Mutation Driven Evolution

Mutation Driven Evolution Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Mutation Driven Evolution book. This book definitely worth reading, it is an incredibly well-written.

Mutation-Driven Evolution

Masatoshi Nei
Mutation Driven Evolution Book PDF

Author : Masatoshi Nei
Publisher : OUP Oxford
Page : 256 pages
File Size : 51,9 Mb
Release : 2013-05-02
Category : Science
ISBN : 9780191637810

Get Book

Mutation-Driven Evolution by Masatoshi Nei Pdf

The purpose of this book is to present a new mechanistic theory of mutation-driven evolution based on recent advances in genomics and evolutionary developmental biology. The theory asserts, perhaps somewhat controversially, that the driving force behind evolution is mutation, with natural selection being of only secondary importance. The word 'mutation' is used to describe any kind of change in DNA such as nucleotide substitution, gene duplication/deletion, chromosomal change, and genome duplication. A brief history of the principal evolutionary theories (Darwinism, mutationism, neo-Darwinism, and neo-mutationism) that preceded the theory of mutation-driven evolution is also presented in the context of the last 150 years of research. However, the core of the book is concerned with recent studies of genomics and the molecular basis of phenotypic evolution, and their relevance to mutation-driven evolution. In contrast to neo-Darwinism, mutation-driven evolution is capable of explaining real examples of evolution such as the evolution of olfactory receptors, sex-determination in animals, and the general scheme of hybrid sterility. In this sense the theory proposed is more realistic than its predecessors, and gives a more logical explanation of various evolutionary events. Mutation-Driven Evolution is suitable for graduate level students as well as professional researchers (both empiricists and theoreticians) in the fields of molecular evolution and population genetics. It assumes that the readers are acquainted with basic knowledge of genetics and molecular biology.

Mutation-Driven Evolution

Masatoshi Nei
Mutation Driven Evolution Book PDF

Author : Masatoshi Nei
Publisher : OUP Oxford
Page : 256 pages
File Size : 52,6 Mb
Release : 2013-05-02
Category : Science
ISBN : 9780191637827

Get Book

Mutation-Driven Evolution by Masatoshi Nei Pdf

The purpose of this book is to present a new mechanistic theory of mutation-driven evolution based on recent advances in genomics and evolutionary developmental biology. The theory asserts, perhaps somewhat controversially, that the driving force behind evolution is mutation, with natural selection being of only secondary importance. The word 'mutation' is used to describe any kind of change in DNA such as nucleotide substitution, gene duplication/deletion, chromosomal change, and genome duplication. A brief history of the principal evolutionary theories (Darwinism, mutationism, neo-Darwinism, and neo-mutationism) that preceded the theory of mutation-driven evolution is also presented in the context of the last 150 years of research. However, the core of the book is concerned with recent studies of genomics and the molecular basis of phenotypic evolution, and their relevance to mutation-driven evolution. In contrast to neo-Darwinism, mutation-driven evolution is capable of explaining real examples of evolution such as the evolution of olfactory receptors, sex-determination in animals, and the general scheme of hybrid sterility. In this sense the theory proposed is more realistic than its predecessors, and gives a more logical explanation of various evolutionary events. Mutation-Driven Evolution is suitable for graduate level students as well as professional researchers (both empiricists and theoreticians) in the fields of molecular evolution and population genetics. It assumes that the readers are acquainted with basic knowledge of genetics and molecular biology.

Genetics of Adaptation

Rodney Mauricio
Genetics of Adaptation Book PDF

Author : Rodney Mauricio
Publisher : Springer Science & Business Media
Page : 209 pages
File Size : 51,8 Mb
Release : 2006-03-30
Category : Science
ISBN : 9781402038365

Get Book

Genetics of Adaptation by Rodney Mauricio Pdf

An enduring controversy in evolutionary biology is the genetic basis of adaptation. Darwin emphasized "many slight differences" as the ultimate source of variation to be acted upon by natural selection. In the early 1900’s, this view was opposed by "Mendelian geneticists", who emphasized the importance of "macromutations" in evolution. The Modern Synthesis resolved this controversy, concluding that mutations in genes of very small effect were responsible for adaptive evolution. A decade ago, Allen Orr and Jerry Coyne reexamined the evidence for this neo-Darwinian view and found that both the theoretical and empirical basis for it were weak. Orr and Coyne encouraged evolutionary biologists to reexamine this neglected question: what is the genetic basis of adaptive evolution? In this volume, a new generation of biologists have taken up this challenge. Using advances in both molecular genetic and statistical techniques, evolutionary geneticists have made considerable progress in this emerging field. In this volume, a diversity of examples from plant and animal studies provides valuable information for those interested in the genetics and evolution of complex traits.

Crumbling Genome

Alexey S. Kondrashov
Crumbling Genome Book PDF

Author : Alexey S. Kondrashov
Publisher : John Wiley & Sons
Page : 309 pages
File Size : 47,5 Mb
Release : 2017-07-12
Category : Science
ISBN : 9781118952115

Get Book

Crumbling Genome by Alexey S. Kondrashov Pdf

A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by pre ]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.

