Non Neutral Evolution

Author : Brian Golding
Publisher : Springer Science & Business Media
Page : 261 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461523833

Get Book

Non-Neutral Evolution by Brian Golding Pdf

All organisms--from the AIDS virus, to bacteria, to fish, to humans--must evolve to survive. Despite the central place of evolution within biology, there are many things that are still poorly understood. For Charles Darwin, the driving force behind all evolution was natural selection. More recently, evolutionary biologists have considered that many mutations are essentially neutral with respect to natural selection. Many questions remain. Are molecular differences between species adaptive? Are differences within species adaptive? Modern biotechnology has enabled us to identify precisely the actual DNA structure from many individuals within a population, and thus to see how these DNA sequences have changed over time and to answer some of these questions. At the same time, this knowledge poses new challenges to our ability to understand the observed patterns. This exciting volume outlines the biological problems, provides new perspectives on theoretical treatments of the consequences of natural selection, examines the consequences of molecular data, and relates molecular events to speciation. Every evolutionary biologist will find it of interest.

Author : Motoo Kimura
Publisher : Cambridge University Press
Page : 388 pages
File Size : 51,7 Mb
Release : 1983
Category : Science
ISBN : 0521317932

Get Book

The Neutral Theory of Molecular Evolution by Motoo Kimura Pdf

This book is the first comprehensive treatment of this subject.

Author : Supratim Choudhuri
Publisher : Elsevier
Page : 238 pages
File Size : 54,9 Mb
Release : 2014-05-09
Category : Medical
ISBN : 9780124105102

Get Book

Bioinformatics for Beginners by Supratim Choudhuri Pdf

Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools provides a coherent and friendly treatment of bioinformatics for any student or scientist within biology who has not routinely performed bioinformatic analysis. The book discusses the relevant principles needed to understand the theoretical underpinnings of bioinformatic analysis and demonstrates, with examples, targeted analysis using freely available web-based software and publicly available databases. Eschewing non-essential information, the work focuses on principles and hands-on analysis, also pointing to further study options. Avoids non-essential coverage, yet fully describes the field for beginners Explains the molecular basis of evolution to place bioinformatic analysis in biological context Provides useful links to the vast resource of publicly available bioinformatic databases and analysis tools Contains over 100 figures that aid in concept discovery and illustration

Author : Arlin Stoltzfus
Publisher : Oxford University Press
Page : 283 pages
File Size : 55,9 Mb
Release : 2021
Category : Science
ISBN : 9780198844457

Get Book

Mutation, Randomness, and Evolution by Arlin Stoltzfus Pdf

What does it mean to say that mutation is random? How does mutation influence evolution? Are mutations merely the raw material for selection to shape adaptations? The author draws on a detailed knowledge of mutational mechanisms to argue that the randomness doctrine is best understood, not as a fact-based conclusion, but as the premise of a neo-Darwinian research program focused on selection. The successes of this research program created a blind spot - in mathematical models and verbal theories of causation - that has stymied efforts to re-think the role of variation. However, recent theoretical and empirical work shows that mutational biases can and do influence the course of evolution, including adaptive evolution, through a first come, first served mechanism. This thought-provoking book cuts through the conceptual tangle at the intersection of mutation, randomness, and evolution, offering a fresh, far-reaching, and testable view of the role of variation as a dispositional evolutionary factor. The arguments will be accessible to philosophers and historians with a serious interest in evolution, as well as to researchers and advanced students of evolution focused on molecules, microbes, evo-devo, and population genetics.

