Neurotransmitter Release The Neuromuscular Junction

Author : Francesco Clementi
Publisher : Elsevier
Page : 248 pages
File Size : 40,8 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323159180

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Neurotransmitter Release the Neuromuscular Junction by Francesco Clementi Pdf

Neurotransmitter Release: The Neuromuscular Junction is a collection of papers presented at a small meeting organized in the University of Milan to honor Bruno Ceccarelli. Ceccarelli was particularly interested in the structure and functioning of the neuromuscular junction and spent the rest of his career characterizing the process of neurotransmitter release, and eventually providing the strongest available support for the widely accepted ""vesicle hypothesis"" of neurotransmitter release. The meeting was intended to gather as many scientists who had been directly in touch with Bruno as possible and to discuss together problems of Bruno's interest. Organized into 20 chapters, the book first discusses the organelles of distinct secretory pathways involved in distinct types of neuronal signaling, such as synapsins, synaptophysin , and synaptobrevin. It then examines the role of coated vesicles, acetylcholine compartments, and potassium and calcium channels on neurotransmission processes. Other topics considered are the regeneration of nerve-evoked neurotransmission; the single-channel recordings of KNa in avian sensory neurons; the modulation of voltage-dependent calcium currents in identified snail neurons; and the agonistic/antagonistic action of calcium channel in mammalian peripheral neurons. Cross-talks between receptors coupled to calcium currents and between different intracellular signaling are provided in the last chapters of the book. These chapters also look into the relevance of lipoxygenase metabolites of arachidonic acid to cell-to-cell communication in the central nervous system. This book is an invaluable source for scientists, researchers, and students who are interested in basic neurology.

Author : B. Ceccarelli,Francesco Clementi
Publisher : Unknown
Page : 6 pages
File Size : 52,8 Mb
Release : 1989
Category : Myoneural junction
ISBN : OCLC:21241689

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Neurotransmitter Release by B. Ceccarelli,Francesco Clementi Pdf

Author : Zhao-Wen Wang
Publisher : Springer Science & Business Media
Page : 354 pages
File Size : 41,5 Mb
Release : 2010-11-16
Category : Medical
ISBN : 9781597454810

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Molecular Mechanisms of Neurotransmitter Release by Zhao-Wen Wang Pdf

Neurons in the nervous system organize into complex networks and their functions are precisely controlled. The most important means for neurons to communicate with each other is transmission through chemical synapses, where the release of neurotransmitters by the presynaptic nerve terminal of one neuron influences the function of a second neuron. Since the discovery of chemical neurotransmission by Otto Loewi in the 1920s, great progress has been made in our understanding of mol- ular mechanisms of neurotransmitter release. The last decade has seen an explosion of knowledge in this field. The aim of Molecular Mechanisms of Neurotransmitter Release is to provide up-to-date, in-depth coverage of essentially all major mole- lar mechanisms of neurotransmitter release. The contributors have made great efforts to write concisely but with sufficient background information, and to use figures/diagrams to present clearly key concepts or experiments. It is hoped that this book may serve as a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for people who have a general interest in neuroscience. I was fortunate to be able to gather contributions from a group of outstanding scientists. I thank them for their efforts. In particular, I want to thank Dr. Erik Jorgensen who offered valuable suggestions about the book in addition to contrib- ing an excellent chapter. I thank US National Science Foundation and National Institute of Health for their supports.

Author : Hugo J. Bellen
Publisher : Unknown
Page : 466 pages
File Size : 48,8 Mb
Release : 1999
Category : Cellular signal transduction
ISBN : UOM:39015048547338

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Neurotransmitter Release by Hugo J. Bellen Pdf

Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons thatcommunicate with each other and their targets. This fast and accurate intercellular signalling most occurs at synapses, specialized processes of neurons that release chemical signals, called neurotransmitters. Neurotransmitters: Frontiers in Molecular Biology will provide the reader withextensive background information on neurotransmitter release. It takes a multidisciplinary approach, but does not assume previous knowledge having basic introductions to most topics. Topics however are covered in enough detail to be of interest to experts in the field. Throughout, emphasis is placedon the rationale by which proteins are assigned specific functions rather than just providing facts about function. The first chapter provides an introduction to the basic features and properties of the synapse and is followed by a chapter detailing several important techniques used to elucidatevarious aspects of release. Chapters 3 describes many of the biochemical approaches used to identify proteins involved in neurotransmitter release and then chapters 4 and 5 focus on more specific aspects of synaptic transmission: the proteins that transport neurotransmitters and the role ofphosphlipids in the process. The next five chapters concentrate on approaches to unravel the function of many proteins in vivo by using toxins, giant squid axons, C. elegans, Drosophila, and mice. The final chapter summarizes current knowledge on endocytosis and recycling. Knowledge of themolecular mechanisms underlying neurotransmitter release has expanded tremendously over the last 10 years. Many of the proteins involved have been isolated, but their roles have yet to be determined. These discoveries will be a major challenge and it is therefore the major aim of this book not onlyto provide information but also to generate excitement.

