Personalized Epigenetics

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Personalized Epigenetics

Trygve Tollefsbol

Author : Trygve Tollefsbol
Publisher : Academic Press
Page : 610 pages
File Size : 45,9 Mb
Release : 2015-04-28
Category : Science
ISBN : 9780128004364

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Personalized Epigenetics by Trygve Tollefsbol Pdf

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

Epigenetic Biomarker and Personalized Precision Medicine

Jiucun Wang,Dongyi He,Momiao Xiong,Yun Liu

Author : Jiucun Wang,Dongyi He,Momiao Xiong,Yun Liu
Publisher : Frontiers Media SA
Page : 485 pages
File Size : 42,7 Mb
Release : 2020-12-21
Category : Science
ISBN : 9782889661848

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Epigenetic Biomarker and Personalized Precision Medicine by Jiucun Wang,Dongyi He,Momiao Xiong,Yun Liu Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Change Your Genes, Change Your Life

Dr Kenneth R. Pelletier

Author : Dr Kenneth R. Pelletier
Publisher : Red Wheel/Weiser
Page : 214 pages
File Size : 47,8 Mb
Release : 2018-10-01
Category : Health & Fitness
ISBN : 9781579830571

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Change Your Genes, Change Your Life by Dr Kenneth R. Pelletier Pdf

Our biology is no longer destiny. Our genes respond to everything we do, according to the revolutionary new science of epigenetics. In other words, our inherited DNA doesn’t rigidly determine our health and disease prospects as the previous generation of geneticists believed. Especially in the last ten years, scientists have confirmed that the vast majority of our genes are actually fluid and dynamic. An endless supply of new studies prove that our health is an expression of how we live our lives—that what we eat and think and how we handle daily stress, plus the toxicity of our immediate environment—creates an internal biochemistry that can actually turn genes on or off. Managing these biochemical effects on our genome is the new key to radiant wellness and healthy longevity. Now gaining broad credibility among scientists, the study of epigenetics is at the forefront of modern medicine. According to the author, the real upshot of the epigenetic revolution is that it opens the door to what futurists call personalized medicine. For the first time in a trade book, Dr. Pelletier explains in layperson’s language the genetic biomarkers that will become the standard reference for measuring which specific lifestyle changes are required to optimize a given individual’s health. In the very near future, each person’s state-of-the-art genetic and epigenetic profile—matched with other precise indicators such as assays of the gut microbiome—will guide their daily health practices. This short but profound book by a world-renowned pioneer in integrative medicine introduces readers to this exciting new field, and reveals the steps that each of us can take today to change our genetic expression and thereby optimize our health for a lifetime.

The Epigenetics of Autoimmunity

Rongxin Zhang

Author : Rongxin Zhang
Publisher : Academic Press
Page : 432 pages
File Size : 43,9 Mb
Release : 2018-04-25
Category : Medical
ISBN : 9780128099285

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The Epigenetics of Autoimmunity by Rongxin Zhang Pdf

The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment. Provides the accurate and cutting-edge information on autoimmunity epigenetics Wide coverage appeals to those interested in fundamental epigenetics and inheritance to those with more clinical interests Critical reviews of the mean of deriving and analysing autoimmunity epigenetics information as well as its translational potential Up-to-date coverage of emerging topics in autoimmunity epigenetics

Clinical Epigenetics

Luke B. Hesson,Antonia L. Pritchard

Author : Luke B. Hesson,Antonia L. Pritchard
Publisher : Springer Nature
Page : 265 pages
File Size : 44,5 Mb
Release : 2019-08-31
Category : Medical
ISBN : 9789811389580

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Clinical Epigenetics by Luke B. Hesson,Antonia L. Pritchard Pdf

In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.

Prognostic Epigenetics

Anonim

Author : Anonim
Publisher : Academic Press
Page : 442 pages
File Size : 49,8 Mb
Release : 2019-11-01
Category : Medical
ISBN : 9780128142608

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Prognostic Epigenetics by Anonim Pdf

This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can be applied in drug development and for better diagnosis and prognosis of diseases. Prognostic Epigenetics is the most-inclusive volume to-date specifically dedicated to epigenetic markers that have been developed for prognosis of diseases, recent advances in this field, the clinical implementation of this research, and the future outlook. Compiles all known information on prognostic epigenetics and its role in preventive medicine and drug discovery Covers the basic functionality of epigenetic mechanisms involved in early disease prognosis and diagnosis, and provides tools for the identification and development of these biomarkers for a wide range of diseases Enables clinicians, researchers, and pharmacologists to improve preventive medicine and precision therapeutics throughout a person’s lifetime Features chapter contributions from leading international researchers

Personalized Precision Medicine: Role of Epigenetic Biomarkers

Tommy Royal

Author : Tommy Royal
Publisher : American Medical Publishers
Page : 0 pages
File Size : 40,9 Mb
Release : 2023-09-19
Category : Medical
ISBN : 9798887403717

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Personalized Precision Medicine: Role of Epigenetic Biomarkers by Tommy Royal Pdf