My Life As a Molecular Evolutionist

Masatoshi Nei
My Life As a Molecular Evolutionist Book PDF

Author : Masatoshi Nei
Publisher : Unknown
Page : 128 pages
File Size : 52,8 Mb
Release : 2022-02-05
Category : Electronic
ISBN : 1034958380

Get Book

My Life As a Molecular Evolutionist by Masatoshi Nei Pdf

Renowned molecular evolutionist, Masatoshi Nei, recounts his time growing up in Japan and later conducting research on molecular evolution in both Japan and the United States. He also discusses the origin and development of molecular evolution, including some of the joys and disappointments in working in the field. He emphasizes the importance of international collaboration in advancing scientific research and shows how he succeeded.

The Neutral Theory of Molecular Evolution

Motoo Kimura
The Neutral Theory of Molecular Evolution Book PDF

Author : Motoo Kimura
Publisher : Cambridge University Press
Page : 388 pages
File Size : 50,6 Mb
Release : 1983
Category : Science
ISBN : 0521317932

Get Book

The Neutral Theory of Molecular Evolution by Motoo Kimura Pdf

This book is the first comprehensive treatment of this subject.

Genetics and Evolution of Infectious Diseases

Michel Tibayrenc
Genetics and Evolution of Infectious Diseases Book PDF

Author : Michel Tibayrenc
Publisher : Elsevier
Page : 773 pages
File Size : 52,5 Mb
Release : 2010-12-17
Category : Medical
ISBN : 9780123848901

Get Book

Genetics and Evolution of Infectious Diseases by Michel Tibayrenc Pdf

Genetics and Evolution of Infectious Diseases is at the crossroads between two major scientific fields of the 21st century: evolutionary biology and infectious diseases. The genomic revolution has upset modern biology and has revolutionized our approach to ancient disciplines such as evolutionary studies. In particular, this revolution is profoundly changing our view on genetically driven human phenotypic diversity, and this is especially true in disease genetic susceptibility. Infectious diseases are indisputably the major challenge of medicine. When looking globally, they are the number one killer of humans and therefore the main selective pressure exerted on our species. Even in industrial countries, infectious diseases are now far less under control than 20 years ago. The first part of this book covers the main features and applications of modern technologies in the study of infectious diseases. The second part provides detailed information on a number of the key infectious diseases such as malaria, SARS, avian flu, HIV, tuberculosis, nosocomial infections and a few other pathogens that will be taken as examples to illustrate the power of modern technologies and the value of evolutionary approaches. Takes an integrated approach to infectious diseases Includes contributions from leading authorities Provides the latest developments in the field

Mutation and Evolution

Ronny C. Woodruff,James N. Thompson
Mutation and Evolution Book PDF

Author : Ronny C. Woodruff,James N. Thompson
Publisher : Springer Science & Business Media
Page : 561 pages
File Size : 46,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401152105

Get Book

Mutation and Evolution by Ronny C. Woodruff,James N. Thompson Pdf

Although debated since the time of Darwin, the evolutionary role of mutation is still controversial. In over 40 chapters from leading authorities in mutation and evolutionary biology, this book takes a new look at both the theoretical and experimental measurement and significance of new mutation. Deleterious, nearly neutral, beneficial, and polygenic mutations are considered in their effects on fitness, life history traits, and the composition of the gene pool. Mutation is a phenomenon that draws attention from many different disciplines. Thus, the extensive reviews of the literature will be valuable both to established researchers and to those just beginning to study this field. Through up-to-date reviews, the authors provide an insightful overview of each topic and then share their newest ideas and explore controversial aspects of mutation and the evolutionary process. From topics like gonadal mosaicism and mutation clusters to adaptive mutagenesis, mutation in cell organelles, and the level and distribution of DNA molecular changes, the foundation is set for continuing the debate about the role of mutation, fitness, and adaptability. It is a debate that will have profound consequences for our understanding of evolution.

The Selfish Gene

Richard Dawkins
The Selfish Gene Book PDF

Author : Richard Dawkins
Publisher : Oxford University Press, USA
Page : 372 pages
File Size : 51,8 Mb
Release : 1989
Category : Medical
ISBN : 0192860925

Get Book

The Selfish Gene by Richard Dawkins Pdf

Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science

Mutation, Randomness, and Evolution

Arlin Stoltzfus
Mutation Randomness and Evolution Book PDF

Author : Arlin Stoltzfus
Publisher : Oxford University Press
Page : 304 pages
File Size : 45,5 Mb
Release : 2021-04-22
Category : Science
ISBN : 9780192582966

