Heparanase

Author : Israel Vlodavsky,Ralph D. Sanderson,Neta Ilan
Publisher : Springer Nature
Page : 871 pages
File Size : 51,5 Mb
Release : 2020-04-09
Category : Medical
ISBN : 9783030345211

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Heparanase by Israel Vlodavsky,Ralph D. Sanderson,Neta Ilan Pdf

Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Author : Dieter Marmé,Norbert Fusenig
Publisher : Springer Science & Business Media
Page : 840 pages
File Size : 41,8 Mb
Release : 2007-12-05
Category : Medical
ISBN : 9783540331773

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Tumor Angiogenesis by Dieter Marmé,Norbert Fusenig Pdf

Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.

Author : Giuliana Cassinelli,Cinzia Lanzi,Edwin Alexander Yates
Publisher : Frontiers Media SA
Page : 131 pages
File Size : 50,6 Mb
Release : 2020-03-25
Category : Electronic
ISBN : 9782889636167

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Heparan Sulfate Proteoglycans and Their Endogenous Modifying Enzymes: Cancer Players, Biomarkers and Therapeutic Targets by Giuliana Cassinelli,Cinzia Lanzi,Edwin Alexander Yates Pdf

Author : Albrecht Reichle
Publisher : Springer Science & Business Media
Page : 552 pages
File Size : 43,6 Mb
Release : 2010-09-09
Category : Medical
ISBN : 9789048195312

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From Molecular to Modular Tumor Therapy: by Albrecht Reichle Pdf

Presenting a holistic and abstract perspective of tumors, this volume aims to provide personalized diagnostic and therapeutic strategies for the control of metastatic tumor disease. Readers will find ways to record tumor biology that are based on different sciences, in addition to other strategies.

Author : Manfred Schwab
Publisher : Springer Science & Business Media
Page : 4071 pages
File Size : 41,8 Mb
Release : 2011-10-14
Category : Medical
ISBN : 9783642164828

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Encyclopedia of Cancer by Manfred Schwab Pdf

The merging of different basic and clinical science disciplines towards the common goal of fighting against cancer has long ago called for the establishment of a comprehensive reference source both as a tool to close the language gap between clinical and basic science investigators and as a platform of information for students and informed laymen alike. The Encyclopedia of Cancer provides rapid access to focused information on all topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the Second Edition, which appeared in 2009, and fast recent development in the different fields of cancer research, it has been decided to publish a third fully revised and expanded edition, following the principal concept of the first edition that has proven so successful. Recent developments are seeing a dynamic progress in basic and clinical cancer science, with translational research increasingly becoming a new paradigm in cancer research. In particular, new approaches to both Personalized Cancer Medicine and Targeted Therapies have made promising progress. While the Second Edition featured scholarly contributions from approximately 1.000 scientists/clinicians in four Volumes, the Third Edition includes 1.300 contributors in 7 Volumes with an A-Z format of approx. 7000 entries. It provides definitions of common acronyms and short definitions of related terms and processes in the form of keyword entries. In addition, there are detailed essays, which provide comprehensive information on syndromes, genes and molecules, and processes and methods. Each essay is well-structured, with extensive cross-referencing between all entries. In the Third Edition, topical Essays present a comprehensive picture of major cancers, such as Breast Cancer, Colorectal Cancer, Prostate Cancer, Ovarian Cancer, Renal Cancer, Lung Cancer, and Hematological Maligancies, Leukemias and Lymphomas. For each of these cancers, different authoritative Essays are included that cover topics ranging from Pathology, to Clinical Oncology and Targeted Therapies. This new feature should meet the expectance that a wide community has towards a major cancer reference works. The Encyclopedia of Cancer will be accessible both in print and online, and this information source should be of value to both the clinical and basic scientific community as well as to the public.

Author : Hari G. Garg,Robert J. Linhardt,Charles A. Hales
Publisher : Elsevier
Page : 792 pages
File Size : 52,9 Mb
Release : 2011-10-10
Category : Science
ISBN : 0080529054

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Chemistry and Biology of Heparin and Heparan Sulfate by Hari G. Garg,Robert J. Linhardt,Charles A. Hales Pdf

The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area. Comprehensively reviews all aspects of heparin and heparan sulfate research Uniquely describes the chemistry, biology and clinical application of heparins and heparan sulfates in one work Provides an invaluable source of knowledge of current developments for chemists, biochemists, medical doctors, researchers, students and practitioners

Author : Joris J. Roelofs,Liffert Vogt
Publisher : Springer
Page : 548 pages
File Size : 47,9 Mb
Release : 2018-10-29
Category : Medical
ISBN : 9783319935218

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Diabetic Nephropathy by Joris J. Roelofs,Liffert Vogt Pdf

This book provides an overview of the most up-to-date research on diabetic nephropathy and the current understanding of its pathogenesis, clinical features and socio-economic developments. Written by leading experts in the field, it provides a comprehensive synthesis of clinical and pathophysiological aspects from a mechanism-based point of view, and reviews evidence-based treatment modalities for the prevention and management of diabetic nephropathy. In addition, closely related areas such as diabesity, diabetic eye disease and macrovascular involvement in diabetes are addressed. Diabetic Nephropathy will be of interest for nephrologists, diabetologists, internists, transplant physicians, public health professionals, basic scientists, geneticists, epidemiologists, pathologists, and molecular and cell biologists working in the field of diabetes and its complications.

