Nonanticoagulant Actions Of Glycosaminoglycans

Author : B. Casu,J. Harenberg
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 45,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461303718

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Nonanticoagulant Actions of Glycosaminoglycans by B. Casu,J. Harenberg Pdf

Prophylaxis and treatment of thromboembolism have made one of the major impacts in medicine. Heparin has widely been used as the most effective drug during the last 50 years. However, its potential side effects have led to the search for equally effective but safer alternatives. At present, the low-molecular-weight heparins are the most promising steps in this direction. Considerable interest has been generated at the same time in exploring other gly cosaminoglycans of the nonheparin type for therapeutic use. The existence of these com pounds has been known for a long time and substantial information has been gathered on glycosaminoglycans such as heparinsulfate, dermatansulfate, and chondroitinsulfate. Many of these substances are derived from animal or plant sources, and some of them have now been synthesized. The aim of the Fourth Symposium on Glycosaminoglycan Research at Villa Vigoni in Loveno at Lake Comolltaly was to summarize the considerable new information in this field. The articles of the present volume are mainly based on a German-Italian collaboration supported by the Vigoni Program. The selected articles describe many different, nonheparin glycosaminoglycans, some of them already in clinical trials as antithrombotic agents. In particular, the interaction of glycosaminoglycans with some cellular elements of blood, especially leukocytes and platelets, are discussed. New methods for their identification and assays are described and considerable emphasis is placed on the pharmacokinetic aspects of these new compounds. Particularly, some nonanticoagulant activities of the glycosamino glycans are discussed in detail.

Author : A. Sessa
Publisher : Karger Medical and Scientific Publishers
Page : 148 pages
File Size : 43,9 Mb
Release : 2000-01-01
Category : Medical
ISBN : 9783805570640

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Cigarette Smoking and the Kidney by A. Sessa Pdf

Cigarette smoking is also a risk factor for diffuse atherosclerosis, ischemic heart disease and peripheral vascular lesions, renal microvessels being another potential target. Furthermore, the relationships of chronic cigarette smoking and nitric oxide with endothelial dysfunction and vascular disease are well proven, and the association between eNOS gene polymorphisms and vascular disease and their dependence on chronic tobacco smoking has been stressed. But although there is definite evidence that the risk of progression of acquired or genetic renal disease is higher in chronic cigarette smokers and the negative effect on patient survival in chronic dialytic treatment is well known, these issues are still neglected by clinical nephrologists and the mechanisms involved have not yet been classified.

Author : Yoshikuni Mizuno,Abraham Fisher,Israel Hanin
Publisher : Springer Science & Business Media
Page : 596 pages
File Size : 40,5 Mb
Release : 2002-03-31
Category : Medical
ISBN : 0306467631

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Mapping the Progress of Alzheimer’s and Parkinson’s Disease by Yoshikuni Mizuno,Abraham Fisher,Israel Hanin Pdf

1h The 5 International Conference on the Progress in Alzheimer's Disease and Parkinson's 51 1 Disease took place from March 31 to April 5 \ 2001 in Kroto, Japan. This international 1 conference was organized as a joint Congress with the 9 International Catecholamine Symposium. A total of 1258 clinicians and researchers participated in this joint congress 1h from 38 countries in the world. This book represents the proceedings of the 5 Conference on Alzheimer's and Parkinson's disease. The International Conference on the Progress in Alzheimer's and Parkinson's disease was first launched by Professor Abraham Fisher of Israel and Professor Israel Hanin of USA. The first conference was held in Eilat, Israel in 1985. The second conference was organized in Kyoto, Japan in 1989; the third one in Chicago, USA, in 1993, and the fourth one in Eilat, Israel in 1997. The International Catecholamine Symposium (ICS) is an international meeting devoted to the development of basic as well as clinical research on catecholamines. The first Catecholamine Symposium was held in Bethesda, USA in 1958. Since then this symposium has occurred every 5 years. Professor Toshiharu Nagatsu was appointed as 1h the president of the 9 International Catecholamine Symposium, which was to be held in 200 I also in Japan. Therefore, we decided to organize a joint congress of the two meetings, because there is much overlap in research between Alzheimer's disease, Parkinson's disease, and catecholamines. We thank Professor Nagatsu very much for agreeing to organizing this joint congress.

Author : Bertram O. Fraser-Reid,Kuniaki Tatsuta,Joachim Thiem
Publisher : Springer Science & Business Media
Page : 2817 pages
File Size : 49,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642568749

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Glycoscience: Chemistry and Chemical Biology I–III by Bertram O. Fraser-Reid,Kuniaki Tatsuta,Joachim Thiem Pdf

Glycostructures play a highly diverse and crucial role in a myriad of organisms and systems in biology, physiology, medicine, and bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and chemistry behind them. In this set the editors present up-to-date information on glycostructures, their chemistry and chemical biology, in the form of a comprehensive survey. The text is accompanied by over 2000 figures, chemical structures and reaction schemes and more than 9000 references. The accompanying CD-ROM enables, besides text searches, searches for structures, schemes, and other information.

