Nucleic Acids As Gene Anticancer Drug Delivery Therapy

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Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Loutfy H. Madkour
Nucleic Acids as Gene Anticancer Drug Delivery Therapy Book PDF

Author : Loutfy H. Madkour
Publisher : Academic Press
Page : 650 pages
File Size : 45,5 Mb
Release : 2019-08-27
Category : Business & Economics
ISBN : 9780128197783

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Nucleic Acids as Gene Anticancer Drug Delivery Therapy by Loutfy H. Madkour Pdf

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Nucleic Acid Therapeutics in Cancer

Alan M. Gewirtz
Nucleic Acid Therapeutics in Cancer Book PDF

Author : Alan M. Gewirtz
Publisher : Springer Science & Business Media
Page : 271 pages
File Size : 40,6 Mb
Release : 2004-03-25
Category : Medical
ISBN : 9781592597772

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Nucleic Acid Therapeutics in Cancer by Alan M. Gewirtz Pdf

A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, and strategies for targeting these molecules to accessible regions within the mRNA. They also provide some examples of how these new therapeutic compounds are being used clinically.

Pharmaceutical Perspectives of Nucleic Acid-Based Therapy

Ram I. Mahato,Sung Wan Kim
Pharmaceutical Perspectives of Nucleic Acid Based Therapy Book PDF

Author : Ram I. Mahato,Sung Wan Kim
Publisher : CRC Press
Page : 521 pages
File Size : 55,6 Mb
Release : 2002-06-27
Category : Medical
ISBN : 9780203300961

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Pharmaceutical Perspectives of Nucleic Acid-Based Therapy by Ram I. Mahato,Sung Wan Kim Pdf

Emphasizing its uses in cancer and cardiovascular and autoimmune diseases, Pharmaceutical Perspectives of Nucleic Acid-Based Therapy presents a comprehensive account of gene therapy, from development in the laboratory to clinical applications. Internationally acclaimed scientists discuss the potential use of lipids, peptides and polymers for the in

Nanotechnology for the Delivery of Therapeutic Nucleic Acids

Dan Peer
Nanotechnology for the Delivery of Therapeutic Nucleic Acids Book PDF

Author : Dan Peer
Publisher : CRC Press
Page : 240 pages
File Size : 50,9 Mb
Release : 2013-03-27
Category : Medical
ISBN : 9789814411059

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Nanotechnology for the Delivery of Therapeutic Nucleic Acids by Dan Peer Pdf

Nucleic acid (NA) therapeutics has been extensively studied both in the academia and in the pharmaceutical industry and is still considered the promise for new therapeutic modalities, especially in personalized medicine. The only hurdle that limits the translation of NA therapeutics from an academic idea to the new therapeutic modality is the lack of efficient and safe delivery strategies. Nanotechnology for the Delivery of Therapeutic Nucleic Acids, written by world experts in the field of nanotechnology for NA delivery, the contributing authors bring together the state of the art in delivery strategies with strong emphasis on aspects that are of essence to the pharmaceutical industry, such as stability, general toxicity, immune-toxicity, pharmacokinetics, efficacy, and validation of new drug targets using unique approaches based on exquisite nanotechnology strategies.

Therapeutic Oligonucleotides

Jens Kurreck
Therapeutic Oligonucleotides Book PDF

Author : Jens Kurreck
Publisher : Royal Society of Chemistry
Page : 362 pages
File Size : 47,6 Mb
Release : 2008
Category : Medical
ISBN : 9780854041169

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Therapeutic Oligonucleotides by Jens Kurreck Pdf

This book provides a compelling overall update on current status of RNA interference

Synthetic Nucleic Acids as Inhibitors of Gene Expression

Levon Michael Khachigian
Synthetic Nucleic Acids as Inhibitors of Gene Expression Book PDF

Author : Levon Michael Khachigian
Publisher : CRC Press
Page : 200 pages
File Size : 53,6 Mb
Release : 2004-11-29
Category : Science
ISBN : 9781420037890

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Synthetic Nucleic Acids as Inhibitors of Gene Expression by Levon Michael Khachigian Pdf

