alvarez Pdf

This book provides a clinical focus on neuroinflammatory diseases as well as a review in pathophysiology and treatment approaches. Organized into six parts, the book begins with a basic review of the immune system and concepts for learning and treating neuroimmune conditions. The next four sections cover specific subfields of neuroimmunology and autoimmune neurology - the clinical and diagnostic features of multiple sclerosis, other autoimmune conditions of the central nervous system, autoimmune conditions of the peripheral nervous system, and systemic autoimmune conditions that affect the nervous system. To conclude, Section six discusses various clinical approaches to specific presentations in neuroimmunology, including pediatric demyelinating diseases. These sections provide practical clinical information to improve the reader’s knowledge in this complex field. The chapters are written by world renown authors with extensive knowledge to help provide up to date information. The full scope of autoimmune neurology is discussed, which is a unique feature of this book. Neuroimmunology serves as a resource for those in training including residents and fellows to provide clear clinical reasoning and background in a rapidly advancing field.

Author : Mia Levite
Publisher : Springer Science & Business Media
Page : 360 pages
File Size : 41,7 Mb
Release : 2012-02-14
Category : Medical
ISBN : 9783709108888

Get Book

Nerve-Driven Immunity by Mia Levite Pdf

“Nerve-Driven Immunity: Neurotransmitters and Neuropeptides in the Immune System” summarizes, analyzes and sheds new light on an unrecognized, yet very important role of key neurotransmitters and neuropeptides in the immune system. Each chapter of the book deals with a different neurotransmitter/neuropeptide from the following list: Dopamine, Adrenaline, Noradrenaline, Acetylcholine, Glutamate, GABA, Somatostatin, Neuropeptide Y (NPY), Vasoactive intestinal polypeptide (VIP), Calcitonin gene related peptide (CGRP), Opioids and Cannabinoids. For each of these neurotransmitters/neuropeptides, the following four topics are discussed: The specific receptors for the neurotransmitter/neuropeptide expressed in various types of immune cells The direct effects induced by the neurotransmitter/neuropeptide in various types of immune cells (either resting or activated), and the specific immune functions and features it activates/elevates or rather inhibits in specific concentrations The production of the neurotransmitter/neuropeptide in, and its release by, various types of immune cells The involvement of the neurotransmitter/neuropeptide in various diseases of the immune system (among them autoimmune diseases, immunodeficiency diseases and hematological cancers) The book includes many original figures, overview tables, and proposed models of events which are instrumental, enriching and stimulating for the reader. In light of the above-mentioned aspects, “Nerve-Driven Immunity: Neurotransmitters and Neuropeptides in the Immune System” is ideally suited as a textbook for new courses in Immunology, Neurology, Neuro-immunology or Pharmacology. The book chapters were written by highly skilled authors from 10 countries: the USA, the United Kingdom, Italy, Israel, Sweden, France, Germany, Spain, Serbia and Romania. “Nerve-Driven Immunity” is a term first coined by Dr. Mia Levite (the editor of the book).

Author : Syed A. Rizvi,Patricia K. Coyle
Publisher : Springer Science & Business Media
Page : 404 pages
File Size : 44,7 Mb
Release : 2011-09-03
Category : Medical
ISBN : 1603278605

Get Book

Clinical Neuroimmunology by Syed A. Rizvi,Patricia K. Coyle Pdf

Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders serves as an indispensable resource for physicians interested in, and dealing with, this very complex and evolving branch of neurology. This comprehensive title provides an introduction to basic neuroimmunology and principles of immunotherapy and also serves as a thorough guide to immune-mediated disorders of the central and peripheral nervous system, as well as other systemic disorders with a significant neuroimmunologic component. The chapters are written by experts in their fields and include the most up to date scientific information. This volume is made to simplify complex immunological mechanisms and to focus on practical patient-related issues. Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders is an invaluable addition to the literature and will be of significant interest to neurologists, residents and fellows, internists, and general practitioners who treat patients with neurologic disorders and other systemic autoimmune diseases.

Author : Bernadette Kalman,Thomas H. Brannagan, III
Publisher : John Wiley & Sons
Page : 280 pages
File Size : 46,8 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9780470766187

Get Book

Neuroimmunology in Clinical Practice by Bernadette Kalman,Thomas H. Brannagan, III Pdf

Written by field experts, Neuroimmunology in Clinical Practice fills a void in traditional neuroimmunology literature, which tends to cover the discipline’s scientific aspects with little emphasis on clinical applications. This unique book is essential reading in clinical neuroimmunology. Written by field experts this book provides a comprehensive description of immune mediated neurological disorders complemented with the most pertinent and up to date scientific data Covers inflammatory demyelination in the central nervous system, autoimmune diseases of the peripheral nervous system and the muscle, and disorders of the central and peripheral nervous systems Fills a gap in existing neuroimmunology literature by focusing on clinical applications

Author : Aaron E. Miller,Tracy DeAngelis,Michelle Fabian,Ilana Katz Sand
Publisher : Oxford University Press
Page : 256 pages
File Size : 48,5 Mb
Release : 2018-08-29
Category : Medical
ISBN : 9780190693213

Get Book

Neuroimmunology by Aaron E. Miller,Tracy DeAngelis,Michelle Fabian,Ilana Katz Sand Pdf

Part of the What Do I Do Now?" series, Neuroimmunology uses a case-based approach to cover common and important topics in the examination, investigation, and management of central and peripheral demyelinating diseases, vasculitis, and other immune system related neurological disorders. Each chapter provides a discussion of the diagnosis, key points to remember, and selected references for further reading. For this new edition, all cases and references have been updated and new cases have been added, including POEMS, CASPR2 Antibody Syndrome, Isaac's Syndrome, Histiocytosis, and Churg-Strauss. Neuroimmunology is an engaging collection of thought-provoking cases which clinicians can utilize when they encounter difficult patients. The volume is also a self-assessment tool that tests the reader's ability to answer the question, "What do I do now?"

Author : Lilian M. Johansson
Publisher : Nova Science Publishers
Page : 290 pages
File Size : 43,9 Mb
Release : 2007
Category : Nervous system
ISBN : UVA:X030250694

Get Book

Neuroimmunology Research Perspectives by Lilian M. Johansson Pdf

Neuroimmunology is a rapidly-growing branch of biomedical science that studies of all aspects of the interactions between the immune system and nervous system. It deals with, among other things, the physiological functioning of the neuroimmune system in states of both health and disease; malfunctions of the neuroimmune system in disorders (autoimmune diseases, hypersensitivities, immune deficiency), the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo. Despite the brain's status as an immune privileged site, an extensive bi-directional communication takes place between the nervous and the immune system in both health and disease. Immune cells and neuroimmune molecules such as cytokines, chemokines, and growth factors modulate brain function through multiple signalling pathways throughout the lifespan. Immunological, physiological and psychological stressors engage cytokines and other immune molecules as mediators of interactions with neuroendocrine, neuropeptide, and neurotransmitter systems. For example, brain cytokine levels increase following stress exposure, while treatments designed to alleviate stress reverse this effect. This book presents leading research from around the globe.

Author : Anonim
Publisher : Elsevier
Page : 568 pages
File Size : 46,8 Mb
Release : 2016-03-11
Category : Science
ISBN : 9780444634467

Get Book

Autoimmune Neurology by Anonim Pdf

Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities