Neuronal Mechanics And Transport

Author : Daniel M. Suter,Kyle E. Miller
Publisher : Frontiers Media SA
Page : 214 pages
File Size : 47,5 Mb
Release : 2016-05-26
Category : Electronic book
ISBN : 9782889198238

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Neuronal Mechanics and Transport by Daniel M. Suter,Kyle E. Miller Pdf

Understanding the underlying mechanisms of how axons and dendrites develop is a fundamental problem in neuroscience and a main goal of research on nervous system development and regeneration. Previous studies have provided a tremendous amount of information on signaling and cytoskeletal proteins regulating axonal and dendritic growth and guidance. However, relatively little is known about the relative contribution and role of cytoskeletal dynamics, transport of organelles and cytoskeletal components, and force generation to axonal elongation. Advancing the knowledge of these biomechanical processes is critical to better understand the development of the nervous system, the pathological progression of neurodegenerative diseases, acute traumatic injury, and for designing novel approaches to promote neuronal regeneration following disease, stroke, or trauma. Mechanical properties and forces shape the development of the nervous system from the cellular up to the organ level. Recent advances in quantitative live cell imaging, biophysical, and nanotechnological methods such as traction force microscopy, optical tweezers, and atomic force microscopy have enabled researchers to gain better insights into how cytoskeletal dynamics and motor-driven transport, membrane-dynamics, adhesion, and substrate rigidity influence axonal elongation. Given the complexity and mechanical nature of this problem, mathematical modeling contributes significantly to our understanding of neuronal mechanics. Nonetheless, there has been limited direct interaction and discussions between experimentalists and theoreticians in this research area. The purpose of this Frontiers Research Topic is to highlight exciting, and important work that is currently developing in the fields of neuronal cell biology, neuronal mechanics, intracellular transport, and mathematical modeling in the form of primary research articles, reviews, perspectives, and commentaries.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 42,5 Mb
Release : 2016
Category : Electronic
ISBN : OCLC:1368444197

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Neuronal Mechanics and Transport by Anonim Pdf

Understanding the underlying mechanisms of how axons and dendrites develop is a fundamental problem in neuroscience and a main goal of research on nervous system development and regeneration. Previous studies have provided a tremendous amount of information on signaling and cytoskeletal proteins regulating axonal and dendritic growth and guidance. However, relatively little is known about the relative contribution and role of cytoskeletal dynamics, transport of organelles and cytoskeletal components, and force generation to axonal elongation. Advancing the knowledge of these biomechanical processes is critical to better understand the development of the nervous system, the pathological progression of neurodegenerative diseases, acute traumatic injury, and for designing novel approaches to promote neuronal regeneration following disease, stroke, or trauma. Mechanical properties and forces shape the development of the nervous system from the cellular up to the organ level. Recent advances in quantitative live cell imaging, biophysical, and nanotechnological methods such as traction force microscopy, optical tweezers, and atomic force microscopy have enabled researchers to gain better insights into how cytoskeletal dynamics and motor-driven transport, membrane-dynamics, adhesion, and substrate rigidity influence axonal elongation. Given the complexity and mechanical nature of this problem, mathematical modeling contributes significantly to our understanding of neuronal mechanics. Nonetheless, there has been limited direct interaction and discussions between experimentalists and theoreticians in this research area. The purpose of this Frontiers Research Topic is to highlight exciting and important work that is currently developing in the fields of neuronal cell biology, neuronal mechanics, intracellular transport, and mathematical modeling in the form of primary research articles, reviews, perspectives, and commentaries.

Author : John Elam
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 48,6 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781468411973

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Axonal Transport in Neuronal Growth and Regeneration by John Elam Pdf

Over the past several years, the pace of research on the control of axonal growth has increased at a remarkable rate, and this activity is reflected in a growing literature dealing with various aspects of axonal growth and regener ation. It appears timely to review the role played by axonal transport in the intrinsic responses of neurons in the growth and regrowth processes. Through the cooperation of the senior editors of this series, we have been given the opportunity to bring such a focus to the current volume. We wish to acknowledge that the contributing authors attended a confer ence on "The Role of Axonal Transport in Neuronal Growth and Regenera tion" held in Tallahassee, Florida in March, 1983, sponsored by the Psycho biology Research Center of the Florida State University. It is our hope that many of the perceptions and insights expressed in these chapters resulted from our interactions.

