Novel Strategies Targeting Obesity And Metabolic Diseases Volume Ii

Author : Xinran Ma,Lingyan Xu,Yan Lu,Dechun Feng,Nuo Sun,Jiqiu Wang
Publisher : Frontiers Media SA
Page : 126 pages
File Size : 48,8 Mb
Release : 2024-02-08
Category : Science
ISBN : 9782832544495

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Novel Strategies Targeting Obesity and Metabolic Diseases, Volume II by Xinran Ma,Lingyan Xu,Yan Lu,Dechun Feng,Nuo Sun,Jiqiu Wang Pdf

This Research Topic is part of the Novel Strategies Targeting Obesity and Metabolic Diseases series (Volume I). The 21st century features excessive food availability and prevalent sedentary lifestyle. Unsurprisingly, obesity has become one of the most serious problems threatening public health with a staggering morbidity/mortality rate. Obesity is the leading risk factor for a series of metabolic diseases, i.e. diabetes, cardiovascular disease, hypertension, non-alcoholic hepatic steatosis, osteoporosis and certain types of cancer. Although, theoretically, body weight could be easily controlled by the balance of food intake and caloric burning, the rapid and stressful pace of modern society has made the healthy life style of eating less and exercising more hard to achieve its popularity. Pharmacotherapeutic solutions targeting appetite or energy expenditure are limited and often with undesired and sometimes dangerous side effects. The problem becomes even more complicated when genetic susceptibility for obesity is taken into account. In result, till now, the long and intense battle for obesity-intervention still wages and we are in urgent need for effective weight-losing strategies.

Author : Xinran Ma,Dechun Feng,Yan Lu,Nuo Sun,Jiqiu Wang,Lingyan Xu
Publisher : Frontiers Media SA
Page : 169 pages
File Size : 49,5 Mb
Release : 2019-10-09
Category : Electronic
ISBN : 9782889630417

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Novel Strategies Targeting Obesity and Metabolic Diseases by Xinran Ma,Dechun Feng,Yan Lu,Nuo Sun,Jiqiu Wang,Lingyan Xu Pdf

Author : Dorairaj Prabhakaran,Shuchi Anand,Thomas A. Gaziano,Jean-Claude Mbanya,Rachel Nugent
Publisher : World Bank Publications
Page : 466 pages
File Size : 52,6 Mb
Release : 2017-11-17
Category : Medical
ISBN : 9781464805202

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Disease Control Priorities, Third Edition (Volume 5) by Dorairaj Prabhakaran,Shuchi Anand,Thomas A. Gaziano,Jean-Claude Mbanya,Rachel Nugent Pdf

Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantial burden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significant economic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at the clinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed. This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs.

Author : Debasis Bagchi,Sreejayan Nair
Publisher : Academic Press
Page : 553 pages
File Size : 46,6 Mb
Release : 2012-01-31
Category : Health & Fitness
ISBN : 9780123850836

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Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome by Debasis Bagchi,Sreejayan Nair Pdf

Diabetes mellitus affects approximately 20 million people in the US, or nearly 7% of the population. It is expected to increase by 70% within the next 25 years, and numerous epidemiologic studies have demonstrated that type 2 diabetes increases the risk of cardiovascular morbidity and mortality. It is estimated to cost over $92 billion in health care costs and lost productivity. The increased risk is due to the detrimental vascular effects of prolonged exposure to a hyperglycemic, oxidant-rich environment yielding associated cardiovascular risk factors: atherosclerosis, hypertension and clotting abnormalities. Hypertension and dyslipidemia in diabetic patients produces substantial decreases in cardiovascular and microvascular diseases. Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome provides an overview of the current epidemic, outlines the consequences of this crisis and lays out strategies to forestall and prevent diabetes, obesity and other intricate issues of metabolic syndrome. The contributing experts from around the world give this book relevant and up-to-date global approaches to the critical consequences of metabolic syndrome and make it an important reference for those working with the treatment, evaluation or public health planning for the effects of metabolic syndrome and diabetes. Scientific discussion of the epidemiology and pathophysiology of the relationship between diabetes and metabolic syndrome Includes coverage of Pre-diabetes conditions plus both Type I and Type II Diabetes Presents both prevention and treatment options

