Translational Neuroimmunology Volume 7

Author : Nima Rezaei,Niloufar Yazdanpanah
Publisher : Elsevier
Page : 542 pages
File Size : 45,8 Mb
Release : 2023-06-16
Category : Medical
ISBN : 9780323900713

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Translational Neuroimmunology, Volume 7 by Nima Rezaei,Niloufar Yazdanpanah Pdf

Translational NeuroImmunology: Neuroinflammation updates on bench to bedside studies on neurological disorders that have immunological etiologies. The book covers neuroimmunology and the principles of autoimmune and autoinflammatory neurological disorders, with multiple sclerosis as the main focus. The immunopathology, genetics and epigenetics, microbiome, diagnosis and treatment of multiple sclerosis will be explained in ten chapters. A chapter also examines distinct aspects of pericytes, with final discussions on the neurologic manifestations, diagnostic approaches and treatments of the various neuroimmune disorders and lessons learned from translational research on non-human primates and zebrafish. All sections are presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research. Gives an introduction on neuroimmunological diseases, from bench to bedside Encourages the development of immunologic approaches to analyze the interaction and specific properties of nervous tissue elements during development and disease Focuses on understanding and therapeutically manipulating immunological responses to injury, degeneration and autoimmunity in the central nervous system Proves changes in relevant immune and inflammatory reactions at the cellular and molecular level during the development of nervous system diseases

Author : Nima Rezaei,Niloufar Yazdanpanah
Publisher : Elsevier
Page : 272 pages
File Size : 55,5 Mb
Release : 2023-06-16
Category : Medical
ISBN : 9780443185793

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Translational Neuroimmunology, Volume 8 by Nima Rezaei,Niloufar Yazdanpanah Pdf

Translational Neuroimmunology: Multiple Sclerosis provides an update on bench to bedside studies on Multiple Sclerosis as an autoimmune disease. Divided into twelve chapters, the book begins with an in-depth introduction to the neuroimmunology and immunopathology of multiple sclerosis. Sections also provide content on genetics and epigenetics, the microbiome, diagnosis, and treatment of multiple sclerosis. Finally, various precision treatments are covered. All information is presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research. Provides an introduction on multiple sclerosis as an autoimmune disease, from bench to bedside Encourages the development of immunologic approaches to analyze the interaction and specific properties of nervous tissue elements during development and disease Focuses on understanding and therapeutically manipulating immunological responses to injury, degeneration and autoimmunity in the central nervous system Shows the changes in relevant immune and inflammatory reactions at the cellular and molecular level during the development of nervous system diseases

Author : Ruth Arnon,Ariel Miller
Publisher : Academic Press
Page : 504 pages
File Size : 54,9 Mb
Release : 2016-05-10
Category : Science
ISBN : 9780128020074

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Translational Neuroimmunology in Multiple Sclerosis by Ruth Arnon,Ariel Miller Pdf

Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the localization and amount of the damage induced by combined inflammatory, demyelinating, and neurodegenerative processes. Although a cure for MS does not currently exist, therapies can help treat MS attacks, attenuate disease activity, reduce progress of the disease, and manage symptoms. Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis, from experimental models and the human disease to the translation of this research to immunotherapeutic strategies. Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers of disease activity, pharmacogenetics, and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon—such as neuroprotective strategies, stem cells, and repair promotion—are discussed. Contributed by renowned leaders in the field, this cross-disciplinary volume is a great resource for basic scientists and clinical practitioners in neuroscience, neurology, immunology, pharmacology, and in-drug development. Provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis and the translation of this research to immunotherapy treatment Edited by renowned leaders in the field of neuroimmunology and multiple sclerosis Contains the latest resource material for basic and clinical scientists and practitioners in neuroscience, neurology, immunology, and pharmacology

Author : Silva Lyman
Publisher : American Medical Publishers
Page : 0 pages
File Size : 50,7 Mb
Release : 2023-09-26
Category : Health & Fitness
ISBN : 9798887405278

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Translational Neuroimmunology: From Disease Mechanisms to Clinical Applications by Silva Lyman Pdf