Author : Bradley Layton
Publisher : CRC Press
Page : 232 pages
File Size : 41,6 Mb
Release : 2015-03-18
Category : Medical
ISBN : 9789814613446

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Molecular and Cellular Biomechanics by Bradley Layton Pdf

This book bridges the gap between life sciences and physical sciences by providing several perspectives on cellular and molecular mechanics on a fundamental level. It begins with a general introduction to the scales and terms that are used in the field of cellular and molecular biomechanics and then moves from the molecular scale to the tissue scale. It discusses various tissues or cellular systems through the chapters written by prominent engineers and physicists working in various fields of biomechanics. "Big picture" items, such as the number of atoms in cells and the number of cells in an organism, are discussed, followed by several of the physical laws that play a central role in nanoscale biomechanics, including the mechanics of the nucleus and its associated molecules. The book provides several case studies in atomic force microscopy and examines the physical relationship between living cells and laboratory substrata. It delves deeply into the molecular mechanisms of axonal growth, transport, and repair and provides a mechanistic framework for understanding the underlying molecular conditions that contribute to heart disease. While the quantitative and straightforward language of the book will help the engineering community grasp the concepts better and utilize them effectively, the questions given in each chapter will encourage upper-level undergraduate students, graduate students, or those generally interested in understanding cellular and molecular mechanics to dig deeper into the material. The complimentary solutions manual is available for qualified instructors upon request.

Author : Horacio D. Espinosa,Gang Bao
Publisher : John Wiley & Sons
Page : 519 pages
File Size : 52,6 Mb
Release : 2012-12-12
Category : Technology & Engineering
ISBN : 9781118482599

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Nano and Cell Mechanics by Horacio D. Espinosa,Gang Bao Pdf

Research in nano and cell mechanics has received much attention from the scientific community as a result of society needs and government initiatives to accelerate developments in materials, manufacturing, electronics, medicine and healthcare, energy, and the environment. Engineers and scientists are currently engaging in increasingly complex scientific problems that require interdisciplinary approaches. In this regard, studies in this field draw from fundamentals in atomistic scale phenomena, biology, statistical and continuum mechanics, and multiscale modeling and experimentation. As a result, contributions in these areas are spread over a large number of specialized journals, which prompted the Editors to assemble this book. Nano and Cell Mechanics: Fundamentals and Frontiers brings together many of the new developments in the field for the first time, and covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. Key features: • Provides an overview of recent advances in nano and cell mechanics. • Covers experimental, analytical, and computational tools used to investigate biological and nanoscale phenomena. • Covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. • Presents multiscale-multiphysics modeling and experimentation techniques. • Examines applications in materials, manufacturing, electronics, medicine and healthcare. Nano and Cell Mechanics: Fundamentals and Frontiers is written by internationally recognized experts in theoretical and applied mechanics, applied physics, chemistry, and biology. It is an invaluable reference for graduate students of nano- and bio-technologies, researchers in academia and industry who are working in nano and cell mechanics, and practitioners who are interested in learning about the latest analysis tools. The book can also serve as a text for graduate courses in theoretical and applied mechanics, mechanical engineering, materials science, and applied physics.

Author : W. Maxwell Cowan,Michel A. Cuénod
Publisher : Elsevier Science & Technology
Page : 394 pages
File Size : 53,8 Mb
Release : 1975
Category : Medical
ISBN : UOM:39015004417021

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The Use of Axonal Transport for Studies of Neuronal Connectivity by W. Maxwell Cowan,Michel A. Cuénod Pdf

Author : Eduardo E. Benarroch
Publisher : Oxford University Press
Page : 833 pages
File Size : 48,6 Mb
Release : 2021
Category : Medical
ISBN : 9780190948894

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Neuroscience for Clinicians by Eduardo E. Benarroch Pdf