Author : Masatoshi Nei
Publisher : Columbia University Press
Page : 526 pages
File Size : 55,5 Mb
Release : 1987
Category : Computers
ISBN : 0231063210

Get Book

Molecular Evolutionary Genetics by Masatoshi Nei Pdf

-- "The Scientist"

Author : Ronny C. Woodruff,James N. Thompson
Publisher : Springer Science & Business Media
Page : 561 pages
File Size : 40,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401152105

Get Book

Mutation and Evolution by Ronny C. Woodruff,James N. Thompson Pdf

Although debated since the time of Darwin, the evolutionary role of mutation is still controversial. In over 40 chapters from leading authorities in mutation and evolutionary biology, this book takes a new look at both the theoretical and experimental measurement and significance of new mutation. Deleterious, nearly neutral, beneficial, and polygenic mutations are considered in their effects on fitness, life history traits, and the composition of the gene pool. Mutation is a phenomenon that draws attention from many different disciplines. Thus, the extensive reviews of the literature will be valuable both to established researchers and to those just beginning to study this field. Through up-to-date reviews, the authors provide an insightful overview of each topic and then share their newest ideas and explore controversial aspects of mutation and the evolutionary process. From topics like gonadal mosaicism and mutation clusters to adaptive mutagenesis, mutation in cell organelles, and the level and distribution of DNA molecular changes, the foundation is set for continuing the debate about the role of mutation, fitness, and adaptability. It is a debate that will have profound consequences for our understanding of evolution.

Author : Ronald C Davidson
Publisher : World Scientific Publishing Company
Page : 755 pages
File Size : 44,9 Mb
Release : 2001-10-22
Category : Science
ISBN : 9781911298199

Get Book

Physics Of Nonneutral Plasmas by Ronald C Davidson Pdf

A nonneutral plasma is a many-body collection of charged particles in which there is not overall charge neutrality. The diverse areas of application of nonneutral plasmas include: precision atomic clocks, trapping of antimatter plasmas and antihydrogen production, quantum computers, nonlinear vortex dynamics and fundamental transport processes in trapped nonneutral plasmas, strongly-coupled one-component plasmas and Coulomb crystals, coherent radiation generation in free electron devices, such as free electron lasers, magnetrons and cyclotron masers, and intense charged particle beam propagation in periodic focusing accelerators and transport systems, to mention a few examples. Physics of Nonneutral Plasmas is a graduate-level text — complete with 138 assigned problems and the results from several classic experiments — which covers a broad range of topics related to the fundamental properties of collective processes and nonlinear dynamics of one-component and multispecies charged particle systems in which there is not overall charge neutrality. The subject matter is treated systematically from first principles, using a unified theoretical approach, and the emphasis is on the development of basic concepts that illustrate the underlying physical processes in circumstances where intense self fields play a major role in determining the evolution of the system. The theoretical analysis includes the full influence of dc space charge effects on detailed equilibrium, stability and transport properties. The statistical models used to describe the properties of nonneutral plasmas are based on the nonlinear Vlasov-Maxwell equations, the macroscopic fluid-Maxwell equations, or the Klimontovich-Maxwell equations, as appropriate, and extensive use is made of theoretical techniques developed in the description of multispecies electrically-neutral plasmas, as well as established techniques in classical mechanics, electrodynamics and statistical physics.Physics of Nonneutral Plasmas emphasizes basic physics principles, and the thorough presentation style is intended to have a lasting appeal to graduate students and researchers alike. Because of the advanced theoretical techniques developed for describing one-component charged particle systems, this book serves as a useful companion volume to Physics of Intense Charged Particle Beams in High Energy Accelerators by Ronald C Davidson and Hong Qin.

Author : Xuhua Xia
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 49,5 Mb
Release : 2007-05-08
Category : Science
ISBN : 9780306468933

Get Book

Data Analysis in Molecular Biology and Evolution by Xuhua Xia Pdf

Data Analysis in Molecular Biology and Evolution introduces biologists to DAMBE, a proprietary, user-friendly computer program for molecular data analysis. The unique combination of this book and software will allow biologists not only to understand the rationale behind a variety of computational tools in molecular biology and evolution, but also to gain instant access to these tools for use in their laboratories. Data Analysis in Molecular Biology and Evolution serves as an excellent resource for advanced level undergraduates or graduates as well as for professionals working in the field.

Author : Davidson
Publisher : Allied Publishers
Page : 760 pages
File Size : 53,9 Mb
Release : 1990
Category : Nonneutral plasma
ISBN : 8177648489

Get Book

Physics of Nonneutral Plasmas by Davidson Pdf

Author : David Mittelman
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 47,8 Mb
Release : 2013-03-12
Category : Medical
ISBN : 9781461462804

Get Book

Stress-Induced Mutagenesis by David Mittelman Pdf

The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes. This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.