Epigenetics is the study of heritable phenotype changes that do not entail changes in the DNA sequence. Epigenetic abnormalities have emerged as the most promising biomarkers for diagnosis and prognosis in the early stage of illnesses, such as cancer, autoimmune diseases and psychological disorders. A medical model in which people are divided into groups with medical decisions, practices, interventions and products being tailored to the individual patient based on their predicted response or risk of disease is referred as personalized medicine. The terms precision medicine and personalized medicine are utilized interchangeably for describing the concept. Diagnostic testing is used often in personalized medicine to determine suitable and optimal therapies based on a patient's genetic content, or other molecular or cellular analysis. Certain aspects of personalized medicine utilize genetic information, such as pharmacogenomics. With the help of genomics, proteomics and imaging techniques, molecular scale data of the patients is obtained easily. These molecular biomarkers are then used in determining the prognosis of diseases such as cancer. The readers would gain knowledge that would broaden their perspective about personalized precision medicine through this book. Also included herein is a detailed explanation of the role of epigenetic biomarkers. This book will help the readers in keeping pace with the rapid changes in this field of study.

Personalized Medicine in the Making

Chiara Beneduce,Marta Bertolaso

Author : Chiara Beneduce,Marta Bertolaso
Publisher : Springer Nature
Page : 334 pages
File Size : 45,8 Mb
Release : 2022-03-07
Category : Medical
ISBN : 9783030748043

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Personalized Medicine in the Making by Chiara Beneduce,Marta Bertolaso Pdf

This book offers a multidisciplinary look at the much-debated concept of “personalized medicine”. By combining a humanistic and a scientific approach, the book builds up a multidimensional way to understand the limits and potentialities of a personalized approach in medicine and healthcare. The book reflects on personalized medicine and complex diseases, the relationship between personalized medicine and the new bio-technologies, personalized medicine and personalized nutrition, and on some ethical, political, economic, and social implications of personalized medicine. This volume is of interest to researchers from several disciplines including philosophy, bio-medicine, and the social sciences. Chapter 16, “The Impact of Fantasy” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Epigenetics and Metabolomics

Paban K. Agrawala,Poonam Rana

Author : Paban K. Agrawala,Poonam Rana
Publisher : Elsevier
Page : 478 pages
File Size : 53,5 Mb
Release : 2021-08-25
Category : Medical
ISBN : 9780323856539

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Epigenetics and Metabolomics by Paban K. Agrawala,Poonam Rana Pdf

Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare. Offers a synthesized discussion of epigenetic regulation of metabolic activity and systems-based approaches to power new research Discusses epigenetic control of metabolic pathways and possible therapeutic targets for cancer, neurodegenerative, and neuroendocrine diseases, among others Provides guidance in epigenomics and metabolomic research methodology

Epigenetic Biomarkers and Diagnostics

José Luis García-Giménez

Author : José Luis García-Giménez
Publisher : Academic Press
Page : 696 pages
File Size : 42,6 Mb
Release : 2015-12-07
Category : Science
ISBN : 9780128019214

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Epigenetic Biomarkers and Diagnostics by José Luis García-Giménez Pdf

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

Epigenetics in Cardiovascular Disease

Yvan Devaux,Emma Louise Robinson

Author : Yvan Devaux,Emma Louise Robinson
Publisher : Academic Press
Page : 500 pages
File Size : 47,7 Mb
Release : 2021-03-06
Category : Medical
ISBN : 9780128222591

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Epigenetics in Cardiovascular Disease by Yvan Devaux,Emma Louise Robinson Pdf

Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease. Offers a thorough overview of role of epigenetics mechanisms in cardiovascular disease Includes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics research Explores biomarkers and drug targets of therapeutic potential to advance personalized healthcare Features chapter contributions from a wide range of international researchers in the field

Medical Epigenetics

Anonim

Author : Anonim
Publisher : Academic Press
Page : 972 pages
File Size : 53,5 Mb
Release : 2021-08-27
Category : Medical
ISBN : 9780128243268

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Medical Epigenetics by Anonim Pdf

Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs. Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Organized from system disorders to multi-system disorders that involve epigenetic aberrations Examines the role of epigenetics in precision medicine

Epigenetics Explained. How Modern Biology is Changing the Concepts of Genetics and Inheritance. How the environment can affect our genes.

