Nmr In Structural Biology

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Fundamentals of Protein NMR Spectroscopy

Gordon S. Rule,T. Kevin Hitchens
Fundamentals of Protein NMR Spectroscopy Book PDF

Author : Gordon S. Rule,T. Kevin Hitchens
Publisher : Springer Science & Business Media
Page : 543 pages
File Size : 47,5 Mb
Release : 2006-02-16
Category : Science
ISBN : 9781402035005

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Fundamentals of Protein NMR Spectroscopy by Gordon S. Rule,T. Kevin Hitchens Pdf

NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basic understanding of the phenomenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a set of practical rules is presented and used to describe many commonly employed multi-dimensional, multi-nuclear NMR pulse sequences. A modular analysis of NMR pulse sequence building blocks also provides a basis for understanding and developing novel pulse programs. This text not only covers topics from chemical shift assignment to protein structure refinement, as well as the analysis of protein dynamics and chemical kinetics, but also provides a practical guide to many aspects of modern spectrometer hardware, sample preparation, experimental set-up, and data processing. End of chapter exercises are included to emphasize important concepts. Fundamentals of Protein NMR Spectroscopy not only offer students a systematic, in-depth, understanding of modern NMR spectroscopy and its application to biomolecular systems, but will also be a useful reference for the experienced investigator.

Nmr In Structural Biology: A Collection Of Papers By Kurt Wuthrich

Kurt Wuthrich
Nmr In Structural Biology A Collection Of Papers By Kurt Wuthrich Book PDF

Author : Kurt Wuthrich
Publisher : World Scientific
Page : 760 pages
File Size : 47,5 Mb
Release : 1995-07-31
Category : Science
ISBN : 9789814500494

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Nmr In Structural Biology: A Collection Of Papers By Kurt Wuthrich by Kurt Wuthrich Pdf

The volume presents a survey of the research by Kurt Wüthrich and his associates during the period 1965 to 1994. A selection of reprints of original papers on the use of NMR spectroscopy in structural biology is supplemented with an introduction, which outlines the foundations and the historical development of the use of NMR spectroscopy for the determination of three-dimensional structures of biological macromolecules in solution. The original papers are presented in groups highlighting protein structure determination by NMR, studies of dynamic properties and hydration of biological macromolecules, and practical applications of the NMR methodology in fields such as enzymology, transcriptional regulation, immunosuppression and protein folding.

Biological NMR Spectroscopy

John L. Markley,Stanley J. Opella
Biological NMR Spectroscopy Book PDF

Author : John L. Markley,Stanley J. Opella
Publisher : Oxford University Press
Page : 375 pages
File Size : 42,6 Mb
Release : 1997-01-30
Category : Science
ISBN : 9780195357424

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Biological NMR Spectroscopy by John L. Markley,Stanley J. Opella Pdf

This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.

Structural Biology

Quincy Teng
Structural Biology Book PDF

Author : Quincy Teng
Publisher : Springer Science & Business Media
Page : 302 pages
File Size : 43,5 Mb
Release : 2005-05-26
Category : Science
ISBN : 9780387243672

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Structural Biology by Quincy Teng Pdf

Over the years since NMR was first applied to solve problems in structural biology, it has undergonedramaticdevelopmentsinbothNMRinstrumenthardwareandmethodology. While it is established that NMR is one of the most powerful tools for understanding biological p- cesses at the atomic level, it has become increasingly difficult for authors and instructors to make valid decisions concerning the content and level for a graduate course of NMR in str- turalbiology. BecausemanyofthedetailsinpracticalNMRarenotdocumentedsystematically, students entering the field have to learn the experiments and methods through communication with other experienced students or experts. Often such a learning process is incomplete and unsystematic. This book is meant to be not only a textbook, but also a handbook for those who routinely use NMR to study various biological systems. Thus, the book is organized with experimentalists in mind, whether they are instructors or students. For those who have a little or no background in NMR structural biology, it is hoped that this book will provide sufficient perspective and insight. Those who are already experienced in NMR research may find new information or different methods that are useful to their research. Because understanding fundamental principles and concepts of NMR spectroscopy is essential for the application of NMR methods to research projects, the book begins with an introduction to basic NMR principles. While detailed mathematics and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR books, Chapter 1 illustrates some of the fundamental principles and concepts of NMR spectroscopy in a more descriptiveandstraightforwardmanner.