Author : Lucien Marie Le Cam,Jerzy Neyman,Elizabeth L. Scott
Publisher : Unknown
Page : 396 pages
File Size : 55,7 Mb
Release : 1972
Category : Biometry
ISBN : IND:30000121523355

Get Book

Darwinian, Neo-Darwinian, and Non-Darwinian Evolution by Lucien Marie Le Cam,Jerzy Neyman,Elizabeth L. Scott Pdf

Author : John H. Gillespie
Publisher : Oxford University Press
Page : 351 pages
File Size : 49,5 Mb
Release : 1994-05-26
Category : Science
ISBN : 9780195357745

Get Book

The Causes of Molecular Evolution by John H. Gillespie Pdf

This work provides a unified theory that addresses the important problem of the origin and maintenance of genetic variation in natural populations. With modern molecular techniques, variation is found in all species, sometimes at astonishingly high levels. Yet, despite these observations, the forces that maintain variation within and between species have been difficult subjects of study. Because they act very weakly and operate over vast time scales, scientists must rely on indirect inferences and speculative mathematical models. However, despite these obstacles, many advances have been made. The author's research in molecular genetics, evolution, and bio-mathematics has enabled him to draw on this work, and present a coherent and valuable view of the field. The book is divided into three parts. The first consists of three chapters on protein evolution, DNA evolution, and molecular mechanisms. This section reviews the experimental observations on genetic variation. The second part gives a unified treatment of the mathematical theory of selection in a fluctuating environment. The final two chapters combine the earlier assessments in a treatment of the scientific status of two competing theories for the maintenance of genetic variation. Steeped in the enormous advances population genetics has made over the past 25 years, this book has proven highly popular among human geneticists, biologists, evolutionary theorists, and bio-mathematicians.

Author : Masatoshi Nei
Publisher : OUP Oxford
Page : 261 pages
File Size : 44,8 Mb
Release : 2013-05-02
Category : Science
ISBN : 9780199661732

Get Book

Mutation-Driven Evolution by Masatoshi Nei Pdf

The purpose of this book is to present a new theory of mutation-driven evolution, which is based on recent advances in genomics and evolutionary developmental biology. This theory asserts that the driving force of evolution is mutation and natural selection is of secondary importance.

Author : Motoo Kimura,Tomoko Ohta
Publisher : Princeton University Press
Page : 236 pages
File Size : 49,8 Mb
Release : 1971-10-21
Category : Science
ISBN : 0691080984

Get Book

Theoretical Aspects of Population Genetics by Motoo Kimura,Tomoko Ohta Pdf

To show the importance of stochastic processes in the change of gene frequencies, the authors discuss topics ranging from molecular evolution to two-locus problems in terms of diffusion models. Throughout their discussion, they come to grips with one of the most challenging problems in population genetics--the ways in which genetic variability is maintained in Mendelian populations. R.A. Fisher, J.B.S. Haldane, and Sewall Wright, in pioneering works, confirmed the usefulness of mathematical theory in population genetics. The synthesis their work achieved is recognized today as mathematical genetics, that branch of genetics whose aim is to investigate the laws governing the genetic structure of natural populations and, consequently, to clarify the mechanisms of evolution. For the benefit of population geneticists without advanced mathematical training, Professors Kimura and Ohta use verbal description rather than mathematical symbolism wherever practicable. A mathematical appendix is included.

Author : Michael Lynch
Publisher : Sinauer
Page : 518 pages
File Size : 42,8 Mb
Release : 2007-06
Category : Medical
ISBN : UOM:49015003406510

Get Book

The Origins of Genome Architecture by Michael Lynch Pdf

The availability of genomic blueprints for hundreds of species has led to a transformation in biology, encouraging the proliferation of adaptive arguments for the evolution of genomic features. This text explains why the details matter and presents a framework for how the architectural diversity of eukaryotic genomes and genes came to arise.