New Prognostic And Predictive Markers In Cancer Progression

Author : Susan Costantini Alfredo Budillon,Alfredo Budillon
Publisher : MDPI
Page : 294 pages
File Size : 52,7 Mb
Release : 2021-02-12
Category : Medical
ISBN : 9783039439775

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New Prognostic and Predictive Markers in Cancer Progression by Susan Costantini Alfredo Budillon,Alfredo Budillon Pdf

Biomarkers are of critical medical importance for oncologists, allowing them to predict and detect disease and to determine the best course of action for cancer patient care. Prognostic markers are used to evaluate a patient’s outcome and cancer recurrence probability after initial interventions such as surgery or drug treatments and, hence, to select follow-up and further treatment strategies. On the other hand, predictive markers are increasingly being used to evaluate the probability of benefit from clinical intervention(s), driving personalized medicine. Evolving technologies and the increasing availability of “multiomics” data are leading to the selection of numerous potential biomarkers, based on DNA, RNA, miRNA, protein, and metabolic alterations within cancer cells or tumor microenvironment, that may be combined with clinical and pathological data to greatly improve the prediction of both cancer progression and therapeutic treatment responses. However, in recent years, few biomarkers have progressed from discovery to become validated tools to be used in clinical practice. This Special Issue comprises eight review articles and five original studies on novel potential prognostic and predictive markers for different cancer types.

Author : Susan Costantini,Alfredo Budillon
Publisher : Unknown
Page : 294 pages
File Size : 54,9 Mb
Release : 2021
Category : Electronic
ISBN : 3039439782

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New Prognostic and Predictive Markers in Cancer Progression by Susan Costantini,Alfredo Budillon Pdf

Biomarkers are of critical medical importance for oncologists, allowing them to predict and detect disease and to determine the best course of action for cancer patient care. Prognostic markers are used to evaluate a patient's outcome and cancer recurrence probability after initial interventions such as surgery or drug treatments and, hence, to select follow-up and further treatment strategies. On the other hand, predictive markers are increasingly being used to evaluate the probability of benefit from clinical intervention(s), driving personalized medicine. Evolving technologies and the increasing availability of “multiomics” data are leading to the selection of numerous potential biomarkers, based on DNA, RNA, miRNA, protein, and metabolic alterations within cancer cells or tumor microenvironment, that may be combined with clinical and pathological data to greatly improve the prediction of both cancer progression and therapeutic treatment responses. However, in recent years, few biomarkers have progressed from discovery to become validated tools to be used in clinical practice. This Special Issue comprises eight review articles and five original studies on novel potential prognostic and predictive markers for different cancer types.

Author : Heinz-Josef Lenz
Publisher : Springer Science & Business Media
Page : 456 pages
File Size : 53,5 Mb
Release : 2012-09-18
Category : Medical
ISBN : 9781441997548

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Biomarkers in Oncology by Heinz-Josef Lenz Pdf

This integrated book covers the entire spectrum of cancer biomarkers in development and clinical use. Predictive and prognostic markers are explored in the context of colon cancer, breast cancer, lung cancer, prostate cancer, and GIST. International experts provide insight into toxicity markers and surrogate markers. Attention is also given to biomarker assay development, validation, and strategies. A powerful tool for determining decisions on therapy, selecting drug regimens, monitoring the efficacy of treatment, and performing individualized surveillance, biomarkers represent the forefront of cancer research and treatment. As these technologies become increasingly available for clinical use, this book will be an essential resource for oncologists and translational researchers.

Author : Cornelis F. M. Sier
Publisher : Frontiers Media SA
Page : 266 pages
File Size : 44,8 Mb
Release : 2022-12-28
Category : Medical
ISBN : 9782832509845

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Prognostic and predictive markers in colorectal cancer by Cornelis F. M. Sier Pdf

Author : Thorsten Ecke,Thomas Otto
Publisher : MDPI
Page : 240 pages
File Size : 44,6 Mb
Release : 2021-02-17
Category : Medical
ISBN : 9783039436859

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Diagnostic, Prognostic and Predictive Biological Markers in Bladder Cancer – Illumination of a Vision 2.0 by Thorsten Ecke,Thomas Otto Pdf

