New Directions In Bioprocess Modeling And Control

Author : Michael A. Boudreau,Gregory K. McMillan
Publisher : ISA
Page : 356 pages
File Size : 42,7 Mb
Release : 2007
Category : Science
ISBN : 1556179057

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New Directions in Bioprocess Modeling and Control by Michael A. Boudreau,Gregory K. McMillan Pdf

Models offer benefits even before they are put on line. Based on years of experience, the authors reveal in New Directions in Bioprocess Modeling and Control that significant improvements can result from the process knowledge and insight that are gained when building experimental and first-principle models for process monitoring and control. Doing modeling in the process development and early commercialization phases is advantageous because it increases process efficiency and provides ongoing opportunities for improving process control. This technology is important for maximizing benefits from analyzers and control tool investments. If you are a process design, quality control, information systems, or automation engineer in the biopharmaceutical, brewing, or bio-fuel industry, this handy resource will help you define, develop, and apply a virtual plant, model predictive control, first-principle models, neural networks, and multivariate statistical process control. The synergistic knowledge discovery on bench top or pilot plant scale can be ported to industrial scale processes. This learning process is consistent with the intent in the Process Analyzer and Process Control Tools sections of the FDA_s Guidance for Industry PAT _ A Framework for Innovative Pharmaceutical Development, Manufacturing and Quality Assurance. It states in the Process Analyzer section of the FDA_s guidance: _For certain applications, sensor-based measurements can provide a useful process signature that may be related to the underlying process steps or transformations. Based on the level of process understanding these signatures may also be useful for the process monitoring, control, and end point determination when these patterns or signatures relate to product and process quality._

Author : Gregory McMillan,Christopher Stuart,Rehman Fazeem,Zachary Sample,Timothy Schieffer
Publisher : Unknown
Page : 128 pages
File Size : 54,5 Mb
Release : 2020-12-15
Category : Electronic
ISBN : 1643311042

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New Directions in Bioprocess Modeling and Control by Gregory McMillan,Christopher Stuart,Rehman Fazeem,Zachary Sample,Timothy Schieffer Pdf

Author : Pablo A. López Pérez,Ricardo Aguilar López,Ricardo Femat
Publisher : John Wiley & Sons
Page : 325 pages
File Size : 50,7 Mb
Release : 2020-03-10
Category : Technology & Engineering
ISBN : 9781119296324

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Control in Bioprocessing by Pablo A. López Pérez,Ricardo Aguilar López,Ricardo Femat Pdf

Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation and the Use of Sensors is divided into three sections. Part I, Mathematical preliminaries and overview of the control and monitoring of bioprocess, provides a general overview of the control and monitoring of bioprocesses, and introduces the mathematical framework necessary for the analysis and characterization of bioprocess dynamics. Part II, Observability and control concepts, presents the observability concepts which form the basis of design online estimation algorithms (software sensor) for bioprocesses, and reviews controllability of these concepts, including automatic feedback control systems. Part III, Software sensors and observer-based control schemes for bioprocesses, features six application cases including dynamic behavior of 3-dimensional continuous bioreactors; observability analysis applied to 2D and 3D bioreactors with inhibitory and non-inhibitory models; and regulation of a continuously stirred bioreactor via modeling error compensation. Applicable across all areas of bioprocess engineering, including food and beverages, biofuels and renewable energy, pharmaceuticals and nutraceuticals, fermentation systems, product separation technologies, wastewater and solid-waste treatment technology, and bioremediation Provides a clear explanation of the mass-balance–based mathematical modelling of bioprocesses and the main tools for its dynamic analysis Offers industry-based applications on: myco-diesel for implementing "quality" of observability; developing a virtual sensor based on the Just-In-Time Model to monitor biological control systems; and virtual sensor design for state estimation in a photocatalytic bioreactor for hydrogen production Control in Bioengineering and Bioprocessing is intended as a foundational text for graduate level students in bioengineering, as well as a reference text for researchers, engineers, and other practitioners interested in the field of estimation and control of bioprocesses.

