New Frontiers In Gene Modified T Cell Technology

Author : Ignazio Caruana,Francesca Del Bufalo,Rayne Rouce,Shigeki Yagyu ,Paul G. Schlegel
Publisher : Frontiers Media SA
Page : 222 pages
File Size : 50,7 Mb
Release : 2024-06-13
Category : Medical
ISBN : 9782832550410

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New Frontiers in Gene-Modified T Cell Technology by Ignazio Caruana,Francesca Del Bufalo,Rayne Rouce,Shigeki Yagyu ,Paul G. Schlegel Pdf

The development, clinical translation and recent efficacy of novel gene therapies targeting refractory malignancies has led to research that extends this technology to a variety of infectious and rheumatological diseases. Unlike conventional drugs or antibodies, T cells have the potential to target and exert effector function in response to disease in a dynamic manner, acting as a “living drug”. The most efficacious form of gene-modified T cells to date is the chimeric antigen receptor (CAR)-modified T cell, which redirects the specificity of T cells to an antigen expressed by tumor cells. Clinical experience with autologous CAR-T cells, primarily in hematologic malignancies, has underscored the feasibility and safety of the approach, while also demonstrating dramatic and sustained antitumor effects through mechanisms orthogonal to those of traditional anticancer therapies. However, several challenging obstacles must be surmounted in order to improve the broader efficacy of this approach.

Author : Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Publisher : Springer Science & Business Media
Page : 469 pages
File Size : 50,9 Mb
Release : 2007-10-26
Category : Medical
ISBN : 9781597452229

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Gene Therapy for Cancer by Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher Pdf

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Author : Bourama Toni
Publisher : Springer
Page : 389 pages
File Size : 55,9 Mb
Release : 2014-09-25
Category : Mathematics
ISBN : 9783319077550

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New Frontiers of Multidisciplinary Research in STEAM-H (Science, Technology, Engineering, Agriculture, Mathematics, and Health) by Bourama Toni Pdf

This highly multidisciplinary volume contains contributions from leading researchers in STEAM-H disciplines (Science, Technology, Engineering, Agriculture, Mathematics and Health). The volume explores new frontiers in multidisciplinary research, including: the mathematics of cardiac arrhythmia; brain research on working memory; penalized ordinal regression to classify melanoma skin samples; forecasting of time series data; dynamics of niche models; analysis of chemical moieties as anticancer agents; study of gene locus control regions; qualitative mathematical modelling; convex quadrics and group circle systems; remanufacturing planning and control; complexity reduction of functional differential equations; computation of viscous interfacial motion; and differentiation in human pluripotent stem cells. An extension of a seminar series at Virginia State University, the collection is intended to foster student interest and participation in interdisciplinary research and to stimulate new research. The content will be of interest to a broad spectrum of scientists, mathematicians and research students working in interdisciplinary fields including the biosciences, mathematics, engineering, neurosciences and behavioral sciences.

Author : The Expert Panel on the Approval and Use of Somatic Gene Therapies in Canada
Publisher : Council of Canadian Academies
Page : 122 pages
File Size : 53,6 Mb
Release : 2020-11-05
Category : Medical
ISBN : 9781926522791

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From Research to Reality by The Expert Panel on the Approval and Use of Somatic Gene Therapies in Canada Pdf

From Research to Reality describes the stages involved in the approval and use of gene therapies in Canada, and examines challenges associated with regulatory oversight, manufacturing, access, and affordability, and identifies promising approaches to address them.

Author : Assessment Office Of Technology
Publisher : CRC Press
Page : 352 pages
File Size : 41,5 Mb
Release : 2020-09-23
Category : Medical
ISBN : 9780429704796

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Genetic Technology: A New Frontier by Assessment Office Of Technology Pdf

First published in 1982 . This report examines the application of classical and molecular genetic technologies to micro-organisms, plants, and animals. This book is one of the first comprehensive documents on emerging genetic technologies and their implications for society. The authors discuss the opportunities and problems involved, describe current techniques, and attempt to project some of the economic, environmental, and institutional impacts of those techniques. The issues they raise go beyond those of technology, utility, and economic feasibility. As we gain the ability to manipulate life, we must face basic questions of just what life means and how far we can reasonably-and safely-allow ourselves to go.

