Nonhuman Primate Models In Preclinical Research

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Nonhuman Primate Models in Preclinical Research

Huifang Chen
Nonhuman Primate Models in Preclinical Research Book PDF

Author : Huifang Chen
Publisher : Unknown
Page : 0 pages
File Size : 51,7 Mb
Release : 2021
Category : Primates as laboratory animals
ISBN : 1536199141

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Nonhuman Primate Models in Preclinical Research by Huifang Chen Pdf

"Due to the phylogenetic relationship and close genetic and biological similarities with humans, non-human primates (NHP) are regularly used in biomedical and behavioural research. However, because of their highly developed cognitive abilities and social skills, the use of these animals in biomedical research is debated more and more. Although it is acknowledged that in specific research areas NHP are still essential, it is recognized that the use of these animals can only be done under strict conditions under the most optimal welfare aspects. Welfare aspects include housing conditions, non-invasive methods and application of the 3Rs policy. Although many refinement methods have been described in nationally and internationally accepted guidelines on animal laboratory practice, recognition of the guidelines is unfortunately not universal. The present book covers a wide range of NHP models in preclinical research and welfare issues. The following chapters will cover: refinement of the use of NHP in biomedical research; NHP ethics and regulations in Europe; biological basis differences in the human and NHP; the major histocompatibility complex (MHC) immunology in NHP; stem cell biology in NHP; neuro and gliogenesis in an NHP ischemia stroke model; NHP models in autoimmune disease, organ transplantation and infectious disease research; viral diseases in NHP; NHP models in Parkinson's disease, in neurodegenerative disorders research and in cardio-cerebrovascular disease research; islet transplantation; ophthalmic diseases research and neurophysiology in NHP; transgenic engineering in NHP; NHP models of cancers; NHP models in respiratory disease research; NHP models in clinical and non-clinical pharmacology; NHP models in lung transplantation; and aging research in NHP. This book encapsulates a large volume of knowledge scientists have achieved in the field of nonhuman primate models in preclinical research. The editors have invited experts from the United States, Canada, and Europe to contribute 23 chapters in their respective fields of their expertise"--

Challenges in Nonhuman Primate Research in the 21st Century

Gerhard F. Weinbauer,Friedhelm Vogel
Challenges in Nonhuman Primate Research in the 21st Century Book PDF

Author : Gerhard F. Weinbauer,Friedhelm Vogel
Publisher : Waxmann Verlag
Page : 180 pages
File Size : 46,6 Mb
Release : 2013
Category : Medical
ISBN : 9783830978398

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Challenges in Nonhuman Primate Research in the 21st Century by Gerhard F. Weinbauer,Friedhelm Vogel Pdf

In continuation of the Covance Primate Symposium Series, the 19th Covance Primate Symposium took place in Münster on 23rd & 24th of May 2012. Altogether, 70 participants representing 43 organisations, gathered for this symposium. The 2012 Primate Symposium focussed on ?Challenges in Nonhuman Primate Research in the 21st Century?. The broad participation and the lively discussions during the symposium underlined the timeliness and importance of this topic. Expert speakers covered four major topics, i.e. biosimilars development: regulatory implications, key considerations and next steps, optimizing nonhuman primate use in nonclinical safety assessment, trends in nonhuman primate developmental & reproductive toxicology (DART) and juvenile toxicity evaluation, and relevance and importance of nonhuman primate models in regulatory toxicology. The development of biosimilar has taken up speed considerably and meanwhile needs to be considered a significant factor of potential drug development, yet there are still some uncertainties und guidelines are under development. With the increased focus on biopharmaceuticals and the associated increase for using nonhuman primates being the relevant animal model, it became necessary to optimize the use of this animal model, e.g. refine study designs and animals numbers but still execute meaningful preclinical studies. It appears that significant progress has been achieved in that context. In the area of nonhuman primate DART and juvenile toxicity evaluation, recent guideline changes had a major impact on species selection, and the experimental design plus the timing of these studies within the preclinical programmes. Finally, given the increasing regulations and justficiations of using nonhuman primates as experimental models. It is paramount to understand the essential and indispensable role that nonhuman primates can play in drug safety evaluation and medical drug development.