Get Book

Mutation, Randomness, and Evolution by Arlin Stoltzfus Pdf

What does it mean to say that mutation is random? How does mutation influence evolution? Are mutations merely the raw material for selection to shape adaptations? The author draws on a detailed knowledge of mutational mechanisms to argue that the randomness doctrine is best understood, not as a fact-based conclusion, but as the premise of a neo-Darwinian research program focused on selection. The successes of this research program created a blind spot - in mathematical models and verbal theories of causation - that has stymied efforts to re-think the role of variation. However, recent theoretical and empirical work shows that mutational biases can and do influence the course of evolution, including adaptive evolution, through a first come, first served mechanism. This thought-provoking book cuts through the conceptual tangle at the intersection of mutation, randomness, and evolution, offering a fresh, far-reaching, and testable view of the role of variation as a dispositional evolutionary factor. The arguments will be accessible to philosophers and historians with a serious interest in evolution, as well as to researchers and advanced students of evolution focused on molecules, microbes, evo-devo, and population genetics.

Molecular and Genome Evolution

Dan Graur
Molecular and Genome Evolution Book PDF

Author : Dan Graur
Publisher : Sinauer
Page : 0 pages
File Size : 47,6 Mb
Release : 2015-01-01
Category : Science
ISBN : 1605354694

Get Book

Molecular and Genome Evolution by Dan Graur Pdf

This book describes the driving forces behind the evolutionary process at the molecular and genome levels, the effects of the various molecular mechanisms on the structure of genes, proteins, and genomes, the methodology and the analytical tools involved in dealing with molecular data from an evolutionary perspective, and the logic of evolutionary hypothesis testing. Evolutionary phenomena at the molecular level are detailed in a way that can be understood without much prerequisite knowledge of molecular biology, evolution, or mathematics. Numerous examples that support and clarify the theoretical arguments and methodological discussions are included.

Origin and Evolution of Viruses

Esteban Domingo,Colin R. Parrish,John J. Holland
Origin and Evolution of Viruses Book PDF

Author : Esteban Domingo,Colin R. Parrish,John J. Holland
Publisher : Elsevier
Page : 573 pages
File Size : 51,9 Mb
Release : 2008-06-23
Category : Science
ISBN : 9780080564968

Get Book

Origin and Evolution of Viruses by Esteban Domingo,Colin R. Parrish,John J. Holland Pdf

New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts

Cancer Evolution

Charles Swanton
Cancer Evolution Book PDF

Author : Charles Swanton
Publisher : Perspectives Cshl
Page : 350 pages
File Size : 46,6 Mb
Release : 2017
Category : Medical
ISBN : 1621821439

Get Book

Cancer Evolution by Charles Swanton Pdf

Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

Diversity and Evolution of Butterfly Wing Patterns

Toshio Sekimura,H. Frederik Nijhout
Diversity and Evolution of Butterfly Wing Patterns Book PDF

Author : Toshio Sekimura,H. Frederik Nijhout
Publisher : Springer
Page : 321 pages
File Size : 48,8 Mb
Release : 2017-08-29
Category : Science
ISBN : 9789811049569

Get Book

Diversity and Evolution of Butterfly Wing Patterns by Toshio Sekimura,H. Frederik Nijhout Pdf

This book facilitates an integrative understanding of the development, genetics and evolution of butterfly wing patterns. To develop a deep and realistic understanding of the diversity and evolution of butterfly wing patterns, it is essential and necessary to approach the problem from various kinds of key research fields such as “evo-devo,” “eco-devo,” ”developmental genetics,” “ecology and adaptation,” “food plants,” and “theoretical modeling.” The past decade-and-a-half has seen a veritable revolution in our understanding of the development, genetics and evolution of butterfly wing patterns. In addition, studies of how environmental and climatic factors affect the expression of color patterns has led to increasingly deeper understanding of the pervasiveness and underlying mechanisms of phenotypic plasticity. In recognition of the great progress in research on the biology, an international meeting titled “Integrative Approach to Understanding the Diversity of Butterfly Wing Patterns (IABP-2016)” was held at Chubu University, Japan in August 2016. This book consists of selected contributions from the meeting. Authors include main active researchers of new findings of corresponding genes as well as world leaders in both experimental and theoretical approaches to wing color patterns. The book provides excellent case studies for graduate and undergraduate classes in evolution, genetics/genomics, developmental biology, ecology, biochemistry, and also theoretical biology, opening the door to a new era in the integrative approach to the analysis of biological problems. This book is open access under a CC BY 4.0 license.

The Mutation Theory: Experiments and Observations On the Origin of Species in the Vegetable Kingdom

Hugo De Vries
The Mutation Theory Experiments and Observations On the Origin of Species in the Vegetable Kingdom Book PDF

Author : Hugo De Vries
Publisher : Legare Street Press
Page : 0 pages
File Size : 50,9 Mb
Release : 2022-10-27
Category : Nature
ISBN : 1017372322

Get Book

The Mutation Theory: Experiments and Observations On the Origin of Species in the Vegetable Kingdom by Hugo De Vries Pdf

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.