Author : Institute of Medicine,Committee to Develop Criteria for Evaluating the Outcomes of Approaches to Prevent and Treat Obesity
Publisher : National Academies Press
Page : 296 pages
File Size : 54,8 Mb
Release : 1995-03-01
Category : Medical
ISBN : 9780309132572

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Weighing the Options by Institute of Medicine,Committee to Develop Criteria for Evaluating the Outcomes of Approaches to Prevent and Treat Obesity Pdf

Nearly one out of every three adults in America is obese and tens of millions of people in the United States are dieting at any one time. This has resulted in a weight-loss industry worth billions of dollars a year and growing. What are the long-term results of weight-loss programs? How can people sort through the many programs available and select one that is right for them? Weighing the Options strives to answer these questions. Despite widespread public concern about weight, few studies have examined the long-term results of weight-loss programs. One reason that evaluating obesity management is difficult is that no other treatment depends so much on an individual's own initiative and state of mind. Now, a distinguished group of experts assembled by the Institute of Medicine addresses this compelling issue. Weighing the Options presents criteria for evaluating treatment programs for obesity and explores what these criteria meanâ€"to health care providers, program designers, researchers, and even overweight people seeking help. In presenting its criteria the authors offer a wealth of information about weight loss: how obesity is on the rise, what types of weight-loss programs are available, how to define obesity, how well we maintain weight loss, and what approaches and practices appear to be most successful. Information about weight-loss programsâ€"their clients, staff qualifications, services, and success ratesâ€"necessary to make wise program choices is discussed in detail. The book examines how client demographics and characteristicsâ€"including health status, knowledge of weight-loss issues, and attitude toward weight and body imageâ€"affect which programs clients choose, how successful they are likely to be with their choices, and what this means for outcome measurement. Short- and long-term safety consequences of weight loss are discussed as well as clinical assessment of individual patients. The authors document the health risks of being overweight, summarizing data indicating that even a small weight loss reduces the risk of disease and depression and increases self-esteem. At the same time, weight loss has been associated with some poor outcomes, and the book discusses the implications for program evaluation. Prevention can be even more important than treatment. In Weighing the Options, programs for population groups, efforts targeted to specific groups at high risk for obesity, and prevention of further weight gain in obese individuals get special attention. This book provides detailed guidance on how the weight-loss industry can improve its programs to help people be more successful at long-term weight loss. And it provides consumers with tips on selecting a program that will improve their chances of permanently losing excess weight.

Author : Soo-Kyoung Choi,María Galán,Modar Kassan
Publisher : Frontiers Media SA
Page : 145 pages
File Size : 50,6 Mb
Release : 2023-02-10
Category : Science
ISBN : 9782832514269

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Diabetes, hypertension and cardiovascular diseases, volume II by Soo-Kyoung Choi,María Galán,Modar Kassan Pdf

Author : Debasis Bagchi
Publisher : Academic Press
Page : 506 pages
File Size : 45,9 Mb
Release : 2019-02-06
Category : Medical
ISBN : 9780128128411

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Global Perspectives on Childhood Obesity by Debasis Bagchi Pdf

Global Perspectives on Childhood Obesity: Current Status, Consequences and Prevention, Second Edition examines the current childhood obesity epidemic, outlines the consequences of this crisis, and develops strategies to forestall and prevent it. This book provides a thorough investigation of the causes of childhood obesity and, more importantly, offers specific prevention strategies that can be used by medical and mental health professionals, policymakers, community organizers, and individuals. New chapters on BMI and cardiovascular disease, exercise, neurotransmitters, neurocognition, nutrigenomics and combined prevention strategies are included, making this a solid introduction on the childhood obesity crisis. Researchers, practitioners, and advanced students in public health, health policy, and health economics, as well those working in medicine, pharmacy, nutrition, school health, physiology, and neuroscience related to obesity will find this to be a comprehensive resource. Covers the multifaceted factors contributing to the rapidly growing childhood obesity epidemic Includes new chapters on BMI and cardiovascular disease, exercise, neurotransmitters, self-regulation, and prevention strategies Examines strategies for childhood obesity prevention and treatment, such as physical activity and exercise, personalized nutrition plans, and school and community involvement

Author : Alan W. Partin,Louis R. Kavoussi,Craig A. Peters,Roger R. Dmochowski
Publisher : Elsevier Health Sciences
Page : 898 pages
File Size : 51,7 Mb
Release : 2021-11-22
Category : Medical
ISBN : 9780323827485

