Long Non Coding Rnas In Human Disease

Author : Kevin V. Morris
Publisher : Springer
Page : 262 pages
File Size : 54,8 Mb
Release : 2016-04-13
Category : Medical
ISBN : 9783319239071

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Long Non-coding RNAs in Human Disease by Kevin V. Morris Pdf

This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.

Author : Yujing Li,Ge Shan,Zhao-Qian Teng,Thomas S. Wingo
Publisher : Frontiers Media SA
Page : 346 pages
File Size : 41,7 Mb
Release : 2020-07-08
Category : Electronic
ISBN : 9782889638321

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Non-Coding RNAs and Human Diseases by Yujing Li,Ge Shan,Zhao-Qian Teng,Thomas S. Wingo Pdf

Author : Jing Zhang,Jingmin Ou,Tao Zeng,Xiang Zhang,Song Zhao,Jinshui Zhu
Publisher : Frontiers Media SA
Page : 325 pages
File Size : 51,5 Mb
Release : 2023-04-14
Category : Science
ISBN : 9782832520802

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RNA modification and non-coding RNAs in human disease by Jing Zhang,Jingmin Ou,Tao Zeng,Xiang Zhang,Song Zhao,Jinshui Zhu Pdf

Author : Lütfi Tutar,Sumer Aras,Esen Tutar
Publisher : BoD – Books on Demand
Page : 150 pages
File Size : 53,8 Mb
Release : 2020-03-04
Category : Medical
ISBN : 9781789856552

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Non-Coding RNAs by Lütfi Tutar,Sumer Aras,Esen Tutar Pdf

Noncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics.

Author : Junjie Xiao
Publisher : Springer
Page : 426 pages
File Size : 40,8 Mb
Release : 2021-04-28
Category : Science
ISBN : 9811516731

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Non-coding RNAs in Cardiovascular Diseases by Junjie Xiao Pdf

This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.

Author : Lin Zhang,Xiaowen Hu
Publisher : Humana
Page : 0 pages
File Size : 45,8 Mb
Release : 2022-09-04
Category : Medical
ISBN : 1071616994

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Long Non-Coding RNAs by Lin Zhang,Xiaowen Hu Pdf

This second edition provides a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Chapters guide readers through studies used to circular RNAs, RNA splicing, and findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Long Non-Coding RNAs: Methods and Protocols,Second Edition aims to ensure successful results in the further study of this vital field.

Author : Syed Mudasir Andrabi,Nazir Ahmad Ganai
Publisher : Cambridge Scholars Publishing
Page : 201 pages
File Size : 40,6 Mb
Release : 2020-09-03
Category : Science
ISBN : 9781527559103

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Long Non-Coding RNA by Syed Mudasir Andrabi,Nazir Ahmad Ganai Pdf

Long non-coding RNAs (LncRNAs) were originally regarded as “noise” in the genome due to their lack of protein-encoding capacity. However, their roles are now understood to cover various biological functions like gene regulation, cell proliferation, survival, differentiation, and chromatin remodeling. As an emerging group of non-coding RNA molecules, LncRNAs are involved in diverse diseases like cancer, cardiovascular, autoimmune, hormonal disorders, neurodegeneration, and infection, among others. However, knowledge of the mechanisms by which they act is still ambiguous. As such, this book meets the essential need for a textbook dedicated to this topic and provides a comprehensive and captivating account of lncRNA research.

Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
Page : 678 pages
File Size : 40,5 Mb
Release : 2017-10-23
Category : Science
ISBN : 9783527322817

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Gene Regulation, Epigenetics and Hormone Signaling by Subhrangsu S. Mandal Pdf

The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

Author : Anonim
Publisher : Academic Press
Page : 444 pages
File Size : 46,7 Mb
Release : 2020-08-19
Category : Medical
ISBN : 9780128171943

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RNA-Based Regulation in Human Health and Disease by Anonim Pdf

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

Author : Haiming Cao
Publisher : Humana
Page : 351 pages
File Size : 42,7 Mb
Release : 2021-12-18
Category : Science
ISBN : 1071611607

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Functional Analysis of Long Non-Coding RNAs by Haiming Cao Pdf

This detailed volume presents a comprehensive bioinformatic and experimental toolbox for prioritizing, annotating, and functionally analyzing long non-coding RNAs (lncRNAs). Playing a vital role in diverse biological progresses and human disease, lncRNAs have proven to be a challenging subject of study due to our limited understanding of their sequence-function relationships, lack of complete genetic annotation, and the unavailability of systems required to define their functional importance and molecular mechanisms, all of which this book seeks to address. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Functional Analysis of Long Non-Coding RNAs: Methods and Protocols provides a timely and convenient resource to facilitate the identification and characterization of disease-associated human lncRNAs, which aims to shed light on their role in biology and pathophysiology and ultimately lead toward novel therapeutic approaches targeting lncRNAs for the amelioration of human diseases.

Author : Ahmad M. Khalil
Publisher : Springer
Page : 187 pages
File Size : 53,6 Mb
Release : 2019-06-06
Category : Medical
ISBN : 9783030170868

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Molecular Biology of Long Non-coding RNAs by Ahmad M. Khalil Pdf

This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.

Author : Xia Li,Juan Xu,Yun Xiao,Shangwei Ning,Yunpeng Zhang
Publisher : Springer
Page : 126 pages
File Size : 42,5 Mb
Release : 2018-09-06
Category : Science
ISBN : 9789811307195

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Non-coding RNAs in Complex Diseases by Xia Li,Juan Xu,Yun Xiao,Shangwei Ning,Yunpeng Zhang Pdf

This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas. Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.

Author : Jayprokas Chakrabarti,Sanga Mitra
Publisher : Academic Press
Page : 576 pages
File Size : 54,5 Mb
Release : 2017-10-13
Category : Medical
ISBN : 9780128134375

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Cancer and Noncoding RNAs by Jayprokas Chakrabarti,Sanga Mitra Pdf

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field

Author : Mohammadreza Hajjari,Seyed Javad Mowla, Mohammad Ali Faghihi
Publisher : Frontiers Media SA
Page : 73 pages
File Size : 46,8 Mb
Release : 2016-12-14
Category : Electronic book
ISBN : 9782889450022

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Molecular Function and Regulation of Non-coding RNAs in Multifactorial Diseases by Mohammadreza Hajjari,Seyed Javad Mowla, Mohammad Ali Faghihi Pdf

Our understanding of the mechanisms underlying the development of multifactorial diseases such as diabetes, autism, Alzheimer's disease, and cancer has been greatly advanced. Non-coding RNAs (ncRNAs), generally including microRNAs and long non-coding RNAs, have recently been found to have potential roles in these diseases, and provide new opportunities for developing both specific biomarkers and therapeutic targets. However, the molecular function and regulation of these RNAs still remains challenging. Numerous studies are focusing on this field in order to fully appreciate the role and regulation of these molecules in human medicine and biology. This e-book aims to bring together new findings on Non-coding RNAs in different complex diseases. It will highlight the characterization, roles, mechanism, and mode of action of these RNAs in complex disorders. We believe that the publications on this topic would be exponentially extended in future. The improved approaches at multiple levels may pave the way for designing and applying new biomarker and therapeutic targets for specific diseases based on these attractive molecules.

Author : Stefan Jurga,Jan Barciszewski
Publisher : Springer Nature
Page : 545 pages
File Size : 54,8 Mb
Release : 2020-10-01
Category : Medical
ISBN : 9783030447434

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The Chemical Biology of Long Noncoding RNAs by Stefan Jurga,Jan Barciszewski Pdf

This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.