Neuropeptide Y And Related Peptides

Author : William F. Colmers,Claes Wahlestedt
Publisher : Springer Science & Business Media
Page : 577 pages
File Size : 55,7 Mb
Release : 1993-03-24
Category : Medical
ISBN : 9781592594658

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The Biology of Neuropeptide Y and Related Peptides by William F. Colmers,Claes Wahlestedt Pdf

Leading experts critically summarize the state of knowledge concerning the molecular, anatomical, physiological, and behavioral aspects of NPY and its congeners. Each article provides a comprehensive and in-depth survey, an overview of the role of NPY in the discipline covered, a discussion of the likely future direction that the field will take, and an up-to-date bibliography. Chapters include a treatment of the evolution of the PP family of genes, the structure of the NPY gene, and the distribution of NPY on the cardiovascular system, actions of NPY on the electrophysiological properties of nerve cells, and the effects of NPY on feeding and behavior. The chapters are written in an accessible style and serve both as an introduction to the field and as an extensive and detailed treatment of the current state of knowledge.

Author : Martin C. Michel
Publisher : Springer Science & Business Media
Page : 556 pages
File Size : 50,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642187643

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Neuropeptide Y and Related Peptides by Martin C. Michel Pdf

After a little more than 20 years since the original discovery of neuropeptide Y (NPY) by Tatemoto and colleagues, the field of NPY research has made remarkable progress and is coming of age.The present volume addresses all major topics in connection with NPY and related peptides by established leaders in their respective areas. Experienced NPY-aficionados will certainly find new and useful additional information in this volume and newcomers to the field will hopefully discover how much exciting research this still has to offer.

Author : William Colmers,Claes Wahlestedt
Publisher : Unknown
Page : 584 pages
File Size : 49,6 Mb
Release : 2014-01-15
Category : Electronic
ISBN : 1475767242

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The Biology of Neuropeptide Y and Related Peptides by William Colmers,Claes Wahlestedt Pdf

Author : Janet M. Allen,James Irvin Koenig
Publisher : Unknown
Page : 562 pages
File Size : 55,9 Mb
Release : 1990
Category : Baltimore, MD
ISBN : UVA:X001855073

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Central and Peripheral Significance of Neuropeptide Y and Its Related Peptides by Janet M. Allen,James Irvin Koenig Pdf

Author : Ambikaipakan Balasubramaniam
Publisher : Springer Science & Business Media
Page : 244 pages
File Size : 41,7 Mb
Release : 2008-02-05
Category : Medical
ISBN : 9781592590421

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Neuropeptide Y Protocols by Ambikaipakan Balasubramaniam Pdf

The observation that neuropeptide Y (NPY) is the most abundant peptide present in the mammalian nervous system and the finding that it elicits the most powerful orexigenic signal have led to active investigations of the properties of the NPY family of hormones, including peptide YY (PYY) and pancreatic polypeptide (PP). Nearly two decades of research have led to the identification of several NPY receptor subtypes and the development of useful receptor selective ligands. Moreover, these investigations have imp- cated NPY in the pathophysiology of a number of diseases, including feeding disorders, seizures, memory loss, anxiety, depression, and heart failure. Vigorous efforts are therefore continuing, not only to understand the bioche- cal aspects of NPY actions, but also toward developing NPY-based treatments for a variety of disorders. To facilitate these efforts, it was decided to produce the first handbook on NPY research techniques as part of the Methods in Molecular Biology Series. In compiling Neuropeptide Y Protocols, I have gathered contributions on techniques considered critical for the advancement of the NPY field from experts in various disciplines. Each chapter starts with a brief introduction, with Materials and Methods sections following. The latter sections are presented in an easy to follow step-by-step format. The last section of the chapter, Notes, highlights pitfalls and the maneuvers employed to overcome them. This information, not usually disseminated in standard research pub- cations, may prove extremely useful for investigators employing these te- niques in NYP research.

Author : Lars Grundemar,Stephen R. Bloom
Publisher : Elsevier
Page : 242 pages
File Size : 48,9 Mb
Release : 1996-11-15
Category : Medical
ISBN : 9780080537450

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Neuropeptide Y and Drug Development by Lars Grundemar,Stephen R. Bloom Pdf

Neuropeptide Y (NPY) is a ubiquitous and important messenger in the nervous system, with a wide range of physiological roles. It is involved in the body energy balance and is one of the most potent stimuli of food intake known. NPY also acts to regulate central and peripheral autonomic functions. This book, written by academic and industrial experts in the field, links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance. This book will be of interest to those working in all areas of research affected by NPY, such as food intake and energy homeostasis, cardiovascular regulation and G-protein-coupled receptors, as well as those interested in the development of drugs as NPY targets. The hypothalamic role of NPY and its relationship with eating disorders and diabetes The sympathetic nervous system role of NPY and its involvement in cardiovascular disorders Characterization of NPY receptor types and their brain distribution, molecular biology and pharmacology Development of peptide and non-peptide receptor antagonists

Author : Ramon Lim,Abel Lajtha
Publisher : Springer Science & Business Media
Page : 691 pages
File Size : 50,5 Mb
Release : 2006-09-18
Category : Medical
ISBN : 9780387303482

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Handbook of Neurochemistry and Molecular Neurobiology by Ramon Lim,Abel Lajtha Pdf

"The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies. It represents the valuable contributions of the many authors of the chapters and the guidance of the editors and most important, it represents support for research in this discipline. Based on the rapid advances in the years since the second edition."--Publisher's website.