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Campbell Walsh Wein Handbook of Urology by Alan W. Partin,Louis R. Kavoussi,Craig A. Peters,Roger R. Dmochowski Pdf

Brush up on important clinical topics and prepare for exams or recertification with this easily accessible handbook. Campbell Walsh Wein Handbook of Urology contains essential, reliable information from the same author team as Campbell Walsh Wein Urology, 12th Edition, providing practical, well-illustrated diagnosis and treatment information on a wide range of urological conditions. It’s an ideal resource for residents, practitioners, and nurse practitioners in urology who need quick access to key clinical information in a concise, easy-to-read format. Find information quickly and easily with a high-yield, templated format that includes numerous algorithms, tables, and figures. Effectively review for the boards or recertification using the self-assessment questions at the end of each chapter. Stay abreast of new AUA and ICI incontinence guidelines as well as up-to-date information on incontinence treatment recommendations, therapy for castrate-resistant prostate cancer, and active surveillance for prostate cancer. Focus on hot topics in urology including stress and mixed urinary incontinence, therapy for prolapse, overactive bladder, male subfertility and androgen deficiency, and renal cell carcinoma. Review the major categories of urologic diseases along with integrated content on radiology, radiation therapy, nephrology, pediatric urology, transplantation surgery, and vascular surgery.

Author : James M. Rippe,John P. Foreyt
Publisher : CRC Press
Page : 236 pages
File Size : 52,6 Mb
Release : 2021-09-23
Category : Health & Fitness
ISBN : 9781000456622

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Obesity Prevention and Treatment by James M. Rippe,John P. Foreyt Pdf

The World Health Organization estimates that there are 2.1 billion individuals with obesity globally. Nearly three quarters of adults in the United States are overweight or obese. The average individual with obesity cuts ten years off their life expectancy, yet less than 40% of physicians routinely counsel individuals concerning the adverse health consequences of obesity. Obesity Prevention and Treatment: A Practical Guide equips healthcare practitioners to include effective weight management counselling in the daily practice of medicine. Written by lifestyle medicine pioneer and cardiologist, Dr. James Rippe and obesity expert Dr. John Foreyt, this book provides evidence-based discussions of obesity and its metabolic consequences. A volume in the Lifestyle Medicine Series, it provides evidence-based information about the prevention and treatment of obesity through lifestyle measures, such as regular physical activity and sound nutrition, as well as the use of new medications or bariatric surgery available to assist in weight management. Provides a framework and practical strategies to assist practitioners in safe and effective treatments of obesity. Contains information explaining the relationship between obesity and increased risk of heart disease, diabetes, cancer, osteoarthritis, and other chronic conditions. Chapters begin with bulleted key points and conclude with a list of Clinical Applications. Written for practitioners at all levels, this user-friendly, evidence-based book on obesity prevention and treatment will be valuable to practitioners in general medicine or subspecialty practices.

Author : Thomas Seyfried
Publisher : John Wiley & Sons
Page : 482 pages
File Size : 43,5 Mb
Release : 2012-05-18
Category : Science
ISBN : 9781118310304

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Cancer as a Metabolic Disease by Thomas Seyfried Pdf

The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Author : Zhiguo Wang,Baofeng Yang
Publisher : Springer Nature
Page : 870 pages
File Size : 45,5 Mb
Release : 2022-08-01
Category : Medical
ISBN : 9783031049989

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Polypharmacology by Zhiguo Wang,Baofeng Yang Pdf

There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.

Author : Masayuki Miyasaka,Kiyoshi Takatsu
Publisher : Springer
Page : 702 pages
File Size : 44,6 Mb
Release : 2016-11-01
Category : Medical
ISBN : 9784431560685

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Chronic Inflammation by Masayuki Miyasaka,Kiyoshi Takatsu Pdf

