New Frontiers And Applications Of Synthetic Biology

Author : Vijai Singh
Publisher : Academic Press
Page : 487 pages
File Size : 49,5 Mb
Release : 2022-01-12
Category : Science
ISBN : 9780323859868

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New Frontiers and Applications of Synthetic Biology by Vijai Singh Pdf

New Frontiers and Applications of Synthetic Biology presents a collection of chapters from eminent synthetic biologists across the globe who have established experience and expertise working with synthetic biology. This book offers several important areas of synthetic biology which allow us to read and understand easily. It covers the introduction of synthetic biology and design of promoter, new DNA synthesis and sequencing technology, genome assembly, minimal cells, small synthetic RNA, directed evolution, protein engineering, computational tools, de novo synthesis, phage engineering, a sensor for microorganisms, next-generation diagnostic tools, CRISPR-Cas systems, and more. This book is a good source for not only researchers in designing synthetic biology, but also for researchers, students, synthetic biologists, metabolic engineers, genome engineers, clinicians, industrialists, stakeholders and policymakers interested in harnessing the potential of synthetic biology in many areas. Offers basic understanding and knowledge in several aspects of synthetic biology Covers state-of-the-art tools and technologies of synthetic biology, including promoter design, DNA synthesis, DNA sequencing, genome design, directed evolution, protein engineering, computational tools, phage design, CRISPR-Cas systems, and more Discusses the applications of synthetic biology for smart drugs, vaccines, therapeutics, drug discovery, self-assembled materials, cell free systems, microfluidics, and more

Author : Christina Smolke
Publisher : John Wiley & Sons
Page : 426 pages
File Size : 42,8 Mb
Release : 2018-06-05
Category : Science
ISBN : 9783527330751

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Synthetic Biology by Christina Smolke Pdf

A review of the interdisciplinary field of synthetic biology, from genome design to spatial engineering. Written by an international panel of experts, Synthetic Biology draws from various areas of research in biology and engineering and explores the current applications to provide an authoritative overview of this burgeoning field. The text reviews the synthesis of DNA and genome engineering and offers a discussion of the parts and devices that control protein expression and activity. The authors include information on the devices that support spatial engineering, RNA switches and explore the early applications of synthetic biology in protein synthesis, generation of pathway libraries, and immunotherapy. Filled with the most recent research, compelling discussions, and unique perspectives, Synthetic Biology offers an important resource for understanding how this new branch of science can improve on applications for industry or biological research.

Author : Huimin Zhao
Publisher : Academic Press
Page : 352 pages
File Size : 53,6 Mb
Release : 2013-03-21
Category : Science
ISBN : 9780123978202

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Synthetic Biology by Huimin Zhao Pdf

Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems. Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems. Includes contributions from leaders in the field presents examples of ambitious synthetic biology efforts including creation of artificial cells from scratch, cell-free synthesis of chemicals, fuels, and proteins, engineering of artificial photosynthesis for biofuels production, and creation of unnatural living organisms Describes the latest state-of-the-art tools developed for low-cost synthesis of ever-increasing sizes of DNA and efficient modification of proteins, pathways, and genomes Highlights key technologies for analyzing biological systems at the genomic, proteomic, and metabolomic levels which are especially valuable in pathway, whole cell, and multi-cell applications Details mathematical modeling tools and computational tools which can dramatically increase the speed of the design process as well as reduce the cost of development.

Author : Vikram Singh,Pawan K. Dhar
Publisher : Springer
Page : 385 pages
File Size : 46,6 Mb
Release : 2014-12-15
Category : Science
ISBN : 9789401795142

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Systems and Synthetic Biology by Vikram Singh,Pawan K. Dhar Pdf

This textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M.Sc. and Ph.D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section will deal with systems biology – in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section deals with the engineering concepts, design strategies of the biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell will be described. Finally, the book will offer expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.

Author : Benjamin D. Trump,Christopher L. Cummings,Jennifer Kuzma,Igor Linkov
Publisher : Springer Nature
Page : 421 pages
File Size : 53,5 Mb
Release : 2019-11-28
Category : Technology & Engineering
ISBN : 9783030272647

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Synthetic Biology 2020: Frontiers in Risk Analysis and Governance by Benjamin D. Trump,Christopher L. Cummings,Jennifer Kuzma,Igor Linkov Pdf

Synthetic biology offers powerful remedies for some of the world’s most intractable problems, but these solutions are clouded by uncertainty and risk that few strategies are available to address. The incentives for continued development of this emerging technology are prodigious and obvious, and the public deserves assurances that all potential downsides are duly considered and minimized accordingly. Incorporating social science analysis within the innovation process may impose constraints, but its simultaneous support in making the end products more acceptable to society at large should be considered a worthy trade-off. Contributing authors in this volume represent diverse perspectives related to synthetic biology’s social sciences, and reflect on different areas of risk analysis and governance that have developed for the field. Such perspectives include leading scholarly discussion pertaining to risk assessment, governance, ethics, and communication. The chapters of this volume note that while the first twenty years of synthetic biology development have focused strongly on technological innovation and product development, the next twenty should emphasize the synergy between developers, policymakers, and publics to generate the most beneficial, well governed, and transparent technologies and products possible. Many chapters in this volume provide new data and approaches that demonstrate the feasibility for multi-stakeholder efforts involving policymakers, regulators, industrial developers, workers, experts, and societal representatives to share responsibilities in the production of effective and acceptable governance in the face of uncertain risk probabilities. A full consideration of such perspectives may prevent a world of draconian regulations based on an insufficient or incomplete understanding of the science that underpins synthetic biology, as well as any hesitancy or fear by the public to adopt its eventual products.