Author : Anonim
Publisher : Unknown
Page : 1014 pages
File Size : 48,5 Mb
Release : 2004
Category : Cancer
ISBN : RUTGERS:44008000315003

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Journal of the National Cancer Institute by Anonim Pdf

Author : Nikos Karamanos
Publisher : Walter de Gruyter
Page : 940 pages
File Size : 54,8 Mb
Release : 2012-08-31
Category : Science
ISBN : 9783110258776

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Extracellular Matrix: Pathobiology and Signaling by Nikos Karamanos Pdf

Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden

Author : Ali Salajegheh
Publisher : Springer
Page : 423 pages
File Size : 50,6 Mb
Release : 2016-03-10
Category : Medical
ISBN : 9783319281407

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Angiogenesis in Health, Disease and Malignancy by Ali Salajegheh Pdf

This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer. New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.

Author : Nicoletta Gagliano
Publisher : MDPI
Page : 428 pages
File Size : 55,7 Mb
Release : 2019-11-11
Category : Science
ISBN : 9783039216284

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Extracellular Matrix Remodeling by Nicoletta Gagliano Pdf

The extracellular matrix (ECM) is where cells live. It is composed of collagen and elastic fibers, glycosaminoglycans and proteoglycans, and several glycoproteins. In most tissues, fibril-forming collagen type I is the major constituent of ECM.The function of the ECM goes beyond providing mechanical support to cells and tissues. As cells are embedded into the ECM and interact with its components through their surface receptors, cell–ECM interaction plays a key role in influencing different cell activities, such as cell proliferation and migration. The ECM also sequesters and releases growth factors affecting important cellular pathways. Overall, the ECM strongly influences and affects cell behavior and tissue homeostasis. ECM is a highly dynamic structural network that continuously undergoes controlled remodeling mediated by matrix-degrading enzymes, the matrix metalloproteinases (MMPs), under normal conditions. Quantitative and qualitative deregulation of ECM remodeling and, especially, of collagen turnover, is responsible for the alteration of ECM composition and structure, associated with the development and progression of several pathological conditions, such as organ fibrosis (determined by the abnormal accumulation of ECM components) and tumor invasion. The understanding of the diverse biological roles and properties of the ECM components is pivotal to the development of new therapeutic tools for disease treatment.

Author : Dimitrios Kardamakis,Vassilios Vassiliou,Edward Chow
Publisher : Springer Science & Business Media
Page : 404 pages
File Size : 52,7 Mb
Release : 2009-07-21
Category : Medical
ISBN : 9781402098192

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Bone Metastases by Dimitrios Kardamakis,Vassilios Vassiliou,Edward Chow Pdf

Bone Metastases: A Translational and Clinical Approach serves as both an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume: describes the molecular and cellular mechanisms involved in the formation of bone metastases, comments on the role of angiogenesis, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. This volume also covers the use of radiotherapy, surgery and systemic treatments for the management of metastatic bone disease and new therapeutic approaches. Moreover it may also serve as a guide for the clinical and therapeutic management of patients with metastatic bone disease. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for medical researchers, oncologists, orthopaedic surgeons and clinicians.

Author : Anonim
Publisher : ScholarlyEditions
Page : 423 pages
File Size : 48,5 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464921971

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Hemic and Immune Systems: Advances in Research and Application: 2011 Edition by Anonim Pdf

Hemic and Immune Systems: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Hemic and Immune Systems. The editors have built Hemic and Immune Systems: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hemic and Immune Systems in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hemic and Immune Systems: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Binghe Wang,Geert-Jan Boons
Publisher : John Wiley & Sons
Page : 448 pages
File Size : 49,7 Mb
Release : 2011-09-09
Category : Medical
ISBN : 9781118017579

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Carbohydrate Recognition by Binghe Wang,Geert-Jan Boons Pdf

This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.

Author : Anonim
Publisher : Unknown
Page : 216 pages
File Size : 44,5 Mb
Release : 1990-12
Category : Cancer
ISBN : UCBK:C044891912

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Journal of the National Cancer Institute by Anonim Pdf