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer
The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment Book PDF

Author : Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer
Publisher : Academic Press
Page : 716 pages
File Size : 53,6 Mb
Release : 2015-03-13
Category : Medical
ISBN : 9780124171466

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The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment by Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer Pdf

The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Primate Models of Children's Health and Developmental Disabilities

Thomas Burbacher,Kimberly Grant,Gene P. Sackett
Primate Models of Children s Health and Developmental Disabilities Book PDF

Author : Thomas Burbacher,Kimberly Grant,Gene P. Sackett
Publisher : Academic Press
Page : 472 pages
File Size : 51,7 Mb
Release : 2011-10-10
Category : Medical
ISBN : 0080554067

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Primate Models of Children's Health and Developmental Disabilities by Thomas Burbacher,Kimberly Grant,Gene P. Sackett Pdf

The rate of neurodevelopmental disabilities, including autism, mental retardation, hearing loss and attention deficit hyperactivity disorder is rising in the United States. Although estimates of the prevalence of these disorders vary, figures from the CDC indicate that 4% of all school age children are developmentally disabled. During infancy, many important milestones in behavioral development are shared between human and nonhuman primates. Learning more about the causes of abnormal development in monkeys has provided important insights into the mechanisms underlying neurodevelopmental disabilities in human infants. This book documents the latest research not commonly found in other references, and provides a comprehensive look at the results from decades of work with nonhuman primates as it relates to child development and disability. Includes hot topics such as early chemical exposures, immunological influences on development, low birth weight, endocrine disrupters, pediatric AIDS, origin of childhood psychopathologies and assisted reproductive technology Represents the significant body of work accumulated since funding for research on developmental disabilities has increased substantially in recent years

Transgenic Neuroscience Research

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Transgenic Neuroscience Research Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 91 pages
File Size : 50,6 Mb
Release : 2019-05-03
Category : Medical
ISBN : 9780309488730

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Transgenic Neuroscience Research by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

To examine the promise, concerns, and challenges related to neuroscience research using genetically modified nonhuman primates, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop on October 4, 2018, bringing together an international group of experts and stakeholders representing academia, industry, laboratory animal management, disease-focused foundations, and federal agencies. The workshop was designed to explore the current state and future promise of research using genetically modified nonhuman primate models of disease to understand the complex functions of the brain that control behavior, movement, and cognition in both health and disease states. This publication summarizes the presentations and discussions from the workshop.

Occupational Health and Safety in the Care and Use of Nonhuman Primates

National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Occupational Health and Safety in the Care and Use of Nonhuman Primates
Occupational Health and Safety in the Care and Use of Nonhuman Primates Book PDF

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Occupational Health and Safety in the Care and Use of Nonhuman Primates
Publisher : National Academies Press
Page : 181 pages
File Size : 55,8 Mb
Release : 2003-07-13
Category : Science
ISBN : 9780309089142

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Occupational Health and Safety in the Care and Use of Nonhuman Primates by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Occupational Health and Safety in the Care and Use of Nonhuman Primates Pdf

The field of occupational health and safety constantly changes, especially as it pertains to biomedical research. New infectious hazards are of particular importance at nonhuman-primate facilities. For example, the discovery that B virus can be transmitted via a splash on a mucous membrane raises new concerns that must be addressed, as does the discovery of the Reston strain of Ebola virus in import quarantine facilities in the U.S. The risk of such infectious hazards is best managed through a flexible and comprehensive Occupational Health and Safety Program (OHSP) that can identify and mitigate potential hazards. Occupational Health and Safety in the Care and Use of Nonhuman Primates is intended as a reference for vivarium managers, veterinarians, researchers, safety professionals, and others who are involved in developing or implementing an OHSP that deals with nonhuman primates. The book lists the important features of an OHSP and provides the tools necessary for informed decision-making in developing an optimal program that meets all particular institutional needs.