"The aim of this book is to provide the clinician with a comprehensive and clinical relevant survey of emerging concepts on the organization and function of the nervous system and neurologic disease mechanisms, at the molecular, cellular and system levels. The content of is based on the review of information obtained from recent advances in genetic, molecular and cell biology techniques, electrophysiological recordings, brain mapping, and mouse models, emphasizing the clinical and possible therapeutic implications. Many chapters of this book contain information that will be relevant not only clinical neurologists but also to psychiatrists and physical therapists. The scope includes the mechanisms and abnormalities of DNA/RNA metabolism, proteostasis, vesicular biogenesis, and axonal transport and mechanisms of neurodegeneration; the role of the mitochondria in cell function and death mechanisms; ion channels, neurotransmission and mechanisms of channelopathies and synaptopathies; the functions of astrocytes, oligodendrocytes and microglia and their involvement in disease; the local circuits and synaptic interactions at the level of the cerebral cortex, thalamus, basal ganglia, cerebellum, brainstem and spinal cord transmission regulating sensory processing, behavioral state and motor functions; the peripheral and central mechanisms of pain and homeostasis; and networks involved in emotion, memory, language, and executive function"--

Author : Haym Benaroya,Mark Nagurka,Seon Mi Han
Publisher : Rutgers University Press
Page : 615 pages
File Size : 42,6 Mb
Release : 2022-07-15
Category : Technology & Engineering
ISBN : 9781978831070

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Mechanical Vibration by Haym Benaroya,Mark Nagurka,Seon Mi Han Pdf

The Fifth edition of this classic textbook includes a solutions manual. Extensive supplemental instructor resources are forthcoming in the Fall of 2022. Mechanical Vibration: Theory and Application presents comprehensive coverage of the fundamental principles of mechanical vibration, including the theory of vibration, as well as discussions and examples of the applications of these principles to practical engineering problems. The book also addresses the effects of uncertainties in vibration analysis and design and develops passive and active methods for the control of vibration. Many example problems with solutions are provided. These examples as well as compelling case studies and stories of real-world applications of mechanical vibration have been carefully chosen and presented to help the reader gain a thorough understanding of the subject. There is a solutions manual for instructors who adopt this book. Request a solutions manual here (https://www.rutgersuniversitypress.org/mechanical-vibration).

Author : Gregory Kolt,Lynn Snyder-Mackler
Publisher : Elsevier Health Sciences
Page : 640 pages
File Size : 45,6 Mb
Release : 2007-08-22
Category : Medical
ISBN : 9780443103513

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Physical Therapies in Sport and Exercise by Gregory Kolt,Lynn Snyder-Mackler Pdf

Physical Therapies in Sport and Exercise provides a truly comprehensive source of the latest evidence-based approaches to the assessment, management, rehabilitation and prevention of injuries related to sport and exercise. Written by an international, multidisciplinary team of contributors, all of whom are leaders in their fields, it has been expertly compiled and edited by two experienced and well-respected practitioners from Australia/New Zealand and the USA. Fully referenced and research based International team of experts are contributors Applied/practical approach New chapters on Cartilage, Prevention of Injury, and Rehabilitation of lower limb muscle and tendon injuries Authors are world leading experts in their fields representing 10 countries

Author : Irwin B. Levitan,Leonard K. Kaczmarek
Publisher : Oxford University Press, USA
Page : 640 pages
File Size : 46,9 Mb
Release : 2002
Category : Molecular neurobiology
ISBN : 0195145232

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The Neuron by Irwin B. Levitan,Leonard K. Kaczmarek Pdf

Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.

Author : Yitian Shao
Publisher : Springer Nature
Page : 148 pages
File Size : 43,8 Mb
Release : 2022-02-24
Category : Computers
ISBN : 9783030908393

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Tactile Sensing, Information, and Feedback via Wave Propagation by Yitian Shao Pdf

A longstanding goal of haptic engineering is to develop haptic interfaces that can provide realistic sensations of touch. A fundamental step towards this goal is to understand what mechanical tactile signals the hand feels during daily touch interactions. This book reveals the complex patterns of mechanical waves propagating throughout the hand that can be elicited even by simple touch interactions, which helps in expanding existing knowledge of tactile function beyond the region of near skin-object contact and inspires new designs for haptic sensing and feedback technologies. The first part of this book describes new methods for capturing dynamic, spatially distributed tactile signals in the whole hand during natural hand interactions. The second part characterizes these signals and evaluates how well and how efficiently they encode the information of touch, relating to the transmission of mechanical waves in hand tissues. The final part demonstrates how these findings can be utilized to create novel haptic effects and tactile displays. Tactile Sensing, Information, and Feedback via Wave Propagation provides a unique view of tactile sensing and feedback and will appeal to researchers, engineers, and students who are interested in learning cutting-edge haptic science and technology.