Frank Brown

Author : Frank Brown
Publisher : Youcanprint
Page : 340 pages
File Size : 45,9 Mb
Release : 2021-09-15
Category : Medical
ISBN : 9791220357975

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Epigenetics Explained. How Modern Biology is Changing the Concepts of Genetics and Inheritance. How the environment can affect our genes. by Frank Brown Pdf

You Are About To Develop A Comprehensive Understanding Of The Concept Of Epigenetics, Its Place In Modern Day Medicine, And Health Optimization And Why It Is Literally Changing How We Approach The Treatment Of Various Health Problems! Modern research has now confirmed that the behavior of your genes doesn't always depend on their DNA sequence, but also on factors referred to epigenetics, and that changes in these factors can play a critical role in disease, life structures, behavior and all aspects of life. And that's not all; research also shows that therapies based on these factors have proven effective in reversing some conditions, boosting the immune system, optimizing psychology and human adaptation. Epigenetics have thus taken the center stage in understanding human biology at a deeper level, life, and evolution. But what are epigenetics, and how to they work? How does the environment affect them, and how is this "remembered" in the body? How does epigenetic therapy work? What does it treat? Isn't it risky? What is the relationship between epigenetics and the human psychology? How can we benefit from the discovery and understanding of epigenetics? If you have these and other related questions, this 2 in 1 book is for you so keep reading. Here is a bit of what you'll learn from this 2 in 1 book: • What epigenetics are, why they're important and how they work • How epigenetics relate with our experiences • How cells divide, and how genes control the growth and division of cells • The difference between the DNA, gene and chromosomes •The existing evidence of epigenetic changes, including in transgenerational epigenetic inheritance • The ins and outs of epigenetics mechanisms • The types of epigenetic therapies available today, including their risks, benefits and research on them • The effect of epigenetic control in transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping • How epigenetics work at the molecular level and the effect of DNA damage in epigenetic change • The functions of epigenetics, and how they boost mindfulness training, healthy eating and exercise • How epigenetic therapy and modifications affects diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia, mesothelioma and many more • How epigenetic modifications are used in understanding plant and animal evolution • How epigenetic mechanisms are used in understanding human adaptation, boosting memory formation, growth and reinforcing infant neurobehavior. • The role of epigenetic mechanisms in maternal care • The role of environmental chemicals in epigenetics • How epigenetics are involved in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more. • The role of environmental exposures in pathophysiology of IPF • Modulation of epigenetic marks by environmental exposures • How epigenetic regulation affects the immune system …And so much more! Whether you are a beginner or an intermediate in epigenetics, you will find this book educative, as you learn the A-Z of factors that are quickly changing our understanding of the structure of life. Don't wait…. Scroll up and click Buy Now with 1-Click or Buy Now to get started!

Perinatal and Developmental Epigenetics

Garima Singh

Author : Garima Singh
Publisher : Academic Press
Page : 406 pages
File Size : 44,9 Mb
Release : 2022-12-02
Category : Medical
ISBN : 9780128217863

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Perinatal and Developmental Epigenetics by Garima Singh Pdf

Perinatal and Developmental Epigenetics, Volume 32, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental and perinatal stages, illuminating pathways for drug discovery and clinical advances. Here, over 25 international researchers examine recent steps forward in our understanding of epigenetic programming during perinatal and early development. The book opens with an in-depth introduction to known and newly discovered epigenetic marks and how they regulate various cellular processes. Later sections examine various prenatal and perinatal environmental experiences and their ability to derail the normal developmental trajectory via epigenetic reprogramming. Insights and suggestions for future research illuminate approaches for identifying individual disease susceptibility. Concluding chapters highlight preventative and targeted therapeutic pathways to improve quality of life into adulthood. Examines disease onset stemming from epigenetic changes during the perinatal periods Features contributions from international experts in the field, including basic biology, disease research and drug discovery Offers intervention strategies to mitigate adverse developmental programming to improve health outcomes

Epigenetics in Biology and Medicine

Manel Esteller

Author : Manel Esteller
Publisher : CRC Press
Page : 312 pages
File Size : 47,5 Mb
Release : 2008-09-17
Category : Science
ISBN : 1420007076

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Epigenetics in Biology and Medicine by Manel Esteller Pdf

Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its

Personalized Epigenetics

Personalized Epigenetics by Trygve Tollefsbol Pdf

Epigenetic Biomarker and Personalized Precision Medicine by Jiucun Wang,Dongyi He,Momiao Xiong,Yun Liu Pdf

Change Your Genes, Change Your Life by Dr Kenneth R. Pelletier Pdf

The Epigenetics of Autoimmunity by Rongxin Zhang Pdf

Clinical Epigenetics by Luke B. Hesson,Antonia L. Pritchard Pdf

Prognostic Epigenetics by Anonim Pdf

Personalized Precision Medicine: Role of Epigenetic Biomarkers by Tommy Royal Pdf

Personalized Medicine in the Making by Chiara Beneduce,Marta Bertolaso Pdf

Epigenetics and Metabolomics by Paban K. Agrawala,Poonam Rana Pdf

Epigenetic Biomarkers and Diagnostics by José Luis García-Giménez Pdf

Epigenetics in Cardiovascular Disease by Yvan Devaux,Emma Louise Robinson Pdf

Medical Epigenetics by Anonim Pdf

Epigenetics Explained. How Modern Biology is Changing the Concepts of Genetics and Inheritance. How the environment can affect our genes. by Frank Brown Pdf

Perinatal and Developmental Epigenetics by Garima Singh Pdf

Epigenetics in Biology and Medicine by Manel Esteller Pdf

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