Non Coding Rnas And Cancer

Author : Jayprokas Chakrabarti,Sanga Mitra
Publisher : Academic Press
Page : 576 pages
File Size : 40,8 Mb
Release : 2017-10-13
Category : Medical
ISBN : 9780128134375

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Cancer and Noncoding RNAs by Jayprokas Chakrabarti,Sanga Mitra Pdf

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field

Author : Muller Fabbri
Publisher : Springer Science & Business Media
Page : 287 pages
File Size : 44,9 Mb
Release : 2013-10-28
Category : Medical
ISBN : 9781461484448

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Non-coding RNAs and Cancer by Muller Fabbri Pdf

The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of the non-coding genome in cancer. Moreover, completely new and unexpected functions for microRNAs are being revealed, leading to the identification of new anticancer molecular targets. This book represents a comprehensive guide on non-coding RNAs and cancer, spanning from its role as cancer biomarkers, to providing the most useful bioinformatic tools, to presenting some of the most relevant discoveries, which indicates how these fascinating molecules act as fine orchestrators of cancer biology.

Author : Erwei Song
Publisher : Springer
Page : 458 pages
File Size : 49,9 Mb
Release : 2016-07-04
Category : Medical
ISBN : 9789811014987

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The Long and Short Non-coding RNAs in Cancer Biology by Erwei Song Pdf

The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.

Author : M.R.S. Rao
Publisher : Springer
Page : 323 pages
File Size : 53,7 Mb
Release : 2017-08-16
Category : Medical
ISBN : 9789811052033

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Long Non Coding RNA Biology by M.R.S. Rao Pdf

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Author : Lütfi Tutar,Sumer Aras,Esen Tutar
Publisher : BoD – Books on Demand
Page : 150 pages
File Size : 52,6 Mb
Release : 2020-03-04
Category : Medical
ISBN : 9781789856552

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Non-Coding RNAs by Lütfi Tutar,Sumer Aras,Esen Tutar Pdf

Noncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics.

Author : Subash Gupta,Kishore Challagundla
Publisher : Academic Press
Page : 479 pages
File Size : 42,9 Mb
Release : 2022-01-19
Category : Science
ISBN : 9780128245514

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Clinical Applications of Noncoding RNAs in Cancer by Subash Gupta,Kishore Challagundla Pdf

Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides a comprehensive collection of information on the utility of noncoding RNAs in the diagnosis, prognosis, and therapy of cancer. It also discusses the evolutionary significance of noncoding RNAs and how the molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE, and quantitative real-time PCR help in the detection and elucidation of the functions of noncoding RNAs. Additionally, the challenges associated with noncoding RNA approaches and future developments are discussed. It is a valuable resource for cancer researchers, oncologists, clinicians, and other biomedical field members who want to learn more about noninvasive ways to diagnose and efficiently treat diverse cancer types. Presents a beginning chapter summary to help readers understand the content thoroughly Encompasses detailed description of information from clinical studies on noncoding RNAs in cancer therapy Discusses one cancer type per chapter making the content easy to reference

Author : Gautam Sethi,Milad Ashrafizadeh
Publisher : World Scientific
Page : 377 pages
File Size : 40,7 Mb
Release : 2023-03-14
Category : Medical
ISBN : 9789811267406

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Non-coding Rna Transcripts In Cancer Therapy: Pre-clinical And Clinical Implications by Gautam Sethi,Milad Ashrafizadeh Pdf

'Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications' provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described.

Author : Kevin V. Morris
Publisher : Springer
Page : 262 pages
File Size : 45,6 Mb
Release : 2016-04-13
Category : Medical
ISBN : 9783319239071

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Long Non-coding RNAs in Human Disease by Kevin V. Morris Pdf

This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.

Author : Wenwen Zhang,Naoyuki Kataoka,Xiaoxiang Guan
Publisher : Frontiers Media SA
Page : 158 pages
File Size : 44,6 Mb
Release : 2022-01-06
Category : Medical
ISBN : 9782889719747

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Non-coding RNAs in Breast Cancer by Wenwen Zhang,Naoyuki Kataoka,Xiaoxiang Guan Pdf

Author : Alfons Navarro
Publisher : Humana
Page : 0 pages
File Size : 52,5 Mb
Release : 2022-06-25
Category : Medical
ISBN : 1071615831

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Long Non-Coding RNAs in Cancer by Alfons Navarro Pdf

This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.

Author : Yujing Li,Ge Shan,Zhao-Qian Teng,Thomas S. Wingo
Publisher : Frontiers Media SA
Page : 346 pages
File Size : 49,8 Mb
Release : 2020-07-08
Category : Electronic
ISBN : 9782889638321

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Non-Coding RNAs and Human Diseases by Yujing Li,Ge Shan,Zhao-Qian Teng,Thomas S. Wingo Pdf

Author : Giovanni Blandino,Hernandes F. Carvalho,Jawed A. Siddiqui,Valeria Poli
Publisher : Frontiers Media SA
Page : 256 pages
File Size : 45,5 Mb
Release : 2023-01-05
Category : Medical
ISBN : 9782832510667

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Roles Of Non-coding RNAs In Tumor Growth And Development by Giovanni Blandino,Hernandes F. Carvalho,Jawed A. Siddiqui,Valeria Poli Pdf

Author : Ondrej Slaby,George A. Calin
Publisher : Springer
Page : 252 pages
File Size : 43,5 Mb
Release : 2016-08-29
Category : Medical
ISBN : 9783319420592

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Non-coding RNAs in Colorectal Cancer by Ondrej Slaby,George A. Calin Pdf

This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology.

Author : Bibekanand Mallick
Publisher : Academic Press
Page : 387 pages
File Size : 42,7 Mb
Release : 2019-01-20
Category : Science
ISBN : 9780128156704

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AGO-Driven Non-Coding RNAs by Bibekanand Mallick Pdf

The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world’s leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases. Provides a unified cutting-edge resource for both miRNAs and piRNAs, two promising AGO-clade small ncRNAs, their functions and potential applications Showcase high-throughput technologies and other approaches for discovery of these small ncRNAs and their targets Unveils the diverse molecular mechanisms by which miRNAs and piRNAs regulate gene expression in animal cells Showcase recent discoveries on involvement of Argonaute and Piwi proteins in different biological processes and diseases as well as their possible use in diagnosis Report breakthroughs in the use of small ncRNAs for diagnosis and personalized therapy

Author : Yongye Huang,Yue Hou,Peng Qu,Yong Cai
Publisher : Frontiers Media SA
Page : 200 pages
File Size : 47,8 Mb
Release : 2021-11-05
Category : Medical
ISBN : 9782889715961

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Combating Cancer with Natural Products: What Would Non-Coding RNAs Bring? by Yongye Huang,Yue Hou,Peng Qu,Yong Cai Pdf