Novel Anticancer Agents

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Novel Anticancer Agents

Alex A. Adjei,John K. Buolamwini
Novel Anticancer Agents Book PDF

Author : Alex A. Adjei,John K. Buolamwini
Publisher : Academic Press
Page : 464 pages
File Size : 51,8 Mb
Release : 2011-04-28
Category : Medical
ISBN : 9780080537757

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Novel Anticancer Agents by Alex A. Adjei,John K. Buolamwini Pdf

This book offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic anticancer agents. At present, there is no book that provides such an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively. * Addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the field * Presents drug discovery strategies * Discusses regulatory issues surrounding drug development *

Handbook of Anticancer Drugs from Marine Origin

Se-Kwon Kim
Handbook of Anticancer Drugs from Marine Origin Book PDF

Author : Se-Kwon Kim
Publisher : Springer
Page : 805 pages
File Size : 51,7 Mb
Release : 2014-11-27
Category : Science
ISBN : 9783319071459

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Handbook of Anticancer Drugs from Marine Origin by Se-Kwon Kim Pdf

This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.

Anticancer Drugs

Niamh M O’Boyle,Mary J Meegan
Anticancer Drugs Book PDF

Author : Niamh M O’Boyle,Mary J Meegan
Publisher : MDPI
Page : 214 pages
File Size : 48,7 Mb
Release : 2019-10-11
Category : Medical
ISBN : 9783039215867

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Anticancer Drugs by Niamh M O’Boyle,Mary J Meegan Pdf

The past decades have seen major developments in the understanding of the cellular and molecular biology of cancer. Significant progress has been achieved regarding long-term survival for the patients of many cancers with the use of tamoxifen for treatment of breast cancer, treatment of chronic myeloid leukaemia with imatinib, and the success of biological drugs. The transition from cytotoxic chemotherapy to targeted cancer drug discovery and development has resulted in an increasing selection of tools available to oncologists. In this Special Issue of Pharmaceuticals, we highlight the opportunities and challenges in the discovery and design of innovative cancer therapies, novel small-molecule cancer drugs and antibody–drug conjugates, with articles covering a variety of anticancer therapies and potential relevant disease states and applications. Significant efforts are being made to develop and improve cancer treatments and to translate basic research findings into clinical use, resulting in improvements in survival rates and quality of life for cancer patients. We demonstrate the possibilities and scope for future research in these areas and also highlight the challenges faced by scientists in the area of anticancer drug development leading to improved targeted treatments and better survival rates for cancer patients.

Anticancer Agents from Natural Products

Gordon M. Cragg,David G. I. Kingston,David J. Newman
Anticancer Agents from Natural Products Book PDF

Author : Gordon M. Cragg,David G. I. Kingston,David J. Newman
Publisher : CRC Press
Page : 610 pages
File Size : 48,5 Mb
Release : 2005-06-13
Category : Medical
ISBN : 9781420039658

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Anticancer Agents from Natural Products by Gordon M. Cragg,David G. I. Kingston,David J. Newman Pdf

Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen

Medicinal Chemistry of Anticancer Drugs

Carmen Avendaño,J. Carlos Menéndez
Medicinal Chemistry of Anticancer Drugs Book PDF

Author : Carmen Avendaño,J. Carlos Menéndez
Publisher : Elsevier
Page : 767 pages
File Size : 54,8 Mb
Release : 2015-06-11
Category : Science
ISBN : 9780444626677

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Medicinal Chemistry of Anticancer Drugs by Carmen Avendaño,J. Carlos Menéndez Pdf

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Advances in Anticancer Agents in Medicinal Chemistry

Michelle Prudhomme
Advances in Anticancer Agents in Medicinal Chemistry Book PDF

Author : Michelle Prudhomme
Publisher : Bentham Science Publishers
Page : 495 pages
File Size : 53,6 Mb
Release : 2013-06-14
Category : Medical
ISBN : 9781608054961

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Advances in Anticancer Agents in Medicinal Chemistry by Michelle Prudhomme Pdf

Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The second Volume of this eBook series gathers updated reviews on several classes of molecules exhibiting anticarcinogenic potential as well as some important targets for the development of novel anticancer drugs.