Neuroimmunology is a field that combines neuroscience, the study of the nervous system and immunology, the study of the immune system, into one discipline within this field neuroimmunology. The interaction of these two complex systems is studied the neuroimmunologists throughout development, homeostasis, and response to injuries. The adaptive and innate immune systems continuously monitor the nervous system. The immune system identifies and responds to changes in cell identity and neural connectivity during development and adult life. The immune system and nervous system require suitable degrees of cellular differentiation, organizational integrity, and neural network connectivity. Pro-inflammatory cytokines which are released by activated macrophages and monocytes during infection, can impact neural targets that control thermogenesis, behavior, sleep, and mood. Cytokines are produced in the central nervous system due to brain injury, during bacterial and viral infections, and neurodegenerative processes. This book is a valuable compilation of topics, ranging from the basic to the most complex advancements in the field of translational neuroimmunology. It includes contributions of experts and scientists which will provide innovative insights on neuroimmunology and its clinical applications. This book will provide comprehensive knowledge to the readers.

Author : Sandra Amor,Fabienne Brilot,David Brown,Judith M. Greer,Marc J. Ruitenberg
Publisher : Frontiers Media SA
Page : 253 pages
File Size : 52,5 Mb
Release : 2020-12-29
Category : Medical
ISBN : 9782889662951

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Update on Translational Neuroimmunology - Research of ISNI 2018 by Sandra Amor,Fabienne Brilot,David Brown,Judith M. Greer,Marc J. Ruitenberg Pdf

The 14th International Congress of Neuroimmunology, ISNI 2018, was held in August 2018 in Brisbane, Australia, and is a biennial event organized by the International Society of Neuroimmunology (ISNI). The theme of ISNI 2018 was “Travelling the Neuroimmunological Translational Highway”, and the Congress highlighted many research discoveries that bridge the gap between basic and clinical sciences, and which impact our understanding of pathogenic immune-mediated mechanisms in diseases affecting the nervous system. In this Research Topic, we aim to give a comprehensive overview of topics highlighted at the Congress, showcasing the current state of the field of neuroimmunology and where it is going in the near future.

Author : Anonim
Publisher : Unknown
Page : 368 pages
File Size : 53,5 Mb
Release : 1987
Category : Immunology
ISBN : OCLC:17525810

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Neuroimmunology by Anonim Pdf

Author : Bernadette Kalman,Thomas H. Brannagan, III
Publisher : John Wiley & Sons
Page : 279 pages
File Size : 46,9 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9780470766187

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Neuroimmunology in Clinical Practice by Bernadette Kalman,Thomas H. Brannagan, III Pdf

Written by field experts, Neuroimmunology in Clinical Practice fills a void in traditional neuroimmunology literature, which tends to cover the discipline’s scientific aspects with little emphasis on clinical applications. This unique book is essential reading in clinical neuroimmunology. Written by field experts this book provides a comprehensive description of immune mediated neurological disorders complemented with the most pertinent and up to date scientific data Covers inflammatory demyelination in the central nervous system, autoimmune diseases of the peripheral nervous system and the muscle, and disorders of the central and peripheral nervous systems Fills a gap in existing neuroimmunology literature by focusing on clinical applications

Author : Amanda L. Piquet,Enrique Alvarez
Publisher : Springer
Page : 0 pages
File Size : 41,7 Mb
Release : 2021-03-09
Category : Medical
ISBN : 303061882X

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Neuroimmunology by Amanda L. Piquet,Enrique Alvarez Pdf

This book provides a clinical focus on neuroinflammatory diseases as well as a review in pathophysiology and treatment approaches. Organized into six parts, the book begins with a basic review of the immune system and concepts for learning and treating neuroimmune conditions. The next four sections cover specific subfields of neuroimmunology and autoimmune neurology - the clinical and diagnostic features of multiple sclerosis, other autoimmune conditions of the central nervous system, autoimmune conditions of the peripheral nervous system, and systemic autoimmune conditions that affect the nervous system. To conclude, Section six discusses various clinical approaches to specific presentations in neuroimmunology, including pediatric demyelinating diseases. These sections provide practical clinical information to improve the reader’s knowledge in this complex field. The chapters are written by world renown authors with extensive knowledge to help provide up to date information. The full scope of autoimmune neurology is discussed, which is a unique feature of this book. Neuroimmunology serves as a resource for those in training including residents and fellows to provide clear clinical reasoning and background in a rapidly advancing field.

