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Author : Águeda González Rodríguez,Javier Egea,Oscar Escribano,Daniel E. Francés,Yolanda F. Otero
Publisher : Frontiers Media SA
Page : 223 pages
File Size : 54,5 Mb
Release : 2022-01-07
Category : Medical
ISBN : 9782889719884
Author : Ju-Seop Kang
Publisher : Intechopen
Page : 0 pages
File Size : 40,8 Mb
Release : 2023
Category : Electronic
ISBN : 1839680903
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis that develops in the absence of competing for liver disease etiologies such as alcohol consumption, monogenic hereditary conditions, or iatrogenic causes. The pathogenesis of NAFLD is multifactorial and its understanding is still incomplete. Although knowledge of the cellular and molecular mechanisms underlying disease development and progression has grown significantly in recent years, the exact contribution of environmental and genetic factors as well as that of extrahepatic and intrahepatic events in determining the disease phenotype remains ill defined. This book discusses topics highly correlated with NAFLD such as the regulation of iron metabolism, the role of the enzyme heparanase in liver steatosis, transcriptional regulation by ERR and its role in pathogenesis, hepatic lipid homeostasis, therapeutic approaches to NAFLD, and pathogenesis and significance of HDL as a molecular modifier in NAFLD.
Author : Ramón Anibal Rodrigo Salinas
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 49,5 Mb
Release : 2016
Category : Fatty liver
ISBN : 1634842170
Non-alcoholic fatty liver disease, or NAFLD, represents a spectrum of pathologic liver histologic findings ranging from the simple accumulation of fat, known as steatosis, to nonalcoholic steatohepatitis and cirrhosis. It is estimated that NAFLD in all of its forms would have a 20% prevalence worldwide, but the evidence suggests a higher rate for developed countries, exceeding 30% for the US general population. Major risk factors for NAFLD, such as ageing, obesity and insulin resistance, are projected to increase in the following decades, causing the prevalence and relevance of NAFLD to rise in the future. In obese populations and type 2 diabetes patients, the prevalence of this disease exceeds 70%. NAFLD has been called the "silent epidemic" for its lack of symptoms, relatively complex diagnosis and its deleterious effects. The association between NAFLD with cardiovascular diseases, energy metabolism disorders and polycystic ovarian syndrome has promoted the inclusion of this liver pathology within the metabolic syndrome. From a biochemical point of view, current evidence suggests the existence of a bidirectional causal relationship between NAFLD and oxidative stress, where various alterations energy metabolism and important inflammatory components are involved. An abnormal glucose and fatty acid metabolism lead to glucotoxicity and lipotoxicity, respectively, which promote oxidative stress through different pathways. Oxidative stress induces the expression of pro-inflammatory mediators, including transcription factors and cytokines, which trigger an immune activation, a key step in the transition from simple steatosis to steatohepatitis. An early diagnosis and optimal therapy are essential for NAFLD treatment. First-line treatment of NAFLD focuses on lifestyle changes. Weight reduction through an increase in physical activity and/or nutritional management is considered safe and effective, but pharmacological management of common comorbidities such as hyperglycemia, dyslipidemias and hypertension are also essential. The key role of oxidative stress in NAFLD pathophysiology suggests that antioxidant interventions based in natural substances such as polyphenols would be effective. Recently, it was shown that the antioxidant properties of these compounds are beyond their free radical scavenging. This book presents an update of research advances contributing to a better understanding of relevant clinical models of NAFLD, particularly, the disorder in energy metabolism and the role of oxidative stress. It also highlights the clinical and pathophysiological association between NAFLD and the metabolic syndrome, and presents an overview of current diagnosis and treatment and the future avenues for the management of this disease.
Author : Geoffrey C. Farrell,Arthur J. McCullough,Christopher P. Day
Publisher : John Wiley & Sons
Page : 438 pages
File Size : 48,6 Mb
Release : 2013-02-06
Category : Medical
ISBN : 9781118556221
The sharp rise in cases of Non-alcoholic fatty liver disease is fast becoming one of the major concerns for hepatologists worldwide. This comprehensive clinical guide explains how to diagnose NAFLD and manage patients according to the best standards of care. Contributors from the world's leading institutions concentrate on patient care, drawing on their extensive experience.