Chemistry and Pharmacology of Anticancer Drugs

David E. Thurston
Chemistry and Pharmacology of Anticancer Drugs Book PDF

Author : David E. Thurston
Publisher : CRC Press
Page : 312 pages
File Size : 42,6 Mb
Release : 2006-11-22
Category : Medical
ISBN : 9781420008906

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Chemistry and Pharmacology of Anticancer Drugs by David E. Thurston Pdf

While drug therapies developed in the last 50 years have markedly improved the management of some types of cancers, treatment outcomes, and drug side-effects for the most common types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells.

Novel Anticancer Drug Protocols

John K. Buolamwini,Alex A. Adjei
Novel Anticancer Drug Protocols Book PDF

Author : John K. Buolamwini,Alex A. Adjei
Publisher : Springer Science & Business Media
Page : 349 pages
File Size : 47,6 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9781592593804

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Novel Anticancer Drug Protocols by John K. Buolamwini,Alex A. Adjei Pdf

We are in an exciting era in the war against cancer, with real prospects for novel anticancer drugs that are cancer cell-specific without the toxicities that have been the hallmark of conventional cytotoxic cancer chemotherapy. Advances in cancer cell biology fueled by the molecular biology revolution have resulted in the uncovering of many novel potential molecular targets for cancer therapy. New anticancer drug discovery and development is now largely focused on exploiting these new molecular targets, which encompass oncogenes, tumor s- pressor genes, and their gene products, as well as targets involved in tumor angiogenesis, metastasis, survival, and longevity mechanisms. Exploitation of some of these targets has already yielded fruits and introduced new paradigms of molecularly targeted cancer therapy into the clinic, namely, protein kinase in- bition by antibodies or small molecules, exemplified by Herceptin® (trastuzumab), a humanized antibody targeted against the HER-2 growth factor receptor tyrosine kinase for the treatment of metastatic breast cancer; and Gleevec, a small molecule bcr-abl kinase inhibitor for the treatment of chronic myel- enous leukemia.

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents

Manju Rawat Singh,Deependra Singh,Jagat Kanwar,Nagendra Singh Chauhan
Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents Book PDF

Author : Manju Rawat Singh,Deependra Singh,Jagat Kanwar,Nagendra Singh Chauhan
Publisher : Academic Press
Page : 657 pages
File Size : 53,8 Mb
Release : 2020-04-07
Category : Business & Economics
ISBN : 9780128199183

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Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents by Manju Rawat Singh,Deependra Singh,Jagat Kanwar,Nagendra Singh Chauhan Pdf

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications. Advances information on various bioactive based medications, their sources, clinical consequences and transport strategies Illustrates diverse transport systems for bioactives and derivatives, novel techniques for formulations, targeting strategies and fundamental qualities of developed bioactive carriers, and their safety concerns and standardization Discusses distinctive transport systems, stability, upgraded dissolvability, and enhanced bioavailability of bioactives

Chemistry and Pharmacology of Anticancer Drugs

David E. Thurston,Ilona Pysz
Chemistry and Pharmacology of Anticancer Drugs Book PDF

Author : David E. Thurston,Ilona Pysz
Publisher : CRC Press
Page : 834 pages
File Size : 53,9 Mb
Release : 2021-03-18
Category : Medical
ISBN : 9781315357089

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Chemistry and Pharmacology of Anticancer Drugs by David E. Thurston,Ilona Pysz Pdf

While drug therapies developed in the last 80 years have markedly improved treatment outcomes and the management of some types of cancers, the lack of effectiveness and side effects associated with the most common treatment types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents and therapeutic approaches currently in use or in advanced stages of clinical trials, including biological-based therapies. The book is unique in providing molecular structures for all anticancer agents, discussing them in terms of history of development, chemistry, mechanism of action, structure–function relationships, and pharmacology. It also provides relevant information on side effects, dosing, and formulation. The authors, renowned scientists in cancer research and drug discovery, also provide up-to-date information on the drug discovery process, including discussions of new research tools, tumor-targeting strategies, and fundamental concepts in the relatively new areas of precision medicine and chemoprevention. Chemistry and Pharmacology of Anticancer Drugs is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists involved in the development of new anticancer therapies. Its breadth of coverage, clear explanations, and illustrations also make it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, dentistry, nutrition, the biomedical sciences, and related disciplines. Key Features: Summarizes the fundamental causes of cancer, modes of treatment, and strategies for cancer drug discovery Brings together a broad spectrum of information relating to the chemistry and pharmacology of all families of anticancer agents and therapies Includes up-to-date information on cutting-edge aspects of cancer treatments such as biomarkers, pharmacogenetics, and pharmacogenomics Features new chapters on the "Evolution of Anticancer Therapies", "Antibody-Based Therapies", and "Cancer Chemoprevention"