Author : Maria Cristina Galli
Publisher : Springer Nature
Page : 243 pages
File Size : 55,7 Mb
Release : 2023-08-01
Category : Science
ISBN : 9783031345678

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Regulatory Aspects of Gene Therapy and Cell Therapy Products by Maria Cristina Galli Pdf

This book discusses the different regulatory pathways for Advanced Therapy Medicinal Products implemented by national agencies in North and South America, Europe and Asia and by international bodies in the effort of international harmonization. This book represents an update of the first edition, as it covers regulatory novelties and accumulated experience in the regions already addressed. In addition, this new edition offers a wider international perspective: new chapters are included covering Advanced Therapy Medicinal Products regulations in India, Malaysia, Spain and Thailand, the European Pharmacopoeia texts for gene therapy medicinal products as well as international harmonization programs. Each chapter, authored by experts from various regulatory bodies throughout the international community, walks the reader through the applications of nonclinical research to translational clinical research to licensure and therapeutic use of these innovative products. More specifically, each chapter offers insights into fundamental considerations that are essential for developers of Advanced Therapy Medicinal Products in the areas of product quality, pharmacology and toxicology, clinical trial design and HTA pathways, as well as pertinent ‘must-know’ guidelines and regulations. Regulatory Aspects of Gene Therapy and Cell Therapy Products: a Global Perspective is part of the American Society of Gene & Cell Therapy sub-series of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students, clinicians, and researchers interested in gene and cell therapy and the regulation of pharmaceuticals.

Author : Shreefal S. Mehta
Publisher : Cambridge University Press
Page : 457 pages
File Size : 43,8 Mb
Release : 2022-11-17
Category : Technology & Engineering
ISBN : 9781009302333

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Commercializing Successful Biomedical Technologies by Shreefal S. Mehta Pdf

Transform your research into commercial biomedical products with this revised and updated second edition. Covering drugs, devices and diagnostics, this book provides a step-by-step introduction to the process of commercialization, and will allow you to create a realistic business plan to develop your ideas into approved biomedical technologies. This new edition includes: Over 25% new material, including practical tips on startup creation from experienced entrepreneurs. Tools for starting, growing and managing a new venture, including business planning and commercial strategy, pitching investors, and managing operations. Global real-world case studies, including emerging technologies such as regulated medical software and Artificial Intelligence (AI), offer insights into key challenges and help illustrate complex points. Tips and operational tools from established industry insiders, suitable for graduate students and new biomedical entrepreneurs.

Author : Julie G. Burel,Cecilia Lindestam Arlehamn,Chetan Seshadri,Jayne S. Sutherland
Publisher : Frontiers Media SA
Page : 169 pages
File Size : 52,6 Mb
Release : 2022-02-16
Category : Medical
ISBN : 9782889744053

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Exploring Immune Variability in Susceptibility to Tuberculosis Infection in Humans by Julie G. Burel,Cecilia Lindestam Arlehamn,Chetan Seshadri,Jayne S. Sutherland Pdf

Author : Helen Michelle McGettrick,Sian M. Henson,Vicky L. Morrison,Ronen Sumagin
Publisher : Frontiers Media SA
Page : 172 pages
File Size : 55,9 Mb
Release : 2022-02-04
Category : Medical
ISBN : 9782889742851

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Targeting Leukocyte Trafficking: Insights and Future Directions by Helen Michelle McGettrick,Sian M. Henson,Vicky L. Morrison,Ronen Sumagin Pdf

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Agriculture and Natural Resources,Committee on Genetically Engineered Crops: Past Experience and Future Prospects
Publisher : National Academies Press
Page : 607 pages
File Size : 43,7 Mb
Release : 2017-01-28
Category : Science
ISBN : 9780309437387

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Genetically Engineered Crops by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Agriculture and Natural Resources,Committee on Genetically Engineered Crops: Past Experience and Future Prospects Pdf

Genetically engineered (GE) crops were first introduced commercially in the 1990s. After two decades of production, some groups and individuals remain critical of the technology based on their concerns about possible adverse effects on human health, the environment, and ethical considerations. At the same time, others are concerned that the technology is not reaching its potential to improve human health and the environment because of stringent regulations and reduced public funding to develop products offering more benefits to society. While the debate about these and other questions related to the genetic engineering techniques of the first 20 years goes on, emerging genetic-engineering technologies are adding new complexities to the conversation. Genetically Engineered Crops builds on previous related Academies reports published between 1987 and 2010 by undertaking a retrospective examination of the purported positive and adverse effects of GE crops and to anticipate what emerging genetic-engineering technologies hold for the future. This report indicates where there are uncertainties about the economic, agronomic, health, safety, or other impacts of GE crops and food, and makes recommendations to fill gaps in safety assessments, increase regulatory clarity, and improve innovations in and access to GE technology.