Author : Paul S. FREEMONT,Richard I. KITNEY
Publisher : World Scientific
Page : 194 pages
File Size : 44,5 Mb
Release : 2015-08-24
Category : Science
ISBN : 9781783268801

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Synthetic Biology - a Primer (revised Edition) by Paul S. FREEMONT,Richard I. KITNEY Pdf

Synthetic Biology -- A Primer (Revised Edition) presents an updated overview of the field of synthetic biology and the foundational concepts on which it is built. This revised edition includes new literature references, working and updated URL links, plus some new figures and text where progress in the field has been made.The book introduces readers to fundamental concepts in molecular biology and engineering and then explores the two major themes for synthetic biology, namely 'bottom-up' and 'top-down' engineering approaches. 'Top-down' engineering uses a conceptual framework of systematic design and engineering principles focused around the Design-Build-Test cycle and mathematical modelling. The 'bottom-up' approach involves the design and building of synthetic protocells using basic chemical and biochemical building blocks from scratch exploring the fundamental basis of living systems.Examples of cutting-edge applications designed using synthetic biology principles are presented, including: The book also describes the Internationally Genetically Engineered Machine (iGEM) competition, which brings together students and young researchers from around the world to carry out summer projects in synthetic biology. Finally, the primer includes a chapter on the ethical, legal and societal issues surrounding synthetic biology, illustrating the integration of social sciences into synthetic biology research.Final year undergraduates, postgraduates and established researchers interested in learning about the interdisciplinary field of synthetic biology will benefit from this up-to-date primer on synthetic biology.

Author : Vijai Singh
Publisher : Springer Nature
Page : 349 pages
File Size : 51,7 Mb
Release : 2020-04-13
Category : Science
ISBN : 9789811500817

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Advances in Synthetic Biology by Vijai Singh Pdf

This book addresses the design of emerging conceptual tools, technologies and systems including novel synthetic parts, devices, circuits, oscillators, biological gates, and small regulatory RNAs (riboregulators and riboswitches), which serve as versatile control elements for regulating gene expression. Synthetic biology, a rapidly growing field that involves the application of engineering principles in biology, is now being used to develop novel systems for a wide range of applications including diagnostics, cell reprogramming, therapeutics, enzymes, vaccines, biomaterials, biofuels, fine chemicals and many more. The book subsequently summarizes recent developments in technologies for assembling synthetic genomes, minimal genomes, synthetic biology toolboxes, CRISPR-Cas systems, cell-free protein synthesis systems and microfluidics. Accordingly, it offers a valuable resource not only for beginners in synthetic biology, but also for researchers, students, scientists, clinicians, stakeholders and policymakers interested in the potential held by synthetic biology.

Author : Arshad, Muhammad
Publisher : IGI Global
Page : 481 pages
File Size : 54,7 Mb
Release : 2023-10-02
Category : Science
ISBN : 9781668465783

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Applications of Synthetic Biology in Health, Energy, and Environment by Arshad, Muhammad Pdf

The application of genetic engineering techniques by redesigning and repurposing biological systems for novel biotechnical applications has paved the way for the field of synthetic biology. This field boosted the evolution and discovery of various novel technologies essential to the conquest of biological problems related to health, disease, the environment, and energy. The field of synthetic biology is growing rapidly, and further research is required. Applications of Synthetic Biology in Health, Energy, and Environment deliberates on principles and the advancement of synthetic biology and their translation in the fields of health, disease, energy, and the environment. Covering topics such as climate change, bioremediation, and smart drugs, this premier reference source is an excellent resource for students and educators of higher education, industrialists, medical professionals, hospital administrators, policymakers, environmental scientists, pharmacists, librarians, researchers, and academicians.