Author : Jeffrey Feigenbaum,Menachem Hanani
Publisher : Unknown
Page : 516 pages
File Size : 44,6 Mb
Release : 1991
Category : Electronic
ISBN : UCLA:L0072026107

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Presynaptic Regulation of Neurotransmitter Release by Jeffrey Feigenbaum,Menachem Hanani Pdf

Author : Thomas C. Südhof,Klaus Starke
Publisher : Springer Science & Business Media
Page : 582 pages
File Size : 51,9 Mb
Release : 2007-12-07
Category : Medical
ISBN : 9783540748052

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Pharmacology of Neurotransmitter Release by Thomas C. Südhof,Klaus Starke Pdf

It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. In the second part of the book, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process.

Author : David Chambers,Christopher Huang,Gareth Matthews
Publisher : Cambridge University Press
Page : 469 pages
File Size : 51,7 Mb
Release : 2019-07-25
Category : Medical
ISBN : 9781108463997

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Basic Physiology for Anaesthetists by David Chambers,Christopher Huang,Gareth Matthews Pdf

Easily understood, up-to-date and clinically relevant, this book provides junior anaesthetists with an essential physiology resource.

Author : Bernard Katz
Publisher : Unknown
Page : 80 pages
File Size : 49,8 Mb
Release : 1969
Category : Science
ISBN : STANFORD:36105031302958

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The Release of Neural Transmitter Substances by Bernard Katz Pdf

Author : Andreas Rummel,Thomas Binz
Publisher : Springer Science & Business Media
Page : 322 pages
File Size : 41,8 Mb
Release : 2012-12-14
Category : Medical
ISBN : 9783642335709

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Botulinum Neurotoxins by Andreas Rummel,Thomas Binz Pdf

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

Author : Constance Hammond
Publisher : Academic Press
Page : 444 pages
File Size : 43,7 Mb
Release : 2014-12-30
Category : Medical
ISBN : 9780123973221

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Cellular and Molecular Neurophysiology by Constance Hammond Pdf

Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. 70% new or updated material in full color throughout, with more than 350 carefully selected and constructed illustrations Fifteen appendices describing neurobiological techniques are interspersed in the text

Author : Alex S. Evers,Mervyn Maze,Evan D. Kharasch
Publisher : Cambridge University Press
Page : 128 pages
File Size : 53,6 Mb
Release : 2011-03-10
Category : Medical
ISBN : 9781139497022

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Anesthetic Pharmacology by Alex S. Evers,Mervyn Maze,Evan D. Kharasch Pdf

In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

Author : Scott Brady,George Siegel,R. Wayne Albers,Donald Price
Publisher : Academic Press
Page : 1120 pages
File Size : 41,5 Mb
Release : 2011-11-02
Category : Science
ISBN : 9780080959016

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Basic Neurochemistry by Scott Brady,George Siegel,R. Wayne Albers,Donald Price Pdf

Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475

Author : D. J. Aidley
Publisher : Cambridge University Press
Page : 553 pages
File Size : 46,9 Mb
Release : 1979-01-31
Category : Science
ISBN : 0521293081

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The Physiology of Excitable Cells by D. J. Aidley Pdf

This book provides the reader with an account of some of the experimental evidence on which our present knowledge is based. The third edition of this highly successful book has been extensively revised and restructured to incorporate the many recent advances in the subject, including new information on the properties of single ionic channels and the molecular biology of membrane proteins. There are many new illustrations and numerous references to recent work. The essential philosophy of the book remains the same: fundamental concepts are clearly explained and key experiments are examined in some detail. The contents of the book that was so successfully launched in 1971 are now appropriate to the challenges of the 1990s. The book is primarily intended for use by students of physiology, biophysics, neuroscience or zoology, and will be useful to those beginning research, and to scientists of related disciplines. Copyright © Libri GmbH. All rights reserved.

Author : S. Pögün
Publisher : Springer Science & Business Media
Page : 336 pages
File Size : 41,8 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783642607042

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Neutrotransmitter Release and Uptake by S. Pögün Pdf

Even though transmitter release and re-uptake are very complementary and physically in close proximity, researchers usually focus on only one of these two aspects. This volume, however, covers both processes and brings together two major presynaptic events in transcellular communication. It comprises 24 chapters and is divided into two parts: Part I, Neurotransmitter Release, and Part II, Neurotransmitter Uptake. The included topics range from ultrastructure and molecular control mechanisms to pathophysiology of some diseased states. Neuronal as well as non-neuronal mechanisms are treated. The concluding chapter emphasizes the importance of interdisciplinary collaboration and provides a link between the events in the presynaptic terminal and behavior.

Author : David A. Powis
Publisher : Cambridge University Press
Page : 382 pages
File Size : 46,8 Mb
Release : 1995-08-24
Category : Medical
ISBN : 0521446163

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Neurotransmitter Release and Its Modulation by David A. Powis Pdf

A uniquely comprehensive and integrated account of neurotransmitter modulation. Suitable for neuroscientists and non-specialists alike.