In the post-genomic era we have, at our fingertips, an incredible array of genomic sequences from a multitude of complex organisms. There remains, however, the critical need to understand the precise roles individual genes play in complex biological milieu. Synthetic nucleic acids are at the cutting-edge of molecular strategies that target genes of interest in a specific, efficient and cost-effective manner. These tools are now being used as new and exciting gene-silencing agents in vitro, in a panoply of animal models, and as novel therapeutics in human disease. Synthetic Nucleic Acids as Inhibitors of Gene Expression: Mechanisms, Applications, and Therapeutic Implications brings together timely, authoritative reviews by renowned international leaders in the fields of ribozymes, RNA interference, DNAzymes and oligonucleotide decoys, with emphasis on biochemistry and translational research. The chapters on ribozymes include discussions of ribozyme subtypes, structure-function aspects, and therapeutic applications. This is followed by a comprehensive discussion of DNAzymes, their various subtypes, kinetics and biochemistry, and applications in target validation. Finally, the mechanisms and multiple therapeutic applications of double-stranded oligonucleotide decoys are described. For readers ranging from graduate students to researchers seeking target validation for pharmaceuticals to clinicians seeking innovative cancer and cardiovascular therapies, no resource is more complete and up to date than Synthetic Nucleic Acids as Inhibitors of Gene Expression: Mechanisms, Applications and Therapeutic Implications.

Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer

Chad A. Mirkin,Thomas J. Meade,Sarah Hurst Petrosko,Alexander H. Stegh
Nanotechnology Based Precision Tools for the Detection and Treatment of Cancer Book PDF

Author : Chad A. Mirkin,Thomas J. Meade,Sarah Hurst Petrosko,Alexander H. Stegh
Publisher : Springer
Page : 322 pages
File Size : 54,7 Mb
Release : 2015-04-20
Category : Medical
ISBN : 9783319165554

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Nanotechnology-Based Precision Tools for the Detection and Treatment of Cancer by Chad A. Mirkin,Thomas J. Meade,Sarah Hurst Petrosko,Alexander H. Stegh Pdf

This book discusses emerging nanotechnology-based tools that have the potential to dramatically impact cancer research, diagnostics, and treatment. Cancer is a complex, devastating, and debilitating disease and, although much progress has been made, novel, more effective diagnostic and treatment options are still needed, especially for advanced cancers. The ultimate goal is to detect cancer early and non-invasively and to provide efficacious and targeted precision treatments that cause fewer harmful side effects. This book explains how nanotechnology can exploit the size-, shape-, and composition-dependent properties of nanomaterials to provide novel tools for precision cancer medicine. It will be of interest to researchers and professionals working in the fields of chemistry, biology, materials science and engineering, and medicine who want to learn more about this fascinating and fast-paced area of research.

Advanced Drug Delivery Systems in the Management of Cancer

Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Advanced Drug Delivery Systems in the Management of Cancer Book PDF

Author : Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Publisher : Elsevier
Page : 572 pages
File Size : 40,7 Mb
Release : 2021-06-24
Category : Business & Economics
ISBN : 9780323900799

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Advanced Drug Delivery Systems in the Management of Cancer by Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone Pdf

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Nanotechnology for Nucleic Acid Delivery

Manfred Ogris,David Oupicky
Nanotechnology for Nucleic Acid Delivery Book PDF

Author : Manfred Ogris,David Oupicky
Publisher : Humana Press
Page : 300 pages
File Size : 50,7 Mb
Release : 2016-05-01
Category : Science
ISBN : 1493959328

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Nanotechnology for Nucleic Acid Delivery by Manfred Ogris,David Oupicky Pdf

This Methods in Molecular Biology series book covers nanoparticulate delivery of nucleic acids in terms of biosafety, particle synthesis as well as its application in cell culture. Includes materials and reagents, protocols, notes on troubleshooting and more."

Nanopharmaceuticals: Principles and Applications Vol. 3

Vinod Kumar Yata,Shivendu Ranjan,Nandita Dasgupta,Eric Lichtfouse
Nanopharmaceuticals Principles and Applications Vol 3 Book PDF

Author : Vinod Kumar Yata,Shivendu Ranjan,Nandita Dasgupta,Eric Lichtfouse
Publisher : Springer Nature
Page : 340 pages
File Size : 40,6 Mb
Release : 2020-08-19
Category : Technology & Engineering
ISBN : 9783030471200

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Nanopharmaceuticals: Principles and Applications Vol. 3 by Vinod Kumar Yata,Shivendu Ranjan,Nandita Dasgupta,Eric Lichtfouse Pdf

This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Bionanotechnology in Cancer

