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Author : Sylwia Bobis-Wozowicz,Eduardo Marbán
Publisher : Frontiers Media SA
Page : 163 pages
File Size : 55,8 Mb
Release : 2022-06-02
Category : Science
ISBN : 9782889763108
Author : Peter Holzer
Publisher : Springer Science & Business Media
Page : 574 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642188916
The tachykinins represent one of the most thoroughly investigated family of neuropeptides, whose members and receptors have been characterized at the genetic and molecular level and whose pharmacology has now been advanced to the first clinical application. These exciting accomplishments and prospects are reviewed and discussed in this volume in an authoritative manner. Particular emphasis is laid on the development of selective non-peptide antagonists for all 3 tachykinin receptors and their potential as novel drugs in a variety of diseases. The approval of the first tachykinin receptor antagonist as an antiemetic drug is particularly highlighted, and the utility of tachykinin receptor antagonists in affective disorders, chronic obstructive airway disease and irritable bowel syndrome, to name a few indications, is extensively considered.
Author : Atta-ur Rahman,M. Iqbal Choudhary
Publisher : Bentham Science Publishers
Page : 653 pages
File Size : 40,9 Mb
Release : 2011-08-12
Category : Medical
ISBN : 9781608051595
"Frontiers in CNS Drug Discovery" is an Ebook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design an
Author : Larry R. Squire
Publisher : Academic Press
Page : 12505 pages
File Size : 40,8 Mb
Release : 2009-06-12
Category : Medical
ISBN : 9780080963938
The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before acceptance into the encyclopedia. Each article contains a glossary, introduction, a reference section, and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields.
Author : Kenneth L. Davis,American College of Neuropsychopharmacology
Publisher : Lippincott Williams & Wilkins
Page : 1964 pages
File Size : 51,5 Mb
Release : 2002
Category : Medical
ISBN : 0781728371
Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of all neuropsychiatric disorders. Nine sections focus on specific groups of disorders, covering clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC
Author : Bo Dupont
Publisher : Springer
Page : 636 pages
File Size : 52,5 Mb
Release : 2013-12-20
Category : Medical
ISBN : 9783662399460
This set reports the results of the 10th International Histocompatibility Workshop, in which 362 laboratories collaborated over a three year period in research projects on the classification of HLA genes and their products. Volume 1 describes the experimental design of the workshop studies and their results. Volume 2 is a collection of papers on the latest developments in the molecular biology of HLA systems. Immunobiology of HLA is a valuable reference for tissue typing laboratories, blood banks, and general research programs on HLA and related diseases because it identifies common sources of HLA genes and gene products to be used as reference reagents, and because it is the only complete compilation of the latest research and results in the field.
Author : Jeffrey S. Albert,Michael W. Wood
Publisher : John Wiley & Sons
Page : 565 pages
File Size : 50,5 Mb
Release : 2012-06-06
Category : Medical
ISBN : 9781118309407
New and emerging directions in pharmaceutical research to better treat schizophrenia Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of the disease. Moreover, many schizophrenia patients fail to respond to current antipsychotics. Integrating chemistry, biology, and pharmacology, this book explores emerging directions in pharmaceutical research for drug targeting and discovery in order to find more effective treatments for schizophrenia, one of the most serious and widespread psychiatric diseases. Targets and Emerging Therapies for Schizophrenia presents the basics of schizophrenia, drug targets for the disease, and potential new drugs and therapeutics. It begins with a discussion of prevalence and etiology. Then, it describes therapies such as dopamine agonists and phosphodiesterase (PDE) inhibitors as well as growing research aimed at addressing untreated symptoms. Next, the authors discuss receptor modulators, inhibitors, and targeting strategies for drug discovery. Both the neurobiological and chemical aspects of all major pharmacological targets are examined. With contributions from an international team of pioneering pharmaceutical researchers, this book compiles the current knowledge in the field, setting the stage for new breakthroughs in the treatment of schizophrenia. Targets and Emerging Therapies for Schizophrenia: Provides a comprehensive resource for neuro-drug discovery and the development of molecular targets for schizophrenia treatment Draws from chemistry, biology, and pharmacology for more effective drug targeting and discovery Explores a wide range of receptors and molecular targets, including dopamine, PDEs, and neuropeptides With Targets and Emerging Therapies for Schizophrenia as their guide, drug discovery and development scientists have the information they need to advance their own research so that new, more effective treatments for schizophrenia will soon be a reality.
