New Approaches In Eukaryotic Dna Replication

Author : A. De Recondo
Publisher : Springer Science & Business Media
Page : 361 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468443974

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New Approaches in Eukaryotic DNA Replication by A. De Recondo Pdf

DNA replication in eukaryotes is an important field, particular ly because of its direct impact on the study of cancer. The under standing of molecular mechanisms of replication and their regulation should allow a better comprehension of the alterations that lead to the proliferation of tumor cells and to error-prone repair in cells exposed to radiation or chemical carcinogens. During the last several years, many enzymes and proteins which participate in replication of DNA in eukaryotic cells have been identified, isolated and characterized. New concepts in chromatin structure have refocused attention on the study of replication of DNA complexed with his tones and non-histone chromosomal proteins. However, progress has been noticeably slower than for prokaryotes, essentially because of the difficulty in genetic analysis of eukaryo tic DNA replication. In June 1980, a workshop was organized in Cargese, Corsica (France) to facilitate exchanges of information between workers spe cializing in prokaryotes and those specializing in eukaryotes, and to allow discussion of new experimental approaches. With this in mind, special interest has been taken in the origin and termination of chromosome cycles and how they are controlled.

Author : Hisao Masai,Marco Foiani
Publisher : Springer
Page : 581 pages
File Size : 54,9 Mb
Release : 2018-01-22
Category : Science
ISBN : 9789811069550

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DNA Replication by Hisao Masai,Marco Foiani Pdf

This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.

Author : Sue Cotterill
Publisher : OUP Oxford
Page : 304 pages
File Size : 52,8 Mb
Release : 1999-02-18
Category : Science
ISBN : 9780191565762

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Eukaryotic DNA Replication by Sue Cotterill Pdf

Eukaryotic DNA Replication: A Practical Approach is a comprehensive practical manual, with each of its eleven chapters describing an aspect of the methods currently used to investigate DNA replication in eukaryotes. The sequence of the chapters corresponds roughly to the order of events during DNA replication. The first chapters are concerned with initiation, looking at methods to characterize origins of replication and the proteins that interact with them. There then follow chapters describing protocols for the study of the elongation phase and the synthesis of the telomeres. The final chapters provide a more general overview of the study of DNA replication - including its investigation in model systems such as yeast, xenopus and viruses, and looks into methods used to study DNA:protein interactions that could be applied to the study of replication proteins. This exciting new volume provides over 120 tried and tested protocols for the analysis of eukaryotic DNA replication and will be of major interest to a wide variety of molecular and cell biologists, biochemists and medical researchers.

Author : Samuel H. Wilson
Publisher : CRC Press
Page : 446 pages
File Size : 52,9 Mb
Release : 1990-08-31
Category : Science
ISBN : 0936923393

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Eukaryotic Nucleus by Samuel H. Wilson Pdf

Author : Samuel H. Wilson,Phyllis Strauss
Publisher : CRC Press
Page : 446 pages
File Size : 43,6 Mb
Release : 1990-08-09
Category : Science
ISBN : 0936923326

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The Eukaryotic Nucleus by Samuel H. Wilson,Phyllis Strauss Pdf

This series provides, in two volumes, a complete and exhaustive review of the subject of the eukaryotic nucleus, the site of the DNA. The focus of the book is how the information in the DNA is transcribed, accessed and maintained.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 47,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1456 pages
File Size : 53,9 Mb
Release : 1983
Category : Medicine
ISBN : MINN:31951D00170007S

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National Library of Medicine Current Catalog by National Library of Medicine (U.S.) Pdf

Author : Havukkala Ilkka
Publisher : World Scientific Publishing Company
Page : 324 pages
File Size : 51,9 Mb
Release : 2010-06-23
Category : Science
ISBN : 9789813107083

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Biodata Mining And Visualization: Novel Approaches by Havukkala Ilkka Pdf

There is a lack of an exposition on interdisciplinary and innovative methods of data mining and visualization for biodata. This book fills the gap by introducing an interdisciplinary set of the most recent methods and references on novel techniques from artificial intelligence, data mining, engineering, pattern recognition, and ontological data mining fields that are applicable to bioinformatics. The latest novel approaches are explained in detail, their advantages and disadvantages are summarized, and pointers to the future development of new applications are given. By widening the pool from which biologists and bioinformaticians can adopt methods for biodata mining and visualization, computational data mining experts in nonbiological fields are also encouraged to utilize their expertise in order to contribute to the progress of computational biology, thus enhancing the collaboration between these two disciplines.