NMR in Structural Biology

Kurt Wthrich
NMR in Structural Biology Book PDF

Author : Kurt Wthrich
Publisher : World Scientific
Page : 770 pages
File Size : 44,8 Mb
Release : 1995
Category : Science
ISBN : 9810223846

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NMR in Structural Biology by Kurt Wthrich Pdf

The volume presents a survey of the research by Kurt Wthrich and his associates during the period 1965 to 1994. A selection of reprints of original papers on the use of NMR spectroscopy in structural biology is supplemented with an introduction, which outlines the foundations and the historical development of the use of NMR spectroscopy for the determination of three-dimensional structures of biological macromolecules in solution. The original papers are presented in groups highlighting protein structure determination by NMR, studies of dynamic properties and hydration of biological macromolecules, and practical applications of the NMR methodology in fields such as enzymology, transcriptional regulation, immunosuppression and protein folding.

NMR in Biological Systems

K.V.R. Chary,Girjesh Govil
NMR in Biological Systems Book PDF

Author : K.V.R. Chary,Girjesh Govil
Publisher : Springer Science & Business Media
Page : 552 pages
File Size : 44,5 Mb
Release : 2008-04-01
Category : Science
ISBN : 9781402066801

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NMR in Biological Systems by K.V.R. Chary,Girjesh Govil Pdf

During teaching NMR to students and researchers, we felt the need for a text-book which can cover modern trends in the application of NMR to biological systems. This book covers the entire area of NMR in Biological Sciences (Biomolecules, cells and tissues, animals, plants and drug design). As well as being useful to researchers, this is an excellent book for teaching a course on NMR in Biological Systems.

NMR Spectroscopy Explained

Neil E. Jacobsen
NMR Spectroscopy Explained Book PDF

Author : Neil E. Jacobsen
Publisher : John Wiley & Sons
Page : 640 pages
File Size : 43,6 Mb
Release : 2007-09-10
Category : Science
ISBN : 9780470173343

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NMR Spectroscopy Explained by Neil E. Jacobsen Pdf

NMR Spectroscopy Explained : Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology provides a fresh, practical guide to NMR for both students and practitioners, in a clearly written and non-mathematical format. It gives the reader an intermediate level theoretical basis for understanding laboratory applications, developing concepts gradually within the context of examples and useful experiments. Introduces students to modern NMR as applied to analysis of organic compounds. Presents material in a clear, conversational style that is appealing to students. Contains comprehensive coverage of how NMR experiments actually work. Combines basic ideas with practical implementation of the spectrometer. Provides an intermediate level theoretical basis for understanding laboratory experiments. Develops concepts gradually within the context of examples and useful experiments. Introduces the product operator formalism after introducing the simpler (but limited) vector model.

Structural Biology

Quincy Teng
Structural Biology Book PDF

Author : Quincy Teng
Publisher : Springer Science & Business Media
Page : 295 pages
File Size : 50,8 Mb
Release : 2007-08-02
Category : Science
ISBN : 9780387243689

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Structural Biology by Quincy Teng Pdf