Author : Michael E. Selzer,Stephanie Clarke,Leonardo G. Cohen,Gert Kwakkel (Professor),Robert H. Miller (Professor)
Publisher : Cambridge University Press
Page : 693 pages
File Size : 46,7 Mb
Release : 2014
Category : Nervous system
ISBN : 9781107011670

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Textbook of Neural Repair and Rehabilitation by Michael E. Selzer,Stephanie Clarke,Leonardo G. Cohen,Gert Kwakkel (Professor),Robert H. Miller (Professor) Pdf

In two freestanding volumes, the Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal central nervous system, mechanisms of neuronal death, axonal regeneration, stem cell biology, and research strategies targeted at axon regeneration and neuron replacement. New chapters have been added covering pathophysiology and plasticity in cerebral palsy, stem cell therapies for brain disorders and neurotrophin repair of spinal cord damage, along with numerous others. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.

Author : Sid Becker,Andrey Kuznetsov
Publisher : Newnes
Page : 570 pages
File Size : 46,8 Mb
Release : 2013-05-21
Category : Technology & Engineering
ISBN : 9780123978493

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Transport in Biological Media by Sid Becker,Andrey Kuznetsov Pdf

Transport in Biological Media is a solid resource of mathematical models for researchers across a broad range of scientific and engineering problems such as the effects of drug delivery, chemotherapy, or insulin intake to interpret transport experiments in areas of cutting edge biological research. A wide range of emerging theoretical and experimental mathematical methodologies are offered by biological topic to appeal to individual researchers to assist them in solving problems in their specific area of research. Researchers in biology, biophysics, biomathematics, chemistry, engineers and clinical fields specific to transport modeling will find this resource indispensible. Provides detailed mathematical model development to interpret experiments and provides current modeling practices Provides a wide range of biological and clinical applications Includes physiological descriptions of models

Author : S. Amari,M. A. Arbib
Publisher : Springer Science & Business Media
Page : 460 pages
File Size : 48,6 Mb
Release : 2013-03-08
Category : Medical
ISBN : 9783642464669

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Competition and Cooperation in Neural Nets by S. Amari,M. A. Arbib Pdf

The human brain, wi th its hundred billion or more neurons, is both one of the most complex systems known to man and one of the most important. The last decade has seen an explosion of experimental research on the brain, but little theory of neural networks beyond the study of electrical properties of membranes and small neural circuits. Nonetheless, a number of workers in Japan, the United States and elsewhere have begun to contribute to a theory which provides techniques of mathematical analysis and computer simulation to explore properties of neural systems containing immense numbers of neurons. Recently, it has been gradually recognized that rather independent studies of the dynamics of pattern recognition, pattern format::ion, motor control, self-organization, etc. , in neural systems do in fact make use of common methods. We find that a "competition and cooperation" type of interaction plays a fundamental role in parallel information processing in the brain. The present volume brings together 23 papers presented at a U. S. -Japan Joint Seminar on "Competition and Cooperation in Neural Nets" which was designed to catalyze better integration of theory and experiment in these areas. It was held in Kyoto, Japan, February 15-19, 1982, under the joint sponsorship of the U. S. National Science Foundation and the Japan Society for the Promotion of Science. Participants included brain theorists, neurophysiologists, mathematicians, computer scientists, and physicists. There are seven papers from the U. S.

Author : Selwin K. Wu,Guillermo Alberto Gomez,Samantha Jane Stehbens,Anne Karine Lagendijk,Bipul R. Acharya,Aparna Ratheesh,Rashmi Priya,Alexander Bershadsky
Publisher : Frontiers Media SA
Page : 154 pages
File Size : 40,7 Mb
Release : 2023-01-05
Category : Science
ISBN : 9782832510636

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Forces in Biology: Cell and Developmental Mechanobiology and Its Implications in Disease, volume II by Selwin K. Wu,Guillermo Alberto Gomez,Samantha Jane Stehbens,Anne Karine Lagendijk,Bipul R. Acharya,Aparna Ratheesh,Rashmi Priya,Alexander Bershadsky Pdf