Chimpanzees in Biomedical and Behavioral Research

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Institute of Medicine,Board on Health Sciences Policy,Committee on the Use of Chimpanzees in Biomedical and Behavioral Research
Chimpanzees in Biomedical and Behavioral Research Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Institute of Medicine,Board on Health Sciences Policy,Committee on the Use of Chimpanzees in Biomedical and Behavioral Research
Publisher : National Academies Press
Page : 200 pages
File Size : 49,7 Mb
Release : 2012-01-05
Category : Science
ISBN : 9780309220392

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Chimpanzees in Biomedical and Behavioral Research by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Institute of Medicine,Board on Health Sciences Policy,Committee on the Use of Chimpanzees in Biomedical and Behavioral Research Pdf

For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.

Critical Contributions of Primate Models for Biopharmaceutical Drug Development

Gerhard F. Weinbauer
Critical Contributions of Primate Models for Biopharmaceutical Drug Development Book PDF

Author : Gerhard F. Weinbauer
Publisher : Waxmann Verlag
Page : 184 pages
File Size : 54,5 Mb
Release : 2008
Category : Animal models in research
ISBN : 3830921047

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Critical Contributions of Primate Models for Biopharmaceutical Drug Development by Gerhard F. Weinbauer Pdf

"In continuation of the Covance Primate Symposium Series, the 17th Covance Primate Symposium took place in Münster during April 16 and 17, 2008. Altogether, 131 participants -- the largest attendance so far -- representing 13 countries and 56 organisations assembled for this symposium. The 2008 Primate Symposium focussed on 'Critical Contributions of Primate Models for Biopharmaceutical Drug Development'. This is obviously a very timely topic since numerous biopharmaceuticals, in particular monoclonal antibodies, are in preclinical development and, in many instances, nonhuman primates represent the relevant model. Also, there are efforts, at least in Europe, to substantially change the environmental conditions for primates in research which will also impact pharmaceutical drug development. Beyond this, current topics such as developmental and juvenile toxicity testing and the perspectives of stem cell-derived therapeutics were also covered. In general, it is assumed that the demand for research on nonhuman primates in preclinical development will increase over the coming years. Expert speakers discussed four topics in particular, i.e.:stem cell-derived therapeutics as a potential new horizon for new therapeutic drugs; the European environment for primate research and whether this presents a barrier or rather an opportunity; new approaches for developmental and juvenile toxicity testing in nonhuman primates; and current challenges in biopharmaceutical drug development."--Back cover.

Species, Species Concepts and Primate Evolution

William H. Kimbel,Lawrence B. Martin
Species Species Concepts and Primate Evolution Book PDF

Author : William H. Kimbel,Lawrence B. Martin
Publisher : Springer Science & Business Media
Page : 561 pages
File Size : 42,6 Mb
Release : 2013-12-18
Category : Science
ISBN : 9781489937452

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Species, Species Concepts and Primate Evolution by William H. Kimbel,Lawrence B. Martin Pdf

A world of categones devmd of spirit waits for life to return. Saul Bellow, Humboldt's Gift The stock-in-trade of communicating hypotheses about the historical path of evolution is a graphical representation called a phylogenetic tree. In most such graphics, pairs of branches diverge from other branches, successively marching across abstract time toward the present. To each branch is tied a tag with a name, a binominal symbol that functions as does the name given to an individual human being. On phylogenetic trees the names symbolize species. What exactly do these names signify? What kind of information is communicated when we claim to have knowledge of the following types? "Tetonius mathewzi was ancestral to Pseudotetonius ambiguus. " "The sample of fossils attributed to Homo habzlis is too variable to contain only one species. " "Interbreeding populations of savanna baboons all belong to Papio anubis. " "Hylobates lar and H. pileatus interbreed in zones of geographic overlap. " While there is nearly universal agreement that the notion of the speczes is fundamental to our understanding of how evolution works, there is a very wide range of opinion on the conceptual content and meaning of such particular statements regarding species. This is because, oddly enough, evolutionary biolo gists are quite far from agreement on what a species is, how it attains this status, and what role it plays in evolution over the long term.

Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents

National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Life Sciences,Committee on Animal Models for Testing Interventions Against Aerosolized Bioterrorism Agents
Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents Book PDF

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Life Sciences,Committee on Animal Models for Testing Interventions Against Aerosolized Bioterrorism Agents
Publisher : National Academies Press
Page : 87 pages
File Size : 48,5 Mb
Release : 2006-08-07
Category : Political Science
ISBN : 9780309180900

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Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Life Sciences,Committee on Animal Models for Testing Interventions Against Aerosolized Bioterrorism Agents Pdf

The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testing their effectiveness in animals since human clinical trials would be unethical. At the request of NIAID, the National Academies conducted a study to examine how such testing could be improved. Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents provides recommendations to researchers on selecting the kinds of animal models, aerosol generators, and bioterrorism agent doses that would produce conditions that most closely mimic the disease process in humans. It also urges researchers to fully document experimental parameters in the literature so that studies can be reproduced and compared. The book recommends that all unclassified data on bioterrorism agent studies-including unclassified, unpublished data from U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID)-be published in the open literature. The book also calls on the U.S. Food and Drug Administration to improve the process by which bioterrorism countermeasures are approved based on the results of animal studies.

Modeling Neuropsychiatric Disorders in Laboratory Animals

Kurt Leroy Hoffman
Modeling Neuropsychiatric Disorders in Laboratory Animals Book PDF

Author : Kurt Leroy Hoffman
Publisher : Woodhead Publishing
Page : 324 pages
File Size : 53,8 Mb
Release : 2015-08-28
Category : Medical
ISBN : 9780081001066

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Modeling Neuropsychiatric Disorders in Laboratory Animals by Kurt Leroy Hoffman Pdf

Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. Chapters contain discussions on both classical and modern views on the validation of animal models for neuropsychiatric disorders, also discussing the utility of endophenotypes in modeling neuropsychiatric disease. Subsequent chapters deal with four specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders. Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research. Focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders Serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals Discusses specific classes of disorders, including anxiety disorders, depressive disorders, obsessive-compulsive and related disorders

Use of Laboratory Animals in Biomedical and Behavioral Research

National Research Council,Institute of Medicine,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research
Use of Laboratory Animals in Biomedical and Behavioral Research Book PDF

Author : National Research Council,Institute of Medicine,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research
Publisher : National Academies Press
Page : 113 pages
File Size : 41,6 Mb
Release : 1988-02-01
Category : Science
ISBN : 9780309038393

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Use of Laboratory Animals in Biomedical and Behavioral Research by National Research Council,Institute of Medicine,Institute for Laboratory Animal Research,Commission on Life Sciences,Committee on the Use of Laboratory Animals in Biomedical and Behavioral Research Pdf

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.

International Animal Research Regulations

National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs,Committee on Science, Technology, and Law,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
International Animal Research Regulations Book PDF

Author : National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs,Committee on Science, Technology, and Law,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 102 pages
File Size : 54,5 Mb
Release : 2012-06-26
Category : Science
ISBN : 9780309252119

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International Animal Research Regulations by National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs,Committee on Science, Technology, and Law,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.

Animal Experimentation

Kathrin Herrmann,Kimberley Jayne
Animal Experimentation Book PDF

Author : Kathrin Herrmann,Kimberley Jayne
Publisher : Unknown
Page : 0 pages
File Size : 40,9 Mb
Release : 2019
Category : Animal experimentation
ISBN : 9004356185

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Animal Experimentation by Kathrin Herrmann,Kimberley Jayne Pdf

Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.

Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Care Use and Welfare of Marmosets as Animal Models for Gene Editing Based Biomedical Research Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Publisher : National Academies Press
Page : 123 pages
File Size : 47,7 Mb
Release : 2019-08-26
Category : Science
ISBN : 9780309488518

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Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use Pdf

The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.