Over the years since NMR was first applied to solve problems in structural biology, it has undergonedramaticdevelopmentsinbothNMRinstrumenthardwareandmethodology. While it is established that NMR is one of the most powerful tools for understanding biological p- cesses at the atomic level, it has become increasingly difficult for authors and instructors to make valid decisions concerning the content and level for a graduate course of NMR in str- turalbiology. BecausemanyofthedetailsinpracticalNMRarenotdocumentedsystematically, students entering the field have to learn the experiments and methods through communication with other experienced students or experts. Often such a learning process is incomplete and unsystematic. This book is meant to be not only a textbook, but also a handbook for those who routinely use NMR to study various biological systems. Thus, the book is organized with experimentalists in mind, whether they are instructors or students. For those who have a little or no background in NMR structural biology, it is hoped that this book will provide sufficient perspective and insight. Those who are already experienced in NMR research may find new information or different methods that are useful to their research. Because understanding fundamental principles and concepts of NMR spectroscopy is essential for the application of NMR methods to research projects, the book begins with an introduction to basic NMR principles. While detailed mathematics and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR books, Chapter 1 illustrates some of the fundamental principles and concepts of NMR spectroscopy in a more descriptiveandstraightforwardmanner.

In-cell NMR Spectroscopy

Yutaka Ito,Volker Dötsch,Masahiro Shirakawa
In cell NMR Spectroscopy Book PDF

Author : Yutaka Ito,Volker Dötsch,Masahiro Shirakawa
Publisher : Royal Society of Chemistry
Page : 322 pages
File Size : 44,6 Mb
Release : 2019-12-09
Category : Science
ISBN : 9781839160936

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In-cell NMR Spectroscopy by Yutaka Ito,Volker Dötsch,Masahiro Shirakawa Pdf

In-cell NMR spectroscopy is a relatively new field. Despite its short history, recent in-cell NMR-related publications in major journals indicate that this method is receiving significant general attention. This book provides the first informative work specifically focused on in-cell NMR. It details the historical background of in-cell NMR, host cells for in-cell NMR studies, methods for in-cell biological techniques and NMR spectroscopy, applications, and future perspectives. Researchers in biochemistry, biophysics, molecular biology, cell biology, structural biology as well as NMR analysts interested in biological applications will all find this book valuable reading.

Structural Biology in Drug Discovery

Jean-Paul Renaud
Structural Biology in Drug Discovery Book PDF

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
Page : 1367 pages
File Size : 43,5 Mb
Release : 2020-01-09
Category : Medical
ISBN : 9781118900505

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Structural Biology in Drug Discovery by Jean-Paul Renaud Pdf

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

NMR of Biomolecules

Ivano Bertini,Kathleen S. McGreevy,Giacomo Parigi
NMR of Biomolecules Book PDF

Author : Ivano Bertini,Kathleen S. McGreevy,Giacomo Parigi
Publisher : John Wiley & Sons
Page : 15 pages
File Size : 42,5 Mb
Release : 2012-04-16
Category : Science
ISBN : 9783527328505

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NMR of Biomolecules by Ivano Bertini,Kathleen S. McGreevy,Giacomo Parigi Pdf

NMR is one of the most powerful methods for imaging of biomolecules. This book is the ultimate NMR guide for researchers in the biomedical community and gives not only background and practical tips but also a forward looking view on the future of NMR in systems biology.

Perspectives on Solid State NMR in Biology

S.R. Kiihne,H.J.M. de Groot
Perspectives on Solid State NMR in Biology Book PDF

Author : S.R. Kiihne,H.J.M. de Groot
Publisher : Springer Science & Business Media
Page : 227 pages
File Size : 54,5 Mb
Release : 2013-03-14
Category : Science
ISBN : 9789401725798

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Perspectives on Solid State NMR in Biology by S.R. Kiihne,H.J.M. de Groot Pdf

Solid state NMR is rapidly emerging as a universally applicable method for the characterization of ordered structures that cannot be studied with solution methods or diffraction techniques. This proceedings -; from a recent international workshop - captures an image of the latest developments and future directions for solid state NMR in biological research, particularly on membrane proteins. Detailed information on how hormones or drugs bind to their membrane receptor targets is needed, e.g. for rational drug design. Higher fields are bringing clear improvements, and the power of solid state NMR techniques for studying amorphous and membrane associated peptides, proteins and complexes is shown by examples of applications at ultra-high fields. Progress in protein expression, experimental design and data analysis are also presented by leaders in these research areas.