This book provides readers with the most up-to-date information on cutting-edge research concerning chronic inflammation. We now know that when inflammation becomes chronic, it acts as a strong disease-promoting factor in a variety of disorders including arteriosclerosis, obesity, cancer, and Alzheimer disease. Chronic inflammation is hence called as the “silent killer”; it upsets the body’s homeostatic mechanism insidiously. In spite of these developments, we know very little about the mechanism underlying chronic inflammation. Particularly, we do not know precisely what induces chronic inflammation or what promotes its prolongation in a spatiotemporal framework. Neither do we have clear knowledge about how chronic inflammation destroys various tissues or how it predisposes individuals to many different diseases. To make the situation worse, we have no effective treatment against chronic inflammation. Since 2010, two major research programs (CREST and PRESTO) aimed at clarifying the mechanisms underlying chronic inflammation were launched in Japan, and investigators of different research areas with a brilliant track record were selected by their research proposals. Subsequently they have made their best efforts to answer the conundrum concerning chronic inflammation. This book is a compendium of such research efforts. In each chapter, the CREST- or PRESTO-funded researchers summarize their original work concerning mechanisms of induction, progression, or resolution underlying chronic inflammation. The most emphasized characteristic is the molecular aspect of chronic inflammation. The book thus presents the most recent progress made in the molecular understanding of chronic inflammation.

Author : Che-Pei Kung,Maureen E. Murphy,Hua Lu
Publisher : Frontiers Media SA
Page : 130 pages
File Size : 48,7 Mb
Release : 2019-09-23
Category : Electronic
ISBN : 9782889630301

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Double-edged Swords: Genetic Factors That Influence the Pathogenesis of Both Metabolic Disease and Cancer by Che-Pei Kung,Maureen E. Murphy,Hua Lu Pdf

Metabolic diseases and cancers account for half of all mortalities in the world, underscoring the significance of understanding the etiology of these diseases and developing effective therapies. Genomic research in the 21st century has brought cancer and metabolic disease, two once seemingly parallel ailments, as close to each other as they’ve ever been. Many genetic factors have been found to display functions regulating both cancer and metabolic disease. In this research topic: "Double-edged Swords: Genetic Factors That Influence The Pathogenesis of Both MetabolicDisease and Cancer", you will be introduced to individual genes, as well as genetic pathways that play important roles in influencing the progression of both metabolic disease and cancer. By no means covering an exhaustive list of genes qualified, this collection of articles rather serves as a precursor of what is yet to come in biomedical research. It paints the big picture of one of the major fields contributing to the future of “precision medicine”.

Author : John P. H. Wilding
Publisher : Springer Science & Business Media
Page : 127 pages
File Size : 44,8 Mb
Release : 2008-01-08
Category : Medical
ISBN : 9783764374259

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Pharmacotherapy of Obesity by John P. H. Wilding Pdf

After three introductory chapters that deal with the general theme of obesity – now regarded as a chronic disease – this volume discusses the drugs sibutramine and orlistat, which are approved for long-term use in the US and in much of the rest of the world. The three final chapters discuss future drug targets, like the central nervous system and gut hormones, and how to influence energy expenditure and substrate utilization.

Author : Harish Dureja,Narasimha Murthy,Peter Wich,Kamal Dua
Publisher : Academic Press
Page : 527 pages
File Size : 49,6 Mb
Release : 2022-08-26
Category : Business & Economics
ISBN : 9780323996334

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Drug Delivery Systems for Metabolic Disorders by Harish Dureja,Narasimha Murthy,Peter Wich,Kamal Dua Pdf

Drug Delivery Systems for Metabolic Disorders presents the most recent developments on the targeted delivery of drugs to deal with metabolic disorders in a safe, compliant and continuous way. The book covers recent developments in advanced drug delivery systems in various metabolic disorders, including disturbances in protein, lipid, carbohydrate and hormone metabolism and lysosomal and mitochondrial disorders. It provides a brief introduction to metabolic disorders, along with a focus on the current landscape and trends in understanding disease pathology using different in vitro and in vivo models required for clinical applications and developments of new therapeutics. Each subsequent chapter covers drug delivery systems dedicated to metabolic diseases caused by disturbances in protein, lipid, carbohydrate and hormone metabolism. Then, it moves on to cover lysosomal storage disorders and applications of phytopharmaceuticals in this context. This is the perfect reference for researchers in pharmaceutical science who are interested in developing new treatments for metabolic diseases. Offers comprehensive coverage of drug delivery to treat metabolic diseases Provides insights into how advanced drug delivery systems can be effectively used for the management of various types of metabolic disorders Includes the most recent research on diagnostic methods and treatment strategies using controlled drug delivery systems