D. Sakthi Kumar,Aswathy Ravindran Girija
Bionanotechnology in Cancer Book PDF

Author : D. Sakthi Kumar,Aswathy Ravindran Girija
Publisher : CRC Press
Page : 592 pages
File Size : 53,8 Mb
Release : 2022-10-27
Category : Medical
ISBN : 9780429750403

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Bionanotechnology in Cancer by D. Sakthi Kumar,Aswathy Ravindran Girija Pdf

The cancer research world is looking forward to bionanotechnology to find the best solutions for a complete cure from cancer, which is not possible with the current established treatment methods. The past decade of research on nano imaging and drug delivery in cancer has witnessed many interesting papers and reviews, but there has not been a concise resource that discusses all fields related to nano cancer research in diagnosis and drug delivery. This book fills this gap and presents the latest bionano research in cancer, focusing on nanodiagnostics and nanotherapy. The book is organized into two sections. The section on nanodiagnostics focuses on topics such as diagnostic methods in cancer-related therapy and use of radiolabeled nanoparticles, magnetic nanoparticles, acoustically reflective nanoparticles, X-ray computed tomography, and optical nanoprobes for diagnosis. The section on nanotherapy focuses on nanomaterials in chemotherapy, magnetic nanoparticles for hyperthermia against cancer, phototherapy, nanotechnology-mediated radiation therapy, nanoparticle-mediated small-RNA deliveries for molecular therapies, and theranostics. The book will serve as the gateway to enter the beautiful and elegant field of bionanoscience, which is considered the last hope for the fight against cancer and will be a highly useful resource for the students, researchers, teachers, and curious readers working in this field or related fields.

Nanomedicine for Drug Delivery and Therapeutics

Ajay Kumar Mishra
Nanomedicine for Drug Delivery and Therapeutics Book PDF

Author : Ajay Kumar Mishra
Publisher : John Wiley & Sons
Page : 372 pages
File Size : 40,7 Mb
Release : 2013-02-01
Category : Science
ISBN : 9781118635841

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Nanomedicine for Drug Delivery and Therapeutics by Ajay Kumar Mishra Pdf

This book describes a broad area of nanomedicine which involves mainly applications, diseases, and diagnostics. The comprehensive coverage provides researchers, academics, and health specialists with a great tool, that includes techniques applicable to various uses.

DNA-targeting Molecules as Therapeutic Agents

Michael J Waring
DNA targeting Molecules as Therapeutic Agents Book PDF

Author : Michael J Waring
Publisher : Royal Society of Chemistry
Page : 432 pages
File Size : 46,5 Mb
Release : 2018-03-08
Category : Science
ISBN : 9781788014281

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DNA-targeting Molecules as Therapeutic Agents by Michael J Waring Pdf

There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.

Nucleic Acid Drugs

Akira Murakami
Nucleic Acid Drugs Book PDF

Author : Akira Murakami
Publisher : Springer
Page : 180 pages
File Size : 51,9 Mb
Release : 2012-07-04
Category : Technology & Engineering
ISBN : 9783642304637

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Nucleic Acid Drugs by Akira Murakami Pdf

New Antisense Strategies: Chemical Synthesis of RNA Oligomers, by Junichi Yano und Gerald E. Smyth Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application, by Mariana Kiomy Osako, Hironori Nakagami und Ryuichi Morishita Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides, by Ekambar R. Kandimalla und Sudhir Agrawal Delivery of Nucleic Acid Drugs, by Yan Lee und Kazunori Kataoka Aptamer: Biology to Applications, by Yoshikazu Nakamura Development and Clinical Applications of Nucleic Acid Therapeutics, by Veenu Aishwarya, Anna Kalota und Alan M. Gewirtz

Minicircle and Miniplasmid DNA Vectors

Martin Schleef
Minicircle and Miniplasmid DNA Vectors Book PDF

Author : Martin Schleef
Publisher : John Wiley & Sons
Page : 373 pages
File Size : 43,5 Mb
Release : 2013-02-14
Category : Science
ISBN : 9783527670444

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Minicircle and Miniplasmid DNA Vectors by Martin Schleef Pdf

This first title on the topic provides complete coverage, including the molecular basis, production and possible biomedical applications. Written by the most prominent academic researchers in the field as well as by researchers at one of the world's leading companies in industrial production of minicircle DNA, this practical book is aimed at everyone who is directly or indirectly involved in the development of gene therapies.