Author : Claire Komives,Weichang Zhou
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 40,6 Mb
Release : 2018-12-27
Category : Science
ISBN : 9781118361986

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Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts by Claire Komives,Weichang Zhou Pdf

Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: • Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries • Includes illustrative case studies that review six milestone bio-products • Discuses a wide selection of host strain types and disruptive bioprocess technologies

Author : Ramon Vilanova,Antonio Visioli
Publisher : Springer Science & Business Media
Page : 600 pages
File Size : 48,6 Mb
Release : 2012-02-03
Category : Technology & Engineering
ISBN : 9781447124252

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PID Control in the Third Millennium by Ramon Vilanova,Antonio Visioli Pdf

The early 21st century has seen a renewed interest in research in the widely-adopted proportional-integral-differential (PID) form of control. PID Control in the Third Millennium provides an overview of the advances made as a result. Featuring: new approaches for controller tuning; control structures and configurations for more efficient control; practical issues in PID implementation; and non-standard approaches to PID including fractional-order, event-based, nonlinear, data-driven and predictive control; the nearly twenty chapters provide a state-of-the-art resumé of PID controller theory, design and realization. Each chapter has specialist authorship and ideas clearly characterized from both academic and industrial viewpoints. PID Control in the Third Millennium is of interest to academics requiring a reference for the current state of PID-related research and a stimulus for further inquiry. Industrial practitioners and manufacturers of control systems with application problems relating to PID will find this to be a practical source of appropriate and advanced solutions.

Author : Miodrag Darko Matovic
Publisher : BoD – Books on Demand
Page : 556 pages
File Size : 47,6 Mb
Release : 2013-04-30
Category : Technology & Engineering
ISBN : 9789535111054

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Biomass Now by Miodrag Darko Matovic Pdf

This two-volume book on biomass is a reflection of the increase in biomass related research and applications, driven by overall higher interest in sustainable energy and food sources, by increased awareness of potentials and pitfalls of using biomass for energy, by the concerns for food supply and by multitude of potential biomass uses as a source material in organic chemistry, bringing in the concept of bio-refinery. It reflects the trend in broadening of biomass related research and an increased focus on second-generation bio-fuels. Its total of 40 chapters spans over diverse areas of biomass research, grouped into 9 themes.

Author : George Buckbee (P.E.),Joseph Alford (Ph. D.)
Publisher : ISA
Page : 324 pages
File Size : 44,5 Mb
Release : 2008
Category : Biopharmaceutics
ISBN : 1934394254

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Automation Applications in Bio-pharmaceuticals by George Buckbee (P.E.),Joseph Alford (Ph. D.) Pdf

A guide for engineers and designers new to the field of bio-pharmaceutical process control. For the experienced automation professional, it outlines the unique design and application issues for the bio-pharmaceutical industry. For those already familiar with this industry, it provides specific advice for automating these processes.

Author : Hansjörg Hauser,Roland Wagner
Publisher : Walter de Gruyter GmbH & Co KG
Page : 717 pages
File Size : 53,7 Mb
Release : 2014-11-10
Category : Science
ISBN : 9783110278965

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Animal Cell Biotechnology by Hansjörg Hauser,Roland Wagner Pdf

This book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell cultures. A broad spectrum of subjects relevant to biologics production and manufacturing are reviewed, including the generation of robust cell lines, a survey of functional genomics for a better understanding of cell lines and processes, as well as advances in regulatory compliant upstream and downstream development. The book is an essential reference for all those interested in translational animal cell-based pharmaceutical biotechnology.

