The Dna Replication Repair Interface

Author : Anonim
Publisher : Academic Press
Page : 454 pages
File Size : 52,7 Mb
Release : 2021-11-12
Category : Science
ISBN : 9780323907347

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The DNA Replication-Repair Interface by Anonim Pdf

Replication-Coupled Repair, Volume 661 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including the Repair of replication-born DNA breaks by sister chromatid recombination, High resolution and high throughput DNA cyclization measurements to interrogate DNA bendability, A programmable detection method for genomic signatures: from disease diagnosis to genome editing, Characterization of the telomerase modulating activities of yeast DNA helicases, Eukaryotic DNA replication with purified budding yeast proteins, Single molecule studies of yeast Rad51 paralogs, Light activation and deactivation of Cas9 for DNA repair studies, and more. Other chapters explore MIDAS: Direct sequencing to map mitotic DNA synthesis and common fragile sites at high precision, Studying the DNA damage response in embryonic systems, GLASS-ChIP to map Mre11 cleavage sites in the human genome, New chemical biology approaches to trap reaction intermediates in living cells, Single-molecule imaging approaches for monitoring replication fork conflicts at genomic DNA G4 structures and R-loops in human cells, Monitoring the replication of structured DNA through heritable epigenetic change, Visualizing replication fork encounters with DNA interstrand crosslinks, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology series Includes the latest information on replication-coupled repair

Author : Clark Chen
Publisher : BoD – Books on Demand
Page : 498 pages
File Size : 49,5 Mb
Release : 2015-11-18
Category : Medical
ISBN : 9789535122098

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Advances in DNA Repair by Clark Chen Pdf

This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of DNA repair to the interface between DNA repair and a spectrum on cellular process to the clinical relevance of DNA repair in oncologic paradigms. The information in this text should provide a foundation from which one can explore the various topics in depth. The book serve as a supplementary text in seminar courses with focus on DNA repair as well as a general reference for scholars with an interest in DNA repair.

Author : Anonim
Publisher : Unknown
Page : 70 pages
File Size : 53,7 Mb
Release : 1995
Category : Electronic
ISBN : OCLC:174024966

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DNA Replication, Recombination and Repair by Anonim Pdf

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 50,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Anonim
Publisher : Academic Press
Page : 512 pages
File Size : 42,9 Mb
Release : 2017-07-11
Category : Medical
ISBN : 9780128125168

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DNA Repair Enzymes: Structure, Biophysics, and Mechanism by Anonim Pdf

DNA Repair Enzymes, Part B, Volume 592 is the latest volume in the Methods in Enzymology series and the first part of a thematic that focuses on DNA Repair Enzymes. Topics in this updated volume include MacroBac: New Technologies for Robust and Efficient Large-Scale Production of Recombinant Multiprotein Complexes, Production and Assay of Recombinant Multisubunit Chromatin Remodeling Complexes, Analysis of Functional Dynamics of Modular Multidomain Proteins by SAXS and NMR, the Use of Single-Cysteine Variants for Trapping Transient States in DNA Mismatch Repair, and Structural Studies of RNases H2 as an Example of Crystal Structure Determination of Protein-Nucleic Acid Complexes. Includes contributions from leading authorities working in enzymology Focuses on DNA repair enzymes Informs and updates on all the latest developments in the field of enzymology

Author : Roger J. A. Grand,John J. Reynolds
Publisher : Garland Science
Page : 368 pages
File Size : 54,6 Mb
Release : 2018-09-03
Category : Science
ISBN : 9780429876547

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DNA Repair and Replication by Roger J. A. Grand,John J. Reynolds Pdf

DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response, emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease, with particular focus on both the causes and treatments which make use of DNA Damage Repair (DDR) pathways. Key Selling Features: Chapters written by leading researchers Includes description of replication processes, causes of damage, and methods of repair

Author : Wolfram Siede,Paul W. Doetsch
Publisher : CRC Press
Page : 872 pages
File Size : 53,5 Mb
Release : 2005-09-19
Category : Science
ISBN : 9780849352683

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DNA Damage Recognition by Wolfram Siede,Paul W. Doetsch Pdf

Stands as the most comprehensive guide to the subject—covering every essential topic related to DNA damage identification and repair. Covering a wide array of topics from bacteria to human cells, this book summarizes recent developments in DNA damage repair and recognition while providing timely reviews on the molecular mechanisms employed by cells to distinguish between damaged and undamaged sites and stimulate the appropriate repair pathways. about the editors... WOLFRAM SIEDE is Associate Professor, Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth. He received the Ph.D. degree (1986) from Johann Wolfgang Goethe University, Frankfurt Germany. YOKE WAH KOW is Professor, Department of Radiation Oncology, Emory University School of Medicine, Atlanta, Georgia. He received the Ph.D. degree (1981) from Brandeis University, Waltham, Massachusetts. PAUL W. DOETSCH is Professor, Departments of Biochemistry, Radiation Oncology, and Hematology and Oncology, and Associate Director for Basic Research, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia. He received the Ph.D. degree (1982) from Temple University School of Medicine, Philadelphia, Pennsylvania.