In-cell NMR Spectroscopy

Yutaka Ito,Volker Dötsch,Masahiro Shirakawa
In cell NMR Spectroscopy Book PDF

Author : Yutaka Ito,Volker Dötsch,Masahiro Shirakawa
Publisher : Royal Society of Chemistry
Page : 322 pages
File Size : 48,9 Mb
Release : 2019-12-13
Category : Science
ISBN : 9781788012171

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In-cell NMR Spectroscopy by Yutaka Ito,Volker Dötsch,Masahiro Shirakawa Pdf

In-cell NMR spectroscopy is a relatively new field. Despite its short history, recent in-cell NMR-related publications in major journals indicate that this method is receiving significant general attention. This book provides the first informative work specifically focused on in-cell NMR. It details the historical background of in-cell NMR, host cells for in-cell NMR studies, methods for in-cell biological techniques and NMR spectroscopy, applications, and future perspectives. Researchers in biochemistry, biophysics, molecular biology, cell biology, structural biology as well as NMR analysts interested in biological applications will all find this book valuable reading.

Fundamentals of Protein NMR Spectroscopy

Gordon S. Rule,T. Kevin Hitchens
Fundamentals of Protein NMR Spectroscopy Book PDF

Author : Gordon S. Rule,T. Kevin Hitchens
Publisher : Springer Science & Business Media
Page : 543 pages
File Size : 54,5 Mb
Release : 2005-10-28
Category : Science
ISBN : 9781402034992

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Fundamentals of Protein NMR Spectroscopy by Gordon S. Rule,T. Kevin Hitchens Pdf

NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basic understanding of the phenomenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a set of practical rules is presented and used to describe many commonly employed multi-dimensional, multi-nuclear NMR pulse sequences. A modular analysis of NMR pulse sequence building blocks also provides a basis for understanding and developing novel pulse programs. This text not only covers topics from chemical shift assignment to protein structure refinement, as well as the analysis of protein dynamics and chemical kinetics, but also provides a practical guide to many aspects of modern spectrometer hardware, sample preparation, experimental set-up, and data processing. End of chapter exercises are included to emphasize important concepts. Fundamentals of Protein NMR Spectroscopy not only offer students a systematic, in-depth, understanding of modern NMR spectroscopy and its application to biomolecular systems, but will also be a useful reference for the experienced investigator.

Structural Biology

Quincy Teng
Structural Biology Book PDF

Author : Quincy Teng
Publisher : Springer
Page : 0 pages
File Size : 47,8 Mb
Release : 2005-05-26
Category : Science
ISBN : 0387243674

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Structural Biology by Quincy Teng Pdf

Over the years since NMR was first applied to solve problems in structural biology, it has undergonedramaticdevelopmentsinbothNMRinstrumenthardwareandmethodology. While it is established that NMR is one of the most powerful tools for understanding biological p- cesses at the atomic level, it has become increasingly difficult for authors and instructors to make valid decisions concerning the content and level for a graduate course of NMR in str- turalbiology. BecausemanyofthedetailsinpracticalNMRarenotdocumentedsystematically, students entering the field have to learn the experiments and methods through communication with other experienced students or experts. Often such a learning process is incomplete and unsystematic. This book is meant to be not only a textbook, but also a handbook for those who routinely use NMR to study various biological systems. Thus, the book is organized with experimentalists in mind, whether they are instructors or students. For those who have a little or no background in NMR structural biology, it is hoped that this book will provide sufficient perspective and insight. Those who are already experienced in NMR research may find new information or different methods that are useful to their research. Because understanding fundamental principles and concepts of NMR spectroscopy is essential for the application of NMR methods to research projects, the book begins with an introduction to basic NMR principles. While detailed mathematics and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR books, Chapter 1 illustrates some of the fundamental principles and concepts of NMR spectroscopy in a more descriptiveandstraightforwardmanner.