Author : Abba Kastin,Abba J. Kastin
Publisher : Elsevier
Page : 1640 pages
File Size : 43,5 Mb
Release : 2011-04-28
Category : Science
ISBN : 9780080463797
Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar. *Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar. *Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.
Author : Anonim
Publisher : ScholarlyEditions
Page : 310 pages
File Size : 44,8 Mb
Release : 2013-06-21
Category : Medical
ISBN : 9781481674102
Catecholamines—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Catecholamines—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Catecholamines—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Ian Stolerman
Publisher : Springer Science & Business Media
Page : 1433 pages
File Size : 41,5 Mb
Release : 2010-07-31
Category : Medical
ISBN : 9783540686989
Here is a broad overview of the central topics and issues in psychopharmacology, biological psychiatry and behavioral neurosciences, with information about developments in the field, including novel drugs and technologies. The more than 2000 entries are written by leading experts in pharmacology and psychiatry and comprise in-depth essays, illustrated with full-color figures, and are presented in a lucid style.
Author : P. Michael Conn
Publisher : Academic Press
Page : 588 pages
File Size : 51,9 Mb
Release : 2013-10-22
Category : Nature
ISBN : 9781483268132
Methods in Neurosciences, Volume 5: Neuropeptide Technology: Gene Expression and Neuropeptide Receptors discusses procedures and tools of assay useful for the identification, purification, and quantification of neuropeptides and their receptors. This volume is divided into two sections—neuropeptide gene expression and neuropeptide receptors. In these sections, this book specifically discusses the assays for peptide products of somatostatin gene expression; molecular assays for rat thyrotropin-releasing hormone gene; and structure, expression, and chromosomal localization of human gene. The gastrin-releasing peptide or mammalian bombesin; semiquantitative analysis of cellular somatostatin mRNA Levels; and atrial natriuretic factor receptor assays are also elaborated. This text likewise covers the receptors for opioid peptides in brain and autoradiography of somatostatin receptors in rat cerebellum. This publication is beneficial to neuroscientists and students intending to acquire knowledge of gene expression and neuropeptide receptors.
Author : Fleur L. Strand
Publisher : MIT Press
Page : 678 pages
File Size : 52,6 Mb
Release : 1999
Category : Neuropeptides
ISBN : 0262194074
This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. In recent years there has been increasing interest and, subsequently, active research in neuropeptides. These neuroactive molecules coordinate, integrate, and regulate physiological processes in all organisms, throughout all phases of development. Acting as neurohormones, neurotransmitters, and/or neuromodulators, they maintain physiological homeostasis and influence important behavioral patterns. This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. The book is divided into two parts. In Part I the author defines the basic principles of neuropeptide action, including their biosynthesis, processing, transport, distribution, and interactions with receptors and second messenger systems. Strand also discusses the intimate interaction between the neuropeptides, stress, and the immune system. In Part II she discusses the regulatory functions of the families of neuropeptide in sufficient detail to provide both the advanced student and senior investigator with a thorough understanding of the most important neuropeptides. The text also contains a complete and up-to-date reference/reading list.
Author : Anonim
Publisher : ScholarlyEditions
Page : 124 pages
File Size : 41,9 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464928895
Kinins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Kinins. The editors have built Kinins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Kinins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Kinins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Brendan J. Canning,Domenico Spina
Publisher : Springer Science & Business Media
Page : 623 pages
File Size : 54,6 Mb
Release : 2009-08-05
Category : Medical
ISBN : 9783540790907
The intention of this book is to provide a comprehensive and contemporary review of the biology of sensory nerves. The book is unique, as it comprehensively covers the role of sensory nerves across many therapeutic areas.
Author : Nancy Childress
Publisher : Springer Science & Business Media
Page : 230 pages
File Size : 41,8 Mb
Release : 2008-10-28
Category : Mathematics
ISBN : 9780387724904
Class field theory brings together the quadratic and higher reciprocity laws of Gauss, Legendre, and others, and vastly generalizes them. This book provides an accessible introduction to class field theory. It takes a traditional approach in that it attempts to present the material using the original techniques of proof, but in a fashion which is cleaner and more streamlined than most other books on this topic. It could be used for a graduate course on algebraic number theory, as well as for students who are interested in self-study. The book has been class-tested, and the author has included lots of challenging exercises throughout the text.