Author : Anonim
Publisher : ScholarlyEditions
Page : 21 pages
File Size : 49,8 Mb
Release : 2012-12-10
Category : Medical
ISBN : 9781464984471

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Bloom Syndrome: New Insights for the Healthcare Professional: 2012 Edition by Anonim Pdf

Bloom Syndrome: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Bloom Syndrome in a compact format. The editors have built Bloom Syndrome: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bloom Syndrome in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bloom Syndrome: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Donald Voet,Judith G. Voet
Publisher : John Wiley & Sons
Page : 1526 pages
File Size : 40,5 Mb
Release : 2010-12-01
Category : Science
ISBN : 9780470570951

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Biochemistry by Donald Voet,Judith G. Voet Pdf

The "Gold Standard" in Biochemistry text books, Biochemistry 4e, is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge.

Author : Hisao Masai,Marco Foiani
Publisher : Springer
Page : 581 pages
File Size : 47,8 Mb
Release : 2018-01-22
Category : Science
ISBN : 9789811069550

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DNA Replication by Hisao Masai,Marco Foiani Pdf

This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.

Author : Trygve Tollefsbol
Publisher : Academic Press
Page : 639 pages
File Size : 49,5 Mb
Release : 2010-11-21
Category : Science
ISBN : 9780123757104

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Handbook of Epigenetics by Trygve Tollefsbol Pdf

Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon. This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders. Contributions by leading international investigators involved in molecular research and clinical and therapeutic applications Integrates methods and biological topics with basic and clinical discoveries Includes coverage of new topics in epigenetics such as prions, regulation of long-term memory by epigenetics, metabolic aspects of epigenetics, and epigenetics of neuronal disorders

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 48,5 Mb
Release : 2024-06-13
Category : Electronic
ISBN : 9789814477116

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DNA Repair, Genetic Instability, and Cancer by Anonim Pdf

Author : Inna Kruman
Publisher : BoD – Books on Demand
Page : 652 pages
File Size : 54,5 Mb
Release : 2011-11-07
Category : Medical
ISBN : 9789533076973

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DNA Repair by Inna Kruman Pdf

The book consists of 31 chapters, divided into six parts. Each chapter is written by one or several experts in the corresponding area. The scope of the book varies from the DNA damage response and DNA repair mechanisms to evolutionary aspects of DNA repair, providing a snapshot of current understanding of the DNA repair processes. A collection of articles presented by active and laboratory-based investigators provides a clear understanding of the recent advances in the field of DNA repair.

Author : Maga Giovanni,Spadari Silvio,Villani Giuseppe
Publisher : World Scientific
Page : 400 pages
File Size : 50,5 Mb
Release : 2017-11-10
Category : Science
ISBN : 9789813226425

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Human Dna Polymerases: Biology, Medicine And Biotechnology by Maga Giovanni,Spadari Silvio,Villani Giuseppe Pdf

Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, next generation sequencing, nucleic acids based diagnostics and in techniques to analyze ancient and otherwise damaged DNA (e.g. for forensic applications). Moreover, some diseases are related to DNA polymerase defects and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. This book focuses on (i) biology of DNA polymerases, (ii) medical aspects of DNA polymerases and (iii) biotechnological applications of DNA polymerases. It is intended for a wide audience from basic scientists, to diagnostic laboratories, to companies and to clinicians, who seek a better understanding and the practical use of these fascinating enzymes. Contents: PrefaceAbout the AuthorsHistory of DNA PolymerasesDNA Polymerases: General AspectsHuman DNA Polymerases: From Structure to FunctionHuman DNA Polymerases in Different DNA TransactionsDNA Polymerases and Human DiseasesHuman DNA Polymerases and ChemotherapyPolymerases Chain Reaction and Heat-Stable DNA Polymerases: The History and the Potential of Evolved DNA PolymerasesSynthetic Evolution of DNA Polymerases for Novel PropertiesMarket for Evolved DNA Polymerases in Routine and Medical Applications Readership: Academic and industry research scientists, from PhD students to senior professors, as well as R&D specialists and marketing experts working in biotech and pharmaceutical companies. Keywords: DNA Polymerase;DNA Replication;DNA Repair;DNA Recombination, PCR;Cancer;Neurological Diseases;Medicine;Biology;Chemotherapy;Structural Biology;Enzymology;BiotechnologyReview: Key Features: The only book to merge basic science, biotechnological applications and marketing opportunities of DNA polymerasesThe most extensive literature coverage of the field, with more than 1,000 cited references and updated with the most recent contributions received by scientists all over the worldWritten by four leading experts in DNA polymerases, it gives the most complete overview of the field from its historical origins to the latest developments

Author : Fumio Hanaoka,Kaoru Sugasawa
Publisher : Springer
Page : 555 pages
File Size : 51,9 Mb
Release : 2016-01-22
Category : Science
ISBN : 9784431558736

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DNA Replication, Recombination, and Repair by Fumio Hanaoka,Kaoru Sugasawa Pdf

This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.