Author : Gregory K. McMillan
Publisher : Momentum Press
Page : 780 pages
File Size : 47,7 Mb
Release : 2014-12-18
Category : Technology & Engineering
ISBN : 9781606501719

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Tuning and Control Loop Performance, Fourth Edition by Gregory K. McMillan Pdf

Tuning and Control Loop Performance, Fourth Edition provides the knowledge to eliminate the misunderstandings, realize the difference between theoretical and industrial application of PID control, address practical difficulties, improve field automation system design, use the latest PID features, and ultimately get the best tuning settings that enables the PID to achieve its full potential. The proportional-integral-derivative (PID) controller is the heart of every control system in the process industry. Given the proper setup and tuning, the PID has proven to have the capability and flexibility needed to meet nearly all of industry’s basic control requirements. However, the information to support the best use of these features has fallen behind the progress of improved functionality. Additionally, there is considerable disagreement on the tuning rules that largely stems from a misunderstanding of how tuning rules have evolved and the lack of recognition of the effect of automation system dynamics and the incredible spectrum of process responses, disturbances, and performance objectives.

Author : Saeid Mokhatab,William A. Poe
Publisher : Gulf Professional Publishing
Page : 828 pages
File Size : 43,8 Mb
Release : 2012-08-08
Category : Technology & Engineering
ISBN : 9780123869753

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Handbook of Natural Gas Transmission and Processing by Saeid Mokhatab,William A. Poe Pdf

A unique, well-documented, and forward-thinking work, the second edition of Handbook of Natural Gas Transmission and Processing continues to present a thoroughly updated, authoritative, and comprehensive description of all major aspects of natural gas transmission and processing. It provides an ideal platform for engineers, technologists, and operations personnel working in the natural gas industry to get a better understanding of any special requirements for optimal design and operations of natural gas transmission pipelines and processing plants. First book of its kind that covers all aspects of natural gas transmission and processing Provides pivotal updates on the latest technologies, which have not been addressed in-depth in any existing books Offers practical advice for design and operation based on sound engineering principles and established techniques Examines ways to select the best processing route for optimal design of gas-processing plants Contains new discussions on process modeling, control, and optimization in gas processing industry

Author : Aidan O'Dwyer
Publisher : Imperial College Press
Page : 623 pages
File Size : 49,6 Mb
Release : 2009
Category : Technology & Engineering
ISBN : 9781848162433

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Handbook of PI and PID Controller Tuning Rules by Aidan O'Dwyer Pdf

The vast majority of automatic controllers used to compensate industrial processes are PI or PID type. This book comprehensively compiles, using a unified notation, tuning rules for these controllers proposed from 1935 to 2008. The tuning rules are carefully categorized and application information about each rule is given. The book discusses controller architecture and process modeling issues, as well as the performance and robustness of loops compensated with PI or PID controllers. This unique publication brings together in an easy-to-use format material previously published in a large number of papers and books.This wholly revised third edition extends the presentation of PI and PID controller tuning rules, for single variable processes with time delays, to include additional rules compiled since the second edition was published in 2006.

Author : Laurent Simon
Publisher : John Wiley & Sons
Page : 388 pages
File Size : 51,5 Mb
Release : 2013-01-04
Category : Technology & Engineering
ISBN : 9780470903230

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Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering by Laurent Simon Pdf

Enables readers to apply process dynamics and control theory to solve bioprocess and drug delivery problems The control of biological and drug delivery systems is critical to the health of millions of people worldwide. As a result, researchers in systems biology and drug delivery rely on process dynamics and control theory to build our knowledge of cell behavior and to develop more effective therapeutics, controlled release devices, and drug administration protocols to manage disease. Written by a leading expert and educator in the field, this text helps readers develop a deep understanding of process dynamics and control theory in order to analyze and solve a broad range of problems in bioprocess and drug delivery systems. For example, readers will learn how stability criteria can be used to gain new insights into the regulation of biological pathways and lung mechanics. They'll also learn how the concept of a time constant is used to capture the dynamics of diffusive processes. Readers will also master such topics as external disturbances, transfer functions, and input/output models with the support of the author's clear explanations, as well as: Detailed examples from the biological sciences and novel drug delivery technologies 160 end-of-chapter problems with step-by-step solutions Demonstrations of how computational software such as MATLAB and Mathematica solve complex drug delivery problems Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering is written primarily for undergraduate chemical and biomedical engineering students; however, it is also recommended for students and researchers in pharmaceutical engineering, process control, and systems biology. All readers will gain a new perspective on process dynamics and control theory that will enable them to develop new and better technologies and therapeutics to treat human disease.