Author : Hisao Masai,Marco Foiani
Publisher : Unknown
Page : 581 pages
File Size : 55,5 Mb
Release : 2017
Category : Biochemistry
ISBN : 9811069565

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DNA Replication by Hisao Masai,Marco Foiani Pdf

Author : Samson T. Jacob
Publisher : CRC Press
Page : 441 pages
File Size : 52,7 Mb
Release : 2018-01-18
Category : Medical
ISBN : 9781351088756

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Enzymes of Nucleic Acid Synthesis and Modification by Samson T. Jacob Pdf

The First volume gives an overview of the enzymes involved in DNA synthesis and modification; the second volume deals with the RNA-enzymes. Although the major emphasis of the book is on eukaryotic enzymes, a separate chapter dealing with prokaryotic DNA repair enzymes has been included to discuss the major advances in this field in recent years. There are two separate chapters on RNA polymerases to provide a comprehensive coverage of the enzymes from lower eukaryotes, plants and higher eukaryotes.

Author : Anonim
Publisher : Unknown
Page : 814 pages
File Size : 52,5 Mb
Release : 1993
Category : Nucleic acids
ISBN : UVA:X002542900

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Cambridge Scientific Biochemistry Abstracts by Anonim Pdf

Author : Anonim
Publisher : Academic Press
Page : 454 pages
File Size : 46,5 Mb
Release : 2021-11-12
Category : Science
ISBN : 9780323907347

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The DNA Replication-Repair Interface by Anonim Pdf

Replication-Coupled Repair, Volume 661 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including the Repair of replication-born DNA breaks by sister chromatid recombination, High resolution and high throughput DNA cyclization measurements to interrogate DNA bendability, A programmable detection method for genomic signatures: from disease diagnosis to genome editing, Characterization of the telomerase modulating activities of yeast DNA helicases, Eukaryotic DNA replication with purified budding yeast proteins, Single molecule studies of yeast Rad51 paralogs, Light activation and deactivation of Cas9 for DNA repair studies, and more. Other chapters explore MIDAS: Direct sequencing to map mitotic DNA synthesis and common fragile sites at high precision, Studying the DNA damage response in embryonic systems, GLASS-ChIP to map Mre11 cleavage sites in the human genome, New chemical biology approaches to trap reaction intermediates in living cells, Single-molecule imaging approaches for monitoring replication fork conflicts at genomic DNA G4 structures and R-loops in human cells, Monitoring the replication of structured DNA through heritable epigenetic change, Visualizing replication fork encounters with DNA interstrand crosslinks, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology series Includes the latest information on replication-coupled repair

Author : Beatrice Singer,D. Grunberger
Publisher : Springer Science & Business Media
Page : 352 pages
File Size : 49,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461337720

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Molecular Biology of Mutagens and Carcinogens by Beatrice Singer,D. Grunberger Pdf

This book originated in numerous Gordon Research Conferences and many other meetings of scientists working in chemistry, biophysics, biochemistry, and biology related to mutagenesis and carcinogenesis. It seemed the appro priate time to sit back and summarize the results of several decades of research in laboratories in different countries. We are very grateful to the Rockefeller Foundation for inviting us to formulate and begin writing the book at the Center for International Studies in Bellagio, Italy, where we were Resident Scholars. We are fortunate to have had the assistance of so many colleagues around the world who cheerfully sent original data, figures, and preprints and lis tened patiently to us as we worked out the various conflicting ideas in this fast-moving. field. The names of these scientists are found within the tables, figures, and references. There is one person whose contributions we especially wish to acknowl edge. Professor Heinz Fraenkel-Conrat was present at the inception of this book and throughout the writing encouraged and criticized in apprOximately equal proportion. Finally, his editing and amalgamation of our two styles gave us great comfort. B.S. D.G.

Author : J. Julian Blow
Publisher : Oxford University Press
Page : 232 pages
File Size : 49,8 Mb
Release : 1996
Category : Literary Criticism
ISBN : 0199635854

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Eukaryotic DNA Replication by J. Julian Blow Pdf

DNA replication is an area of intense research effort which has recently yielded fascinating new insights into the phenomenon. In this book, leading researchers review this rapidly advancing field. The book begins with reviews of the molecular and genetic components of the replication machinery, and builds into a detailed picture of how the replication process is regulated within the cell cycle. Topics include the initiation of replication, origin recognition, the enzymology of the replication fork, the use of SV40 to identify key components of the replication machinery, and how replication is co-ordinated with other cell cycle events in Xenopus cell-free extracts and in budding and fission yeasts. Eukaryotic DNA Replication is a unique and very timely description of the latest research findings in this key subject area. It is essential reading for all researchers and advanced undergraduates interested in the topic.

Author : Arthur Kornberg,Tania A. Baker
Publisher : University Science Books
Page : 964 pages
File Size : 52,9 Mb
Release : 2005-06-24
Category : Science
ISBN : 1891389440

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DNA Replication by Arthur Kornberg,Tania A. Baker Pdf

DNA Replication, second edition, a classic of modernscience, is now back in print in a paperback edition. Kornberg and Baker'sinsightful coverage of DNA replication and related cellular processes have madethis the standard reference in the field.