Author : Anonim
Publisher : ScholarlyEditions
Page : 22 pages
File Size : 40,8 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464913136
Alcoholic Fatty Liver: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Alcoholic Fatty Liver in a compact format. The editors have built Alcoholic Fatty Liver: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Alcoholic Fatty Liver in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Alcoholic Fatty Liver: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Paul C. Guest
Publisher : Springer
Page : 303 pages
File Size : 53,6 Mb
Release : 2019-03-27
Category : Science
ISBN : 9783030126681
The book recognizes that throughout the scientific, medical, and economic communities, new tests incorporating biomarkers are needed to improve the diagnosis of patients suffering from metabolic disorders. The early identification of those at risk of developing obesity will help to place these individuals on the best treatment course as early as possible for improved treatment outcomes. This will also help to cut costs incurred by the healthcare services. For all of this to occur, new research efforts are needed to identify novel biomarkers that can be used to predict the disease in the presymptomatic stage, for disease monitoring and for prediction of treatment response. It is also possible that new drug targets can be identified using these approaches which, in turn, can lead to the development of new treatment approaches. This volume also includes a series of reviews on biomarker discovery and usage in the study of diseases marked by perturbations in metabolism. It will describe the pros and cons of the various approaches and cover the successes and failures in this important research field.
Author : Domenico Corica,Malgorzata Gabriela Wasniewska,Iwona Ben-Skowronek,Rade Vukovic
Publisher : Frontiers Media SA
Page : 130 pages
File Size : 51,8 Mb
Release : 2023-05-11
Category : Medical
ISBN : 9782832523186
Author : Anonim
Publisher : ScholarlyEditions
Page : 63 pages
File Size : 41,8 Mb
Release : 2012-12-10
Category : Medical
ISBN : 9781464974335
Fatty Liver: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Fatty Liver in a concise format. The editors have built Fatty Liver: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Fatty Liver in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Fatty Liver: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Robinson Ramírez-Vélez,Mikel Izquierdo
Publisher : Frontiers Media SA
Page : 130 pages
File Size : 50,9 Mb
Release : 2019-10-09
Category : Electronic
ISBN : 9782889630639
Author : Aparajita Dey
Publisher : Springer Science & Business Media
Page : 269 pages
File Size : 46,9 Mb
Release : 2013-02-12
Category : Medical
ISBN : 9789400758810
The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.
Author : Judith Fraussen,Deborah K. Dunn-Walters,Veerle Somers,Mirjam van der Burg
Publisher : Frontiers Media SA
Page : 232 pages
File Size : 51,6 Mb
Release : 2022-03-04
Category : Medical
ISBN : 9782889745654
Author : Anonim
Publisher : ScholarlyEditions
Page : 59 pages
File Size : 43,8 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464905070
Fatty Liver: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Fatty Liver in a concise format. The editors have built Fatty Liver: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Fatty Liver in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Fatty Liver: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Anonim
Publisher : ScholarlyEditions
Page : 112 pages
File Size : 46,8 Mb
Release : 2013-07-22
Category : Medical
ISBN : 9781481652490
Fatty Liver: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Diagnosis and Screening in a concise format. The editors have built Fatty Liver: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Fatty Liver: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Michael Praktiknjo,Dominik Bettinger,Golo Ahlenstiel,Xiaolong Qi
Publisher : Frontiers Media SA
Page : 145 pages
File Size : 51,5 Mb
Release : 2023-09-07
Category : Medical
ISBN : 9782832533468
Author : Nicholas J. Talley,G. Richard Locke III,Yuri A. Saito
Publisher : John Wiley & Sons
Page : 289 pages
File Size : 46,6 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9780470691458
Authoritative new text from the experts in GI populationstudies This book covers both key methodological issues and the mostimportant information in the field, disease by disease. It focuseson population-based information and studies looking at principlesand approaches to diagnosis and treatment of diseases. GI Epidemiology brings together world authorities inmultiple disciplines for the very first time, to create one clearand comprehensive source. The bulk of the chapters are divided intotwo parts, covering methodological issues and the epidemiology ofspecific GI diseases. Each chapter begins with a list of keypoints, followed by a review written in a clear and simplestyle. The methodologic chapters cover evidence-based medicine,meta-analysis, systematic reviews, genetic and molecularepidemiology, clinical trials, questionnaire design, and healtheconomics. The disease-specific chapters note the current gaps inknowledge and suggest areas for further study. GI Epidemiology serves as both a useful refresher and areliable reference on the methods and techniques used inepidemiological studies for consultants and researchers ingastroenterology. It is also an invaluable tool for fellows/trainees ingastroenterology, candidates for recertification in the combineddisciplines of gastroenterology, pediatric gastroenterology andcolorectal surgery, and anyone completing MPH training.