Author : Seng-Lai Tan
Publisher : Academic Press
Page : 384 pages
File Size : 50,6 Mb
Release : 2015-11-18
Category : Medical
ISBN : 9780128017579

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Translational Immunology by Seng-Lai Tan Pdf

Translational Immunology: Mechanisms and Pharmacologic Approaches highlights and summarizes the most important advances in human immunology, clinical translations, new tools to analyze therapeutic targets, and new pharmacological approaches for autoimmunity, inflammatory disorders, and cancer. The book is an essential resource for those seeking to understand the potential translational applications of burgeoning studies in human immunology, helping readers make sense of the existing and emerging scientific advances. The book grounds fundamental science in the translational realm, providing insights from world renowned researchers at the top of their game in their respective fields, in both industry and academic settings. Readers will gain an understanding of the rationale and mechanisms underlying current and emerging pharmacologic approaches for interventional immunology, the gaps therein, and new ideas for better and safer therapeutic approaches, and physicians will glean information about pharmacological limitations in altering disease progression and complications. This reference on the translational realization of the burgeoning findings in immunology provides a go-to reference for experienced professional clinicians, researchers, industry scientists, and those seeking more information on the field. Delivers comprehensive coverage of seminal human immunology discoveries and the resulting impact on therapeutic strategies Presents potential novel targets and approaches for clinical applications in organ specific and systemic autoimmunity, transplant rejection, cancer, and vaccine development Discusses lessons learned from successful and failed clinical trials with specific interventions, including pharmacological issues and limitations, and complications due to immunosuppression Provides information on new strategies and outstanding issues that should be addressed in future research

Author : P. Michael Conn
Publisher : Academic Press
Page : 776 pages
File Size : 49,9 Mb
Release : 2016-09-28
Category : Medical
ISBN : 9780128025963

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Conn's Translational Neuroscience by P. Michael Conn Pdf

Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance Features contributions from leading global basic and clinical investigators in the field Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes Relates and translates the current science to the understanding of neurological disorders and their treatment

Author : Alessandro Russo,David Paterson,Matteo Bassetti
Publisher : Frontiers Media SA
Page : 292 pages
File Size : 55,9 Mb
Release : 2021-09-29
Category : Medical
ISBN : 9782889714063

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Spotlight on the Relationship between Sepsis and Infection: from Mechanisms to Therapy by Alessandro Russo,David Paterson,Matteo Bassetti Pdf

Author : Lijie Zhai,Chunsheng Kang
Publisher : Frontiers Media SA
Page : 225 pages
File Size : 47,5 Mb
Release : 2023-04-05
Category : Medical
ISBN : 9782832518359

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Innovative theranostic approaches towards neuro-immunology in gliomas by Lijie Zhai,Chunsheng Kang Pdf

Author : Sergiu Groppa,Sven G. Meuth
Publisher : Humana
Page : 335 pages
File Size : 51,5 Mb
Release : 2021-08-03
Category : Medical
ISBN : 1071612123

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Translational Methods for Multiple Sclerosis Research by Sergiu Groppa,Sven G. Meuth Pdf

This volume explores the recent advances in the study of translational paths in central inflammation and focuses on ongoing pathophysiological processes and the transition between inflammatory stages and progressive states with neurodegeneration. Chapters cover topics such as pathophysiological hallmarks of neuroinflammation from tissue damage to reorganization; connecting studies of mouse models; and investigations of humans with multiple sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Methods for Multiple Sclerosis Research is a valuable resource for researchers who want to learn more about this chronic ad progressive disease, and pave the way for new advancements.

Author : Karl Bechter,David Brown,Souhel Najjar
Publisher : Frontiers Media SA
Page : 189 pages
File Size : 52,7 Mb
Release : 2019-08-12
Category : Electronic
ISBN : 9782889459506

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Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis by Karl Bechter,David Brown,Souhel Najjar Pdf

Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.

Author : ConferenceSeries
Publisher : ConferenceSeries
Page : 91 pages
File Size : 42,5 Mb
Release : 2024-06-03
Category : Electronic
ISBN : 8210379456XXX

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Proceedings of 13th European Pathology Congress 2017 by ConferenceSeries Pdf

August 02-03, 2017 Milan, Italy Key Topics : Surgical Pathology, Clinical Pathology, Diagnostic Pathology, Oncopathology, Digital Pathology, Breast Pathology, Reproductive Pathology, Dermatopathology, Cancer Cytopathology, Comparative Pathology, Head & Neck Pathology, Renal Pathology, Hematopathology, Experimental Pathology, Histopathology, Veterinary pathology, Neuropathology, Plant pathology, Immunopathology, Speech & language pathology, Microbial Pathology, Psychopathology, Pathology Case Reports, Chemical Pathology,