Author : Gregory K. McMillan
Publisher : ISA
Page : 593 pages
File Size : 51,8 Mb
Release : 2010
Category : Technology & Engineering
ISBN : 9781936007233

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Essentials of Modern Measurements and Final Elements in the Process Industry by Gregory K. McMillan Pdf

Aims to increase awareness of the opportunities afforded by measurement instruments and final elements. This title shows how to get maximum benefit from the revolution in smart technologies. It builds an understanding of the fundamental aspects of measurements, measurement instruments, and final elements for applications in the process industry.

Author : Terrence L. Blevins,Mark Nixon
Publisher : ISA
Page : 425 pages
File Size : 53,8 Mb
Release : 2011
Category : Science
ISBN : 9781936007547

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Control Loop Foundation by Terrence L. Blevins,Mark Nixon Pdf

In this in-depth book, the authors address the concepts and terminology that are needed to work in the field of process control. The material is presented in a straightforward manner that is independent of the control system manufacturer. It is assumed that the reader may not have worked in a process plant environment and may be unfamiliar with the field devices and control systems. Much of the material on the practical aspects of control design and process applications is based on the authors personal experience gained in working with process control systems. Thus, the book is written to act as a guide for engineers, managers, technicians, and others that are new to process control or experienced control engineers who are unfamiliar with multi-loop control techniques. After the traditional single-loop and multi-loop techniques that are most often used in industry are covered, a brief introduction to advanced control techniques is provided. Whether the reader of this book is working as a process control engineer, working in a control group or working in an instrument department, the information will set the solid foundation needed to understand and work with existing control systems or to design new control applications. At various points in the chapters on process characterization and control design, the reader has an opportunity to apply what was learned using web-based workshops. The only items required to access these workshops are a high-speed Internet connection and a web browser. Dynamic process simulations are built into the workshops to give the reader a realistic "hands-on" experience. Also, one chapter of the book is dedicated to techniques that may be used to create process simulations using tools that are commonly available within most distributed control systems. At various points in the chapters on process characterization and control design, the reader has an opportunity to apply what was learned using web-based workshops. The only items required to access these workshops are a high-speed Internet connection and a web browser. Dynamic process simulations are built into the workshops to give the reader a realistic "hands-on" experience. Also, one chapter of the book is dedicated to techniques that may be used to create process simulations using tools that are commonly available within most distributed control systems. As control techniques are introduced, simple process examples are used to illustrate how these techniques are applied in industry. The last chapter of the book, on process applications, contains several more complex examples from industry that illustrate how basic control techniques may be combined to meet a variety of application requirements. As control techniques are introduced, simple process examples are used to illustrate how these techniques are applied in industry. The last chapter of the book, on process applications, contains several more complex examples from industry that illustrate how basic control techniques may be combined to meet a variety of application requirements.

Author : Dale E. Seborg,Thomas F. Edgar,Duncan A. Mellichamp,Francis J. Doyle, III
Publisher : John Wiley & Sons
Page : 512 pages
File Size : 43,9 Mb
Release : 2016-09-13
Category : Technology & Engineering
ISBN : 9781119285915

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Process Dynamics and Control by Dale E. Seborg,Thomas F. Edgar,Duncan A. Mellichamp,Francis J. Doyle, III Pdf

The new 4th edition of Seborg’s Process Dynamics Control provides full topical coverage for process control courses in the chemical engineering curriculum, emphasizing how process control and its related fields of process modeling and optimization are essential to the development of high-value products. A principal objective of this new edition is to describe modern techniques for control processes, with an emphasis on complex systems necessary to the development, design, and operation of modern processing plants. Control process instructors can cover the basic material while also having the flexibility to include advanced topics.