Author : Steven L. Parker
Publisher : Unknown
Page : 0 pages
File Size : 54,8 Mb
Release : 2013
Category : Neuropeptide Y
ISBN : 1626184216

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Neuropeptide Y by Steven L. Parker Pdf

This book presents a broad summary of current knowledge concerning the structure and biochemistry of neuropeptide Y in relation to its role in feeding and interactions with receptors, transducers, effectors and channels that can also connect to food intake. The very high conservation of NPY sequence indicates its critical importance in basal metabolic regulation. Mutations connecting to NPY are virtually absent, and those affecting the Y1 and Y2 receptors are very few. From the evidence presented across vertebrate classes, NPY appears mainly as metabotropic driver via the Y1 group of receptors, and its negative metabotropicity through the Y2 receptor is only of importance in the mammal, and then tempered by Y2 receptor masking in the hypothalamus and low numbers in the cortex, and by low availability of NPY outside the forebrain. Anatomically, NPY is well-represented especially in limbic areas of the forebrain, but the feeding-critical presence of Y1 receptors is, at least in the rodent, highest in the neocortex, and evidence presented in this book points to much larger involvement of cortical NPY receptors in feeding regulation than is usually perceived. The strong presence of this highly conserved peptide in the vertebrate forebrain is increasingly documented as linked not only to the regulation of glucose metabolism (and insulin activity), but also as directly involved in the operation of transducers, effectors and channels. This should be enabled especially by the high interactivity of the acidic sector of NPY (which is not shared by NPY-related systemic peptides, peptide YY and pancreatic polypeptide), and results in partial agonism and possibly also in accumulation in the bilayer. NPY could be involved as a helper agonist in several parts of the vertebrate metabolome.

Author : Zofia Zukowska,Giora Z. Feuerstein
Publisher : Springer Science & Business Media
Page : 276 pages
File Size : 46,7 Mb
Release : 2006-03-28
Category : Medical
ISBN : 9783764374174

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NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics by Zofia Zukowska,Giora Z. Feuerstein Pdf

The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists which are in clinical development for obesity while NPY Y1 receptors are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders are also actively pursued. This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders, written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine.

Author : Trygve Tollefsbol
Publisher : Elsevier
Page : 0 pages
File Size : 50,9 Mb
Release : 2024-08-01
Category : Science
ISBN : 9780443238031

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Personalized Epigenetics by Trygve Tollefsbol Pdf

Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Includes new chapters on topics such as the limitations of personalized epigenetic variation comparisons; personalized epigenetics technologies; epigenetics of personalized nanomedicine; personalized epigenetic management of diabetes; epigenetics and chemoresistance; and personalized epigenetics and neurological disorders Covers key methodological processes that are important in personalized medicine Offers disease research case studies to provide in-depth discussion of examples of recent epigenetic research on a disease area Features topics such as forensic epigenetics, epigenetics of personalized toxicity, limitations of epigenetic variation comparisons, and nanomedicine and nutrigenomics as applied to personalized epigenetics

Author : Timothy G. Geary,Aaron Maule
Publisher : Springer Science & Business Media
Page : 246 pages
File Size : 44,5 Mb
Release : 2011-01-13
Category : Medical
ISBN : 9781441969026

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Neuropeptide Systems as Targets for Parasite and Pest Control by Timothy G. Geary,Aaron Maule Pdf

The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.

Author : Hubert Vaudry,Marie-Christine Tonon,David Vaudry
Publisher : Frontiers Media SA
Page : 282 pages
File Size : 44,6 Mb
Release : 2018-07-24
Category : Electronic
ISBN : 9782889455379

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Trends in Regulatory Peptides by Hubert Vaudry,Marie-Christine Tonon,David Vaudry Pdf

Regulatory peptides represent the most diverse and versatile family of messenger molecules. They are produced by all living organisms from bacteria to mammals. They are involved in a wide variety of biological functions. Biologically active peptides and their receptors thus constitute an unlimited source of inspiration for the development of innovative drugs and cosmetics. The present eBook is a unique collection of research articles and reviews that provide a representative examplification of the latest progress in regulatory peptide research.

Author : Charles D. Barnes,Craig Johnston
Publisher : CRC Press
Page : 306 pages
File Size : 46,9 Mb
Release : 1991-09-20
Category : Medical
ISBN : 0849388481

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Brain-gut Peptides and Reproductive Function by Charles D. Barnes,Craig Johnston Pdf

This book elucidates the role of brain-gut peptides in neuroendocrine regulation for understanding how these peptides interact with the reproductive neuroendocrine axis and for developing novel therapeutic agents for fertility or contraceptive therapies.

Author : Viktor Mutt
Publisher : Unknown
Page : 392 pages
File Size : 45,9 Mb
Release : 1989
Category : Medical
ISBN : UOM:39015015447264

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Neuropeptide Y by Viktor Mutt Pdf

Author : Yvette Tache,John E. Morley,Marvin R. Brown
Publisher : Springer Science & Business Media
Page : 360 pages
File Size : 52,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461235149

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Neuropeptides and Stress by Yvette Tache,John E. Morley,Marvin R. Brown Pdf

Neuropeptides and Stress presents a comprehensive survey by leading pioneers in the field of the knowledge and concepts implicating neuropeptides in the regulations of responses to stress. Topics covered include: recent advances on the regulation and modulation of the behavioral, endocrine, autonomic, gastrointestinal, immune and analgesic responses to stress by neuropeptides. Neuroanatomical and biological data are considered. Special emphasis is given to corticotropin-releasing factor (CRF) and opioid peptides.