After our successful first Special Issue about bladder cancer, we proceeded with the second issue. Again, many international scientists submitted their newest research results in that extremely interesting field and followed our call for submissions. It is not only the collection and combination of old and new markers that could develop new possibilities, but also the focus on different classifications and sub-classifications that will unveil new ways in diagnostic and therapeutic approaches. It seems that the two established diagnostic tools will still play an important role, but new markers and diagnostics tools will present more detailed and more differentiated possibilities in the treatment of urinary bladder cancer. This second Special Issue is full of scientific results that could provide new ways to help patients with instruments for early diagnostics and with predictive and prognostic markers on their way to finding new and personalized strategies for therapy. The editors thank all of the submitting authors for their efforts and time spent on each manuscript. We hope that this Special Issue will prove useful to research work in bladder cancer in the future. We hope that many talented researchers will use multiple forms of art to improve their professional successes and to ameliorate diagnostics and therapy in bladder cancer.

Author : Giampietro Gasparini,Daniel F. Hayes
Publisher : Springer Science & Business Media
Page : 335 pages
File Size : 44,9 Mb
Release : 2008-01-17
Category : Medical
ISBN : 9781592599158

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Biomarkers in Breast Cancer by Giampietro Gasparini,Daniel F. Hayes Pdf

Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

Author : Bulent Aydogan,James A. Radosevich
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 43,6 Mb
Release : 2020-11-02
Category : Medical
ISBN : 9781119432449

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Precision Medicine in Oncology by Bulent Aydogan,James A. Radosevich Pdf

A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.

Author : Paul Hermanek,Mary K. Gospodarowicz,Donald E. Henson,Robert V.P. Hutter,Leslie H. Sobin
Publisher : Springer Science & Business Media
Page : 303 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642793950

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Prognostic Factors in Cancer by Paul Hermanek,Mary K. Gospodarowicz,Donald E. Henson,Robert V.P. Hutter,Leslie H. Sobin Pdf

M. K. Gospodarowicz, P. Hermanek, and D. E. Henson Attention to innovations in cancer treatment has tended to eclipse the importance of prognostic assessment. However, the recognition that prognostic factors often have a greater impact on outcome than available therapies and the proliferation of biochemical, molecular, and genetic markers have resulted in renewed interest in this field. The outcome in patients with cancer is determined by a combination of numerous factors. Presently, the most widely recognized are the extent of disease, histologic type of tumor, and treatment. It has been known for some time that additional factors also influence outcome. These include histologic grade, lymphatic or vascular invasion, mitotic index, performance status, symptoms, and most recently genetic and biochemical markers. It is the aim of this volume to compile those prognostic factors that have emerged as important determinants of outcome for tumors at various sites. This compilation represents the first phase of a more extensive process to integrate all prognostic factors in cancer to further enhance the prediction of outcome following treatment. Certain issues surround ing the assessment and reporting of prognostic factors are also considered. Importance of Prognostic Factors Prognostic factors in cancer often have an immense influence on outcome, while treatment often has a much weaker effect. For example, the influence of the presence of lymph node involvement on survival of patients with metastatic breast cancer is much greater than the effect of adjuvant treatment with tamoxifen in the same group of patients [5].

Author : Mu Wang,Frank Witzmann
Publisher : BoD – Books on Demand
Page : 262 pages
File Size : 55,9 Mb
Release : 2016-08-17
Category : Medical
ISBN : 9789535125051

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Role of Biomarkers in Medicine by Mu Wang,Frank Witzmann Pdf

The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.

Author : Richard D. Riley,Danielle van der Windt,Peter Croft,Karel G. M. Moons
Publisher : Oxford University Press
Page : 384 pages
File Size : 40,7 Mb
Release : 2019-01-17
Category : Medical
ISBN : 9780192516657

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Prognosis Research in Healthcare by Richard D. Riley,Danielle van der Windt,Peter Croft,Karel G. M. Moons Pdf

"What is going to happen to me?" Most patients ask this question during a clinical encounter with a health professional. As well as learning what problem they have (diagnosis) and what needs to be done about it (treatment), patients want to know about their future health and wellbeing (prognosis). Prognosis research can provide answers to this question and satisfy the need for individuals to understand the possible outcomes of their condition, with and without treatment. Central to modern medical practise, the topic of prognosis is the basis of decision making in healthcare and policy development. It translates basic and clinical science into practical care for patients and populations. Prognosis Research in Healthcare: Concepts, Methods and Impact provides a comprehensive overview of the field of prognosis and prognosis research and gives a global perspective on how prognosis research and prognostic information can improve the outcomes of healthcare. It details how to design, carry out, analyse and report prognosis studies, and how prognostic information can be the basis for tailored, personalised healthcare. In particular, the book discusses how information about the characteristics of people, their health, and environment can be used to predict an individual's future health. Prognosis Research in Healthcare: Concepts, Methods and Impact, addresses all types of prognosis research and provides a practical step-by-step guide to undertaking and interpreting prognosis research studies, ideal for medical students, health researchers, healthcare professionals and methodologists, as well as for guideline and policy makers in healthcare wishing to learn more about the field of prognosis.