Author : Anonim
Publisher : Elsevier
Page : 492 pages
File Size : 44,8 Mb
Release : 2002-02-06
Category : Science
ISBN : 0080522254

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Advances in Carbohydrate Chemistry and Biochemistry by Anonim Pdf

Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists who integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

Author : Anonim
Publisher : Unknown
Page : 1438 pages
File Size : 54,6 Mb
Release : 1996-05
Category : American literature
ISBN : UOM:39015079622448

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American Book Publishing Record by Anonim Pdf

Author : 978-3-03842-836-7
Publisher : MDPI
Page : 247 pages
File Size : 48,7 Mb
Release : 2018-07-04
Category : Electronic books
ISBN : 9783038428350

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Glycosaminoglycans and Proteoglycans by 978-3-03842-836-7 Pdf

This book is a printed edition of the Special Issue "Glycosaminoglycans and Proteoglycans" that was published in Pharmaceuticals

Author : Anonim
Publisher : Unknown
Page : 416 pages
File Size : 41,5 Mb
Release : 1998
Category : Engineering
ISBN : UOM:39015039117570

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Directory of Published Proceedings by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 2312 pages
File Size : 49,9 Mb
Release : 1997
Category : American literature
ISBN : UOM:39015058373732

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The Cumulative Book Index by Anonim Pdf

A world list of books in the English language.

Author : Arthur James Wells
Publisher : Unknown
Page : 1672 pages
File Size : 48,7 Mb
Release : 1996
Category : Bibliography, National
ISBN : UOM:39015079755982

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The British National Bibliography by Arthur James Wells Pdf

Author : Rebecca Lever,Barbara Mulloy,Clive P. Page
Publisher : Springer Science & Business Media
Page : 457 pages
File Size : 41,9 Mb
Release : 2012-05-08
Category : Medical
ISBN : 9783642230561

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Heparin - A Century of Progress by Rebecca Lever,Barbara Mulloy,Clive P. Page Pdf

Heparins remain amongst the most commonly used drugs in clinical practice. Almost 100 years have passed since the initial discovery of this complex substance and, during this time, understanding of the nature and uses of heparin and related molecules has grown dramatically. The aim of this volume is to summarise the developments that have led to the current status of both heparins as drugs and the field of heparin research, with a focus on the particularly rapid progress that has been made over the past three decades. Individual sections are dedicated to the nature of heparin as a biological molecule, the current approaches and techniques that are used to ensure the safety and reliability of heparin as a medicine, the clinical pharmacology of heparin as an anticoagulant drug, effects and potential applications of heparin aside of those involving haemostasis and, finally, the nature and potential uses of heparin-like materials from both natural and synthetic sources.

Author : Victor J. Marder,William C. Aird,Joel S. Bennett,Sam Schulman,Gilbert C. White, II
Publisher : Lippincott Williams & Wilkins
Page : 5220 pages
File Size : 40,9 Mb
Release : 2012-12-27
Category : Medical
ISBN : 9781451177695

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Hemostasis and Thrombosis by Victor J. Marder,William C. Aird,Joel S. Bennett,Sam Schulman,Gilbert C. White, II Pdf

Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs. NEW to the Sixth Edition... • A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives. • Full color throughout • A companion website that offers full text online and an image bank. • A new introductory section of chapters on basic sciences as related to the field • Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups. • Overview chapters preceding each section address broad topics of general importance. This is the tablet version which does not include access to the supplemental content mentioned in the text.

Author : Israel Vlodavsky,Ralph D. Sanderson,Neta Ilan
Publisher : Springer Nature
Page : 871 pages
File Size : 51,5 Mb
Release : 2020-04-09
Category : Medical
ISBN : 9783030345211

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Heparanase by Israel Vlodavsky,Ralph D. Sanderson,Neta Ilan Pdf

Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Author : Anonim
Publisher : Unknown
Page : 1796 pages
File Size : 53,5 Mb
Release : 2000
Category : Medicine
ISBN : OSU:32436010864583

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Cumulated Index Medicus by Anonim Pdf

Author : Silvia Nair Goyanes,Norma Beatriz D’Accorso
Publisher : Springer
Page : 332 pages
File Size : 47,6 Mb
Release : 2017-08-10
Category : Technology & Engineering
ISBN : 9783319612881

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Industrial Applications of Renewable Biomass Products by Silvia Nair Goyanes,Norma Beatriz D’Accorso Pdf

This book effectively links the latest scientific advances to current technological applications of polymers, mainly focusing on biodegradable polymers obtained from biomass. The individual chapters were written by academic and industry researchers alike, introducing readers to topics that have received little attention in the literature to date. Key topics covered include polymers used in various areas such as food packaging, pharmaceuticals, energy production and the cosmetics industry, as well as the treatment of aqueous effluents.