Author : Luan Luong Chu,Jae Kyung Sohng,Dipesh Dhakal,Jingwen Zhou
Publisher : Frontiers Media SA
Page : 125 pages
File Size : 45,7 Mb
Release : 2022-02-09
Category : Science
ISBN : 9782889743094

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Recent Advances in Application of Synthetic Biology for Production of Bioactive Compounds by Luan Luong Chu,Jae Kyung Sohng,Dipesh Dhakal,Jingwen Zhou Pdf

Author : Rodrigo Ledesma-Amaro,Pablo Ivan Nikel,Francesca Ceroni
Publisher : Frontiers Media SA
Page : 142 pages
File Size : 49,7 Mb
Release : 2020-05-05
Category : Electronic
ISBN : 9782889637089

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Synthetic Biology-Guided Metabolic Engineering by Rodrigo Ledesma-Amaro,Pablo Ivan Nikel,Francesca Ceroni Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 570 pages
File Size : 54,6 Mb
Release : 2011-12-30
Category : Science
ISBN : 9780309219396

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The Science and Applications of Synthetic and Systems Biology by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Author : Weiwen Zhang,David Nielsen
Publisher : Frontiers E-books
Page : 130 pages
File Size : 42,6 Mb
Release : 2014-12-03
Category : Bioengineering
ISBN : 9782889193424

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Synthetic biology applications in industrial microbiology by Weiwen Zhang,David Nielsen Pdf

Exponentially increasing information on biological organisms coupled with increasing computational power in the past decade have broadened the perspective of fundamental biological research, bringing about considerable promise and unprecedented potential for practical applications in biotechnology. As one emergent discipline, synthetic biology aims to design and engineer novel biologically-based parts, devices, and systems, in addition to redesigning existing, natural biological systems. Although previously relegated to demonstration studies, more recent research in synthetic biology has focused on the rational engineering of industrial microorganisms with the potential to address many of society’s critical challenges. Within the realm of industrial microbiology, progress in the field of synthetic biology has enabled the development of, for example, new biosynthetic pathways for the production of renewable fuels and chemicals, programmable logic controls to regulate and optimize cell function, and robust microbes for the destruction of harmful environmental contaminants. Some of the exciting examples included producing anti-malarial drug, anti- cancer taxol precursor and various biofuel molecules in E. coli and yeast. In addition, these researches have also greatly enhanced our understanding of the cellular machinery and its regulation in some of the industry important microbes, laying an important foundation for further design and engineering of biological function for even greater application. For these reasons, we present here a collection of articles from the leading edge of the field of synthetic biology, with a specific focus on the development in industrial microorganisms. It is the intent of this collection to reach a wide audience whose interests and expertise spans from development of novel synthetic biology methodologies and theories (both experimental and computational) to practical applications seeking to address issues facing the world today.

Author : Shailza Singh
Publisher : Springer
Page : 259 pages
File Size : 48,5 Mb
Release : 2018-10-01
Category : Medical
ISBN : 9789811086939

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Synthetic Biology by Shailza Singh Pdf

The book uses an integrated approach to predict the behavior of various biological interactions. It further discusses how synthetic biology gathers the information about various systems, in order to either devise an entirely new system, or, to modulate existing systems. The book also tackles the concept of modularity, where biological systems are visualized in terms of their parts. The chapters discuss how the principles of engineering are being used in biomedical sciences, to design biological circuits that can harbor multiple inputs and generate multiple outputs; to create genetic networks and control gene activity, in order to generate a desired response. The book aims to help the readers develop an array of biological parts, and to use these parts to develop synthetic circuits that can be assembled like electronic circuits. The ultimate aim of the book will be to serve as an amalgamation of key ideas of how judiciously synthetic biology could be exploited in therapeutic device and delivery mechanism.

Author : Jian Li,Yong-Chan Kwon,Yuan Lu,Simon J. Moore
Publisher : Frontiers Media SA
Page : 205 pages
File Size : 47,5 Mb
Release : 2022-01-13
Category : Science
ISBN : 9782889740802

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Cell-Free Synthetic Biology by Jian Li,Yong-Chan Kwon,Yuan Lu,Simon J. Moore Pdf

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 51,9 Mb
Release : 2014
Category : Electronic
ISBN : OCLC:1368419918

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Synthetic Biology Applications in Industrial Microbiology by Anonim Pdf

Exponentially increasing information on biological organisms coupled with increasing computational power in the past decade have broadened the perspective of fundamental biological research, bringing about considerable promise and unprecedented potential for practical applications in biotechnology. As one emergent discipline, synthetic biology aims to design and engineer novel biologically-based parts, devices, and systems, in addition to redesigning existing, natural biological systems. Although previously relegated to demonstration studies, more recent research in synthetic biology has focused on the rational engineering of industrial microorganisms with the potential to address many of society's critical challenges. Within the realm of industrial microbiology, progress in the field of synthetic biology has enabled the development of, for example, new biosynthetic pathways for the production of renewable fuels and chemicals, programmable logic controls to regulate and optimize cell function, and robust microbes for the destruction of harmful environmental contaminants. Some of the exciting examples included producing anti-malarial drug, anti- cancer taxol precursor and various biofuel molecules in E. coli and yeast. In addition, these researches have also greatly enhanced our understanding of the cellular machinery and its regulation in some of the industry important microbes, laying an important foundation for further design and engineering of biological function for even greater application. For these reasons, we present here a collection of articles from the leading edge of the field of synthetic biology, with a specific focus on the development in industrial microorganisms. It is the intent of this collection to reach a wide audience whose interests and expertise spans from development of novel synthetic biology methodologies and theories (both experimental and computational) to practical applications seeking to address issues facing the world today.