Author : W. H. O. Classification WHO Classification of Tumours Editorial Board
Publisher : Unknown
Page : 500 pages
File Size : 51,6 Mb
Release : 2021-04-21
Category : Electronic
ISBN : 9283245067

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Thoracic Tumours by W. H. O. Classification WHO Classification of Tumours Editorial Board Pdf

****When not purchasing directly from the official sales agents of the WHO, especially at online bookshops, please note that there have been issues with counterfeited copies. Buy only from known sellers and if there are quality issues, please contact the seller for a refund.***** Thoracic Tumoursis the fifth available volume in the fifth edition of the WHO series on the classification of human tumours. This series (also known as the WHO Blue Books) is regarded as the gold standard for the diagnosis of tumours and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology. These authoritative and concise reference books provide indispensable international standards for anyone involved in the care of patients with cancer or in cancer research, underpinning individual patient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education. What's new in this edition? The fifth edition, guided by the WHO Classification of Tumours Editorial Board, establishes a single coherent cancer classification presented across a collection of individual volumes organized on the basis of anatomical site (digestive system, breast, soft tissue and bone, etc.) and structured in a systematic manner, with each tumour type listed within a taxonomic classification: site, category, family (class), type, and subtype. In each volume, the entities are now listed from benign to malignant and are described under an updated set of headings, including histopathology, diagnostic molecular pathology, staging, and easy-to-read essential and desirable diagnostic criteria. Who should read this book? * Pathologists * Oncologists * Respiratory physicians * Thoracic radiologists * Cancer researchers * Surgeons * Epidemiologists * Cancer registrars This volume: * Prepared by 217 authors and editors * Contributors from around the world * More than 1000 high-quality images * More than 3500 references

Author : Sam Thiagalingam
Publisher : Cambridge University Press
Page : 597 pages
File Size : 40,5 Mb
Release : 2015-04-09
Category : Mathematics
ISBN : 9780521493390

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Systems Biology of Cancer by Sam Thiagalingam Pdf

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Author : Giampietro Gasparini
Publisher : Springer Science & Business Media
Page : 416 pages
File Size : 54,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461551959

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Prognostic variables in node-negative and node-positive breast cancer by Giampietro Gasparini Pdf

Author : Thomas M. Cover,Joy A. Thomas
Publisher : John Wiley & Sons
Page : 788 pages
File Size : 47,6 Mb
Release : 2012-11-28
Category : Computers
ISBN : 9781118585771

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Elements of Information Theory by Thomas M. Cover,Joy A. Thomas Pdf

The latest edition of this classic is updated with new problem sets and material The Second Edition of this fundamental textbook maintains the book's tradition of clear, thought-provoking instruction. Readers are provided once again with an instructive mix of mathematics, physics, statistics, and information theory. All the essential topics in information theory are covered in detail, including entropy, data compression, channel capacity, rate distortion, network information theory, and hypothesis testing. The authors provide readers with a solid understanding of the underlying theory and applications. Problem sets and a telegraphic summary at the end of each chapter further assist readers. The historical notes that follow each chapter recap the main points. The Second Edition features: * Chapters reorganized to improve teaching * 200 new problems * New material on source coding, portfolio theory, and feedback capacity * Updated references Now current and enhanced, the Second Edition of Elements of Information Theory remains the ideal textbook for upper-level undergraduate and graduate courses in electrical engineering, statistics, and telecommunications.

Author : Debmalya Barh,Mehmet Gunduz
Publisher : CRC Press
Page : 516 pages
File Size : 55,9 Mb
Release : 2015-01-22
Category : Medical
ISBN : 9781466569393

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Noninvasive Molecular Markers in Gynecologic Cancers by Debmalya Barh,Mehmet Gunduz Pdf

Early detection is critical for any given cancer. With the advent of the latest omics technologies, molecular markers in combination with conventional diagnostic and screening methods are emerging as next-generation early diagnostic and prognostic strategies that can allow early-stage diagnosis, resulting in more effective treatment and patient car