Anticancer Agents from Natural Products, Second Edition

Gordon M. Cragg,David G. I. Kingston,David J. Newman
Anticancer Agents from Natural Products Second Edition Book PDF

Author : Gordon M. Cragg,David G. I. Kingston,David J. Newman
Publisher : CRC Press
Page : 786 pages
File Size : 43,6 Mb
Release : 2011-10-10
Category : Science
ISBN : 9781439813829

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Anticancer Agents from Natural Products, Second Edition by Gordon M. Cragg,David G. I. Kingston,David J. Newman Pdf

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

Heterocyclic Anticancer Agents

Bimal Krishna Banik,Bubun Banerjee
Heterocyclic Anticancer Agents Book PDF

Author : Bimal Krishna Banik,Bubun Banerjee
Publisher : Walter de Gruyter GmbH & Co KG
Page : 532 pages
File Size : 52,5 Mb
Release : 2022-06-21
Category : Science
ISBN : 9783110735772

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Heterocyclic Anticancer Agents by Bimal Krishna Banik,Bubun Banerjee Pdf

Cancer is an incredibly diverse and difficult disease to treat, and even after decades of research there is no definitive cure. Therefore, it is highly crucial to search for novel and new organic molecules with high potency, low toxicity, and low mutagenicity with selective anticancer properties that are able to overcome frequently developed resistance to available drugs. Heterocyclic anticancer agents are an important class of drugs for cancer therapies. This book explores different heterocycles and their use as anticancer therapies. Topics covered include different heterocyclic derivatives, the impact of heterocycles on anticancer agent development, and naturally occurring heterocycles.

Novel Designs of Early Phase Trials for Cancer Therapeutics

Shivaani Kummar,Chris Takimoto
Novel Designs of Early Phase Trials for Cancer Therapeutics Book PDF

Author : Shivaani Kummar,Chris Takimoto
Publisher : Academic Press
Page : 234 pages
File Size : 50,7 Mb
Release : 2018-05-22
Category : Medical
ISBN : 9780128125700

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Novel Designs of Early Phase Trials for Cancer Therapeutics by Shivaani Kummar,Chris Takimoto Pdf

Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses topics such as statistical perspectives on cohort expansions, the role and application of molecular profiling and how to integrate biomarkers in early phase trials. Additionally, it discusses how to incorporate patient reported outcomes in phase one trials. This book is a valuable resource for medical oncologists, basic and translational biomedical scientists, and trainees in oncology and pharmacology who are interested in learning how to improve their research by using early phase trials. Brings a comprehensive review and recommendations for new clinical trial designs for modern cancer therapeutics Provides the reader with a better understanding on how to design and implement early phase oncology trials Presents a better and updated understanding of the process of developing new treatments for cancer, the exciting scientific advances and how they are informing drug development

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Loutfy H. Madkour
Nucleic Acids as Gene Anticancer Drug Delivery Therapy Book PDF

Author : Loutfy H. Madkour
Publisher : Academic Press
Page : 650 pages
File Size : 52,7 Mb
Release : 2019-08-27
Category : Business & Economics
ISBN : 9780128197783

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Nucleic Acids as Gene Anticancer Drug Delivery Therapy by Loutfy H. Madkour Pdf

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Advances in Anticancer Agents in Medicinal Chemistry

Michelle Prudhomme,Atta-ur-Rahman,M. Iqbal Choudhary,Allen B. Reitz,Jizhou Wang
Advances in Anticancer Agents in Medicinal Chemistry Book PDF

Author : Michelle Prudhomme,Atta-ur-Rahman,M. Iqbal Choudhary,Allen B. Reitz,Jizhou Wang
Publisher : Unknown
Page : 128 pages
File Size : 53,7 Mb
Release : 2013-06-14
Category : Medical
ISBN : 1608057151

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Advances in Anticancer Agents in Medicinal Chemistry by Michelle Prudhomme,Atta-ur-Rahman,M. Iqbal Choudhary,Allen B. Reitz,Jizhou Wang Pdf

Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The second Volume of this eBook series