Author : Magdalena Klink,Izabela Szulc-Kielbik
Publisher : Springer Nature
Page : 358 pages
File Size : 47,8 Mb
Release : 2022-02-14
Category : Medical
ISBN : 9783030913113

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Interaction of Immune and Cancer Cells by Magdalena Klink,Izabela Szulc-Kielbik Pdf

Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.

Author : Vijai Singh
Publisher : Academic Press
Page : 487 pages
File Size : 46,6 Mb
Release : 2022-01-12
Category : Science
ISBN : 9780323859868

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New Frontiers and Applications of Synthetic Biology by Vijai Singh Pdf

New Frontiers and Applications of Synthetic Biology presents a collection of chapters from eminent synthetic biologists across the globe who have established experience and expertise working with synthetic biology. This book offers several important areas of synthetic biology which allow us to read and understand easily. It covers the introduction of synthetic biology and design of promoter, new DNA synthesis and sequencing technology, genome assembly, minimal cells, small synthetic RNA, directed evolution, protein engineering, computational tools, de novo synthesis, phage engineering, a sensor for microorganisms, next-generation diagnostic tools, CRISPR-Cas systems, and more. This book is a good source for not only researchers in designing synthetic biology, but also for researchers, students, synthetic biologists, metabolic engineers, genome engineers, clinicians, industrialists, stakeholders and policymakers interested in harnessing the potential of synthetic biology in many areas. Offers basic understanding and knowledge in several aspects of synthetic biology Covers state-of-the-art tools and technologies of synthetic biology, including promoter design, DNA synthesis, DNA sequencing, genome design, directed evolution, protein engineering, computational tools, phage design, CRISPR-Cas systems, and more Discusses the applications of synthetic biology for smart drugs, vaccines, therapeutics, drug discovery, self-assembled materials, cell free systems, microfluidics, and more

Author : Shivaani Kummar,Chris Takimoto
Publisher : Academic Press
Page : 234 pages
File Size : 40,8 Mb
Release : 2018-05-22
Category : Medical
ISBN : 9780128125700

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Novel Designs of Early Phase Trials for Cancer Therapeutics by Shivaani Kummar,Chris Takimoto Pdf

Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses topics such as statistical perspectives on cohort expansions, the role and application of molecular profiling and how to integrate biomarkers in early phase trials. Additionally, it discusses how to incorporate patient reported outcomes in phase one trials. This book is a valuable resource for medical oncologists, basic and translational biomedical scientists, and trainees in oncology and pharmacology who are interested in learning how to improve their research by using early phase trials. Brings a comprehensive review and recommendations for new clinical trial designs for modern cancer therapeutics Provides the reader with a better understanding on how to design and implement early phase oncology trials Presents a better and updated understanding of the process of developing new treatments for cancer, the exciting scientific advances and how they are informing drug development

Author : Marita Bosticardo,Izumi Ohigashi,Jennifer Elizabeth Cowan,Nuno L. Alves
Publisher : Frontiers Media SA
Page : 177 pages
File Size : 47,5 Mb
Release : 2021-09-30
Category : Medical
ISBN : 9782889714490

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Thymic Epithelial Cells: New Insights into the Essential Driving Force of T-Cell Differentiation by Marita Bosticardo,Izumi Ohigashi,Jennifer Elizabeth Cowan,Nuno L. Alves Pdf

Author : Jianmei Wu Leavenworth,Lewis Z. Shi,Xi Wang,Haiming Wei
Publisher : Frontiers Media SA
Page : 244 pages
File Size : 51,7 Mb
Release : 2022-02-22
Category : Medical
ISBN : 9782889744732

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Immune Cell Lineage Reprogramming in Cancer by Jianmei Wu Leavenworth,Lewis Z. Shi,Xi Wang,Haiming Wei Pdf

Topic Editor Dr. Lewis Shi received financial support from Varian Medical System, Inc. The other Topic Editors declare no competing interests with regard to the Research Topic subject.